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  1. Article ; Online: The pandemic COVID-19

    Adekunle Babajide Rowaiye / Olukemi Adejoke Onuh / Angus Nnamdi Oli / Okiemute Ajiroghene Okpalefe / Solomon Oni / Ezinne Janefrances Nwankwo

    The Pan African Medical Journal, Vol 36, Iss

    a tale of viremia, cellular oxidation and immune dysfunction

    2020  Volume 188

    Abstract: COVID-19, caused by SARS-CoV-2 is a tester of the immune system. While it spares the healthy, it brings severe morbidity and in a few cases, mortality to its victims. This article aims at critically reviewing the key virulence factors of COVID-19 which ... ...

    Abstract COVID-19, caused by SARS-CoV-2 is a tester of the immune system. While it spares the healthy, it brings severe morbidity and in a few cases, mortality to its victims. This article aims at critically reviewing the key virulence factors of COVID-19 which are the viremia, cellular oxidation and immune dysfunction. The averse economic effect of certain disease control measures such as national lock-downs and social distancing, though beneficial, makes them unsustainable. Worse still is the fact that wild animals and domestic pets are carriers of SARS-CoV-2 suggesting that the disease would take longer than expected to be eradicated globally. A better understanding of the pathological dynamics of COVID-19 would help the general populace to prepare for possible infection by the invisible enemy. While the world prospects for vaccines and therapeutic agents against the SARS-CoV-2, clinicians should also seek to modulate the immune system for optimum performance. Immunoprophylactic and immunomodulatory strategies are recommended for the different strata of stakeholders combating the pandemic with the hope that morbidities and mortalities associated with COVID-19 would be drastically reduced.
    Keywords covid-19 ; sars-cov-2 ; immune ; viremia ; cellular oxidation ; immunoprophylactic ; immunomodulatory ; Medicine ; R
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher The Pan African Medical Journal
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Camptothecin shows better promise than Curcumin in the inhibition of the Human Telomerase

    Adekunle Babajide Rowaiye / Yoroshi Joana Teca Mendes / Samson Ayodeji Olofinsae / John Breakthrough Oche / Oluwakemi Hannah Oladipo / Okiemute Ajiroghene Okpalefe / Joyce Oloaigbe Ogidigo

    Heliyon, Vol 7, Iss 8, Pp e07742- (2021)

    A computational study

    2021  

    Abstract: Objectives: The Human Telomerase enzyme has become a drug target in the treatment of cancers and age-related disorders. This study aims to identify potential natural inhibitors of the Human Telomerase from compounds derived from edible African plants. ... ...

    Abstract Objectives: The Human Telomerase enzyme has become a drug target in the treatment of cancers and age-related disorders. This study aims to identify potential natural inhibitors of the Human Telomerase from compounds derived from edible African plants. Materials and methods: A library of 1,126 natural compounds was molecularly docked against the Telomerase Reverse Transcriptase (PDB ID: 5ugw), the catalytic subunit of the target protein. Curcumin, a known Telomerase inhibitor was used as the standard. The front-runner compounds were screened for bioavailability, pharmacokinetic properties, and bioactivity using the SWISSADME, PKCSM, and Molinspiration webservers respectively. The molecular dynamic simulation and analyses of the apo and holo proteins were performed by the Galaxy supercomputing webserver. Results: The results of the molecular docking and virtual screening reveal Augustamine and Camptothecin as lead compounds. Augustamine has better drug-likeness and pharmacokinetic properties while Camptothecin showed better bioactivity and stronger binding affinity (-8.2 kcal/mol) with the target. The holo structure formed by Camptothecin showed greater inhibitory activity against the target with a total RMSF of 169.853, B-Factor of 20.164, and 108 anti-correlating residues. Conclusion: Though they both act at the same binding site, Camptothecin induces greater Telomerase inhibition and better molecular stability than the standard, Curcumin. Further tests are required to investigate the inhibitory activities of the lead compounds.
    Keywords Telomerase ; Molecular dynamic simulation ; Pharmacokinetic ; Augustamine ; Camptothecin ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 540
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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