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  1. Article ; Online: Integration of Three-Dimensional Liver Models in a Multimodal Image-Guided Robotic Liver Surgery Cockpit

    Okker D. Bijlstra / Alexander Broersen / Timo T. M. Oosterveer / Robin A. Faber / Friso B. Achterberg / Rob Hurks / Mark C. Burgmans / Jouke Dijkstra / J. Sven D. Mieog / Alexander L. Vahrmeijer / Rutger-Jan Swijnenburg

    Life, Vol 12, Iss 667, p

    2022  Volume 667

    Abstract: Background: Robotic liver surgery represents the most recent evolution in the field of minimally-invasive liver surgery. For planning and guidance of liver resections, surgeons currently rely on preoperative 2-dimensional (2D) CT and/or MR imaging and ... ...

    Abstract Background: Robotic liver surgery represents the most recent evolution in the field of minimally-invasive liver surgery. For planning and guidance of liver resections, surgeons currently rely on preoperative 2-dimensional (2D) CT and/or MR imaging and intraoperative ultrasonography. Translating 2D images into digital 3-dimensional (3D) models may improve both preoperative planning and surgical guidance. The da Vinci ® robotic surgical system is a platform suitable for the integration of multiple imaging modalities into one single view. In this study, we describe multimodal imaging options and introduce the Robotic Liver Surgery Cockpit; Methods: in-house developed software was used and validated for segmentation and registration to create a virtual reality 3D model of the liver based on preoperative imaging. The accuracy of the 3D models in the clinical setting was objectively assessed in 15 patients by measuring tumor diameters and subjectively with a postoperative conducted questionnaire; Results: Implementation and applicability of the 3D model in the surgical cockpit was feasible in all patients and the quality of the 3D reconstructions was high in 14 (93%) of cases. Tumor diameters measured on CT and/or MR imaging were comparable to automated measurements using the segmentation software and 3D models; Conclusions: the 3D model was successfully incorporated in the robotic surgery console as part of a multimodality imaging platform and aided the surgeon in planning and guidance of the resection. Future studies should focus on further automation of 3D rendering and progress into augmented reality.
    Keywords robotic surgery ; liver surgery ; multimodal imaging ; image-guided surgery ; virtual reality ; 3D ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Near-Infrared Fluorescence Tumor-Targeted Imaging in Lung Cancer

    Lisanne K. A. Neijenhuis / Lysanne D. A. N. de Myunck / Okker D. Bijlstra / Peter J. K. Kuppen / Denise E. Hilling / Frank J. Borm / Danielle Cohen / J. Sven D. Mieog / Willem H. Steup / Jerry Braun / Jacobus Burggraaf / Alexander L. Vahrmeijer / Merlijn Hutteman

    Life, Vol 12, Iss 446, p

    A Systematic Review

    2022  Volume 446

    Abstract: Lung cancer is the most common cancer type worldwide, with non-small cell lung cancer (NSCLC) being the most common subtype. Non-disseminated NSCLC is mainly treated with surgical resection. The intraoperative detection of lung cancer can be challenging, ...

    Abstract Lung cancer is the most common cancer type worldwide, with non-small cell lung cancer (NSCLC) being the most common subtype. Non-disseminated NSCLC is mainly treated with surgical resection. The intraoperative detection of lung cancer can be challenging, since small and deeply located pulmonary nodules can be invisible under white light. Due to the increasing use of minimally invasive surgical techniques, tactile information is often reduced. Therefore, several intraoperative imaging techniques have been tested to localize pulmonary nodules, of which near-infrared (NIR) fluorescence is an emerging modality. In this systematic review, the available literature on fluorescence imaging of lung cancers is presented, which shows that NIR fluorescence-guided lung surgery has the potential to identify the tumor during surgery, detect additional lesions and prevent tumor-positive resection margins.
    Keywords lung cancer ; near-infrared fluorescence imaging ; fluorescence-guided surgery ; molecular imaging ; optical imaging ; Science ; Q
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The Value of 18 F-FDG-PET-CT Imaging in Treatment Evaluation of Colorectal Liver Metastases

    Okker D. Bijlstra / Maud M. E. Boreel / Sietse van Mossel / Mark C. Burgmans / Ellen H. W. Kapiteijn / Daniela E. Oprea-Lager / Daphne D. D. Rietbergen / Floris H. P. van Velden / Alexander L. Vahrmeijer / Rutger-Jan Swijnenburg / J. Sven D. Mieog / Lioe-Fee de Geus-Oei

    Diagnostics, Vol 12, Iss 715, p

    A Systematic Review

    2022  Volume 715

    Abstract: 1) Background: Up to 50% of patients with colorectal cancer either have synchronous colorectal liver metastases (CRLM) or develop CRLM over the course of their disease. Surgery and thermal ablation are the most common local treatment options of choice. ... ...

    Abstract (1) Background: Up to 50% of patients with colorectal cancer either have synchronous colorectal liver metastases (CRLM) or develop CRLM over the course of their disease. Surgery and thermal ablation are the most common local treatment options of choice. Despite development and improvement in local treatment options, (local) recurrence remains a significant clinical problem. Many different imaging modalities can be used in the follow-up after treatment of CRLM, lacking evidence-based international consensus on the modality of choice. In this systematic review, we evaluated 18 F-FDG-PET-CT performance after surgical resection, thermal ablation, radioembolization, and neoadjuvant and palliative chemotherapy based on current published literature. (2) Methods: A systematic literature search was performed on the PubMed database. (3) Results: A total of 31 original articles were included in the analysis. Only one suitable study was found describing the role of 18 F-FDG-PET-CT after surgery, which makes it hard to draw a firm conclusion. 18 F-FDG-PET-CT showed to be of additional value in the follow-up after thermal ablation, palliative chemotherapy, and radioembolization. 18 F-FDG-PET-CT was found to be a poor to moderate predictor of pathologic response after neoadjuvant chemotherapy. (4) Conclusions: 18 F-FDG-PET-CT is superior to conventional morphological imaging modalities in the early detection of residual disease after thermal ablation and in the treatment evaluation and prediction of prognosis during palliative chemotherapy and after radioembolization, and 18 F-FDG-PET-CT could be considered in selected cases after neoadjuvant chemotherapy and surgical resection.
    Keywords positron emission tomography ; colorectal cancer ; colorectal liver metastases ; follow-up ; Medicine (General) ; R5-920
    Subject code 333 ; 610
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: AVOID; a phase III, randomised controlled trial using indocyanine green for the prevention of anastomotic leakage in colorectal surgery

    Hein Putter / Koos Burggraaf / Alexander L Vahrmeijer / J Sven D Mieog / Alexander L. Vahrmeijer / Ruben P J Meijer / Robin A Faber / Okker D Bijlstra / Jeffrey P B M Braak / Elma Meershoek-Klein Kranenbarg / Denise E Hilling / Ruben P.J. Meijer / Robin A. Faber / Okker D. Bijlstra / Jeffrey P.B.M. Braak / E. Meershoek-Klein Kranenbarg / J Hein Putter / Sven D. Mieog / E Denise /
    Hilling Tjeerd S. Aukema / I.M Coen / Johanne G. Bloemen / Annelies Bodegom / Fran Boersma / Koop Bosscha / Mark A.M. Brouwers / Esther C.J. Consten / Pascal G. Doornebosch / Dashti Faraj / Paul D. Gobardhan / Fabian .A. Holman / Tessa Kauwenbergh / Andreas W.K.S. Marinelli / Peter A. Neijenhuis / Koen C.M.J. Peeters / Daan J. Sikkenk / Laurents P.S. Stassen / Willem-Hans Steup / Maxime J.M. van der Valk / Bob J. van Wely / Lissa Wullaert

    BMJ Open, Vol 12, Iss

    2022  Volume 4

    Keywords Medicine ; R
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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