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  1. Article ; Online: Silyl-Group Boosted Internal Redox Reaction: Hydride Shift from an Aliphatic Secondary Position for the Formation of Six- and Seven-Membered Carbocycles.

    Okawa, Hiroto / Kawasaki-Takasuka, Tomoko / Mori, Keiji

    Organic letters

    2024  Volume 26, Issue 8, Page(s) 1662–1666

    Abstract: We report a hydride shift/cyclization reaction at the ... ...

    Abstract We report a hydride shift/cyclization reaction at the aliphatic
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.4c00140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Network of extracellular vesicles surrounding senescent cells.

    Okawa, Hikaru / Tanaka, Yoko / Takahashi, Akiko

    Archives of biochemistry and biophysics

    2024  Volume 754, Page(s) 109953

    Abstract: Extracellular vesicles (EVs) are small lipid bilayers released from cells that contain cellular components such as proteins, nucleic acids, lipids, and metabolites. Biological information is transmitted between cells via the EV content. Cancer and ... ...

    Abstract Extracellular vesicles (EVs) are small lipid bilayers released from cells that contain cellular components such as proteins, nucleic acids, lipids, and metabolites. Biological information is transmitted between cells via the EV content. Cancer and senescent cells secrete more EVs than normal cells, delivering more information to the surrounding recipient cells. Cellular senescence is a state of irreversible cell cycle arrest caused by the accumulation of DNA damage. Senescent cells secrete various inflammatory proteins known as the senescence-associated secretory phenotype (SASP). Inflammatory SASP factors, including small EVs, induce chronic inflammation and lead to various age-related pathologies. Recently, senolytic drugs that selectively induce cell death in senescent cells have been developed to suppress the pathogenesis of age-related diseases. This review describes the characteristics of senescent cells, the functions of EVs released from senescent cells, and the therapeutic effects of EVs on age-related diseases. Understanding the biology of EVs secreted from senescent cells will provide valuable insights for achieving healthy longevity in an aging society.
    MeSH term(s) Humans ; Extracellular Vesicles/metabolism ; Cellular Senescence ; Aging ; Neoplasms/metabolism ; Biological Transport
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 523-x
    ISSN 1096-0384 ; 0003-9861
    ISSN (online) 1096-0384
    ISSN 0003-9861
    DOI 10.1016/j.abb.2024.109953
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.237: Show issues Location:
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  3. Article ; Online: Effect of ultrasound irradiation on asphaltene aggregation and implications to rheological behavior of bitumen.

    Nguele, Ronald / Okawa, Hirokazu

    Ultrasonics sonochemistry

    2021  Volume 80, Page(s) 105811

    Abstract: The present work investigates the contribution of asphaltene aggregation to bitumen viscosity subject to ultrasound irradiation. A West-African bitumen with a viscosity of 12043cP at room temperature was sonicated at low (38 kHz) and mild frequency (200 ... ...

    Abstract The present work investigates the contribution of asphaltene aggregation to bitumen viscosity subject to ultrasound irradiation. A West-African bitumen with a viscosity of 12043cP at room temperature was sonicated at low (38 kHz) and mild frequency (200 kHz) under controlled gas environment including air, nitrogen (N
    Language English
    Publishing date 2021-10-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1208333-1
    ISSN 1873-2828 ; 1350-4177
    ISSN (online) 1873-2828
    ISSN 1350-4177
    DOI 10.1016/j.ultsonch.2021.105811
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    Zs.A 4441: Show issues Location:
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  4. Article ; Online: Mouse gingival single-cell transcriptomic atlas identified a novel fibroblast subpopulation activated to guide oral barrier immunity in periodontitis.

    Kondo, Takeru / Gleason, Annie / Okawa, Hiroko / Hokugo, Akishige / Nishimura, Ichiro

    eLife

    2023  Volume 12

    Abstract: Periodontitis, one of the most common non-communicable diseases, is characterized by chronic oral inflammation and uncontrolled tooth supporting alveolar bone resorption. Its underlying mechanism to initiate aberrant oral barrier immunity has yet to be ... ...

    Abstract Periodontitis, one of the most common non-communicable diseases, is characterized by chronic oral inflammation and uncontrolled tooth supporting alveolar bone resorption. Its underlying mechanism to initiate aberrant oral barrier immunity has yet to be delineated. Here, we report a unique fibroblast subpopulation
    MeSH term(s) Animals ; Mice ; Transcriptome ; Immunity, Innate ; Lymphocytes ; Periodontitis ; Inflammation ; Fibroblasts ; Ascomycota ; Bone Resorption ; Disease Models, Animal
    Language English
    Publishing date 2023-11-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.88183
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  5. Article: Mouse gingival single-cell transcriptomic atlas: An activated fibroblast subpopulation guides oral barrier immunity in periodontitis.

    Kondo, Takeru / Gleason, Annie / Okawa, Hiroko / Hokugo, Akishige / Nishimura, Ichiro

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Periodontitis, one of the most common non-communicable diseases, is characterized by chronic oral inflammation and uncontrolled tooth supporting alveolar bone resorption. Its underlying mechanism to initiate aberrant oral barrier immunity has yet to be ... ...

    Abstract Periodontitis, one of the most common non-communicable diseases, is characterized by chronic oral inflammation and uncontrolled tooth supporting alveolar bone resorption. Its underlying mechanism to initiate aberrant oral barrier immunity has yet to be delineated. Here, we report a unique fibroblast subpopulation activated to guide oral inflammation (AG fibroblasts) identified in a single-cell RNA sequencing gingival cell atlas constructed from the mouse periodontitis models. AG fibroblasts localized beneath the gingival epithelium and in the cervical periodontal ligament responded to the ligature placement and to the discrete application of Toll-like receptor stimulants to mouse maxillary tissue. The upregulated chemokines and ligands of AG fibroblasts linked to the putative receptors of neutrophils in the early stages of periodontitis. In the established chronic inflammation, neutrophils together with AG fibroblasts appeared to induce type 3 innate lymphoid cells (ILC3s) that were the primary source of interleukin-17 cytokines. The comparative analysis of
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.13.536751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Development of Rectus Sheath Hematoma During Hemodialysis.

    Okawa, Hiroyuki / Shimada, Yoshitaka / Ehara, Kaori / Nagaba, Yasushi

    Internal medicine (Tokyo, Japan)

    2022  Volume 61, Issue 24, Page(s) 3759–3760

    MeSH term(s) Humans ; Hematoma/diagnostic imaging ; Hematoma/etiology ; Muscular Diseases ; Fascia ; Gastrointestinal Hemorrhage ; Renal Dialysis/adverse effects ; Rectus Abdominis/diagnostic imaging
    Language English
    Publishing date 2022-04-23
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.8734-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 240: Show issues Location:
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  7. Article: Diarylmethylamine (‘Butterfly’-Type Amine) Unit: A Useful Unit for the Modulation of the Catalytic Activity of Aminothiourea Catalysts

    Ogawa, Hiromasa / Okawa, Hiroto / Mori, Keiji

    Synlett

    2023  Volume 34, Issue 16, Page(s) 1899–1904

    Abstract: We investigated the effects of substituents on the aromatic rings in a diarylmethylamine unit (which we have named the ‘butterfly’-type amine unit) in an aminothiourea catalyst. Detailed examination of the electronic effects of the aromatic rings ... ...

    Abstract We investigated the effects of substituents on the aromatic rings in a diarylmethylamine unit (which we have named the ‘butterfly’-type amine unit) in an aminothiourea catalyst. Detailed examination of the electronic effects of the aromatic rings revealed that the catalyst having a 3,5-bis(trifluoromethyl)phenyl group was the best, realizing an excellent chemical yield and enantioselectivity in an asymmetric Michael reaction between nitrostyrene and dimethyl malonate. Importantly, its catalytic ability as a chiral catalyst is superior to that of the well-known aminothiourea catalyst, the Takemoto catalyst, and this characteristic was observed in various asymmetric reactions.
    Keywords thiourea catalysis ; asymmetric catalysis ; diarylmethylamines ; organocatalysis ; Michael reaction
    Language English
    Publishing date 2023-06-27
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2042012-2
    ISSN 1437-2096 ; 0936-5214
    ISSN (online) 1437-2096
    ISSN 0936-5214
    DOI 10.1055/s-0042-1751471
    Database Thieme publisher's database

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  8. Article: Compression of the left atrium by a reconstructed gastric tube after subtotal oesophagectomy.

    Okawa, H

    Anaesthesia

    2007  Volume 62, Issue 10, Page(s) 1078–1079

    MeSH term(s) Aged ; Constriction, Pathologic/etiology ; Esophageal Neoplasms/surgery ; Esophagectomy ; Heart Atria/pathology ; Humans ; Myocardium/pathology ; Postoperative Complications/diagnostic imaging ; Tomography, X-Ray Computed
    Language English
    Publishing date 2007-10
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/j.1365-2044.2007.05271.x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 388: Show issues Location:
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  9. Article ; Online: Adsorption of an Anionic Surfactant (Sodium Dodecyl Sulfate) from an Aqueous Solution by Modified Cellulose with Quaternary Ammonium.

    Zou, Ming / Zhang, Haixin / Miyamoto, Naoto / Kano, Naoki / Okawa, Hirokazu

    Polymers

    2022  Volume 14, Issue 7

    Abstract: In this study, a method of removing an anionic surfactant sodium dodecyl sulfate (SDS) from an aqueous solution by cellulose modified with quaternary ammonium cation was discussed. Cellulose, as the adsorbent, was obtained from medical cotton balls, and ... ...

    Abstract In this study, a method of removing an anionic surfactant sodium dodecyl sulfate (SDS) from an aqueous solution by cellulose modified with quaternary ammonium cation was discussed. Cellulose, as the adsorbent, was obtained from medical cotton balls, and the quaternary ammonium cation (synthesized from dodecyl dimethyl tertiary amine and epichlorohydrin) was grafted onto the sixth hydroxyl group of D-glucose in the cellulose by the Williamson reaction under alkaline conditions. The modified cellulose was characterized by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS); and the zeta potential of the material was also measured after confirmation of the synthesis of quaternary ammonium salts by nuclear magnetic resonance (NMR). From these analyses, a peak of the quaternary ammonium group was observed at 1637 cm
    Language English
    Publishing date 2022-04-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym14071473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Effects of ultrasound irradiation on Au nanoparticles deposition on carbon-coated LiNi

    Tanaka, Yasuyuki / Okawa, Hirokazu / Kato, Takahiro / Sugawara, Katsuyasu

    Ultrasonics sonochemistry

    2021  Volume 82, Page(s) 105879

    Abstract: ... ...

    Abstract LiNi
    Language English
    Publishing date 2021-12-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1208333-1
    ISSN 1873-2828 ; 1350-4177
    ISSN (online) 1873-2828
    ISSN 1350-4177
    DOI 10.1016/j.ultsonch.2021.105879
    Database MEDical Literature Analysis and Retrieval System OnLINE

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