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  1. AU="Oke, Catherine"
  2. AU="Panter, Fabian"
  3. AU="Yi, Huiyue"
  4. AU="Anger, Michael S"
  5. AU=Maringe Camille
  6. AU="Pondarré, Corinne"
  7. AU="Jensen, Malte Engmann Kjeldskov"
  8. AU=Kouznetsov Vladimir V
  9. AU="Brackenridge, Anna"
  10. AU="Madhavan, Subha"
  11. AU="Tonelli, Giorgio"
  12. AU="Lopez, Anthony"
  13. AU="Belser, Matthias"
  14. AU="Chang, Polun"
  15. AU="Besheer, Joyce"
  16. AU="Rubatto, Marco"
  17. AU="Davies, Matthew E. P."
  18. AU="Cardano, Francesca"
  19. AU="Muller, Thibaut"
  20. AU="Albert, Amy B"
  21. AU="Udupa, Karthik Subramanaya"
  22. AU=Zinzula Luca
  23. AU="Shah, Pallavi"
  24. AU="Kirschnick, Laura Borges"
  25. AU="Nobuyuki Sakai"
  26. AU="Robert van Deursen"
  27. AU="Sentinella, Alexander T"
  28. AU=Budhiraja Rohit
  29. AU="Tonjes, M B"
  30. AU="Vande More, A M"
  31. AU="Gangireddy, Pavan Kumar Reddy"
  32. AU="Marlier, Arnaud"
  33. AU="Nerone, Marta"
  34. AU="Hou, Ping"
  35. AU=Sommerstein Rami AU=Sommerstein Rami
  36. AU="Zocchi, Kent"
  37. AU="Pandey, Jitendra Kumar"
  38. AU=Nzila Alexis
  39. AU="Vallurupalli, Anusha"

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  1. Artikel ; Online: Testing a non-destructive assay to track Plasmodium sporozoites in mosquitoes over time.

    Oke, Catherine E / Reece, Sarah E / Schneider, Petra

    Parasites & vectors

    2023  Band 16, Heft 1, Seite(n) 401

    Abstract: Background: The extrinsic incubation period (EIP), defined as the time it takes for malaria parasites in a mosquito to become infectious to a vertebrate host, is one of the most influential parameters for malaria transmission but remains poorly ... ...

    Abstract Background: The extrinsic incubation period (EIP), defined as the time it takes for malaria parasites in a mosquito to become infectious to a vertebrate host, is one of the most influential parameters for malaria transmission but remains poorly understood. The EIP is usually estimated by quantifying salivary gland sporozoites in subsets of mosquitoes, which requires terminal sampling. However, assays that allow repeated sampling of individual mosquitoes over time could provide better resolution of the EIP.
    Methods: We tested a non-destructive assay to quantify sporozoites of two rodent malaria species, Plasmodium chabaudi and Plasmodium berghei, expelled throughout 24-h windows, from sugar-soaked feeding substrates using quantitative-PCR.
    Results: The assay is able to quantify sporozoites from sugar-soaked feeding substrates, but the prevalence of parasite-positive substrates was low. Various methods were attempted to increase the detection of expelled parasites (e.g. running additional technical replicates; using groups rather than individual mosquitoes), but these did not increase the detection rate, suggesting that expulsion of sporozoites is variable and infrequent.
    Conclusions: We reveal successful detection of expelled sporozoites from sugar-soaked feeding substrates. However, investigations of the biological causes underlying the low detection rate of sporozoites (e.g. mosquito feeding behaviour, frequency of sporozoite expulsion or sporozoite clumping) are needed to maximise the utility of using non-destructive assays to quantify sporozoite dynamics. Increasing detection rates will facilitate the detailed investigation on infection dynamics within mosquitoes, which is necessary to explain the highly variable EIP of Plasmodium and to improve understanding of malaria transmission dynamics.
    Mesh-Begriff(e) Animals ; Sporozoites ; Anopheles/parasitology ; Plasmodium ; Malaria ; Plasmodium berghei ; Sugars
    Chemische Substanzen Sugars
    Sprache Englisch
    Erscheinungsdatum 2023-11-04
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2409480-8
    ISSN 1756-3305 ; 1756-3305
    ISSN (online) 1756-3305
    ISSN 1756-3305
    DOI 10.1186/s13071-023-06015-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Vector control: agents of selection on malaria parasites?

    Oke, Catherine E / Ingham, Victoria A / Walling, Craig A / Reece, Sarah E

    Trends in parasitology

    2022  Band 38, Heft 10, Seite(n) 890–903

    Abstract: Insect vectors are responsible for spreading many infectious diseases, yet interactions between pathogens/parasites and insect vectors remain poorly understood. Filling this knowledge gap matters because vectors are evolving in response to the deployment ...

    Abstract Insect vectors are responsible for spreading many infectious diseases, yet interactions between pathogens/parasites and insect vectors remain poorly understood. Filling this knowledge gap matters because vectors are evolving in response to the deployment of vector control tools (VCTs). Yet, whilst the evolutionary responses of vectors to VCTs are being carefully monitored, the knock-on consequences for parasite evolution have been overlooked. By examining how mosquito responses to VCTs impact upon malaria parasite ecology, we derive a framework for predicting parasite responses. Understanding how VCTs affect the selection pressures imposed on parasites could help to mitigate against parasite evolution that leads to unfavourable epidemiological outcomes. Furthermore, anticipating parasite evolution will inform monitoring strategies for VCT programmes as well as uncovering novel VCT strategies.
    Mesh-Begriff(e) Animals ; Culicidae ; Host-Parasite Interactions ; Humans ; Malaria/parasitology ; Mosquito Vectors/parasitology ; Parasites ; Plasmodium/genetics
    Sprache Englisch
    Erscheinungsdatum 2022-08-16
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2022.07.006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2898: Hefte anzeigen Standort:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  3. Artikel: Vector control: agents of selection on malaria parasites?

    Oke, Catherine E. / Ingham, Victoria A. / Walling, Craig A. / Reece, Sarah E.

    Trends in parasitology. 2022,

    2022  

    Abstract: Insect vectors are responsible for spreading many infectious diseases, yet interactions between pathogens/parasites and insect vectors remain poorly understood. Filling this knowledge gap matters because vectors are evolving in response to the deployment ...

    Abstract Insect vectors are responsible for spreading many infectious diseases, yet interactions between pathogens/parasites and insect vectors remain poorly understood. Filling this knowledge gap matters because vectors are evolving in response to the deployment of vector control tools (VCTs). Yet, whilst the evolutionary responses of vectors to VCTs are being carefully monitored, the knock-on consequences for parasite evolution have been overlooked. By examining how mosquito responses to VCTs impact upon malaria parasite ecology, we derive a framework for predicting parasite responses. Understanding how VCTs affect the selection pressures imposed on parasites could help to mitigate against parasite evolution that leads to unfavourable epidemiological outcomes. Furthermore, anticipating parasite evolution will inform monitoring strategies for VCT programmes as well as uncovering novel VCT strategies.
    Schlagwörter Culicidae ; evolution ; malaria ; parasites ; parasitology ; vector control
    Sprache Englisch
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    Anmerkung Pre-press version
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2022.07.006
    Datenquelle NAL Katalog (AGRICOLA)

    Volltext online

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.B 2898: Hefte anzeigen Standort:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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    Zs.MG 16: Hefte anzeigen
    Zs.MO 251: Hefte anzeigen

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  4. Artikel ; Online: Differential attraction in mosquito-human interactions and implications for disease control.

    Martinez, Julien / Showering, Alicia / Oke, Catherine / Jones, Robert T / Logan, James G

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2020  Band 376, Heft 1818, Seite(n) 20190811

    Abstract: Mosquito-borne diseases are a major burden on human health worldwide and their eradication through vector control methods remains challenging. In particular, the success of vector control interventions for targeting diseases such as malaria is under ... ...

    Abstract Mosquito-borne diseases are a major burden on human health worldwide and their eradication through vector control methods remains challenging. In particular, the success of vector control interventions for targeting diseases such as malaria is under threat, in part due to the evolution of insecticide resistance, while for other diseases effective control solutions are still lacking. The rate at which mosquitoes encounter and bite humans is a key determinant of their capacity for disease transmission. Future progress is strongly reliant on improving our understanding of the mechanisms leading to a mosquito bite. Here, we review the biological factors known to influence the attractiveness of mosquitoes to humans, such as body odour, the skin microbiome, genetics and infection by parasites. We identify the knowledge gaps around the relative contribution of each factor, and the potential links between them, as well as the role of natural selection in shaping vector-host-parasite interactions. Finally, we argue that addressing these questions will contribute to improving current tools and the development of novel interventions for the future. This article is part of the theme issue 'Novel control strategies for mosquito-borne diseases'.
    Mesh-Begriff(e) Animals ; Communicable Disease Control/instrumentation ; Culicidae/physiology ; Humans ; Mosquito Control/instrumentation ; Mosquito Control/methods ; Mosquito Vectors/physiology ; Vector Borne Diseases/prevention & control
    Sprache Englisch
    Erscheinungsdatum 2020-12-28
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2019.0811
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Einzelsignatur: Hefte anzeigen

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  5. Artikel ; Online: Skin microbiome alters attractiveness to Anopheles mosquitoes.

    Showering, Alicia / Martinez, Julien / Benavente, Ernest Diez / Gezan, Salvador A / Jones, Robert T / Oke, Catherine / Tytheridge, Scott / Pretorius, Elizabeth / Scott, Darren / Allen, Rachel L / D'Alessandro, Umberto / Lindsay, Steve W / Armour, John A L / Pickett, John / Logan, James G

    BMC microbiology

    2022  Band 22, Heft 1, Seite(n) 98

    Abstract: Background: Some people produce specific body odours that make them more attractive than others to mosquitoes, and consequently are at higher risk of contracting vector-borne diseases. The skin microbiome can break down carbohydrates, fatty acids and ... ...

    Abstract Background: Some people produce specific body odours that make them more attractive than others to mosquitoes, and consequently are at higher risk of contracting vector-borne diseases. The skin microbiome can break down carbohydrates, fatty acids and peptides on the skin into volatiles that mosquitoes can differentiate.
    Results: Here, we examined how skin microbiome composition of women differs in relation to level of attractiveness to Anopheles coluzzii mosquitoes, to identify volatiles in body odour and metabolic pathways associated with individuals that tend to be poorly-attractive to mosquitoes. We used behavioural assays to measure attractiveness of participants to An. coluzzii mosquitoes, 16S rRNA amplicon sequencing of the bacteria sampled from the skin and gas chromatography of volatiles in body odour. We found differences in skin microbiome composition between the poorly- and highly-attractive groups, particularly eight Amplicon Sequence Variants (ASVs) belonging to the Proteobacteria, Actinobacteria and Firmicutes phyla. Staphylococcus 2 ASVs are four times as abundant in the highly-attractive compared to poorly-attractive group. Associations were found between these ASVs and volatiles known to be attractive to Anopheles mosquitoes. Propanoic pathways are enriched in the poorly-attractive participants compared to those found to be highly-attractive.
    Conclusions: Our findings suggest that variation in attractiveness of people to mosquitoes is related to the composition of the skin microbiota, knowledge that could improve odour-baited traps or other next generation vector control tools.
    Mesh-Begriff(e) Animals ; Anopheles ; Bacteria/genetics ; Bacteria/metabolism ; Female ; Humans ; Microbiota ; Mosquito Vectors ; Odorants/analysis ; RNA, Ribosomal, 16S/genetics
    Chemische Substanzen RNA, Ribosomal, 16S
    Sprache Englisch
    Erscheinungsdatum 2022-04-11
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041505-9
    ISSN 1471-2180 ; 1471-2180
    ISSN (online) 1471-2180
    ISSN 1471-2180
    DOI 10.1186/s12866-022-02502-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Risk of arbovirus emergence via bridge vectors: case study of the sylvatic mosquito Aedes malayensis in the Nakai district, Laos.

    Miot, Elliott F / Calvez, Elodie / Aubry, Fabien / Dabo, Stéphanie / Grandadam, Marc / Marcombe, Sébastien / Oke, Catherine / Logan, James G / Brey, Paul T / Lambrechts, Louis

    Scientific reports

    2020  Band 10, Heft 1, Seite(n) 7750

    Abstract: Many emerging arboviruses of global public health importance, such as dengue virus (DENV) and yellow fever virus (YFV), originated in sylvatic transmission cycles involving wild animals and forest-dwelling mosquitoes. Arbovirus emergence in the human ... ...

    Abstract Many emerging arboviruses of global public health importance, such as dengue virus (DENV) and yellow fever virus (YFV), originated in sylvatic transmission cycles involving wild animals and forest-dwelling mosquitoes. Arbovirus emergence in the human population typically results from spillover transmission via bridge vectors, which are competent mosquitoes feeding on both humans and wild animals. Another related, but less studied concern, is the risk of 'spillback' transmission from humans into novel sylvatic cycles. We colonized a sylvatic population of Aedes malayensis from a forested area of the Nakai district in Laos to evaluate its potential as an arbovirus bridge vector. We found that this Ae. malayensis population was overall less competent for DENV and YFV than an urban population of Aedes aegypti. Olfactometer experiments showed that our Ae. malayensis colony did not display any detectable attraction to human scent in laboratory conditions. The relatively modest vector competence for DENV and YFV, combined with a lack of detectable attraction to human odor, indicate a low potential for this sylvatic Ae. malayensis population to act as an arbovirus bridge vector. However, we caution that opportunistic blood feeding on humans by sylvatic Ae. malayensis may occasionally contribute to bridge sylvatic and human transmission cycles.
    Mesh-Begriff(e) Aedes/physiology ; Aedes/virology ; Animals ; Arboviruses/physiology ; Conservation of Natural Resources ; Humans ; Laos ; Mosquito Vectors/physiology ; Mosquito Vectors/virology ; Odorants ; Risk ; Species Specificity
    Sprache Englisch
    Erscheinungsdatum 2020-05-08
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-64696-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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