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Article ; Online: Identifying subgroups based on self-assessment of ability in patients with schizophrenia and its relationship with vocational outcomes.

Okada, Hiroki

Hong Kong journal of occupational therapy : HKJOT

2022 Volume 35, Issue 1, Page(s) 35–43

Abstract: Background/objectives: People with schizophrenia have defective self-assessment of ability (i.e., loss of introspective accuracy [IA]). Although previous studies grouped people according to the degree of IA, the clinical features of these subgroups have ...

Abstract	Background/objectives: People with schizophrenia have defective self-assessment of ability (i.e., loss of introspective accuracy [IA]). Although previous studies grouped people according to the degree of IA, the clinical features of these subgroups have not been clarified. Additionally, the determinants of outcomes depending on self-assessment remain unknown. We aimed to identify the clinical features that can help distinguish these subgroups and whether the determinants of vocational outcomes differed between the groups. Methods: The self-assessment ability of 100 people with schizophrenia was examined and categorized as accurate, over-, or under-estimators. Multiple discriminant analysis was also performed. After demonstrating statistical validity, the relative effects of positive and negative symptoms, cognitive function, and level of IA on vocational outcomes were also examined for each subgroup. Results: The symptoms that particularly explained the differences between these subgroups were positive and negative (expressing factors) symptoms: Conclusion: Reduced IA can be a core mediator of various symptoms. Thus, tailoring the target and strategy of interventions for vocational outcomes according to the accuracy and quality of IA is important in clinical settings.
Language	English
Publishing date	2022-02-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2202253-3
ISSN	1876-4398 ; 1569-1861
ISSN (online)	1876-4398
ISSN	1569-1861
DOI	10.1177/15691861221075715
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Article: Association of negative symptom domains and other clinical characteristics of schizophrenia on long-term hospitalization.

Okada, Hiroki

Indian journal of psychiatry

2022 Volume 64, Issue 3, Page(s) 277–283

Abstract: Background: Recent studies suggest five domains for negative schizophrenia symptoms: anhedonia, asociality, avolition, blunted affect, and alogia. Avolition has been considered a characteristic symptom in community-dwelling patients. However, few ... ...

Abstract	Background: Recent studies suggest five domains for negative schizophrenia symptoms: anhedonia, asociality, avolition, blunted affect, and alogia. Avolition has been considered a characteristic symptom in community-dwelling patients. However, few studies have explored the association of these symptoms with long-term hospitalization. Purpose: This study explored the relative association of each of the five domains of negative symptoms in two groups of patients with schizophrenia: long-term hospitalized and community-dwelling patients. Methods: Participants included 56 long-term inpatients and 111 community-dwelling patients at Nasukougen Hospital in Japan. The nearest neighbor matching within caliper was used. After matching participants by age, sex, disease duration, and years of education, each group was assigned 30 participants. Model 1 was analyzed with a logistic regression analysis with 5 subdomains as independent variables. Model 2 was analyzed after adding positive symptoms, cognitive function, functional skills, and functional outcomes to the subdomains that were significant in model 1. Results: The results indicated that asociality was significantly associated with long-term hospitalization. When the characteristic clinical factors of schizophrenia were added, asociality, daily living skills, and social and role functions were found to be characteristic of long-term hospitalization. Among the negative symptoms, lack of social motivation was more characteristic among the group with a poor prognosis. Conclusions: Of the negative symptoms associated with long-term hospitalization, asociality, lack of social motivation, rather than avolition was found to be most strongly associated with community-dwelling patients' functional outcomes. Further studies are required to establish a causal association as it may have therapeutic implications.
Language	English
Publishing date	2022-06-08
Publishing country	India
Document type	Journal Article
ZDB-ID	221523-8
ISSN	0019-5545
ISSN	0019-5545
DOI	10.4103/indianjpsychiatry.indianjpsychiatry_134_21
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Article ; Online: [Implementing Clinical Evidences into Community Pharmacies: Results of the COMPASS and COMPASS-BP Studies].

Okada, Hiroshi

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

2022 Volume 142, Issue 3, Page(s) 211–214

Abstract: Evidence-based medicine (EBM) has led to the development of evidence-based guidelines. The quality of guidelines has been improved by measuring their quality with The Appraisal of Guidelines for Research and Evaluation II (AGREE II) and Grading of ... ...

Abstract	Evidence-based medicine (EBM) has led to the development of evidence-based guidelines. The quality of guidelines has been improved by measuring their quality with The Appraisal of Guidelines for Research and Evaluation II (AGREE II) and Grading of Recommendations, Assessment, Development and Evaluation (GRADE). However, evidenced by guidelines not implemented in clinical practice or society, the evidence-practice gap has become apparent. The dissemination and implementation research, which studies methods to solve this problem, has attracted the attention of both clinicians and clinical researchers in recent years. In hypertension and diabetes, it is possible to prevent complications by maintaining good blood pressure and blood glucose levels. However, it is difficult for patients to maintain good laboratory values over the long term, and there has been no solution to this problem. Recently, it has been reported that pharmacists in the U.S. and Canada can improve patient outcomes over the long term by using pharmacies to treat these diseases. This review describes the results of the COMPASS study (diabetes) and the COMPASS-BP study (hypertension), which are the first cluster randomized controlled trials conducted in pharmacies in Japan. In addition, it discusses the possibility of implementation in pharmacies in Japan.
MeSH term(s)	Blood Pressure ; Blood-Borne Infections ; Canada ; Community Pharmacy Services ; Diabetes Mellitus/prevention & control ; Diabetes Mellitus/therapy ; Evidence-Based Pharmacy Practice ; Humans ; Hypertension/prevention & control ; Hypertension/therapy ; Japan ; Pharmacists ; Practice Guidelines as Topic ; Quality of Health Care ; Randomized Controlled Trials as Topic
Language	Japanese
Publishing date	2022-02-28
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	200514-1
ISSN	1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
ISSN (online)	1347-5231
ISSN	0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
DOI	10.1248/yakushi.21-00174-2
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Article ; Conference proceedings ; Online: TERTIARY STRUCTURE OF XYLANASE AND ESTIMATION OF ACTIVE SITES BY SITE DIRECTED MUTAGENESIS

Okada, Hirosuke

2023

Abstract: The nucleotide sequence of xylanase gene(xynA) of Bacillus pumilus IPO, a hyperproducer of xylanase, was determined and the amino acid sequence was deduced from it. Xylanase is produced as a preenzyme consisting of the mature enzyme of 201 amino acid ... ...

Abstract	The nucleotide sequence of xylanase gene(xynA) of Bacillus pumilus IPO, a hyperproducer of xylanase, was determined and the amino acid sequence was deduced from it. Xylanase is produced as a preenzyme consisting of the mature enzyme of 201 amino acid residues and a signal peptide of 27 residues. Xylanase was analyzed by X-ray crystallography at the level of 2.2 A resolution. It is consisted with two domains, smaller and larger, between two a crevasse suitable to accept xylan molecule was observed. The mutant xylanases obtained by site directed mutagenesis having amino acid alteration; Glu93-Ser93 and Glul82_Asp182 had no catalytic activity (less than 1/10,000).
Language	English
Publishing date	2023-11-03
Publisher	GBF Gesellschaft für Biotechnologische Forschung mbH, Braunschweig
Publishing country	de
Document type	Article ; Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: On Accelerating Substrate Optimization Using Computational Gibbs Energy Barriers: A Numerical Consideration Utilizing a Computational Data Set.

Okada, Hiroaki / Maeda, Satoshi

ACS omega

2024 Volume 9, Issue 6, Page(s) 7123–7131

Abstract: Substrate optimization is a time- and resource-consuming step in organic synthesis. Recent advances in chemo- and materials-informatics provide systematic and efficient procedures utilizing tools such as Bayesian optimization (BO). This study explores ... ...

Abstract	Substrate optimization is a time- and resource-consuming step in organic synthesis. Recent advances in chemo- and materials-informatics provide systematic and efficient procedures utilizing tools such as Bayesian optimization (BO). This study explores the possibility of reducing the required experiments further by utilizing computational Gibbs energy barriers. To thoroughly validate the impact of using computational Gibbs energy barriers in BO-assisted substrate optimization, this study employs a computational Gibbs energy barrier data set in the literature and performs an extensive numerical investigation virtually regarding the Gibbs energy barriers as virtual experimental results and those with systematic and random noises as virtual computational results. The present numerical investigation shows that even the computational reactivity affected by noises of as much as 20 kJ/mol helps reduce the number of required experiments.
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c09066
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Article ; Online: Determinants of Recreational Outcomes in Schizophrenia: An Exploratory Study Focusing on Gender Differences.

Okada, Hiroki

Issues in mental health nursing

2021 Volume 43, Issue 4, Page(s) 376–381

Abstract: While recreation is impactful for recovery in schizophrenia, no study has examined the effects of schizophrenic symptoms on recreational outcomes. This study examined the determinants of recreational outcomes based on gender. We investigated the ... ...

Abstract	While recreation is impactful for recovery in schizophrenia, no study has examined the effects of schizophrenic symptoms on recreational outcomes. This study examined the determinants of recreational outcomes based on gender. We investigated the relationship between recreational outcomes, positive and negative symptoms, cognitive function, and factors such as negative self-evaluation and evaluation by others. Motivation had a significant impact on both men and women. However, participation in recreational activities was impacted by negative self-assessment for men and evaluations from others for women. The importance of matching strategies based on gender when using recreation therapeutically was emphasized.
MeSH term(s)	Female ; Humans ; Male ; Motivation ; Recreation/psychology ; Schizophrenia/therapy ; Sex Factors
Language	English
Publishing date	2021-09-16
Publishing country	England
Document type	Journal Article
ZDB-ID	603180-8
ISSN	1096-4673 ; 0161-2840
ISSN (online)	1096-4673
ISSN	0161-2840
DOI	10.1080/01612840.2021.1975331
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Article ; Online: Comparison of Frequency-Domain and Time-Domain Baseline Correction Approaches for Infrared Absorption Spectroscopy of Mixtures Containing Up to 464 Components.

Okada, Haruna / Sanders, Scott T

Applied spectroscopy

2024 Volume 78, Issue 4, Page(s) 376–386

Abstract: Many baseline correction approaches have been developed to address baseline artifacts observed in measured infrared (IR) absorption spectra during post-processing. These approaches offer distinct advantages and disadvantages, and the choice of which one ... ...

Abstract	Many baseline correction approaches have been developed to address baseline artifacts observed in measured infrared (IR) absorption spectra during post-processing. These approaches offer distinct advantages and disadvantages, and the choice of which one to employ depends on the complexity of baseline artifacts present in a particular application. In this paper, we compare the performance of two baseline correction approaches: a frequency-domain polynomial fitting approach and a time-domain modified free induction decay approach, under various baseline scenarios, spectral resolutions, and noise levels for mixtures containing up to 464 species. Our results showed that the frequency-domain approach outperformed the time-domain approach by a factor of up to 16 when the baseline was represented by a sine wave with fewer than two cycles over the full spectral range. On the other hand, the time-domain approach performed up to 12 times better when the baseline featured two cycles of a sine wave. Additionally, we observed that the time-domain approach exhibited higher sensitivity to spectral resolution and underperformed when the noise level was high. The findings of this study emphasize the importance of numerically testing a few candidate approaches for a given application, taking into consideration baseline characteristics, as well as the spectral resolution and noise constraints of the application.
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article
ISSN	1943-3530
ISSN (online)	1943-3530
DOI	10.1177/00037028241226989
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Article ; Online: Assessment of Venous Thromboembolism Risk of Antipsychotic Drugs Using Mendelian Randomization Analysis.

Okada, Hirofumi / Tada, Hayato / Takamura, Masayuki

Journal of atherosclerosis and thrombosis

2024 Volume 31, Issue 4, Page(s) 351–352

MeSH term(s)	Humans ; Venous Thromboembolism/chemically induced ; Venous Thromboembolism/genetics ; Antipsychotic Agents/adverse effects ; Mendelian Randomization Analysis ; Risk Factors ; Genome-Wide Association Study
Chemical Substances	Antipsychotic Agents
Language	English
Publishing date	2024-02-28
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2011474-6
ISSN	1880-3873 ; 1340-3478
ISSN (online)	1880-3873
ISSN	1340-3478
DOI	10.5551/jat.ED255
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Article ; Online: Exploratory` study on driving ability of people with schizophrenia: Relationships among cognitive function, symptoms, and brain activity.

Okada, Hiroki / Morimoto, Takafumi / Ikeda, Nozomu

Schizophrenia research

2024 Volume 264, Page(s) 290–297

Abstract: Background: This study aimed to examine the relationships among cognitive function, symptoms, prefrontal activation, basic driving skills, and collision risk factors using a hazard prediction task in simulated driving.: Methods: Participants included ...

Abstract	Background: This study aimed to examine the relationships among cognitive function, symptoms, prefrontal activation, basic driving skills, and collision risk factors using a hazard prediction task in simulated driving. Methods: Participants included 42 people with schizophrenia aged 20-50 years who had actual experience of driving. The Trail making test (TMT) A and TMTB, Wechsler Memory Test-Revised (WMS-R), and Zoo Map test (ZMT) were used to evaluate cognitive function. Positive and negative syndrome scale was used to assess symptoms, and brain activity was assessed by evaluating cerebral blood flow during a visual working memory task using functional near-infrared spectroscopy. Driving tasks that tested basic skills, such as brake reaction, steering wheel skills, and standard deviation of lateral position, were analyzed using multiple regression analysis. Three hazard prediction tasks were performed using discriminant analysis. Results: Brake reaction associated with cerebral blood flow and TMT-A. Steering wheel skills associated with WMS-R, driving experience and depression. Significant differences were found between the collision and noncollision groups in the hazard prediction task, as shown by the ZMT, driving experience, and brake reaction. Conclusions: Brain activity in the frontal lobe during a desk task may be useful data for driving assessment. Assessment of processing speed and learning ability may be particularly important in the evaluation of basic skills for safe driving. In addition, for people with schizophrenia, foresight, as represented by proactive planning, experience, and quick braking may be an essential characteristic to anticipate danger and react quickly enough to avoid collisions.
MeSH term(s)	Humans ; Schizophrenia ; Cognition ; Trail Making Test ; Frontal Lobe ; Memory, Short-Term
Language	English
Publishing date	2024-01-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	639422-x
ISSN	1573-2509 ; 0920-9964
ISSN (online)	1573-2509
ISSN	0920-9964
DOI	10.1016/j.schres.2023.12.028
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Article ; Online: Changes in the conflicting nongenomic effects of progesterone in rat myometrium during pregnancy.

Yoshida, Aya / Yasuda, Katsuhiko / Okada, Hidetaka

Life sciences

2024 Volume 340, Page(s) 122454

Abstract: Aims: Although the functions of progesterone in the myometrium are well-established, the nongenomic effects of progesterone in pregnant myometrial contractions are still unclear. Therefore, this study aimed to investigate changes in the nongenomic ... ...

Abstract	Aims: Although the functions of progesterone in the myometrium are well-established, the nongenomic effects of progesterone in pregnant myometrial contractions are still unclear. Therefore, this study aimed to investigate changes in the nongenomic effects of progesterone during pregnancy. Main methods: Myometrial strips were obtained from non-pregnant, pregnant, and postpartum rats, and the nongenomic effects of progesterone in the myometrium during pregnancy were examined. Additionally, the influence of actinomycin D and cycloheximide and the effects of Org OD-02-0 (a specific membrane progesterone receptor (mPR) agonist) in the myometrium were investigated. Moreover, DNA microarray and quantitative real-time polymerase chain reaction (qRT-PCR) were performed to identify genes involved in progesterone-induced effects in the myometrium. Key findings: Progesterone did not cause rhythmic contractions in non-pregnant myometrium but induced rhythmic contractions in pregnant myometrium, with the effects peaking at 20 d + 8 h of pregnancy. However, myometrial contractions decreased after delivery and were restored to non-pregnant levels at 7 d postpartum. Additionally, progesterone stably inhibited high KCl-induced myometrial contractions during pregnancy. Moreover, the nongenomic effects of progesterone were unaffected by actinomycin D or cycloheximide, and Org OD-02-0 effectively mimicked these effects. DNA microarray analysis and qRT-PCR revealed a significant increase in mPRβ gene expression during pregnancy. However, mPRα, mPRγ, mPRδ, and mPRε expression levels remained unchanged. Significance: The stimulatory nongenomic effect of progesterone, which was inducible and mPRβ-dependent during pregnancy, may be involved in parturition. The inhibitory effect, which was constitutive and depended on other mPRs, may be involved in pregnancy maintenance.
MeSH term(s)	Pregnancy ; Female ; Rats ; Animals ; Progesterone/pharmacology ; Progesterone/metabolism ; Myometrium/metabolism ; Cycloheximide/pharmacology ; Cycloheximide/metabolism ; Dactinomycin/pharmacology ; Dactinomycin/metabolism ; Receptors, Progesterone/metabolism ; Progestins/pharmacology ; Uterine Contraction
Chemical Substances	Progesterone (4G7DS2Q64Y) ; Cycloheximide (98600C0908) ; Dactinomycin (1CC1JFE158) ; Receptors, Progesterone ; Progestins
Language	English
Publishing date	2024-01-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2024.122454
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