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  1. Article ; Online: Chest pain and Raynaud's phenomenon after COVID-19 vaccination in a patient previously diagnosed with systemic lupus erythematosus: a case report.

    Kawano, Hiroaki / Umeda, Masataka / Okano, Shinji / Kudo, Takashi

    European heart journal. Case reports

    2023  Volume 7, Issue 3, Page(s) ytad102

    Abstract: Background: Cardiovascular events, including pericarditis, myocarditis, and myocardial ischaemia, have been reported as complications following COVID-19 vaccination.: Case summary: A 28-year-old Japanese woman diagnosed 10 years earlier with systemic ...

    Abstract Background: Cardiovascular events, including pericarditis, myocarditis, and myocardial ischaemia, have been reported as complications following COVID-19 vaccination.
    Case summary: A 28-year-old Japanese woman diagnosed 10 years earlier with systemic lupus erythematosus and antiphospholipid syndrome was admitted to our hospital because of chest pain and Raynaud's phenomenon. She had received a second dose of the COVID-19 BNT162b2 mRNA vaccine 28 days earlier.
    Discussion: Our data lead us to speculate that two events in the timeline of the patient, namely, receiving COVID-19 vaccination and the presence of SARS-CoV/SARS-CoV-2 spike protein in small intramural coronary arteries, may be related to the myocardial microangiopathy observed in this patient.
    Language English
    Publishing date 2023-02-24
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytad102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Curved Axillary Incision with Video-Assisted Thoracoscopic Surgery: An Alternative Approach for Teenage Female with Large Apical Chest Wall Tumor.

    Doi, Ryoichiro / Ichikawa, Hiromi / Matsumoto, Keitaro / Tomoshige, Koichi / Machino, Ryusuke / Okano, Shinji / Nagayasu, Takeshi

    Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia

    2024  Volume 30, Issue 1

    Abstract: Primary chest wall tumors are rare, their common clinical features are not well known, and surgical resection remains the main treatment. Apical chest wall tumors require large skin incisions and dissection of the chest wall muscles, making it difficult ... ...

    Abstract Primary chest wall tumors are rare, their common clinical features are not well known, and surgical resection remains the main treatment. Apical chest wall tumors require large skin incisions and dissection of the chest wall muscles, making it difficult to maintain cosmetic appearance, respiratory function, and support of the upper extremity. There are few treatment options and no studies have reported on thoracotomy that spares muscles and preserves cosmetic superiority. However, in benign chest wall tumors in young patients, it is necessary to consider radicality, cosmetic superiority, and muscle sparing. We used a combined axillary incision and thoracoscopic approach to treat a massive myxoid neurofibroma at the apical chest wall in a 14-year-old female and were able to preserve the chest wall, upper limb function, and cosmetic aspects. This report provides a detailed description of the combined axillary incision and thoracoscopic approach for apical chest wall tumors.
    MeSH term(s) Adolescent ; Female ; Humans ; Neoplasms ; Thoracic Surgery, Video-Assisted/methods ; Thoracic Wall/diagnostic imaging ; Thoracic Wall/surgery ; Thoracotomy ; Treatment Outcome
    Language English
    Publishing date 2024-03-04
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 2019756-1
    ISSN 2186-1005 ; 1341-1098
    ISSN (online) 2186-1005
    ISSN 1341-1098
    DOI 10.5761/atcs.cr.23-00189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: DKK3 expression is correlated with poorer prognosis in head and neck squamous cell carcinoma: A bioinformatics study based on the TCGA database.

    Katase, Naoki / Nishimatsu, Shin-Ichiro / Yamauchi, Akira / Okano, Shinji / Fujita, Shuichi

    Journal of oral biosciences

    2023  Volume 65, Issue 4, Page(s) 334–346

    Abstract: Objective: We previously reported that dickkopf WNT signaling pathway inhibitor 3 (DKK3) expression is correlated with poorer prognosis in head and neck squamous cell carcinoma (HNSCC). Here we investigated DKK3 expression by using The Cancer Genome ... ...

    Abstract Objective: We previously reported that dickkopf WNT signaling pathway inhibitor 3 (DKK3) expression is correlated with poorer prognosis in head and neck squamous cell carcinoma (HNSCC). Here we investigated DKK3 expression by using The Cancer Genome Atlas (TCGA) public database and bioinformatic analyses.
    Methods: We used the RNA sequence data and divided the tumor samples into "DKK3-high" and "DKK3-low" groups according to median DKK3 expression. The correlations between DKK3 expression and the clinical data were investigated. Differentially expressed genes (DEGs) were detected using DESEq2 and analyzed by ShinyGO 0.77. A gene set enrichment analysis (GSEA) was also performed using GSEA software. The DEGs were also analyzed with TargetMine to establish the protein-protein interaction (PPI) network.
    Results: DKK3 expression was significantly increased in cancer samples, and a high DKK3 expression was significantly associated with shorter overall survival. We identified 854 DEGs, including 284 up-regulated and 570 down-regulated. Functional enrichment analyses revealed several Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways associated with extracellular matrix remodeling. The PPI network identified COL8A1, AGTR1, FN1, P4HA3, PDGFRB, and CEP126 as the key genes.
    Conclusions: These results suggested the cancer-promoting ability of DKK3, the expression of which is a promising prognostic marker and therapeutic target for HNSCC.
    MeSH term(s) Humans ; Squamous Cell Carcinoma of Head and Neck/genetics ; Head and Neck Neoplasms/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Prognosis ; Computational Biology/methods ; Databases, Genetic ; Procollagen-Proline Dioxygenase/genetics ; Adaptor Proteins, Signal Transducing/genetics
    Chemical Substances P4HA3 protein, human (EC 1.14.11.2) ; Procollagen-Proline Dioxygenase (EC 1.14.11.2) ; DKK3 protein, human ; Adaptor Proteins, Signal Transducing
    Language English
    Publishing date 2023-09-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2218267-6
    ISSN 1880-3865 ; 1349-0079
    ISSN (online) 1880-3865
    ISSN 1349-0079
    DOI 10.1016/j.job.2023.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cardiac Sarcoidosis which Occurred four Years after Successful Treatment of Cutaneous Sarcoidosis with Minocycline.

    Kawano, Hiroaki / Motokawa, Tetsufumi / Eishi, Yoshinobu / Setoguchi, Akito / Ueno, Yuki / Takenaka, Motoi / Okano, Shinji / Ideguchi, Reiko / Ohashi, Kenichi / Maemura, Koji

    Internal medicine (Tokyo, Japan)

    2024  

    Abstract: A 67-year-old woman was admitted to our hospital because of a complete right bundle branch block. She had been treated with minocycline for skin sarcoidosis and her symptoms had ameliorated four years previously. Gallium scintigraphy revealed an abnormal ...

    Abstract A 67-year-old woman was admitted to our hospital because of a complete right bundle branch block. She had been treated with minocycline for skin sarcoidosis and her symptoms had ameliorated four years previously. Gallium scintigraphy revealed an abnormal uptake in the heart but not in the skin or lungs. She was diagnosed with cardiac sarcoidosis, although an endomyocardial biopsy could not detect any sarcoid lesions. Immunohistochemical staining for Cutibacterium acnes was positive for granulomas of the skin lesions which had been previously biopsied. One year after starting the administration of steroids, her condition improved.
    Language English
    Publishing date 2024-02-26
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.3174-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Swallowing-related muscle inflammation and fibrosis induced by a single dose of radiation exposure in mice.

    Soejima, Shuntaro / Wu, Chia-Hsien / Matsuse, Haruna / Terakado, Mariko / Okano, Shinji / Inoue, Tsuyoshi / Kumai, Yoshihiko

    Laboratory animal research

    2024  Volume 40, Issue 1, Page(s) 12

    Abstract: Background: Although radiotherapy is commonly used to treat head and neck cancer, it may lead to radiation-associated dysphagia (RAD). There are various causes of RAD, however, the mechanism has not yet been fully identified. Currently, the only ... ...

    Abstract Background: Although radiotherapy is commonly used to treat head and neck cancer, it may lead to radiation-associated dysphagia (RAD). There are various causes of RAD, however, the mechanism has not yet been fully identified. Currently, the only effective treatment for RAD is rehabilitation. Additionally, there are few available animal models of RAD, necessitating the development of new models to establish and evaluate RAD treatments. We hypothesize that radiation-induced neck muscle fibrosis could be one of the causes of RAD due to impairment of laryngeal elevation. Therefore, in this study, we focused on the changes in inflammation and fibrosis of the strap muscles (Sternohyoid, Sternothyroid, and Thyrohyoid muscles) after a single-dose irradiation. This research aims to provide a reference animal model for future studies on RAD.
    Results: Compared to control mice, those treated with 72-Gy, but not 24-Gy, irradiation had significantly increased tumor necrosis factor-α (TNF-α) (p < 0.01) and α-smooth muscle actin (αSMA) (p < 0.05) expression at 10 days and significantly increased expression levels of motif chemokine ligand-2 (CCL2), α-SMA, tumor growth factor-β1 (TGF-β1), type1 collagen, and interleukin-1β (IL-1β) (p < 0.05) in the muscles at 1 month by real-time PCR analysis. The results of immunohistochemistry showed that the deposition of type 1 collagen gradually increased in extracellular space after radiation exposure, and the positive area was significantly increased at 3 months compared to non-irradiated control.
    Conclusions: A single dose of 72-Gy irradiation induced significant inflammation and fibrosis in the strap muscles of mice at 1 month, with immunohistochemical changes becoming evident at 3 months. This cervical irradiation-induced fibrosis model holds potential for establishing an animal model for RAD in future studies.
    Level of evidence: N/A.
    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2623220-0
    ISSN 2233-7660 ; 1738-6055
    ISSN (online) 2233-7660
    ISSN 1738-6055
    DOI 10.1186/s42826-024-00199-2
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  6. Article ; Online: Fatal systemic capillary leak syndrome in a patient with a COVID-19 infection.

    Kawano, Hiroaki / Umeda, Masataka / Honda, Tomohiro / Iwasaki, Ryosuke / Okano, Shinji / Akashi, Ryohei / Koga, Tomohiro / Izumikawa, Koichi / Kawakami, Atsushi / Maemura, Koji

    Internal medicine (Tokyo, Japan)

    2024  

    Abstract: A 29-year-old Japanese woman was admitted to our hospital with a fever, cardiogenic shock, and cardiac arrest. Laboratory data indicated multiple organ failure in addition to hemoconcentration, hypoalbuminemia, and myocardial damage. The coronary ... ...

    Abstract A 29-year-old Japanese woman was admitted to our hospital with a fever, cardiogenic shock, and cardiac arrest. Laboratory data indicated multiple organ failure in addition to hemoconcentration, hypoalbuminemia, and myocardial damage. The coronary angiography findings were normal, and fulminant myocarditis was suspected. Venoarterial peripheral extracorporeal membrane oxygenation and an Impella CP left ventricular assist device were initiated, along with the administration of positive inotropic agents. However, hypovolemic shock and hypoalbuminemia progressed along with severe anemia, and the patient died 18 hours after admission. The patient was diagnosed with systemic capillary leak syndrome associated with COVID-19.
    Language English
    Publishing date 2024-04-23
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.3637-24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Establishment of anti-DKK3 peptide for the cancer control in head and neck squamous cell carcinoma (HNSCC).

    Katase, Naoki / Nishimatsu, Shin-Ichiro / Yamauchi, Akira / Okano, Shinji / Fujita, Shuichi

    Cancer cell international

    2022  Volume 22, Issue 1, Page(s) 352

    Abstract: Background: Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumor of the head and neck. We identified cancer-specific genes in HNSCC and focused on DKK3 expression. DKK3 gene codes two isoforms of proteins (secreted and non- ... ...

    Abstract Background: Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumor of the head and neck. We identified cancer-specific genes in HNSCC and focused on DKK3 expression. DKK3 gene codes two isoforms of proteins (secreted and non-secreted) with two distinct cysteine rich domains (CRDs). It is reported that DKK3 functions as a negative regulator of oncogenic Wnt signaling and, is therefore, considered to be a tumor suppressor gene. However, our series of studies have demonstrated that DKK3 expression is specifically high in HNSCC tissues and cells, and that DKK3 might determine the malignant potentials of HNSCC cells via the activation of Akt. Further analyses strongly suggested that both secreted DKK3 and non-secreted DKK3 could activate Akt signaling in discrete ways, and consequently exert tumor promoting effects. We hypothesized that DKK3 might be a specific druggable target, and it is necessary to establish a DKK3 inhibitor that can inhibit both secreted and non-secreted isoforms of DKK3.
    Methods: Using inverse polymerase chain reaction, we generated mutant expression plasmids that express DKK3 without CRD1, CRD2, or both CRD1 and CRD2 (DKK3ΔC1, DKK3ΔC2, and DKK3ΔC1ΔC2, respectively). These plasmids were then transfected into HNSCC-derived cells to determine the domain responsible for DKK3-mediated Akt activation. We designed antisense peptides using the MIMETEC program, targeting DKK3-specific amino acid sequences within CRD1 and CRD2. The structural models for peptides and DKK3 were generated using Raptor X, and then a docking simulation was performed using CluPro2. Afterward, the best set of the peptides was applied into HNSCC-derived cells, and the effects on Akt phosphorylation, cellular proliferation, invasion, and migration were assessed. We also investigated the therapeutic effects of the peptides in the xenograft models.
    Results: Transfection of mutant expression plasmids and subsequent functional analyses revealed that it is necessary to delete both CRD1 and CRD2 to inhibit Akt activation and inhibition of proliferation, migration, and invasion. The inhibitory peptides for CRD1 and CRD2 of DKK3 significantly reduced the phosphorylation of Akt, and consequently suppressed cellular proliferation, migration, invasion and in vivo tumor growth at very low doses.
    Conclusions: This inhibitory peptide represents a promising new therapeutic strategy for HNSCC treatment.
    Language English
    Publishing date 2022-11-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091573-1
    ISSN 1475-2867
    ISSN 1475-2867
    DOI 10.1186/s12935-022-02783-9
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  8. Article ; Online: Globotriaosylceramide Immunostaining of Myocardium in a Patient With Fabry Disease.

    Yoshida, Satoru / Kawano, Hiroaki / Ikeda, Satoshi / Sakuraba, Hitoshi / Okano, Shinji / Maemura, Koji

    Circulation journal : official journal of the Japanese Circulation Society

    2022  Volume 86, Issue 9, Page(s) 1479

    MeSH term(s) Fabry Disease/complications ; Humans ; Myocardium ; Trihexosylceramides ; alpha-Galactosidase
    Chemical Substances Trihexosylceramides ; globotriaosylceramide (71965-57-6) ; alpha-Galactosidase (EC 3.2.1.22)
    Language English
    Publishing date 2022-03-25
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-22-0067
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  9. Article ; Online: Severe prolonged liver abnormality with jaundice during treatment for granulomatosis with polyangiitis with rituximab and avacopan.

    Kojima, Kanako / Fukui, Shoichi / Tanigawa, Mai / Sumiyoshi, Remi / Koga, Tomohiro / Shimakura, Akane / Okano, Shinji / Kawakami, Atsushi

    Rheumatology (Oxford, England)

    2023  Volume 63, Issue 3, Page(s) e101–e103

    MeSH term(s) Humans ; Rituximab/therapeutic use ; Granulomatosis with Polyangiitis/complications ; Granulomatosis with Polyangiitis/drug therapy ; Jaundice/drug therapy ; Jaundice/etiology ; Liver ; Aniline Compounds ; Nipecotic Acids
    Chemical Substances Rituximab (4F4X42SYQ6) ; avacopan (O880NM097T) ; Aniline Compounds ; Nipecotic Acids
    Language English
    Publishing date 2023-09-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kead509
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  10. Article ; Online: Differentiation Between Heterogeneous GGN and Part-Solid Nodule Using 2 D Grayscale Histogram Analysis of Thin-Section CT Image.

    Koike, Hirofumi / Ashizawa, Kazuto / Tsutsui, Shin / Kurohama, Hirokazu / Okano, Shinji / Nagayasu, Takeshi / Kido, Shoji / Uetani, Masataka / Toya, Ryo

    Clinical lung cancer

    2023  Volume 24, Issue 6, Page(s) 541–550

    Abstract: Introduction/background: To evaluate cases of surgically resected pulmonary adenocarcinoma (Ad) with heterogenous ground-glass nodules (HGGNs) or part-solid nodules (PSNs) and to clarify the differences between them, and between invasive adenocarcinoma ( ...

    Abstract Introduction/background: To evaluate cases of surgically resected pulmonary adenocarcinoma (Ad) with heterogenous ground-glass nodules (HGGNs) or part-solid nodules (PSNs) and to clarify the differences between them, and between invasive adenocarcinoma (IVA) and minimally invasive adenocarcinoma (MIA) + adenocarcinoma in situ (AIS) using grayscale histogram analysis of thin-section computed tomography (TSCT).
    Materials and methods: 241 patients with pulmonary Ad were retrospectively classified into HGGNs and PSNs on TSCT by three thoracic radiologists. Sixty HGGNs were classified into 17 IVAs, 26 MIAs, and 17 AISs. 181 PSNs were classified into 114 IVAs, 55 MIAs, and 12 AISs.
    Results: We found significant differences in area (P = 0.0024), relative size of solid component (P <0.0001), circumference (P <0.0001), mean CT value (P <0.0001), standard deviation of the CT value (P <0.0001), maximum CT value (P <0.0001), skewness (P <0.0001), kurtosis (P <0.0001), and entropy (P <0.0001) between HGGNs and PSNs. In HGGNs, we found significant differences in relative size of solid component (P <0.0001), mean CT value (P = 0.0005), standard deviation of CT value (P = 0.0071), maximum CT value (P = 0.0237), and skewness (P = 0.0027) between IVAs and MIA+AIS lesions. In PSNs, we found significant differences in area (P = 0.0029), relative size of solid component (P = 0.0003), circumference (P = 0.0004), mean CT value (P = 0.0011), skewness (P = 0.0009), and entropy (P = 0.0002) between IVAs and the MIA+AIS lesions.
    Conclusion: Quantitative evaluations using grayscale histogram analysis can clearly distinguish between HGGNs and PSNs, and may be useful for estimating the pathology of such lesions.
    MeSH term(s) Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/surgery ; Lung Neoplasms/pathology ; Retrospective Studies ; Neoplasm Invasiveness ; Adenocarcinoma of Lung/diagnostic imaging ; Adenocarcinoma of Lung/surgery ; Adenocarcinoma/diagnostic imaging ; Adenocarcinoma/surgery ; Adenocarcinoma/pathology ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2023-06-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2145146-1
    ISSN 1938-0690 ; 1525-7304
    ISSN (online) 1938-0690
    ISSN 1525-7304
    DOI 10.1016/j.cllc.2023.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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