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  1. Article: Effects of continuous supplementation of

    Sato, Takeru / Aoki, Takumi / Ito, Yuki / Oishi, Kan / Fujishima, Masaki / Okumura, Eri / Ishii, Kojiro

    Frontiers in cardiovascular medicine

    2024  Volume 11, Page(s) 1336676

    Abstract: Background: Cardiac autonomic function (CAF) decreases with aging, and : Methods: This double-blind, randomized controlled trial was conducted in the morning in a laboratory setting and was carried out between June 2017 and July 2017 at Kambaikan, ... ...

    Abstract Background: Cardiac autonomic function (CAF) decreases with aging, and
    Methods: This double-blind, randomized controlled trial was conducted in the morning in a laboratory setting and was carried out between June 2017 and July 2017 at Kambaikan, Doshisha University (Karasuma-higashi-iru, Imadegawa-dori, Kamigyo-ku, Kyoto 602-8580, Japan). In total, 28 community-dwelling elderly individuals (mean ± standard deviation = 72.5 ± 4.5 years) were included. Each subject was instructed to consume ASH or placebo supplements twice daily for 4 weeks. An autonomic reflex orthostatic tolerance recorder was used to measure CAF in pre- and post-intervention phases. Parameters were measured in a seated position and included coefficient of variation of R-R intervals (CVRR), low frequency (LF), high frequency (HF), LF/HF ratio, blood pressure, and heart rate (HR). Changes in each parameter were evaluated before and after standing. All parameters were defined as the difference between the mean value obtained in a standing position for 2 min and that obtained in a 2-min seated position.
    Results: A two-way analysis of variance revealed a significant group-time interaction effect on CVRR, HF, and ΔLF/HF ratio. Following the intervention, CVRR, HF, LF/HF ratio, systolic blood pressure (SBP), HR, ΔLF/HF ratio, ΔSBP, and ΔHR improved significantly in the ASH group only.
    Conclusions: Four-week supplementation of ASH improved CAF in community-dwelling elderly individuals during resting and standing tests.
    Clinical trial registration: https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000031218, UMIN Clinical Trials Registry (UMIN000027251).
    Language English
    Publishing date 2024-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2024.1336676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The effect of

    Uchiyama-Tanaka, Yoko / Shimabukuro, Fumi / Okumura, Eri / Fujishima, Masaki

    Food science & nutrition

    2023  Volume 12, Issue 1, Page(s) 292–297

    Abstract: Pregnancy dramatically changes maternal metabolism and the microbiome. Low-grade inflammation can cause maternal complications and fetal abnormalities. The objective of this open-label, randomized, controlled study was to evaluate the efficacy and safety ...

    Abstract Pregnancy dramatically changes maternal metabolism and the microbiome. Low-grade inflammation can cause maternal complications and fetal abnormalities. The objective of this open-label, randomized, controlled study was to evaluate the efficacy and safety of orally administered
    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703010-6
    ISSN 2048-7177
    ISSN 2048-7177
    DOI 10.1002/fsn3.3759
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  3. Article ; Online: Potential of

    Bito, Tomohiro / Okumura, Eri / Fujishima, Masaki / Watanabe, Fumio

    Nutrients

    2020  Volume 12, Issue 9

    Abstract: ... ...

    Abstract Chlorella
    MeSH term(s) Animals ; Antihypertensive Agents ; Antioxidants ; Chlorella/chemistry ; Dietary Supplements ; Drug Synergism ; Ergocalciferols ; Folic Acid ; Heart Disease Risk Factors ; Humans ; Hypoglycemic Agents ; Hypolipidemic Agents ; Immunologic Factors ; Lutein ; Micronutrients/isolation & purification ; Micronutrients/pharmacology ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Vitamin B 12
    Chemical Substances Antihypertensive Agents ; Antioxidants ; Ergocalciferols ; Hypoglycemic Agents ; Hypolipidemic Agents ; Immunologic Factors ; Micronutrients ; Phytochemicals ; Folic Acid (935E97BOY8) ; Vitamin B 12 (P6YC3EG204) ; Lutein (X72A60C9MT)
    Language English
    Publishing date 2020-08-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12092524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Potential of Chlorella as a Dietary Supplement to Promote Human Health

    Bito, Tomohiro / Okumura, Eri / Fujishima, Masaki / Watanabe, Fumio

    Nutrients. 2020 Aug. 20, v. 12, no. 9

    2020  

    Abstract: Chlorella is a green unicellular alga that is commercially produced and distributed worldwide as a dietary supplement. Chlorella products contain numerous nutrients and vitamins, including D and B₁₂, that are absent in plant-derived food sources. ... ...

    Abstract Chlorella is a green unicellular alga that is commercially produced and distributed worldwide as a dietary supplement. Chlorella products contain numerous nutrients and vitamins, including D and B₁₂, that are absent in plant-derived food sources. Chlorella contains larger amounts of folate and iron than other plant-derived foods. Chlorella supplementation to mammals, including humans, has been reported to exhibit various pharmacological activities, including immunomodulatory, antioxidant, antidiabetic, antihypertensive, and antihyperlipidemic activities. Meta-analysis on the effects of Chlorella supplementation on cardiovascular risk factors have suggested that it improves total cholesterol levels, low-density lipoprotein cholesterol levels, systolic blood pressure, diastolic blood pressure, and fasting blood glucose levels but not triglycerides and high-density lipoprotein cholesterol levels. These beneficial effects of Chlorella might be due to synergism between multiple nutrient and antioxidant compounds. However, information regarding the bioactive compounds in Chlorella is limited.
    Keywords Chlorella ; algae ; antioxidants ; blood glucose ; diastolic blood pressure ; dietary supplements ; folic acid ; high density lipoprotein cholesterol ; human health ; information ; iron ; low density lipoprotein cholesterol ; meta-analysis ; plant-based foods ; risk ; synergism ; systolic blood pressure
    Language English
    Dates of publication 2020-0820
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12092524
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Acanthopanax senticosus ameliorates steatohepatitis through HNF4 alpha pathway activation in mice.

    Kawano, Yutaka / Tanaka, Maki / Satoh, Yasushi / Sugino, Shigekazu / Suzuki, Jun / Fujishima, Masaki / Okumura, Eri / Takekoshi, Hideo / Uehara, Osamu / Sugita, Shintaro / Abiko, Yoshihiro / Tomonari, Tetsu / Tanaka, Hironori / Takeda, Hidekatsu / Takayama, Tetsuji

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 110

    Abstract: Non-alcoholic fatty liver disease is a common liver disease worldwide, and is associated with dysregulation of lipid metabolism, leading to inflammation and fibrosis. Acanthopanax senticosus Harms (ASH) is widely used in traditional medicine as an ... ...

    Abstract Non-alcoholic fatty liver disease is a common liver disease worldwide, and is associated with dysregulation of lipid metabolism, leading to inflammation and fibrosis. Acanthopanax senticosus Harms (ASH) is widely used in traditional medicine as an adaptogen food. We examined the effect of ASH on steatohepatitis using a high-fat diet mouse model. Mice were fed a choline-deficient, L-amino acid-defined, high-fat diet with ASH extract (ASHE). After 6 weeks, liver RNA transcriptome sequencing (RNA-Seq) was performed, followed by Ingenuity Pathway Analysis (IPA). Our findings revealed that mice fed a high-fat diet with 5% ASHE exhibited significantly reduced liver steatosis. These mice also demonstrated alleviated inflammation and reduced fibrosis in the liver. IPA of RNA-Seq indicated that hepatocyte nuclear factor 4 alpha (HNF4 alpha), a transcription factor, was the activated upstream regulator (P-value 0.00155, z score = 2.413) in the liver of ASHE-fed mice. Adenosine triphosphate binding cassette transporter 8 and carboxylesterase 2, downstream targets of HNF4 alpha pathway, were upregulated. Finally, ASHE-treated HepG2 cells exposed to palmitate exhibited significantly decreased lipid droplet contents. Our study provides that ASHE can activate HNF4 alpha pathway and promote fat secretion from hepatocytes, thereby serving as a prophylactic treatment for steatohepatitis in mice.
    MeSH term(s) Animals ; Mice ; Hepatocyte Nuclear Factor 4/genetics ; Hepatocyte Nuclear Factor 4/metabolism ; Eleutherococcus/chemistry ; Liver/metabolism ; Non-alcoholic Fatty Liver Disease/metabolism ; Inflammation/pathology ; Disease Models, Animal ; Fibrosis ; Mice, Inbred C57BL ; Diet, High-Fat/adverse effects
    Chemical Substances Hepatocyte Nuclear Factor 4
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-50625-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Phenethylamine in chlorella alleviates high-fat diet-induced mouse liver damage by regulating generation of methylglyoxal.

    Zheng, Yifeng / Martin-Morales, Agustin / Wang, Jing / Fujishima, Masaki / Okumura, Eri / Sato, Kenji

    NPJ science of food

    2021  Volume 5, Issue 1, Page(s) 22

    Abstract: This study examined the effects of oral administration of water extract of chlorella (WEC) (100 mg/kg bodyweight) and phenethylamine (10 μg/kg bodyweight) on high-fat diet (HFD)-induced liver damage in mice. Phenethylamine significantly mitigated HFD- ... ...

    Abstract This study examined the effects of oral administration of water extract of chlorella (WEC) (100 mg/kg bodyweight) and phenethylamine (10 μg/kg bodyweight) on high-fat diet (HFD)-induced liver damage in mice. Phenethylamine significantly mitigated HFD-induced lipid oxidation (generation of malondialdehyde) and liver damage without markedly decreasing hepatic lipid accumulation. WEC exerted similar effects although with decreased efficacy. In addition, WEC and phenethylamine decreased the methylglyoxal levels and increased the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) protein levels in the liver. Methylglyoxal is generated from substrates of GAPDH, dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. These facts indicate that methylglyoxal triggers oxidation of accumulated lipid, which generates malondialdehyde and consequently induces liver damage. Suppression of generation of toxic aldehydes by WEC and phenethylamine was also confirmed by maintaining hepatic cysteine, highly reactive to aldehydes. Thus, trace amounts of phenethylamine alleviate HFD-induced liver damage by regulating methylglyoxal via increase of GAPDH.
    Language English
    Publishing date 2021-07-23
    Publishing country England
    Document type Journal Article
    ISSN 2396-8370
    ISSN (online) 2396-8370
    DOI 10.1038/s41538-021-00105-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Acanthopanax senticosus Harms extract causes G0/G1 cell cycle arrest and autophagy via inhibition of Rubicon in human liver cancer cells.

    Kawano, Yutaka / Tanaka, Maki / Fujishima, Masaki / Okumura, Eri / Takekoshi, Hideo / Takada, Kohichi / Uehara, Osamu / Abiko, Yoshihiro / Takeda, Hidekatsu

    Oncology reports

    2021  Volume 45, Issue 3, Page(s) 1193–1201

    Abstract: Acanthopanax senticosus (Rupr. et Maxim) Harms (ASH), also known as Siberian ginseng or eleuthero, is a hardy shrub native to China, Korea, Russia and the northern region of Japan. ASH is used for the treatment of several diseases such as heart disease, ... ...

    Abstract Acanthopanax senticosus (Rupr. et Maxim) Harms (ASH), also known as Siberian ginseng or eleuthero, is a hardy shrub native to China, Korea, Russia and the northern region of Japan. ASH is used for the treatment of several diseases such as heart disease, hypertension, rheumatoid arthritis, allergies, chronic bronchitis, diabetes and cancer. In the present study, the inhibitory effect of the root extract of ASH (ASHE) on HuH‑7 and HepG2 liver cancer cells was examined. ASHE suppressed liver cancer cell proliferation by inducing cell cycle arrest at the G0/G1 phase, as well as apoptosis, as indicated by the increased number of Annexin V and 7‑AAD‑positive cells. Furthermore, the expression of LC3‑II, an autophagy marker, in these cells also increased post treatment with ASHE. LC3‑II induction was further enhanced by co‑treatment with chloroquine. Fluorescence and transmission electron micrographs of ASHE‑treated liver cancer cells showed the presence of an increased number of autophagic vesicles. A decreased protein expression level of run domain Beclin‑1‑interacting and cysteine‑rich domain‑containing, an autophagy inhibitor, with no change in RUBCN mRNA expression was observed, indicating activation of the autophagosome‑lysosome fusion step of autophagy. In conclusion, ASHE exerts cytostatic activity on liver cancer cells via both apoptosis and autophagy, and may serve as a potential therapeutic agent for management of liver cancer and autophagy‑related diseases.
    MeSH term(s) Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Autophagy/drug effects ; Autophagy-Related Proteins/antagonists & inhibitors ; Autophagy-Related Proteins/metabolism ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Eleutherococcus/chemistry ; Humans ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Plant Extracts/pharmacology ; Plant Roots/chemistry
    Chemical Substances Antineoplastic Agents ; Autophagy-Related Proteins ; Plant Extracts ; RUBCN protein, human
    Language English
    Publishing date 2021-01-22
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 1222484-4
    ISSN 1791-2431 ; 1021-335X
    ISSN (online) 1791-2431
    ISSN 1021-335X
    DOI 10.3892/or.2021.7948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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