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  1. Article ; Online: How Does Antibiotherapy Affect the Clinical Outcomes of the Patients with High Prostate Specific Antigen? An Observational Study

    Oktay Özman / Zübeyr Talat

    Üroonkoloji Bülteni, Vol 19, Iss 4, Pp 196-

    2020  Volume 199

    Abstract: Objective:The purpose of this observational study is to investigate the effect of urologists daily practice antibiotic usage on prostate biopsy rates and clinically insignificant cancer diagnosis rates in patients with gray-zone prostate specific antigen ...

    Abstract Objective:The purpose of this observational study is to investigate the effect of urologists daily practice antibiotic usage on prostate biopsy rates and clinically insignificant cancer diagnosis rates in patients with gray-zone prostate specific antigen (PSA).Materials and Methods:Two hundred thirty two patients who have PSA values between 2.5 and 10 ng/mL were studied prospectively. Patients convinced that he can benefit from the antibiotherapy were treated with levofloxacin 500 mg orally for 14 days by different urologist. At the end of treatment, serum PSA levels were measured again. PSA values of untreated patients were repeated after 14 days. Patients were reevaluated by same urologists with second PSA values for biopsy indication. Groups compared for biopsy rate, biopsy-to-prostate cancer detection rate, prostate cancer rate of population (Table 1, Prostate Cancer Rate 2), and Gleason 6 Prostate Cancer rate.Results:One hundred thirty six patients were treated with levofloxacin 500 mg for 2 weeks. Ninety six patients was untreated. PSA did not change or increased in 47 (35%) of patients which treated with antibiotics. Eight-nine (65%) patients had a decrease in PSA. Fewer biopsy indications were given in the group treated with antibiotics (p<0.001). When the all (biopsied and non-biopsied) patient groups were taken into consideration, fewer patients were diagnosed with prostate cancer in the treatment group (p=0.024). In the treatment group Gleason 6 cancer was 29%. Same rate was 45% in control group.Conclusion:Although antibiotherapy leads urologists to make less biopsy, the rate of cancer diagnosed by biopsy does not increase.
    Keywords psa ; prostate cancer ; antibiotherapy ; Medicine ; R ; Internal medicine ; RC31-1245 ; Specialties of internal medicine ; RC581-951 ; Diseases of the genitourinary system. Urology ; RC870-923 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Subject code 610 ; 616
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher Galenos Yayinevi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Relationship Between AMACR Staining Density of Radical Prostatectomy Specimen and Biochemical Recurrence in Patients with Pathological Stage T2a-b

    Murat Kars / Ersin Gökmen / Oktay Özman / Serkan Gönültaş / Burak Arslan

    Üroonkoloji Bülteni, Vol 19, Iss 1, Pp 38-

    2020  Volume 41

    Abstract: Objective:This study aimed to evaluate the relationship between Alpha-methylacyl-CoA racemase (AMACR) staining intensity of pathologic specimens and Prostate Spesific Antigen (PSA) recurrence of patients with an organ-limited disease who underwent ... ...

    Abstract Objective:This study aimed to evaluate the relationship between Alpha-methylacyl-CoA racemase (AMACR) staining intensity of pathologic specimens and Prostate Spesific Antigen (PSA) recurrence of patients with an organ-limited disease who underwent radical prostatectomy for localized prostate cancer.Materials and Methods:The data of 46 patients who underwent radical retropubic prostatectomy and who had prostate-limited disease without capsule invasion in the pathological evaluation were included in the study. AMACR expression was assessed by immunohistochemical staining. Expression levels were classified as negative (score=0), weak (score=1), moderate (score=2) and strong (score=3) staining. Patients with a PSA value of ≥0.2 ng/mL at postoperative follow-up were considered to have a biochemical recurrence. Patients were divided into two groups, according to biochemical recurrence. Groups were compared in terms of AMACR staining intensities of radical prostatectomy specimens.Results:Twenty-one patients developed PSA recurrence in a mean follow-up period of 32±8 months. The remaining 25 patients were recurrence-free. The mean recurrence time was 24±5 months. According to AMACR staining scores, the biochemical recurrence rates of the patients were 33.3%, 40.7%, and 61.5% for score 1, score 2, and score 3, respectively. Although higher rates of PSA recurrence were observed in patients with more intense AMACR staining, the difference between rates was not statistically significant (p=0.38).Conclusion:PSA recurrence rate increases with increasing AMAC-CR staining intensity. Further studies are needed to obtain statistically significant results.
    Keywords amacr ; psa ; prostate cancer ; Medicine ; R ; Internal medicine ; RC31-1245 ; Specialties of internal medicine ; RC581-951 ; Diseases of the genitourinary system. Urology ; RC870-923 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Subject code 610 ; 616
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher Galenos Yayinevi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Prediction of Possible Factors That Affect Stone-Free Rate of Retrograde Intrarenal Surgery; A Multicenter Study

    Oktay ÖZMAN / Cem BAŞATAÇ / Hacı Murat AKGÜL / Önder ÇINAR / Eyüp Burak SANCAK / Cenk Murat YAZICI / Bülent ÖNAL / Haluk AKPINAR

    Namık Kemal Tıp Dergisi, Vol 8, Iss 3, Pp 398-

    2020  Volume 403

    Abstract: Aim: The aim of the study was to evaluate possible factors predicting stone-free status at retrograde intrarenal surgery for renal stones.Materials and Methods: A retrospective multicenter study was performed using data from 513 patients treated between ... ...

    Abstract Aim: The aim of the study was to evaluate possible factors predicting stone-free status at retrograde intrarenal surgery for renal stones.Materials and Methods: A retrospective multicenter study was performed using data from 513 patients treated between February 2016 and January 2020 at four referral centers in Turkey. The patients were divided into two groups whether they had no residual stone over 3 mm (Group 1) or had residual stones (Group 2). Pre and peroperative parameters were compared in both groups (Table 1). Univariate and multivariate analyzes were performed to identify any factors affecting the stone-free rate (Table 2).Results: Overall stone-free rate was 88.5% (454/513). Lower calyx stones and multipl stones were significantly higher in Group 2 (p=0.006, p=0.02, respectively). Also access sheathless procedure rate was significantly higher and the basket catheter useage rate was significantly lower in Group 2 (p=0.04, p<0.001, respectively) (Table 1). Multiple stone presence and basket catheter usage during the procedure were found as independent factors to predict the stone-free status of Retrograde Intrarenal Surgery according to the results of logistic regression analysis (95%CI 3.3577-0.9999; H-L p= 0.05 and 95%CI 0.4442-0.1290; H-L p< 0.001, respectively) (Table 2).Conclusion:The presence of multiple stones in preoperative imaging and the use of basket catheters peroperatively are independent factors predicting stone-free status in Retrograde Intrarenal Surgery. The presence of multiple stones increases the probability of residual stones after the procedure, while the use of basket catheters is to reduce this possibility.
    Keywords kidney stone ; retrograde intrarenal surgery ; stone-free ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher Galenos Yayincilik
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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