Article ; Online: Zenkeramide: a new iso-benzofuranone propanamide and urease inhibitory constituents of Celtis zenkeri Engl stem bark (Ulmaceae)
Natural Product Research. 2023 Jan. 2, v. 37, no. 1 p.93-98
2023
Abstract: A new iso-benzofuranone propanamide: 3-(3-oxo-1, 3-dihydroisobenzofuran-1-yl) propanamide (zenkeramide) (1) along with three known compounds: Trans-N-coumaroyltyramine (2), β-Sitosterol (3) and β-sitosterol-3-0-β-D-glucopyranoside (4) were isolated from ... ...
| Abstract | A new iso-benzofuranone propanamide: 3-(3-oxo-1, 3-dihydroisobenzofuran-1-yl) propanamide (zenkeramide) (1) along with three known compounds: Trans-N-coumaroyltyramine (2), β-Sitosterol (3) and β-sitosterol-3-0-β-D-glucopyranoside (4) were isolated from the ethyl acetate fraction of the stem-bark of Celtis zenkeri Engl (Ulmaceae). The structure of the new compound was elucidated by extensive spectroscopic analysis. The compounds were examined for Urease Inhibitory Activity. Compounds 1 and 2 showed moderate activities (IC₅₀ values (μM) of 42.3 ± 0.19 and 45.2 ± 0.55, respectively), while compounds 3 and 4 were potent inhibitors of the Jack bean urease (IC₅₀ values (μM) of 20.3 ± 0.37and 27.6 ± 0.52, respectively), when compared to the standard inhibitor (thiourea- IC₅₀ 21.5 ± 0.47). The isolation of all the compounds from C. zenkeri and the urease activity of compounds 1 and 2 are reported for the first time. |
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| Keywords | Canavalia ensiformis ; Celtis ; Ulmaceae ; bark ; ethyl acetate ; research ; spectral analysis ; urease ; Celtis zenkeri ; zenkeramide ; urease inhibitory activity |
| Language | English |
| Dates of publication | 2023-0102 |
| Size | p. 93-98. |
| Publishing place | Taylor & Francis |
| Document type | Article ; Online |
| ZDB-ID | 2185747-7 |
| ISSN | 1478-6427 ; 1478-6419 |
| ISSN (online) | 1478-6427 |
| ISSN | 1478-6419 |
| DOI | 10.1080/14786419.2021.1954643 |
| Database | NAL-Catalogue (AGRICOLA) |
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