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Article ; Online: Hypnotic prescription trends and patterns for the treatment of insomnia in Japan: analysis of a nationwide Japanese claims database.

Okuda, Shoki / Qureshi, Zaina P / Yanagida, Yukiko / Ito, Chie / Homma, Yuji / Tokita, Shigeru

2023 Volume 23, Issue 1, Page(s) 278

Abstract: Background: There is limited consensus regarding the optimal treatment of insomnia. The recent introduction of orexin receptor antagonists (ORA) has increased the available treatment options. However, the prescribing patterns of hypnotics in Japan have ... ...

Abstract	Background: There is limited consensus regarding the optimal treatment of insomnia. The recent introduction of orexin receptor antagonists (ORA) has increased the available treatment options. However, the prescribing patterns of hypnotics in Japan have not been comprehensively assessed. We performed analyses of a claims database to investigate the real-world use of hypnotics for treating insomnia in Japan. Methods: Data were retrieved for outpatients (aged ≥ 20 to < 75 years old) prescribed ≥ 1 hypnotic for a diagnosis of insomnia between April 1 Results: We analyzed data for 130,177 new and 91,215 long-term users (2010-2019). Most new users were prescribed one MOA per year (97.1%-97.9%). In 2010, GABA Conclusion: Prescriptions for hypnotics among new and long-term users in Japan showed distinct patterns and trends. Further understanding of the treatment options for insomnia with accumulating evidence for the risk-benefit balance might be beneficial for physicians prescribing hypnotics in real-world settings.
MeSH term(s)	Aged ; Humans ; Male ; Benzodiazepines/therapeutic use ; Drug Prescriptions/statistics & numerical data ; East Asian People ; Hypnotics and Sedatives/therapeutic use ; Japan/epidemiology ; Sleep Initiation and Maintenance Disorders/drug therapy ; Sleep Initiation and Maintenance Disorders/epidemiology ; Insurance Claim Review/statistics & numerical data ; Databases, Factual/statistics & numerical data ; Female ; Young Adult ; Adult ; Middle Aged ; Receptors, Melatonin/agonists ; GABA-A Receptor Agonists/therapeutic use ; Orexin Receptor Antagonists/therapeutic use ; Sleep Aids, Pharmaceutical/therapeutic use
Chemical Substances	Benzodiazepines (12794-10-4) ; Hypnotics and Sedatives ; Receptors, Melatonin ; GABA-A Receptor Agonists ; Orexin Receptor Antagonists ; Sleep Aids, Pharmaceutical
Language	English
Publishing date	2023-04-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2050438-X
ISSN	1471-244X ; 1471-244X
ISSN (online)	1471-244X
ISSN	1471-244X
DOI	10.1186/s12888-023-04683-2
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Article: Factors Associated with Prescriptions for an Orexin Receptor Antagonist Among Japanese Patients with Insomnia: Analysis of a Nationwide Japanese Claims Database.

Okuda, Shoki / Qureshi, Zaina P / Yanagida, Yukiko / Ito, Chie / Homma, Yuji / Tokita, Shigeru

Drugs - real world outcomes

2023 Volume 10, Issue 2, Page(s) 271–281

Abstract: Background: Few studies have examined the prescribing patterns of orexin receptor antagonists (ORAs) in the real-world clinical setting in Japan.: Objective: We sought to analyze the factors associated with ORA prescriptions for patients with ... ...

Abstract	Background: Few studies have examined the prescribing patterns of orexin receptor antagonists (ORAs) in the real-world clinical setting in Japan. Objective: We sought to analyze the factors associated with ORA prescriptions for patients with insomnia in Japan. Methods: Outpatients (aged ≥ 20 to < 75 years old) prescribed one or more hypnotic for insomnia between April 1, 2018 and March 31, 2020 with continuous enrollment for ≥ 12 months were extracted from the JMDC Claims Database. We performed multivariable logistic regression to identify factors (patient demographics and psychiatric comorbidities) associated with ORA prescription in new or non-new users of hypnotics (patients without or with hypnotics prescription history, respectively). Results: Of 58,907 new users, 11,589 (19.7%) were prescribed ORA at the index date. Male sex (odds ratio [OR] 1.17, 95% confidence interval [CI] 1.12-1.22) and presence of bipolar disorders (OR 1.36, 95% CI 1.20-1.55) were associated with greater odds of ORA prescription. Among 88,611 non-new users, 15,504 (17.5%) were prescribed ORA at the index date. Younger age and several psychiatric comorbidities, such as neurocognitive disorders (OR 1.64, 95% CI 1.15-2.35), substance use disorders (OR 1.19, 95% CI 1.05-1.35), bipolar disorders (OR 1.14, 95% CI 1.07-1.22), schizophrenia spectrum disorders (OR 1.07, 95% CI 1.01-1.14), and anxiety disorders (OR 1.05, 95% CI 1.00-1.10), were associated with greater odds of ORA prescription. Conclusion: This is the first study to determine the factors associated with ORA prescriptions in Japan. Our findings could help guide appropriate insomnia treatment using ORAs.
Language	English
Publishing date	2023-03-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2806600-5
ISSN	2198-9788 ; 2199-1154
ISSN (online)	2198-9788
ISSN	2199-1154
DOI	10.1007/s40801-023-00356-4
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Article ; Online: Association between sleep disturbance in Alzheimer's disease patients and burden on and health status of their caregivers.

Okuda, Shoki / Tetsuka, Jumpei / Takahashi, Kenichi / Toda, Yasuo / Kubo, Takekazu / Tokita, Shigeru

Journal of neurology

2019 Volume 266, Issue 6, Page(s) 1490–1500

Abstract: Background: Sleep disturbance in Alzheimer's disease (AD) patients may have a negative impact not only on patients themselves but also on the physical and mental health of their caregivers. Detailed analysis of these issues is lacking.: Objective: ... ...

Abstract	Background: Sleep disturbance in Alzheimer's disease (AD) patients may have a negative impact not only on patients themselves but also on the physical and mental health of their caregivers. Detailed analysis of these issues is lacking. Objective: This study investigated the association between sleep disturbance in AD patients and the burden on, and health status of, their caregivers in Japan. Methods: We conducted a cross-sectional web-based questionnaire survey among caregivers of AD patients with insomnia symptoms in Japan. Demographic data and Sleep Disorders Inventory (SDI) scores for patients, caregiver burden (Burden Index of Caregivers-11 [BIC-11]) and health status, including Pittsburgh Sleep Quality Index, Patient Health Questionnaire-9, and 12-Item Short Form Health Survey v2, were collected. Multivariate analysis was used to examine the association between the burden and health status of caregivers and sleep disturbance in their care recipients with AD. Results: A total of 496 caregivers of AD patients with insomnia symptoms were examined in this study. We found that the BIC-11 total score increased as the SDI score increased, indicating a significant positive association, even after adjusting for confounding factors. We also found an association between sleep disturbances of AD patients and health of caregivers (sleep quality, depression, and physical/mental quality of life). Conclusion: This study demonstrated that sleep disturbance in AD patients was associated with an increased burden and poorer health status of caregivers. Our findings highlight the importance of sleep management in AD patients.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Alzheimer Disease/complications ; Alzheimer Disease/nursing ; Caregivers ; Cost of Illness ; Cross-Sectional Studies ; Family ; Female ; Health Status ; Humans ; Male ; Middle Aged ; Quality of Life ; Sleep Initiation and Maintenance Disorders/etiology ; Sleep Initiation and Maintenance Disorders/nursing ; Young Adult
Language	English
Publishing date	2019-04-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-019-09286-0
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Article: Podocan Is Expressed in Blood and Adipose Tissue and Correlates Negatively With the Induction of Diabetic Nephropathy.

Nio, Yasunori / Okawara, Mitsugi / Okuda, Shoki / Matsuo, Takanori / Furuyama, Naoki

Journal of the Endocrine Society

2017 Volume 1, Issue 7, Page(s) 772–786

Abstract: Podocan, a member of the small leucine-rich repeat proteoglycans (SLRPs), is expressed in vascular endothelial cells with high levels of expression in the sclerotic glomerular lesions of experimental HIV-associated nephropathy. It is also found in ... ...

Abstract	Podocan, a member of the small leucine-rich repeat proteoglycans (SLRPs), is expressed in vascular endothelial cells with high levels of expression in the sclerotic glomerular lesions of experimental HIV-associated nephropathy. It is also found in vascular smooth muscle cells and is involved in atherosclerosis. Decorin, a protein similar to podocan, also belongs to the SLRP family and is highly expressed in adipose tissues. It is a secreted protein associated with obesity, type 2 diabetes, and diabetic nephropathy. Based on the similarity of podocan to decorin and its functions reported in the renal and cardiovascular systems, we hypothesized that podocan levels might correlate with the occurrence of metabolic syndromes such as obesity, diabetes, and diabetic nephropathy. We found that podocan was highly expressed in the adipose tissue of mice and humans and its expression was regulated by tumor necrosis factor-
Language	English
Publishing date	2017-05-16
Publishing country	United States
Document type	Journal Article
ISSN	2472-1972
ISSN	2472-1972
DOI	10.1210/js.2017-00123
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Article ; Online: Demographic and clinical characteristics of patients with delirium: analysis of a nationwide Japanese medical database.

Ueda, Naoya / Igarashi, Masakazu / Okuyama, Kotoba / Sano, Hideki / Takahashi, Kanae / P Qureshi, Zaina / Tokita, Shigeru / Ogawa, Asao / Okumura, Yasuyuki / Okuda, Shoki

BMJ open

2022 Volume 12, Issue 9, Page(s) e060630

Abstract: Objectives: Delirium commonly occurs during hospitalisation and is associated with increased mortality, especially in elderly patients. This study aimed to determine the demographic and clinical characteristics of patients with delirium in the Japanese ... ...

Abstract	Objectives: Delirium commonly occurs during hospitalisation and is associated with increased mortality, especially in elderly patients. This study aimed to determine the demographic and clinical characteristics of patients with delirium in the Japanese real-world clinical setting using a nationwide database comprising claims and discharge abstract data. Design: This was an observational, cross-sectional, retrospective study in hospitalised patients with an incident delirium identified by a diagnosis based on International Classification of Diseases, 10th Revision codes or initiating antipsychotics recommended for delirium treatment in Japan during their hospitalisation. Setting: Patients from the Medical Data Vision database including more than 400 acute care hospitals in Japan were evaluated from admission to discharge. Participants: Of the 32 910 227 patients who were included in the database between April 2012 and September 2020, a total of 145 219 patients met the criteria for delirium. Primary and secondary outcome measures: Demographic and baseline characteristics, comorbidities, clinical profiles and pharmacological treatments were evaluated in patients with delirium. Results: The mean (SD) patient age was 76.5 (13.8) years. More than half of the patients (n=82 159; 56.6%) were male. The most frequent comorbidities were circulatory system diseases, observed in 81 954 (56.4%) patients. Potentially inappropriate medications (PIMs) with risk of delirium including benzodiazepines and opioids were prescribed to 76 798 (52.9%) patients. Approximately three-fourths of these patients (56 949; 74.2%) were prescribed ≥4 PIMs. The most prescribed treatment for delirium was injectable haloperidol (n=82 490; 56.8%). Mean (SD) length of hospitalisation was 16.0 (12.1) days. Conclusions: The study results provide comprehensive details of the clinical characteristics of patients with delirium and treatment patterns with antipsychotics in the Japanese acute care setting. In this patient population, the prescription rate of injectable haloperidol and PIMs was high, suggesting the need for improved understanding among healthcare providers about the appropriate management of delirium, which may benefit patients.
MeSH term(s)	Aged ; Antipsychotic Agents/therapeutic use ; Cross-Sectional Studies ; Delirium/chemically induced ; Delirium/drug therapy ; Delirium/epidemiology ; Demography ; Female ; Haloperidol/therapeutic use ; Humans ; Japan/epidemiology ; Male ; Retrospective Studies
Chemical Substances	Antipsychotic Agents ; Haloperidol (J6292F8L3D)
Language	English
Publishing date	2022-09-14
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2021-060630
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Article ; Online: Incremental medical cost of delirium in elderly patients with cognitive impairment: analysis of a nationwide administrative database in Japan.

Igarashi, Masakazu / Okuyama, Kotoba / Ueda, Naoya / Sano, Hideki / Takahashi, Kanae / P Qureshi, Zaina / Tokita, Shigeru / Ogawa, Asao / Okumura, Yasuyuki / Okuda, Shoki

BMJ open

2022 Volume 12, Issue 12, Page(s) e062141

Abstract: Objectives: Delirium is a neuropsychiatric disorder that commonly occurs in elderly patients with cognitive impairment. The economic burden of delirium in Japan has not been well characterised. In this study, we assessed incremental medical costs of ... ...

Abstract	Objectives: Delirium is a neuropsychiatric disorder that commonly occurs in elderly patients with cognitive impairment. The economic burden of delirium in Japan has not been well characterised. In this study, we assessed incremental medical costs of delirium in hospitalised elderly Japanese patients with cognitive impairment. Design: Retrospective, cross-sectional, observational study. Setting: Administrative data collected from acute care hospitals in Japan between April 2012 and September 2020. Participants: Hospitalised patients ≥65 years old with cognitive impairment were categorised into groups-with and without delirium. Delirium was identified using a delirium identification algorithm based on the International Classification of Diseases 10 Outcome measures: Total medical costs during hospitalisation were compared between the groups using a generalised linear model. Results: The study identified 297 600 hospitalised patients ≥65 years of age with cognitive impairment: 39 836 had delirium and 257 764 did not. Patient characteristics such as age, sex, inpatient department and comorbidities were similar between groups. Mean (SD) unadjusted total medical cost during hospitalisation was 979 907.7 (871 366.4) yen for patients with delirium and 816 137.0 (794 745.9) yen for patients without delirium. Adjusted total medical cost was significantly greater for patients with delirium compared with those without delirium (cost ratio=1.09, 95% CI: 1.09 to 1.10; p<0.001). Subgroup analyses revealed significantly higher total medical costs for patients with delirium compared with those without delirium in most subgroups except patients with hemiplegia or paraplegia. Conclusions: Medical costs during hospitalisation were significantly higher for patients with delirium compared with those without delirium in elderly Japanese patients with cognitive impairment, regardless of patient subgroups such as age, sex, intensive care unit admission and most comorbidities. These findings suggest that delirium prevention strategies are critical to reducing the economic burden as well as psychological/physiological burden in cognitively impaired elderly patients in Japan.
Language	English
Publishing date	2022-12-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-062141
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Article ; Online: Ameliorative effect of N-desmethylclozapine in animal models of social deficits and cognitive functions.

Maehara, Shunsuke / Okuda, Shoki / Ohta, Hisashi

Brain research bulletin

2011 Volume 86, Issue 3-4, Page(s) 146–151

Abstract: One of the major circulating metabolites of clozapine, N-desmethylclozapine (NDMC), has been demonstrated to exhibit partial agonistic activity at M(1) muscarinic receptors. Some of the unique therapeutic effects of clozapine might involve the ... ...

Abstract	One of the major circulating metabolites of clozapine, N-desmethylclozapine (NDMC), has been demonstrated to exhibit partial agonistic activity at M(1) muscarinic receptors. Some of the unique therapeutic effects of clozapine might involve the pharmacological effects of this metabolite. The purpose of the present study was therefore to examine whether NDMC improved behavioral abnormalities in animal models of social deficits and cognitive deficits of schizophrenia. NDMC (3mg/kg) and clozapine (1-3mg/kg) each improved the reduction of social interaction caused by a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist, 5R,10S-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801) (0.1mg/kg), without affecting locomotor activity in rats. NDMC (3-10mg/kg) and clozapine (1-3mg/kg) each also resulted in better discrimination of a novel from a familiar object 24h after a training trial in a rat object recognition test. These findings suggest that NDMC can improve behavior in animal models of social deficits and cognitive deficits of schizophrenia as well as clozapine.
MeSH term(s)	Animals ; Clozapine/analogs & derivatives ; Clozapine/pharmacology ; Cognition/drug effects ; Dizocilpine Maleate/pharmacology ; Excitatory Amino Acid Antagonists/pharmacology ; Exploratory Behavior/drug effects ; Interpersonal Relations ; Male ; Motor Activity/drug effects ; Psychomotor Performance/drug effects ; Rats ; Rats, Sprague-Dawley ; Recognition (Psychology)/drug effects ; Schizophrenic Psychology ; Social Behavior
Chemical Substances	Excitatory Amino Acid Antagonists ; norclozapine (1I9001LWY8) ; Dizocilpine Maleate (6LR8C1B66Q) ; Clozapine (J60AR2IKIC)
Language	English
Publishing date	2011-10-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	197620-5
ISSN	1873-2747 ; 0361-9230
ISSN (online)	1873-2747
ISSN	0361-9230
DOI	10.1016/j.brainresbull.2011.08.004
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Article: Corticotropin-releasing factor modulates maternal separation-induced ultrasonic vocalization in rat pups via activation of CRF1 receptor.

Ise, Satoko / Nagano, Norihiro / Okuda, Shoki / Ohta, Hisashi

Brain research

2008 Volume 1234, Page(s) 59–65

Abstract: An infant animal isolated from its mother emits vocalizations spanning from the audible to the ultrasonic. These vocalizations are believed to represent distress signals from the pup. However, the neurobiological basis for vocalizations elicited by ... ...

Abstract	An infant animal isolated from its mother emits vocalizations spanning from the audible to the ultrasonic. These vocalizations are believed to represent distress signals from the pup. However, the neurobiological basis for vocalizations elicited by isolation has not been well characterized under different environmental conditions. The present study was designed to clarify the role of the corticotropin-releasing factor (CRF) system in vocalizations elicited by isolating a rat pup at ambient temperatures of 37 degrees C (temperature of the nest in which the mother and littermates are present) and 24 degrees C (room temperature). Sprague-Dawley rat pups at 7 days old were isolated from their dam, then the number of vocalizations was measured for 5 min. The number of vocalizations increased when ambient temperature was changed from 37 degrees C to 24 degrees C. Systemic administration of CRF (3 or 10 mg/kg) increased the number of vocalizations at 37 degrees C in a dose-dependent manner. CRF-induced increases in the number of vocalizations at 3 mg/kg were completely blocked by a selective CRF1 receptor antagonist, NBI27914 (3 mg/kg), but not by a selective CRF2 receptor antagonist, K41498 (3 mg/kg). NBI27914 (30 mg/kg), but not K41498 (3 mg/kg), suppressed the increased number of vocalizations at 24 degrees C. These results demonstrate involvement of the CRF-CRF1 receptor regulatory system on the modulation of ultrasonic vocalizations by rat pups separated from their dam.
MeSH term(s)	Amphibian Proteins/pharmacology ; Aniline Compounds/pharmacology ; Animals ; Anxiety, Separation/psychology ; Corticotropin-Releasing Hormone/pharmacology ; Data Interpretation, Statistical ; Female ; Male ; Peptide Hormones/pharmacology ; Pyrimidines/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Corticotropin-Releasing Hormone/agonists ; Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors ; Skin Temperature/drug effects ; Temperature ; Vocalization, Animal/drug effects
Chemical Substances	2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine ; Amphibian Proteins ; Aniline Compounds ; CRF receptor type 1 ; CRF receptor type 2 ; Peptide Hormones ; Pyrimidines ; Receptors, Corticotropin-Releasing Hormone ; sauvagine (74434-59-6) ; Corticotropin-Releasing Hormone (9015-71-8)
Language	English
Publishing date	2008-10-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1200-2
ISSN	1872-6240 ; 0006-8993
ISSN (online)	1872-6240
ISSN	0006-8993
DOI	10.1016/j.brainres.2008.07.079
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Article: Characteristics of object location memory in mice: Behavioral and pharmacological studies.

Murai, Takeshi / Okuda, Shoki / Tanaka, Takeshi / Ohta, Hisashi

Physiology & behavior

2007 Volume 90, Issue 1, Page(s) 116–124

Abstract: An object location test (OLT) has been developed to test spatial memory in rats. The test is based on the spontaneous tendency of rodents, previously exposed to two identical objects, to later explore one of the objects--replaced in a novel location--for ...

Abstract	An object location test (OLT) has been developed to test spatial memory in rats. The test is based on the spontaneous tendency of rodents, previously exposed to two identical objects, to later explore one of the objects--replaced in a novel location--for a longer time than they explore the non-displaced object. In this study, we established the OLT in mice and investigated its characteristics with behavioral and pharmacological analysis. Mice discriminated the object in the novel location when the test trial was conducted < or =2 h after the acquisition trial. The cognitive ability was influenced neither by a change in the arrangement of the objects in the experimental apparatus, nor by change in the entry position of the mice. Object location memory was disrupted with change in the relative position of the objects to extra-field cues, or under conditions of deprivation of extra-field cues, suggesting that discrimination of the displaced object reflects spatial memory. A muscarinic cholinergic receptor antagonist (scopolamine, 1 mg/kg) impaired object location memory, while an acetylcholine esterase inhibitor (donepezil, 3 mg/kg) increased ability to maintain object location memory. In addition, aged mice showed poorer cognitive performance than young mice on the OLT. These findings indicate that the OLT can be used to assess spatial memory in mice, as well as in rats. The object location memory in mice was sensitive to pharmacological manipulation with cholinergic agents and to aging and could be used to identify agents affecting spatial memory.
MeSH term(s)	Age Factors ; Analysis of Variance ; Animals ; Association Learning/drug effects ; Association Learning/physiology ; Behavioral Research/methods ; Cholinesterase Inhibitors/pharmacology ; Exploratory Behavior/drug effects ; Exploratory Behavior/physiology ; Indans/pharmacology ; Male ; Memory/drug effects ; Memory/physiology ; Mice ; Mice, Inbred ICR ; Muscarinic Antagonists/pharmacology ; Piperidines/pharmacology ; Scopolamine Hydrobromide/pharmacology ; Sensitivity and Specificity ; Space Perception/drug effects ; Space Perception/physiology ; Spatial Behavior/drug effects ; Spatial Behavior/physiology ; Statistics, Nonparametric
Chemical Substances	Cholinesterase Inhibitors ; Indans ; Muscarinic Antagonists ; Piperidines ; Scopolamine Hydrobromide (451IFR0GXB) ; donepezil (8SSC91326P)
Language	English
Publishing date	2007-01-30
Publishing country	United States
Document type	Journal Article ; Validation Studies
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2006.09.013
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Article ; Online: A novel and selective melanin-concentrating hormone receptor 1 antagonist ameliorates obesity and hepatic steatosis in diet-induced obese rodent models.

Kawata, Yayoi / Okuda, Shoki / Hotta, Natsu / Igawa, Hideyuki / Takahashi, Masashi / Ikoma, Minoru / Kasai, Shizuo / Ando, Ayumi / Satomi, Yoshinori / Nishida, Mayumi / Nakayama, Masaharu / Yamamoto, Syunsuke / Nagisa, Yasutaka / Takekawa, Shiro

European journal of pharmacology

2017 Volume 796, Page(s) 45–53

Abstract: Melanin-concentrating hormone (MCH), a cyclic neuropeptide expressed predominantly in the lateral hypothalamus, plays an important role in the control of feeding behavior and energy homeostasis. Mice lacking MCH or ... ...

Abstract	Melanin-concentrating hormone (MCH), a cyclic neuropeptide expressed predominantly in the lateral hypothalamus, plays an important role in the control of feeding behavior and energy homeostasis. Mice lacking MCH or MCH
MeSH term(s)	Animals ; Anti-Obesity Agents/pharmacology ; Anti-Obesity Agents/therapeutic use ; Body Weight/drug effects ; Diet, High-Fat/adverse effects ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Gene Knockout Techniques ; Lipogenesis/drug effects ; Liver/drug effects ; Liver/metabolism ; Male ; Mice ; Non-alcoholic Fatty Liver Disease/chemically induced ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/metabolism ; Obesity/chemically induced ; Obesity/drug therapy ; Obesity/metabolism ; Rats ; Receptors, Pituitary Hormone/antagonists & inhibitors ; Receptors, Pituitary Hormone/deficiency ; Receptors, Pituitary Hormone/genetics
Chemical Substances	Anti-Obesity Agents ; Receptors, Pituitary Hormone ; melanin-concentrating hormone receptor
Language	English
Publishing date	2017-02-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2016.12.018
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