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  1. Article ; Online: Is a return to nature a piece of the health puzzle?

    Martel, Jan / Ojcius, David M

    Biomedical journal

    2023  Volume 46, Issue 1, Page(s) 8–10

    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Editorial
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2023.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The ins and outs of T cell signaling.

    Kanellopoulos, Jean M / Ojcius, David M

    Biomedical journal

    2022  Volume 45, Issue 2, Page(s) 286–288

    Abstract: This special edition summarizes major advances in our understanding of signaling by T lymphocytes. T cell interactions with antigen-presenting cells (APCs) and other immune cells are characterized by changes in T cell adhesion and major rearrangements of ...

    Abstract This special edition summarizes major advances in our understanding of signaling by T lymphocytes. T cell interactions with antigen-presenting cells (APCs) and other immune cells are characterized by changes in T cell adhesion and major rearrangements of the actin cytoskeleton. This issue describes some of the mediators of these changes both within the T cells and on the T cell surface. The five articles focus on "inside-out integrin signaling" in T cells, components of the immunological synapse between lymphocyte and APCs, an unexpected role for T cell receptor (TCR) signaling from endosomes, transfer of membrane constituents from APCs to T cells via trogocytosis, immune deficiencies in these T cell signaling pathways, and the role of thymocyte-expressed molecule involved in selection (THEMIS) in thymocyte development and peripheral T cell function.
    MeSH term(s) Humans ; Immunological Synapses/metabolism ; Lymphocyte Activation ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction ; T-Lymphocytes
    Chemical Substances Receptors, Antigen, T-Cell
    Language English
    Publishing date 2022-04-14
    Publishing country United States
    Document type Editorial
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2022.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Upward trend for "Microbes and Infection".

    Dussurget, Olivier / Ojcius, David M

    Microbes and infection

    2022  Volume 24, Issue 8, Page(s) 105057

    Language English
    Publishing date 2022-10-01
    Publishing country France
    Document type Editorial
    ZDB-ID 1465093-9
    ISSN 1769-714X ; 1286-4579
    ISSN (online) 1769-714X
    ISSN 1286-4579
    DOI 10.1016/j.micinf.2022.105057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Lifestyle interventions to delay senescence.

    Martel, Jan / Ojcius, David M / Young, John D

    Biomedical journal

    2023  Volume 47, Issue 2, Page(s) 100676

    Abstract: Senescence is a condition of cell cycle arrest that increases inflammation and contributes to the development of chronic diseases in the aging human body. While several compounds described as senolytics and senomorphics produce health benefits by ... ...

    Abstract Senescence is a condition of cell cycle arrest that increases inflammation and contributes to the development of chronic diseases in the aging human body. While several compounds described as senolytics and senomorphics produce health benefits by reducing the burden of senescence, less attention has been devoted to lifestyle interventions that produce similar effects. We describe here the effects of exercise, nutrition, caloric restriction, intermittent fasting, phytochemicals from natural products, prebiotics and probiotics, and adequate sleep on senescence in model organisms and humans. These interventions can be integrated within a healthy lifestyle to reduce senescence and inflammation and delay the consequences of aging.
    Language English
    Publishing date 2023-11-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2023.100676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Senescence: No country for old cells.

    Martel, Jan / Ojcius, David M / Young, John D

    Biomedical journal

    2023  Volume 47, Issue 2, Page(s) 100697

    Language English
    Publishing date 2023-12-29
    Publishing country United States
    Document type Editorial
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2023.100697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Neither B cell nor T cell - The unique group of innate lymphoid cells.

    Kanellopoulos, Jean M / Ojcius, David M

    Biomedical journal

    2021  Volume 44, Issue 2, Page(s) 112–114

    Abstract: This special issue contains four review articles that analyze the development and biology of innate lymphoid cells (ILCs), which are the most recently-discovered group of innate immune cells. This unique group of lymphoid cells lacks the RAG gene and ... ...

    Abstract This special issue contains four review articles that analyze the development and biology of innate lymphoid cells (ILCs), which are the most recently-discovered group of innate immune cells. This unique group of lymphoid cells lacks the RAG gene and consequently does not express B cell nor T cell antigen-specific receptors. They are abundant at mucosal surfaces, where they play a role in immunity and homeostasis. The ILCs are the focus of intensive research efforts to understand their development and function.
    MeSH term(s) B-Lymphocytes ; Cytokines ; Immunity, Innate ; T-Lymphocytes
    Chemical Substances Cytokines
    Language English
    Publishing date 2021-04-16
    Publishing country United States
    Document type Editorial
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2021.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Infection of the oral cavity with SARS-CoV-2 variants: Scope of salivary diagnostics.

    Iyer, Parvati / Chino, Takahiro / Ojcius, David M

    Frontiers in oral health

    2022  Volume 3, Page(s) 1001790

    Abstract: Coronaviruses, including SARS-CoV-2, have caused pandemics in the past two decades. The most prevalent SARS-CoV-2 variants of concern can re-infect individuals who have been previously infected with other variants or had protection from vaccines ... ...

    Abstract Coronaviruses, including SARS-CoV-2, have caused pandemics in the past two decades. The most prevalent SARS-CoV-2 variants of concern can re-infect individuals who have been previously infected with other variants or had protection from vaccines targeting the original SARS-CoV-2 variant. Given the high risk of transmission of coronavirus
    Language English
    Publishing date 2022-10-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2673-4842
    ISSN (online) 2673-4842
    DOI 10.3389/froh.2022.1001790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Scaling the tips of the ALPS.

    Rieux-Laucat, Frédéric / Kanellopoulos, Jean M / Ojcius, David M

    Biomedical journal

    2021  Volume 44, Issue 4, Page(s) 383–387

    Abstract: This special issue contains four review articles that describe advances in analysis of mutations responsible for the autoimmune lymphoproliferative syndrome (ALPS). This disease is triggered by a family of mutations in genes involved in the extrinsic ... ...

    Abstract This special issue contains four review articles that describe advances in analysis of mutations responsible for the autoimmune lymphoproliferative syndrome (ALPS). This disease is triggered by a family of mutations in genes involved in the extrinsic apoptotic pathway such as FAS, FASL and CASP10. Advances in sequencing technology have enabled extended genetic testing of patients with various defects in alternative biological have pathways that can cause ALPS-like syndromes. Various gene mutations were identified which affect the CTLA-4 immune checkpoint, the STAT3 pathway and the RAS/MAPK pathway. Tips gleaned from analyses of the different gene mutations involved in ALPS and ALPS-like syndromes are contributing to a better understanding of their functional consequences. Genetic diagnoses of the disease should help us to identify specific therapeutic targets and design personalized treatment for each patient.
    MeSH term(s) Apoptosis ; Autoimmune Lymphoproliferative Syndrome ; Humans ; Mutation/genetics ; fas Receptor/genetics
    Chemical Substances fas Receptor
    Language English
    Publishing date 2021-08-23
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2021.08.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The role of NOD-like receptors in innate immunity.

    Almeida-da-Silva, Cássio Luiz Coutinho / Savio, Luiz Eduardo Baggio / Coutinho-Silva, Robson / Ojcius, David M

    Frontiers in immunology

    2023  Volume 14, Page(s) 1122586

    Abstract: The innate immune system in vertebrates and invertebrates relies on conserved receptors and ligands, and pathways that can rapidly initiate the host response against microbial infection and other sources of stress and danger. Research into the family of ... ...

    Abstract The innate immune system in vertebrates and invertebrates relies on conserved receptors and ligands, and pathways that can rapidly initiate the host response against microbial infection and other sources of stress and danger. Research into the family of NOD-like receptors (NLRs) has blossomed over the past two decades, with much being learned about the ligands and conditions that stimulate the NLRs and the outcomes of NLR activation in cells and animals. The NLRs play key roles in diverse functions, ranging from transcription of MHC molecules to initiation of inflammation. Some NLRs are activated directly by their ligands, while other ligands may have indirect effects on the NLRs. New findings in coming years will undoubtedly shed more light on molecular details involved in NLR activation, as well as the physiological and immunological outcomes of NLR ligation.
    MeSH term(s) Animals ; NLR Proteins ; Ligands ; Immunity, Innate ; Inflammation ; Carrier Proteins
    Chemical Substances NLR Proteins ; Ligands ; Carrier Proteins
    Language English
    Publishing date 2023-03-15
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1122586
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Development of humoral immunity.

    Kanellopoulos, Jean M / Ojcius, David M

    Biomedical journal

    2019  Volume 42, Issue 4, Page(s) 207–208

    MeSH term(s) Adaptive Immunity/immunology ; Animals ; Antigens/immunology ; Humans ; Immunity, Humoral/immunology ; Immunity, Innate/immunology
    Chemical Substances Antigens
    Language English
    Publishing date 2019-09-17
    Publishing country United States
    Document type Editorial
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2319-4170
    ISSN (online) 2320-2890
    ISSN 2319-4170
    DOI 10.1016/j.bj.2019.08.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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