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Article ; Online: The relationship between phthalates and obesity: serum and urine concentrations of phthalates.

Oktar, Suleyman / Sungur, Sana / Okur, Ramazan / Yilmaz, Nigar / Ustun, Ihsan / Gokce, Cumali

2017 Volume 42, Issue 1, Page(s) 46–52

Abstract: Background: A limited number of human and animal studies suggest that a relationship exists between phthalates and obesity, although this is not supported by all research. The purpose of this study was to investigate the relationship between Body Mass ... ...

Abstract	Background: A limited number of human and animal studies suggest that a relationship exists between phthalates and obesity, although this is not supported by all research. The purpose of this study was to investigate the relationship between Body Mass Index (BMI) and the levels of phthalates in human blood and urine samples. Methods: Sixty-four overweight or 132 obese individuals (total=196) of different ages (min-max, 17-62; mean ± SD, 42.07±11.3) and genders (F:M 97:99) enrolled in the study. BMI and waist circumference were measured to diagnose obesity. Venous blood samples were taken after overnight fasting. To compare the urine phthalates among participants, single spot urine (at least 10 mL) was collected from the subject after blood samples were taken. Urine and blood phthalate concentrations were measured using gas chromatography. Results: Total blood/urinary phthalate levels significantly increased in proportion to the degree of obesity. There was a high correlation between the level of total phthalates in serum and BMI (ρ=0.697, P<0.001), and between total urinary phthalate levels and BMI (ρ=0.707, P<0.001). Conclusions: This is the first study to have shown that both blood and urinary phthalates increased in proportion to BMI. The results show a strong association between obesity and phthalates.
MeSH term(s)	Adolescent ; Adult ; Body Mass Index ; Environmental Pollutants/blood ; Environmental Pollutants/urine ; Female ; Humans ; Male ; Middle Aged ; Obesity/blood ; Obesity/epidemiology ; Obesity/urine ; Phthalic Acids/blood ; Phthalic Acids/urine ; Waist Circumference ; Young Adult
Chemical Substances	Environmental Pollutants ; Phthalic Acids
Language	English
Publishing date	2017-03
Publishing country	Italy
Document type	Journal Article
ZDB-ID	423687-7
ISSN	1827-1634 ; 0391-1977
ISSN (online)	1827-1634
ISSN	0391-1977
DOI	10.23736/S0391-1977.16.02295-1
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Article: Using azomethine-H method determination of boron contents of various foods consumed in Hatay Region in Turkey

Sungur, Şana / Okur, Ramazan

Food chemistry. 2009 July 15, v. 115, no. 2

2009

Abstract: In this study, samples of soil and plant (32 species of vegetable and 17 species of fruit) were collected from six different regions of Hatay (Amik Plant, Reyhanlı, Kırıkhan, Samandağ, Dörtyol and İskenderun). The azomethine-H method was used to ... ...

Abstract	In this study, samples of soil and plant (32 species of vegetable and 17 species of fruit) were collected from six different regions of Hatay (Amik Plant, Reyhanlı, Kırıkhan, Samandağ, Dörtyol and İskenderun). The azomethine-H method was used to determine boron content of samples. Furthermore, the correlation among boron content of soil with boron content of plants was investigated. The boron concentrations in the soil samples, were determined between 32.43 (±2.90) and 93.43 (±2.75) ppm. High concentrations of boron were found in thyme (10.44±0.17), mint (6.96±0.15), red cabbage (6.45±0.15), broad-bean (6.28±0.14), quince (5.41±0.11), pomegranate (5.27±0.13) and orange (4.08±0.10). Minimal concentration of boron were found in pumpkin (0.76±0.01), white radish (0.97±0.01), plum (1.16±0.02) and cucumber (1.17±0.01). Most of the foods had boron concentrations in the range of 1.48-3.60ppm.
Keywords	boron ; food analysis ; food composition ; analytical methods ; geographical variation ; foods ; chemical composition ; soil chemical properties ; thyme ; mint ; faba beans ; quinces ; pomegranates ; oranges ; pumpkins ; radishes ; plums ; cucumbers ; bioaccumulation ; cabbage ; Turkey (country)
Language	English
Dates of publication	2009-0715
Size	p. 711-714.
Publishing place	[Amsterdam]: Elsevier Science
Document type	Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2008.11.103
Database	NAL-Catalogue (AGRICOLA)

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Article: Migrated phthalate levels into edible oils

Sungur, Sana / Okur, Ramazan / Turgut, Faruk Hilmi / Ustun, Ihsan / Gokce, Cumali

Food additives & contaminants. 2015 July 3, v. 8, no. 3

2015

Abstract: The determination of phthalates in edible oils (virgin olive oil, olive oil, canola oil, hazelnut oil, sunflower oil, corn oil) sold in Turkish markets was carried out using gas chromatography–mass spectrometry. Mean phthalate concentrations were between ...

Abstract	The determination of phthalates in edible oils (virgin olive oil, olive oil, canola oil, hazelnut oil, sunflower oil, corn oil) sold in Turkish markets was carried out using gas chromatography–mass spectrometry. Mean phthalate concentrations were between 0.102 and 3.863 mg L ⁻¹ in virgin olive oil; 0.172 and 6.486 mg L ⁻¹ in olive oil; 0.501 and 3.651 mg L ⁻¹ in hazelnut oil; 0.457 and 3.415 mg L ⁻¹ in canola oil; 2.227 and 6.673 mg L ⁻¹ in sunflower oil; and 1.585 and 6.248 mg L ⁻¹ in corn oil. Furthermore, the influence of the types of oil and container to the phthalate migration was investigated. The highest phthalate levels were measured in sunflower oil. The lowest phthalate levels were determined in virgin olive oil and hazelnut oil. The highest phthalate levels were determined in oil samples contained in polyethylene terephthalate.
Keywords	canola oil ; cooking fats and oils ; corn oil ; gas chromatography-mass spectrometry ; hazelnut oil ; markets ; phthalates ; polyethylene terephthalates ; sunflower oil ; virgin olive oil
Language	English
Dates of publication	2015-0703
Size	p. 190-194.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2447868-4
ISSN	1939-3229 ; 1939-3210
ISSN (online)	1939-3229
ISSN	1939-3210
DOI	10.1080/19393210.2015.1041065
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Higher Serum Bisphenol A Levels in Diabetic Hemodialysis Patients.

Turgut, Faruk / Sungur, Sana / Okur, Ramazan / Yaprak, Mustafa / Ozsan, Muge / Ustun, Ihsan / Gokce, Cumali

Blood purification

2016 Volume 42, Issue 1, Page(s) 77–82

Abstract: Background: Bisphenol A (BPA) has been implicated as an 'endocrine disruptor'. We aimed at exploring the association between serum BPA levels and patient characteristics, particularly the presence of diabetes mellitus, and laboratory parameters in ... ...

Abstract	Background: Bisphenol A (BPA) has been implicated as an 'endocrine disruptor'. We aimed at exploring the association between serum BPA levels and patient characteristics, particularly the presence of diabetes mellitus, and laboratory parameters in hemodialysis patients. Methods: This study included 47 chronic hemodialysis patients. Patient characteristics were recorded. Blood was drawn before and after hemodialysis session. Serum BPA levels were measured by the high-performance-liquid-chromatography and laboratory parameters were measured by using standard methods. Results: In hemodialysis patients, postdialysis serum BPA levels were significantly higher than predialysis after a single hemodialysis session (5.57 ± 1.2 vs. 4.06 ± 0.73, p < 0.0001). Predialysis serum BPA levels were significantly higher in patients with diabetes than non-diabetics (4.4 ± 0.6 vs. 3.9 ± 0.7, p = 0.025). No association was found between serum BPA levels and patient characteristics, and particularly laboratory parameters. Conclusion: Serum BPA levels were rising significantly after a single dialysis session. Diabetic hemodialysis patients had higher predialysis serum BPA levels.
MeSH term(s)	Adult ; Aged ; Benzhydryl Compounds/blood ; Chromatography, High Pressure Liquid ; Clinical Laboratory Techniques ; Comorbidity ; Diabetes Mellitus/blood ; Endocrine Disruptors/blood ; Humans ; Kidney Failure, Chronic/blood ; Middle Aged ; Phenols/blood ; Renal Dialysis
Chemical Substances	Benzhydryl Compounds ; Endocrine Disruptors ; Phenols ; bisphenol A (MLT3645I99)
Language	English
Publishing date	2016
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	605548-5
ISSN	1421-9735 ; 0253-5068
ISSN (online)	1421-9735
ISSN	0253-5068
DOI	10.1159/000445203
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Migrated phthalate levels into edible oils.

Sungur, Sana / Okur, Ramazan / Turgut, Faruk Hilmi / Ustun, Ihsan / Gokce, Cumali

Food additives & contaminants. Part B, Surveillance

2015 Volume 8, Issue 3, Page(s) 190–194

Abstract: The determination of phthalates in edible oils (virgin olive oil, olive oil, canola oil, hazelnut oil, sunflower oil, corn oil) sold in Turkish markets was carried out using gas chromatography-mass spectrometry. Mean phthalate concentrations were between ...

Abstract	The determination of phthalates in edible oils (virgin olive oil, olive oil, canola oil, hazelnut oil, sunflower oil, corn oil) sold in Turkish markets was carried out using gas chromatography-mass spectrometry. Mean phthalate concentrations were between 0.102 and 3.863 mg L(-1) in virgin olive oil; 0.172 and 6.486 mg L(-1) in olive oil; 0.501 and 3.651 mg L(-1) in hazelnut oil; 0.457 and 3.415 mg L(-1) in canola oil; 2.227 and 6.673 mg L(-1) in sunflower oil; and 1.585 and 6.248 mg L(-1) in corn oil. Furthermore, the influence of the types of oil and container to the phthalate migration was investigated. The highest phthalate levels were measured in sunflower oil. The lowest phthalate levels were determined in virgin olive oil and hazelnut oil. The highest phthalate levels were determined in oil samples contained in polyethylene terephthalate.
MeSH term(s)	Canola Oil ; Corn Oil/adverse effects ; Corn Oil/chemistry ; Corn Oil/economics ; Corylus/chemistry ; Dietary Fats, Unsaturated/adverse effects ; Dietary Fats, Unsaturated/analysis ; Dietary Fats, Unsaturated/economics ; Endocrine Disruptors/analysis ; Endocrine Disruptors/toxicity ; Fatty Acids, Monounsaturated/adverse effects ; Fatty Acids, Monounsaturated/chemistry ; Fatty Acids, Monounsaturated/economics ; Food Contamination ; Food Inspection ; Food Packaging ; Gas Chromatography-Mass Spectrometry ; Humans ; Limit of Detection ; Nuts/chemistry ; Olive Oil/adverse effects ; Olive Oil/chemistry ; Olive Oil/economics ; Olive Oil/standards ; Phthalic Acids/analysis ; Phthalic Acids/toxicity ; Plant Oils/adverse effects ; Plant Oils/chemistry ; Plant Oils/economics ; Plasticizers/analysis ; Plasticizers/toxicity ; Polyethylene Terephthalates/chemistry ; Polyethylene Terephthalates/toxicity ; Risk Assessment ; Sunflower Oil ; Turkey
Chemical Substances	Canola Oil ; Dietary Fats, Unsaturated ; Endocrine Disruptors ; Fatty Acids, Monounsaturated ; Olive Oil ; Phthalic Acids ; Plant Oils ; Plasticizers ; Polyethylene Terephthalates ; Sunflower Oil ; Corn Oil (8001-30-7)
Language	English
Publishing date	2015
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2447868-4
ISSN	1939-3229 ; 1939-3210
ISSN (online)	1939-3229
ISSN	1939-3210
DOI	10.1080/19393210.2015.1041065
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Article: Determination of Phthalates Migrating from Plastic Containers into Beverages

Ustun, Ihsan / Sungur, Sana / Okur, Ramazan / Sumbul, Ahmet Taner / Oktar, Suleyman / Yilmaz, Nigar / Gokce, Cumali

Food analytical methods. 2015 Jan., v. 8, no. 1

2015

Abstract: The determination of phthalates in beverages (soda, lemonade, cola, mineral water) sold in Turkish markets was carried out using gas chromatography-mass spectrometry (GC-MS). The mean phthalate concentrations were determined to be between 0.095 and 0.633 ...

Abstract	The determination of phthalates in beverages (soda, lemonade, cola, mineral water) sold in Turkish markets was carried out using gas chromatography-mass spectrometry (GC-MS). The mean phthalate concentrations were determined to be between 0.095 and 0.633 mg/L in soda, 0.018 and 1.219 mg/L in lemonade, 0.019 and 1.123 mg/L in cola, and 0.085 and 0.312 mg/L in mineral water. bis(2-Ethylhexyl) phthalate (DEHP) showed the highest level of migration into beverages. Furthermore, the influence of the type of preservative (sodium benzoate, potassium sorbate, sodium benzoate + potassium sorbate) and storage time were determined.
Keywords	beverages ; containers ; gas-chromatography-mass spectrometry ; markets ; mineral water ; phthalates ; potassium sorbate ; sodium benzoate ; storage time
Language	English
Dates of publication	2015-01
Size	p. 222-228.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	2429656-9
ISSN	1936-976X ; 1936-9751
ISSN (online)	1936-976X
ISSN	1936-9751
DOI	10.1007/s12161-014-9896-5
Database	NAL-Catalogue (AGRICOLA)

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Article: Higher Serum Bisphenol A Levels in Diabetic Hemodialysis Patients

Turgut, Faruk / Sungur, Sana / Okur, Ramazan / Yaprak, Mustafa / Ozsan, Muge / Ustun, Ihsan / Gokce, Cumali

Blood Purification

2016 Volume 42, Issue 1, Page(s) 77–82

Abstract: Background: Bisphenol A (BPA) has been implicated as an ‘endocrine disruptor'. We aimed at exploring the association between serum BPA levels and patient characteristics, particularly the presence of diabetes mellitus, and laboratory parameters in ... ...

Institution	Department of Nephrology and Department of Endocrinology, Faculty of Medicine, and Department of Chemistry, Faculty of Arts and Sciences, Mustafa Kemal University, Antakya, Hatay, Turkey
Abstract	Background: Bisphenol A (BPA) has been implicated as an ‘endocrine disruptor'. We aimed at exploring the association between serum BPA levels and patient characteristics, particularly the presence of diabetes mellitus, and laboratory parameters in hemodialysis patients. Methods: This study included 47 chronic hemodialysis patients. Patient characteristics were recorded. Blood was drawn before and after hemodialysis session. Serum BPA levels were measured by the high-performance-liquid-chromatography and laboratory parameters were measured by using standard methods. Results: In hemodialysis patients, postdialysis serum BPA levels were significantly higher than predialysis after a single hemodialysis session (5.57 ± 1.2 vs. 4.06 ± 0.73, p < 0.0001). Predialysis serum BPA levels were significantly higher in patients with diabetes than non-diabetics (4.4 ± 0.6 vs. 3.9 ± 0.7, p = 0.025). No association was found between serum BPA levels and patient characteristics, and particularly laboratory parameters. Conclusion: Serum BPA levels were rising significantly after a single dialysis session. Diabetic hemodialysis patients had higher predialysis serum BPA levels.
Keywords	Bisphenol A ; Chronic kidney disease ; Hemodialysis ; Diabetes mellitus
Language	English
Publishing date	2016-05-19
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Original Paper
ZDB-ID	605548-5
ISSN	1421-9735 ; 0253-5068
ISSN (online)	1421-9735
ISSN	0253-5068
DOI	10.1159/000445203
Database	Karger publisher's database

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Article: Determination of Phthalates Migrating from Plastic Containers into Beverages

Ustun, Ihsan / Sungur, Sana / Okur, Ramazan / Sumbul, Ahmet Taner / Oktar, Suleyman / Yilmaz, Nigar / Gokce, Cumali

Food analytical methods

Volume v. 8,, Issue no. 1

Abstract	The determination of phthalates in beverages (soda, lemonade, cola, mineral water) sold in Turkish markets was carried out using gas chromatography-mass spectrometry (GC-MS). The mean phthalate concentrations were determined to be between 0.095 and 0.633 mg/L in soda, 0.018 and 1.219 mg/L in lemonade, 0.019 and 1.123 mg/L in cola, and 0.085 and 0.312 mg/L in mineral water. bis(2-Ethylhexyl) phthalate (DEHP) showed the highest level of migration into beverages. Furthermore, the influence of the type of preservative (sodium benzoate, potassium sorbate, sodium benzoate + potassium sorbate) and storage time were determined.
Keywords	phthalates ; mineral water ; gas-chromatography-mass spectrometry ; containers ; markets ; beverages ; storage time ; sodium benzoate ; potassium sorbate
Language	English
Document type	Article
ISSN	1936-9751
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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