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Article: Remodeling of Paranasal Sinuses Mucosa Functions in Response to Biofilm-Induced Inflammation.

Kaliniak, Szczepan / Fiedoruk, Krzysztof / Spałek, Jakub / Piktel, Ewelina / Durnaś, Bonita / Góźdź, Stanisław / Bucki, Robert / Okła, Sławomir

Journal of inflammation research

2024 Volume 17, Page(s) 1295–1323

Abstract: Rhinosinusitis (RS) is an acute (ARS) or chronic (CRS) inflammatory disease of the nasal and paranasal sinus mucosa. CRS is a heterogeneous condition characterized by distinct inflammatory patterns (endotypes) and phenotypes associated with the presence ( ...

Abstract	Rhinosinusitis (RS) is an acute (ARS) or chronic (CRS) inflammatory disease of the nasal and paranasal sinus mucosa. CRS is a heterogeneous condition characterized by distinct inflammatory patterns (endotypes) and phenotypes associated with the presence (CRSwNP) or absence (CRSsNP) of nasal polyps. Mucosal barrier and mucociliary clearance dysfunction, inflammatory cell infiltration, mucus hypersecretion, and tissue remodeling are the hallmarks of CRS. However, the underlying factors, their priority, and the mechanisms of inflammatory responses remain unclear. Several hypotheses have been proposed that link CRS etiology and pathogenesis with host (eg, "immune barrier") and exogenous factors (eg, bacterial/fungal pathogens, dysbiotic microbiota/biofilms, or staphylococcal superantigens). The abnormal interplay between these factors is likely central to the pathophysiology of CRS by triggering compensatory immune responses. Here, we discuss the role of the sinonasal microbiota in CRS and its biofilms in the context of mucosal zinc (Zn) deficiency, serving as a possible unifying link between five host and "bacterial" hypotheses of CRS that lead to sinus mucosa remodeling. To date, no clear correlation between sinonasal microbiota and CRS has been established. However, the predominance of Corynebacteria and Staphylococci and their interspecies relationships likely play a vital role in the formation of the CRS-associated microbiota. Zn-mediated "nutritional immunity", exerted via calprotectin, alongside the dysregulation of Zn-dependent cellular processes, could be a crucial microbiota-shaping factor in CRS. Similar to cystic fibrosis (CF), the role of SPLUNC1-mediated regulation of mucus volume and pH in CRS has been considered. We complement the biofilms' "mechanistic" and "mucin" hypotheses behind CRS pathogenesis with the "structural" one - associated with bacterial "corncob" structures. Finally, microbiota restoration approaches for CRS prevention and treatment are reviewed, including pre- and probiotics, as well as Nasal Microbiota Transplantation (NMT).
Language	English
Publishing date	2024-02-26
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2494878-0
ISSN	1178-7031
ISSN	1178-7031
DOI	10.2147/JIR.S443420
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Article: From antimicrobial to anticancer: unraveling the potential of pleurocidin and pleurocidin-derived peptides in the treatment of cancers.

Piktel, Ewelina / Wnorowska, Urszula / Gorbacz-Konończuk, Joanna / Sienkiewicz, Jakub / Głuszek, Katarzyna / Okła, Sławomir / Bucki, Robert

Frontiers in pharmacology

2024 Volume 15, Page(s) 1340029

Abstract: Antimicrobial peptides (AMPs), commonly referred to as host defense peptides, are found in a wide range of organisms, including bacteria, plants, and both vertebrate and invertebrate animals. They function as an initial defense mechanism against ... ...

Abstract	Antimicrobial peptides (AMPs), commonly referred to as host defense peptides, are found in a wide range of organisms, including bacteria, plants, and both vertebrate and invertebrate animals. They function as an initial defense mechanism against pathogenic microorganisms, modulate immune responses, and in specific instances, confer protection against the onset of cancer. Pleurocidin (Ple) is a linear antimicrobial peptide with amphipathic α-helical conformation, isolated originally from the winter flounder (
Language	English
Publishing date	2024-01-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1340029
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Article ; Online: Extracellular vimentin as a modulator of the immune response and an important player during infectious diseases.

Suprewicz, Łukasz / Zakrzewska, Magdalena / Okła, Sławomir / Głuszek, Katarzyna / Sadzyńska, Alicja / Deptuła, Piotr / Fiedoruk, Krzysztof / Bucki, Robert

Immunology and cell biology

2024 Volume 102, Issue 3, Page(s) 167–178

Abstract: Vimentin, an intermediate filament protein primarily recognized for its intracellular role in maintaining cellular structure, has recently garnered increased attention and emerged as a pivotal extracellular player in immune regulation and host-pathogen ... ...

Abstract	Vimentin, an intermediate filament protein primarily recognized for its intracellular role in maintaining cellular structure, has recently garnered increased attention and emerged as a pivotal extracellular player in immune regulation and host-pathogen interactions. While the functions of extracellular vimentin were initially overshadowed by its cytoskeletal role, accumulating evidence now highlights its significance in diverse physiological and pathological events. This review explores the multifaceted role of extracellular vimentin in modulating immune responses and orchestrating interactions between host cells and pathogens. It delves into the mechanisms underlying vimentin's release into the extracellular milieu, elucidating its unconventional secretion pathways and identifying critical molecular triggers. In addition, the future perspectives of using extracellular vimentin in diagnostics and as a target protein in the treatment of diseases are discussed.
MeSH term(s)	Humans ; Vimentin ; Intermediate Filaments ; Cytoskeleton ; Communicable Diseases ; Host-Pathogen Interactions
Chemical Substances	Vimentin
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	284057-1
ISSN	1440-1711 ; 0818-9641
ISSN (online)	1440-1711
ISSN	0818-9641
DOI	10.1111/imcb.12721
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Article: Ceragenins and Ceragenin-Based Core-Shell Nanosystems as New Antibacterial Agents against Gram-Negative Rods Causing Nosocomial Infections.

Karasiński, Maciej / Wnorowska, Urszula / Durnaś, Bonita / Król, Grzegorz / Daniluk, Tamara / Skłodowski, Karol / Głuszek, Katarzyna / Piktel, Ewelina / Okła, Sławomir / Bucki, Robert

Pathogens (Basel, Switzerland)

2023 Volume 12, Issue 11

Abstract: The growing number of infections caused by multidrug-resistant bacterial strains, limited treatment options, multi-species infections, high toxicity of the antibiotics used, and an increase in treatment costs are major challenges for modern medicine. To ... ...

Abstract	The growing number of infections caused by multidrug-resistant bacterial strains, limited treatment options, multi-species infections, high toxicity of the antibiotics used, and an increase in treatment costs are major challenges for modern medicine. To remedy this, scientists are looking for new antibiotics and treatment methods that will effectively eradicate bacteria while continually developing different resistance mechanisms. Ceragenins are a new group of antimicrobial agents synthesized based on molecular patterns that define the mechanism of antibacterial action of natural antibacterial peptides and steroid-polyamine conjugates such as squalamine. Since ceragenins have a broad spectrum of antimicrobial activity, with little recorded ability of bacteria to develop a resistance mechanism that can bridge their mechanism of action, there are high hopes that this group of molecules can give rise to a new family of drugs effective against bacteria resistant to currently used antibiotics. Experimental data suggests that core-shell nanosystems, in which ceragenins are presented to bacterial cells on metallic nanoparticles, may increase their antimicrobial potential and reduce their toxicity. However, studies should be conducted, among others, to assess potential long-term cytotoxicity and in vivo studies to confirm their activity and stability in animal models. Here, we summarized the current knowledge on ceragenins and ceragenin-containing nanoantibiotics as potential new tools against emerging Gram-negative rods associated with nosocomial infections.
Language	English
Publishing date	2023-11-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens12111346
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Article: Efficacy of Ceragenins in Controlling the Growth of Oral Microorganisms: Implications for Oral Hygiene Management.

Czarnowski, Michał / Słowińska, Monika / Sawieljew, Mariusz / Wnorowska, Urszula / Daniluk, Tamara / Król, Grzegorz / Karasiński, Maciej / Okła, Sławomir / Savage, Paul B / Piktel, Ewelina / Bucki, Robert

Pharmaceuticals (Basel, Switzerland)

2024 Volume 17, Issue 2

Abstract: Ensuring proper dental hygiene is of paramount importance for individuals' general well-being, particularly for patients receiving medical care. There is a prevailing utilization of conventional oral hygiene items, including toothbrushes and mouthwashes, ...

Abstract	Ensuring proper dental hygiene is of paramount importance for individuals' general well-being, particularly for patients receiving medical care. There is a prevailing utilization of conventional oral hygiene items, including toothbrushes and mouthwashes, which have gained widespread acceptance; nevertheless, their limitations encourage investigating novel options in this domain. Our study indicates that ceragenins (CSAs) being lipid analogs of host defense peptides, well-recognized for their wide-ranging antimicrobial properties, may be a potentially efficacious means to augment oral hygiene in hospitalized individuals. We demonstrate that ceragenins CSA-13, CSA-44, and CSA-131 as well as undescribed to date CSA-255 display potent antimicrobial activities against isolates of fungi, aerobic, and anaerobic bacteria from
Language	English
Publishing date	2024-02-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph17020204
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Article ; Online: Ceragenin-mediated disruption of Pseudomonas aeruginosa biofilms.

Wnorowska, Urszula / Łysik, Dawid / Piktel, Ewelina / Zakrzewska, Magdalena / Okła, Sławomir / Lesiak, Agata / Spałek, Jakub / Mystkowska, Joanna / Savage, Paul B / Janmey, Paul / Fiedoruk, Krzysztof / Bucki, Robert

PloS one

2024 Volume 19, Issue 2, Page(s) e0298112

Abstract: Background: Microbial biofilms, as a hallmark of cystic fibrosis (CF) lung disease and other chronic infections, remain a desirable target for antimicrobial therapy. These biopolymer-based viscoelastic structures protect pathogenic organisms from immune ...

Abstract	Background: Microbial biofilms, as a hallmark of cystic fibrosis (CF) lung disease and other chronic infections, remain a desirable target for antimicrobial therapy. These biopolymer-based viscoelastic structures protect pathogenic organisms from immune responses and antibiotics. Consequently, treatments directed at disrupting biofilms represent a promising strategy for combating biofilm-associated infections. In CF patients, the viscoelasticity of biofilms is determined mainly by their polymicrobial nature and species-specific traits, such as Pseudomonas aeruginosa filamentous (Pf) bacteriophages. Therefore, we examined the impact of microbicidal ceragenins (CSAs) supported by mucolytic agents-DNase I and poly-aspartic acid (pASP), on the viability and viscoelasticity of mono- and bispecies biofilms formed by Pf-positive and Pf-negative P. aeruginosa strains co-cultured with Staphylococcus aureus or Candida albicans. Methods: The in vitro antimicrobial activity of ceragenins against P. aeruginosa in mono- and dual-species cultures was assessed by determining minimum inhibitory concentration (MIC) and minimum bactericidal/fungicidal concentration (MBC/MFC). Inhibition of P. aeruginosa mono- and dual-species biofilms formation by ceragenins alone and in combination with DNase I or poly-aspartic acid (pASP) was estimated by the crystal violet assay. Additionally, the viability of the biofilms was measured by colony-forming unit (CFU) counting. Finally, the biofilms' viscoelastic properties characterized by shear storage (G') and loss moduli (G"), were analyzed with a rotational rheometer. Results: Our results demonstrated that ceragenin CSA-13 inhibits biofilm formation and increases its fluidity regardless of the Pf-profile and species composition; however, the Pf-positive biofilms are characterized by elevated viscosity and elasticity parameters. Conclusion: Due to its microbicidal and viscoelasticity-modifying properties, CSA-13 displays therapeutic potential in biofilm-associated infections, especially when combined with mucolytic agents.
MeSH term(s)	Humans ; Pseudomonas aeruginosa ; Aspartic Acid ; Expectorants ; Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/pharmacology ; Biofilms ; Cystic Fibrosis ; Deoxyribonuclease I ; Microbial Sensitivity Tests ; Pseudomonas Infections ; Steroids
Chemical Substances	ceragenins ; Aspartic Acid (30KYC7MIAI) ; Expectorants ; Anti-Bacterial Agents ; Anti-Infective Agents ; Deoxyribonuclease I (EC 3.1.21.1) ; Steroids
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0298112
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Article: Rehabilitacja głosu i mowy z zastosowaniem wszczepialnych protez głosowych u chorych po całkowitym usunieciu krtani.

Okła, Sławomir

Otolaryngologia polska = The Polish otolaryngology

2007 Volume 61, Issue 5, Page(s) 760–762

Title translation	Vocal rehabilitation after total laryngectomy using a voice prosthesis.
MeSH term(s)	Humans ; Laryngectomy/adverse effects ; Laryngectomy/rehabilitation ; Larynx, Artificial ; Voice/physiology ; Voice Disorders/etiology ; Voice Disorders/rehabilitation ; Voice Quality
Language	Polish
Publishing date	2007
Publishing country	Poland
Document type	Journal Article
ZDB-ID	417458-6
ISSN	2300-8423 ; 0030-6657
ISSN (online)	2300-8423
ISSN	0030-6657
DOI	10.1016/S0030-6657(07)70520-6
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Article ; Online: Biocompatible Materials in Otorhinolaryngology and Their Antibacterial Properties.

Spałek, Jakub / Ociepa, Przemysław / Deptuła, Piotr / Piktel, Ewelina / Daniluk, Tamara / Król, Grzegorz / Góźdź, Stanisław / Bucki, Robert / Okła, Sławomir

International journal of molecular sciences

2022 Volume 23, Issue 5

Abstract: For decades, biomaterials have been commonly used in medicine for the replacement of human body tissue, precise drug-delivery systems, or as parts of medical devices that are essential for some treatment methods. Due to rapid progress in the field of new ...

Abstract	For decades, biomaterials have been commonly used in medicine for the replacement of human body tissue, precise drug-delivery systems, or as parts of medical devices that are essential for some treatment methods. Due to rapid progress in the field of new materials, updates on the state of knowledge about biomaterials are frequently needed. This article describes the clinical application of different types of biomaterials in the field of otorhinolaryngology, i.e., head and neck surgery, focusing on their antimicrobial properties. The variety of their applications includes cochlear implants, middle ear prostheses, voice prostheses, materials for osteosynthesis, and nasal packing after nasal/paranasal sinuses surgery. Ceramics, such as as hydroxyapatite, zirconia, or metals and metal alloys, still have applications in the head and neck region. Tissue engineering scaffolds and drug-eluting materials, such as polymers and polymer-based composites, are becoming more common. The restoration of life tissue and the ability to prevent microbial colonization should be taken into consideration when designing the materials to be used for implant production. The authors of this paper have reviewed publications available in PubMed from the last five years about the recent progress in this topic but also establish the state of knowledge of the most common application of biomaterials over the last few decades.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Biocompatible Materials/pharmacology ; Ceramics ; Humans ; Otolaryngology ; Polymers ; Tissue Scaffolds
Chemical Substances	Anti-Bacterial Agents ; Biocompatible Materials ; Polymers
Language	English
Publishing date	2022-02-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23052575
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Article: Ceragenins exhibit bactericidal properties that are independent of the ionic strength in the environment mimicking cystic fibrosis sputum.

Skłodowski, Karol / Suprewicz, Łukasz / Chmielewska-Deptuła, Sylwia Joanna / Kaliniak, Szczepan / Okła, Sławomir / Zakrzewska, Magdalena / Minarowski, Łukasz / Mróz, Robert / Daniluk, Tamara / Savage, Paul B / Fiedoruk, Krzysztof / Bucki, Robert

Frontiers in microbiology

2023 Volume 14, Page(s) 1290952

Abstract: The purpose of the work was to investigate the impact of sodium chloride (NaCl) on the antimicrobial efficacy of ceragenins (CSAs) and antimicrobial peptides (AMPs) against bacterial and fungal pathogens associated with cystic fibrosis ( ...

Abstract	The purpose of the work was to investigate the impact of sodium chloride (NaCl) on the antimicrobial efficacy of ceragenins (CSAs) and antimicrobial peptides (AMPs) against bacterial and fungal pathogens associated with cystic fibrosis (
Language	English
Publishing date	2023-11-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1290952
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Article ; Online: DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk.

Śnit, Mirosław / Misiołek, Maciej / Ścierski, Wojciech / Koniewska, Anna / Stryjewska-Makuch, Grażyna / Okła, Sławomir / Grzeszczak, Władysław

International journal of environmental research and public health

2021 Volume 18, Issue 14

Abstract: AIM, DIAPH2, PTPRD and HIC1 are the cell glycoprotein, which play an important role in the occurrence and development of tumors. This study was designed to assess the association between DIAPH2, PTPRD and HIC1 SNPs and laryngeal cancer risk.: Patients ... ...

Abstract	AIM, DIAPH2, PTPRD and HIC1 are the cell glycoprotein, which play an important role in the occurrence and development of tumors. This study was designed to assess the association between DIAPH2, PTPRD and HIC1 SNPs and laryngeal cancer risk. Patients and methods: This study including 267 patients with histologically confirmed laryngeal cancer and 157 controls. The relationship between genetic variations DIAPH2 (rs6620138), PTPRD (rs3765142) and HIC1 (rs9901806) and the onset of laryngeal cancer were investigated. Statistical analysis to calculate the relationship between DIAPH2, PTPRD and HIC1 genes polymorphism and pathogenesis of laryngeal cancer. Results: The results showed that rs6620138 DIAPH2 polymorphism could increase the onset risk of laryngeal cancer. Statistically significant differences in allele distribution of rs6620138 DIAPH2 and rs9901806 HIC1 in the case and control groups subgroups. Conclusions: This study results suggested that genetic variation of rs6620138 DIAPH2 polymorphism is related to the susceptibility to laryngeal cancer. Our results provide a basis to begin basic research on the role of DIAPH2 gene in the pathogenesis of laryngeal cancer.
MeSH term(s)	Alleles ; Formins ; Humans ; Kruppel-Like Transcription Factors ; Laryngeal Neoplasms/epidemiology ; Laryngeal Neoplasms/genetics ; Polymorphism, Single Nucleotide ; Receptor-Like Protein Tyrosine Phosphatases, Class 2
Chemical Substances	DIAPH2 protein, human ; Formins ; HIC1 protein, human ; Kruppel-Like Transcription Factors ; PTPRD protein, human (EC 3.1.3.48) ; Receptor-Like Protein Tyrosine Phosphatases, Class 2 (EC 3.1.3.48)
Language	English
Publishing date	2021-07-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph18147486
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