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  1. Article: Akut epiduralis haematoma kezelése arteria meningea media embolisatióval, esetismertetés és irodalmi áttekintés.

    Oláh, Benedek / Oláh, Zsolt Csaba

    Ideggyogyaszati szemle

    2024  Volume 77, Issue 3-4, Page(s) 141–144

    Abstract: ... The treatment of acute epidural haematoma is surgery as soon as possible, elimination of the source of bleeding and evacuation of the haematoma. In case of small epidural haematoma, strict neurological and radiological follow-up is necessary. In a ... ...

    Title translation Middle meningeal artery embolization to treat acute epidural haematoma, case report and literature review.
    Abstract

    The treatment of acute epidural haematoma is surgery as soon as possible, elimination of the source of bleeding and evacuation of the haematoma. In case of small epidural haematoma, strict neurological and radiological follow-up is necessary. In a significant percentage of cases, open surgery must also be performed within a few days. In case of small epidural haematomas, embolization of the middle meningeal artery is considered as an alternative solution. We review the literature on middle meningeal artery embolization and present our first treatment. Our case report is the first European report about an acute epidural haematoma which was treated by embolization of middle meningeal artery. Our case study is the first report in which a patient was treated with both open surgery and endovascular treatment for acute epidural haematoma within a year.

    .
    MeSH term(s) Humans ; Meningeal Arteries/diagnostic imaging ; Meningeal Arteries/surgery ; Hematoma, Epidural, Cranial/diagnostic imaging ; Hematoma, Epidural, Cranial/therapy ; Hematoma, Epidural, Cranial/etiology ; Embolization, Therapeutic/adverse effects ; Tomography, X-Ray Computed
    Language Hungarian
    Publishing date 2024-04-08
    Publishing country Hungary
    Document type Review ; Case Reports ; English Abstract
    ZDB-ID 2240317-6
    ISSN 0019-1442
    ISSN 0019-1442
    DOI 10.18071/isz.77.0141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Vazopresszin használata szeptikus sokkos betegek ellátásában.

    Hajdu, Endre / Berhés, Mariann / László, István / Oláh, Zsolt / Fülesdi, Béla / Asztalos, László

    Orvosi hetilap

    2024  Volume 165, Issue 8, Page(s) 283–290

    Title translation Administration of vasopressin in septic shock.
    MeSH term(s) Humans ; Shock, Septic/drug therapy ; Vasopressins/therapeutic use
    Chemical Substances Vasopressins (11000-17-2)
    Language Hungarian
    Publishing date 2024-02-25
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2024.32992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Obstetrical aspects of the National Blood Donation and Blood Saving Program

    Oláh, Zsolt / Deli, Tamás / Mühl, Diána

    Orvosi hetilap

    2020  Volume 161, Issue 37, Page(s) 1588–1598

    Abstract: The aims of the National Blood Donation and Blood Saving Program are to support the rational and judicious utilization of blood products and abolish irrational transfusion policy to improve patient safety. In addition to the general principles, this ... ...

    Title translation A Nemzeti Véradó és Vérmentő Program szülészeti vonatkozásai.
    Abstract The aims of the National Blood Donation and Blood Saving Program are to support the rational and judicious utilization of blood products and abolish irrational transfusion policy to improve patient safety. In addition to the general principles, this program has got some special obstetrical aspects. Obstetrical, especially the postpartum haemorrhages belong to the leading causes of maternal mortality worldwide. In developed countries, a trend in increasing incidence can be observed. Preparing for delivery includes some important elements such as optimization of hemoglobin level, routinely applied prophylactic or therapeutic iron supplementation and early screening and comprehensive care of patients with high risk of obstetrical bleeding. The main causes of peripartum bleeding are abruptio placentae, placenta praevia, uterine atony, retained tissue in the uterus, trauma during delivery, and haemostatic disorders or their combinations. To prevent postpartum bleeding, it is important to use the active management of the third stage of labour including prophylactic utilization of uterotonics as an essential element. Utilization of blood salvage techniques with adequate indications may be considered in cases of cesarean section or postpartum haemorhage. In cases of obstetrical haemorrhage, management of surgical bleeding has the main priority by the obstetrician. Secondary coagulopathy associated with massive bleeding should be managed by viscoelastic test-guided, individualized and factor concentrate-based algorithm, however, pregnancy-specific reference and target ranges must be used that are different from the non-pregnancy values. Obstetrical bleedings belong to the potentially preventable causes of death. Hopefully, the implementation of the National Blood Donation and Blood Saving Program in the field of obstetrics can decrease the associated morbidity and mortality further. Orv Hetil. 2020; 161(37): 1588-1598.
    MeSH term(s) Blood Donors ; Cesarean Section ; Female ; Humans ; Obstetrics ; Operative Blood Salvage ; Postpartum Hemorrhage/therapy ; Pregnancy
    Language Hungarian
    Publishing date 2020-09-07
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2020.31915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Clinical and Molecular Characterization of Nine Novel Antithrombin Mutations.

    Kállai, Judit / Gindele, Réka / Pénzes-Daku, Krisztina / Balogh, Gábor / Bogáti, Réka / Bécsi, Bálint / Katona, Éva / Oláh, Zsolt / Ilonczai, Péter / Boda, Zoltán / Róna-Tas, Ágnes / Nemes, László / Marton, Imelda / Bereczky, Zsuzsanna

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: Antithrombin (AT) is the major plasma inhibitor of thrombin (FIIa) and activated factor X (FXa), and antithrombin deficiency (ATD) is one of the most severe thrombophilic disorders. In this study, we identified nine novel AT mutations and investigated ... ...

    Abstract Antithrombin (AT) is the major plasma inhibitor of thrombin (FIIa) and activated factor X (FXa), and antithrombin deficiency (ATD) is one of the most severe thrombophilic disorders. In this study, we identified nine novel AT mutations and investigated their genotype-phenotype correlations. Clinical and laboratory data from patients were collected, and the nine mutant AT proteins (p.Arg14Lys, p.Cys32Tyr, p.Arg78Gly, p.Met121Arg, p.Leu245Pro, p.Leu270Argfs*14, p.Asn450Ile, p.Gly456delins_Ala_Thr and p.Pro461Thr) were expressed in HEK293 cells; then, Western blotting, N-Glycosidase F digestion, and ELISA were used to detect wild-type and mutant AT. RT-qPCR was performed to determine the expression of AT mRNA from the transfected cells. Functional studies (AT activity in the presence and in the absence of heparin and heparin-binding studies with the surface plasmon resonance method) were carried out. Mutations were also investigated by in silico methods. Type I ATD caused by altered protein synthesis (p.Cys32Tyr, p.Leu270Argfs*14, p.Asn450Ile) or secretion disorder (p.Met121Arg, p.Leu245Pro, p.Gly456delins_Ala_Thr) was proved in six mutants, while type II heparin-binding-site ATD (p.Arg78Gly) and pleiotropic-effect ATD (p.Pro461Thr) were suggested in two mutants. Finally, the pathogenic role of p.Arg14Lys was equivocal. We provided evidence to understand the pathogenic nature of novel
    MeSH term(s) Humans ; Antithrombins/chemistry ; HEK293 Cells ; Anticoagulants ; Heparin/metabolism ; Mutation ; Antithrombin III Deficiency/genetics
    Chemical Substances Antithrombins ; Anticoagulants ; Heparin (9005-49-6)
    Language English
    Publishing date 2024-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052893
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  5. Article ; Online: Principles of the perioperative Patient Blood Management

    Oláh, Zsolt / Fülesdi, Béla / Gál, János / Matusovits, Andrea / Babik, Barna

    Orvosi hetilap

    2020  Volume 161, Issue 37, Page(s) 1554–1568

    Abstract: The perioperative Patient Blood Management (in Hungary National Blood Donation and Blood Saving Program) is an individualized clinical practice based on a multidisciplinary consensus with a comprehensive and complex approach. It supports the rational and ...

    Title translation A perioperatív vérgazdálkodási program alapelvei.
    Abstract The perioperative Patient Blood Management (in Hungary National Blood Donation and Blood Saving Program) is an individualized clinical practice based on a multidisciplinary consensus with a comprehensive and complex approach. It supports the rational and judicious utilization of blood products and abolishes irrational transfusion policy. Its practical implementation is based upon three pillars: 1. anemia management without transfusion, if possible; restrictive transfusion strategy; 2. minimization of blood loss; 3. enhancement of anemia tolerance. Early detection, clarification of etiology and appropriate treatment are the most important tools for the management of preoperative anemia before surgeries with a high risk of bleeding. Minimization of blood loss can be achieved by identifying patients with congenital or acquired bleeding disorders, preparing them appropriately for surgery, discontinuing anticoagulants and antiplatelet drugs for a sufficient time in the preoperative phase of surgery and reversing their effects to comply with current guidelines. Minimal-invasive approaches are preferable. Intraoperatively, atraumatic technique and accurate topical haemostasis should be provided by surgeons. Autologous blood salvage techniques and controlled hypotension in lack of contraindications can also reduce the amount of blood loss. In cases of perioperative bleeding, protocols based on international guidelines but adapted to local circumstances must be used. Ideally, it should be managed by viscoelastic test-guided, goal-directed, individualized and factor concentrate-based algorithm. Perioperatively, an ideal oxygen demand/supply ratio must be ensured to avoid oxygen debt. Restoration and maintenance of homeostasis are essential for both the effectively functioning haemostatic system and the avoidance of oxygen deficit. Implementation of the Patient Blood Management improves patient safety, reduces the cost of medical care and facilitates the national blood product supply. Its successful introduction is our common interest. Orv Hetil. 2020; 161(37): 1554-1568.
    MeSH term(s) Anemia ; Blood Loss, Surgical/prevention & control ; Blood Transfusion ; Hemorrhage ; Hemostatics ; Humans ; Hungary ; Perioperative Care
    Chemical Substances Hemostatics
    Language Hungarian
    Publishing date 2020-09-07
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2020.31787
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Az új orális antikoagulánsokkal történő kezelés laboratóriumi vonatkozásai.

    Bereczky, Zsuzsanna / Oláh, Zsolt / Ajzner, Éva / Kappelmayer, János

    Orvosi hetilap

    2017  Volume 158, Issue 49, Page(s) 1930–1945

    Abstract: The introduction of novel oral anticoagulants (NOAC) have long been expected drugs and they quickly became used widespread as their clinical effectiveness was as good as, or even better than the previously used only oral anticoagulant drug, the coumarins. ...

    Title translation Laboratory aspects of novel oral anticoagulant treatment.
    Abstract The introduction of novel oral anticoagulants (NOAC) have long been expected drugs and they quickly became used widespread as their clinical effectiveness was as good as, or even better than the previously used only oral anticoagulant drug, the coumarins. Thus, the direct thrombin inhibitor dabigatran and the activated factor X inhibitors (rivaroxaban, apixaban, edoxaban) have become the part of daily therapeutic practice. Their permeation was facilitated by the guideline which suggested that no laboratory monitoring was required during NOAC treatment and this was very convenient for both patients and doctors. The clinical experience obtained in the past years, however have proved that the 'one size fits all' view is oversimplified and there are numerous situations when the determination NOAC levels is unavoidable or highly recommended. This review discusses the laboratory aspects of NOAC treatment, primarily summarizing their effect on the screening tests and special assays of hemostasis and we also describe the correct methods to determine their plasma concentrations. Orv Hetil. 2017; 158(49): 1930-1945.
    MeSH term(s) Administration, Oral ; Anticoagulants/administration & dosage ; Anticoagulants/pharmacokinetics ; Blood Coagulation/drug effects ; Dabigatran/administration & dosage ; Dabigatran/pharmacology ; Drug Monitoring ; Factor Xa Inhibitors/administration & dosage ; Factor Xa Inhibitors/pharmacology ; Humans ; Venous Thromboembolism/drug therapy
    Chemical Substances Anticoagulants ; Factor Xa Inhibitors ; Dabigatran (I0VM4M70GC)
    Language Hungarian
    Publishing date 2017-12
    Publishing country Hungary
    Document type Journal Article ; Review
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2017.30928
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A decade-long clinical experience on the prophylactic use of activated prothrombin complex concentrate in acquired haemophilia A: a case series from a tertiary care centre.

    Árokszállási, Anita / Rázsó, Katalin / Ilonczai, Péter / Oláh, Zsolt / Bereczky, Zsuzsanna / Boda, Zoltán / Schlammadinger, Ágota

    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis

    2018  Volume 29, Issue 3, Page(s) 282–287

    Abstract: In acquired haemophilia A (AHA), risk for recurrent bleeding exists until the inhibitor is detectable. Thus, patients with persisting inhibitor may benefit from prophylaxis with activated prothrombin complex concentrate (aPCC). Potential thromboembolic ...

    Abstract : In acquired haemophilia A (AHA), risk for recurrent bleeding exists until the inhibitor is detectable. Thus, patients with persisting inhibitor may benefit from prophylaxis with activated prothrombin complex concentrate (aPCC). Potential thromboembolic complications and cost are also factors to consider. Today, no high level evidence or clear recommendations are available on aPCC prophylaxis in AHA. Recently, a small prospective study demonstrated a favourable outcome with short-term, daily administered aPCC infusion. Here we report a retrospective case series of 19 patients with AHA to demonstrate our practice on aPCC prophylaxis. In our practice, clinical bleeding tendency guided our decision on the initiation of aPCC prophylaxis. In patients with serious bleeding tendency, aPCC infusion was prolonged beyond bleeding resolution in a twice-weekly or thrice-weekly regimen. Serious bleeding phenotype included a single episode of life-threatening bleeding or recurrent, severe haemorrhages. Patients who did not present such events were treated on-demand. The preventive dose of aPCC was equal with the lowest effective therapeutic dose. Prophylaxis was continued until the inhibitor disappeared. Eleven patients received aPCC prophylaxis. In nine cases, prophylaxis lasted beyond two months. No severe bleeding developed spontaneously and no thromboembolic complication occurred in the median 16 weeks (interquartile range 9-34) duration of prophylaxis. Eight patients of the nonprophylaxis group did not present any severe haemorrhage. According to our experience, we consider prophylaxis with aPCC effective and well tolerated for patients with AHA and serious bleeding tendency, until the acquired inhibitor persists.
    MeSH term(s) Aged ; Blood Coagulation Factor Inhibitors/blood ; Blood Coagulation Factors/adverse effects ; Blood Coagulation Factors/therapeutic use ; Cost-Benefit Analysis ; Hemophilia A/drug therapy ; Hemophilia A/immunology ; Hemorrhage/prevention & control ; Humans ; Middle Aged ; Premedication/methods ; Retrospective Studies ; Tertiary Care Centers ; Thromboembolism/chemically induced
    Chemical Substances Blood Coagulation Factor Inhibitors ; Blood Coagulation Factors ; prothrombin complex concentrates (37224-63-8)
    Language English
    Publishing date 2018-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1033551-1
    ISSN 1473-5733 ; 0957-5235
    ISSN (online) 1473-5733
    ISSN 0957-5235
    DOI 10.1097/MBC.0000000000000716
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  8. Article ; Online: Coagulation: cascade!

    Olah, Zsolt / Bereczky, Zsuzsanna / Szarvas, Mariann / Boda, Zoltan

    Lancet (London, England)

    2011  Volume 378, Issue 9792, Page(s) 740

    MeSH term(s) Aged ; Anticoagulants/adverse effects ; Coumarins/adverse effects ; Enoxaparin/adverse effects ; Enoxaparin/therapeutic use ; Gangrene/chemically induced ; Heparin/adverse effects ; Humans ; International Normalized Ratio ; Male ; Necrosis/chemically induced ; Thrombocytopenia/chemically induced ; Venous Thrombosis/blood ; Venous Thrombosis/chemically induced
    Chemical Substances Anticoagulants ; Coumarins ; Enoxaparin ; Heparin (9005-49-6) ; coumarin (A4VZ22K1WT)
    Language English
    Publishing date 2011-08-20
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(11)60875-1
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  9. Article ; Online: Evaluation of flow cytometric HIT assays in relation to an IgG-Specific immunoassay and clinical outcome.

    Kerényi, Adrienne / Beke Debreceni, Ildikó / Oláh, Zsolt / Ilonczai, Péter / Bereczky, Zsuzsanna / Nagy, Béla / Muszbek, László / Kappelmayer, János

    Cytometry. Part B, Clinical cytometry

    2017  Volume 92, Issue 5, Page(s) 389–397

    Abstract: Background: Heparin-induced thrombocytopenia (HIT) is a severe side effect of heparin treatment caused by platelet activating IgG antibodies generated against the platelet factor 4 (PF4)-heparin complex. Thrombocytopenia and thrombosis are the leading ... ...

    Abstract Background: Heparin-induced thrombocytopenia (HIT) is a severe side effect of heparin treatment caused by platelet activating IgG antibodies generated against the platelet factor 4 (PF4)-heparin complex. Thrombocytopenia and thrombosis are the leading clinical symptoms of HIT.
    Methods: The clinical pretest probability of HIT was evaluated by the 4T score system. Laboratory testing of HIT was performed by immunological detection of antibodies against PF4-heparin complex (EIA) and two functional assays. Heparin-dependent activation of donor platelets by patient plasma was detected by flow cytometry. Increased binding of Annexin-V to platelets and elevated number of platelet-derived microparticles (PMP) were the indicators of platelet activation.
    Results: EIA for IgG isotype HIT antibodies was performed in 405 suspected HIT patients. Based on negative EIA results, HIT was excluded in 365 (90%) of cases. In 40 patients with positive EIA test result functional tests were performed. Platelet activating antibodies were detected in 17 cases by Annexin V binding. PMP count analysis provided nearly identical results. The probability of a positive flow cytometric assay result was higher in patients with elevated antibody titer. 71% of patients with positive EIA and functional assay had thrombosis.
    Conclusions: EIA is an important first line laboratory test in the diagnosis of HIT; however, HIT must be confirmed by a functional test. Annexin V binding and PMP assays using flow cytometry are functional HIT tests convenient in a clinical diagnostic laboratory. The positive results of functional assays may predict the onset of thrombosis. © 2016 International Clinical Cytometry Society.
    MeSH term(s) Blood Platelets/metabolism ; Cell-Derived Microparticles/metabolism ; Female ; Flow Cytometry/methods ; Heparin/blood ; Humans ; Immunoassay/methods ; Male ; Platelet Activation ; Thrombocytopenia/blood ; Thrombocytopenia/diagnosis ; Thrombocytopenia/immunology ; Thrombocytopenia/therapy
    Chemical Substances Heparin (9005-49-6)
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2099657-3
    ISSN 1552-4957 ; 1552-4949 ; 0196-4763
    ISSN (online) 1552-4957
    ISSN 1552-4949 ; 0196-4763
    DOI 10.1002/cyto.b.21362
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  10. Book ; Online: Comprehensive analysis of the nonperforming household mortgage portfolio using micro-level data

    Dancsik, Bálint / Fábián, Gergely / Fellner, Zita / Horváth, Gábor / Lang, Péter / Nagy, Gábor / Oláh, Zsolt / Winkler, Sándor

    (MNB occasional papers ; Special issue 2015)

    2015  

    Abstract: The high ratio of loans over 90 days past due, i.e. nonperforming mortgage loans, is the legacy of the crisis and the excessive lending that preceded it. The volume has continuously grown over the past six years and by the end of 2014 accounted for one ... ...

    Author's details Bálint Dancsik, Gergely Fábián, Zita Fellner, Gábor Horváth, Péter Lang, Gábor Nagy, Zsolt Oláh, Sándor Winkler
    Series title MNB occasional papers ; Special issue 2015
    Abstract The high ratio of loans over 90 days past due, i.e. nonperforming mortgage loans, is the legacy of the crisis and the excessive lending that preceded it. The volume has continuously grown over the past six years and by the end of 2014 accounted for one quarter of the total mortgage portfolio, affecting approximately 140,000 debtors. The degree of exposure within the entire system of financial intermediation is nearly HUF 1,450 billion, nearly 5 per cent of GDP. Terminated contracts now account for over half of the total portfolio, which may essentially lead to execution and thus the loss of the property for debtors. As a result, this is currently one of the most pressing issues for financial stability and a major social risk in Hungary. A deep analysis and broad understanding of the issue is indispensable for finding the proper solution. Despite the importance of the matter, we know little about nonperforming mortgage loans. This study aims to provide a comprehensive picture of the attributes of these loans after settlement and forint conversion on the basis of individual data. The data clearly show that the heart of the matter in terms of both wealth and income is the excessive level of debt. For over 80 per cent of customers, the total debt amount (outstanding principal and arrears) exceeds the advanced loan amount. Since the onset of the crisis, the amount of principal debt has increased substantially compared to the real estate collateral pledged, currently amounting to 110 per cent on average or 140 per cent if we calculate the indicator based on total debt. The severity of the issue is further exacerbated by the fact that 70 per cent of nonperforming debtors live in smaller cities and localities, primarily in regions where the marketability of properties is limited. As a result, the prospects of a new start after selling the collateral may be limited for debtors. In examining nonperforming loan transactions, it is also essential to analyse income positions in depth, mainly in light of the potential rectification of the loan transactions through sustainable restructuring ...
    Language English
    Size 1 Online-Ressource (circa 90 Seiten)
    Publisher Magyar Nemzeti Bank
    Publishing place Budapest
    Document type Book ; Online
    Accompanying material 1 Online-Ressource „Figures of the report“
    Database ECONomics Information System

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