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Article ; Online: Risks of cardio-vascular diseases among highly active antiretroviral therapy (HAART) treated HIV seropositive volunteers at a treatment centre in Lagos, Nigeria.

Ekun, Oloruntoba Ayodele / Fasela, Emmanuel Olusesan / Oladele, David Ayoola / Liboro, Gideon Odemakpore / Raheem, Toyosi Yekeen

The Pan African medical journal

2021 Volume 38, Page(s) 206

Abstract: Introduction: highly active antiretroviral therapy (HAART) has led to a decline in HIV-induced morbidity and mortality in recent years. However, it has been opined that this has led to elevated risks of cardiovascular diseases (CVDs). This study ... ...

Abstract	Introduction: highly active antiretroviral therapy (HAART) has led to a decline in HIV-induced morbidity and mortality in recent years. However, it has been opined that this has led to elevated risks of cardiovascular diseases (CVDs). This study assessed the risks of CVDs among HAART experienced individuals living with HIV. Methods: a cross sectional study involving 196 adults consisting of 118 HAART experienced and 78 HAART naïve was conducted. Anthropometric and blood pressure measurements were recorded for all participants. Blood samples obtained from the volunteers were used to determine glucose, creatinine, HIV viral load, CD4 count and lipid profile using standard methods. Lipid ratios, atherogenic indices and QRISK3 risk score were calculated. Results: the median CD4 lymphocyte, mean body mass index (BMI) and HDL-c in HAART experienced participants were higher (P<0.05) than HAART naive individuals. The QRISK3 risk score and creatinine were higher (p<0.05) among HAART experienced group. In HAART experienced group, the risk of hypertension, increased low-density lipoprotein (LDL-c), atherogenic index of plasma (AIP) and QRISK3 were 3.7, 2.0, 2.38 and 3.85 times (p<0.05) higher respectively than in HAART naive. Atherogenic coefficient (AC) increase was more prevalent among male (p<0.05) participants. Risk of chronic renal disease (eGFR), hypertension and CVD (as measured by QRISK3) was higher (p<0.05) among the female and older participants respectively. Conclusion: the risk of CVDs and renal disease appeared to be higher among HAART experienced volunteers and older (>45 years) volunteers. The risk of renal disease appeared higher in females.
MeSH term(s)	Adult ; Age Factors ; Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/adverse effects ; Antiretroviral Therapy, Highly Active/adverse effects ; Antiretroviral Therapy, Highly Active/methods ; CD4 Lymphocyte Count ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cross-Sectional Studies ; Female ; HIV Infections/drug therapy ; Humans ; Kidney Diseases/epidemiology ; Kidney Diseases/etiology ; Male ; Middle Aged ; Nigeria ; Risk Factors ; Sex Factors
Chemical Substances	Anti-HIV Agents
Language	English
Publishing date	2021-02-23
Publishing country	Uganda
Document type	Journal Article
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2021.38.206.26791
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: An Unstructured Supplementary Service Data System to Verify HIV Self-Testing Among Nigerian Youths: Mixed Methods Analysis of Usability and Feasibility.

Oladele, David Ayoola / Iwelunmor, Juliet / Gbajabiamila, Titilola / Obiezu-Umeh, Chisom / Okwuzu, Jane Ogoamaka / Nwaozuru, Ucheoma / Musa, Adesola Zaidat / Tahlil, Kadija / Idigbe, Ifeoma / Ong, Jason / Tang, Weiming / Tucker, Joseph / Ezechi, Oliver

JMIR formative research

2023 Volume 7, Page(s) e44402

Abstract: Background: Mobile health (mHealth) interventions among adolescents and young adults (AYAs) are increasingly available in African low- and middle-income countries (LMICs). For example, the unstructured supplementary service data (USSD) could be used to ... ...

Abstract	Background: Mobile health (mHealth) interventions among adolescents and young adults (AYAs) are increasingly available in African low- and middle-income countries (LMICs). For example, the unstructured supplementary service data (USSD) could be used to verify HIV self-testing (HIVST) among AYAs with poor bandwidth. Objective: The aim of this study is to describe the creation of an USSD platform and determine its feasibility and usability to promote the verification of HIVST results among AYAs in Nigeria. Methods: We developed and evaluated a USSD platform to verify HIVST results using a user-centered approach. The USSD platform guided AYAs in performing HIVST, interpreting the result, and providing linkage to care after the test. Following the usability assessment, the USSD platform was piloted. We used a mixed methods study to assess the platform's usability through a process of quantitative heuristic assessment, a qualitative think-aloud method, and an exit interview. Descriptive statistics of quantitative data and inductive thematic analysis of qualitative variables were organized. Results: A total of 19 AYAs participated in the usability test, with a median age of 19 (IQR 16-23) years. There were 11 females, 8 males, and 0 nonbinary individuals. All individuals were out-of-school AYAs. Seven of the 10 Nielsen usability heuristics assessed yielded positive results. The participants found the USSD platform easy to use, preferred the simplicity of the system, felt no need for a major improvement in the design of the platform, and were happy the system provided linkage to care following the interpretation of the HIVST results. The pilot field test of the platform enrolled 164 out-of-school AYAs, mostly young girls and women (101, 61.6%). The mean age was 17.5 (SD 3.18) years, and 92.1% (151/164) of the participants reported that they were heterosexual, while 7.9% (13/164) reported that they were gay. All the participants in the pilot study were able to conduct HIVST, interpret their results, and use the linkage to care feature of the USSD platform without any challenge. A total of 7.9% (13/164) of the AYAs had positive HIV results (reactive to the OraQuick kit). Conclusions: This study demonstrated the usability and feasibility of using a USSD system as an alternative to mobile phone apps to verify HIVST results among Nigerian youth without smartphone access. Therefore, the use of a USSD platform has implications for the verification of HIVST in areas with low internet bandwidth. Further pragmatic trials are needed to scale up this approach.
Language	English
Publishing date	2023-09-25
Publishing country	Canada
Document type	Journal Article
ISSN	2561-326X
ISSN (online)	2561-326X
DOI	10.2196/44402
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Training primary healthcare workers on a task-strengthening strategy for integrating hypertension management into HIV care in Nigeria: implementation strategies, knowledge uptake, and lessons learned.

Oladele, David Ayoola / Odusola, Aina Olufemi / Odubela, Oluwatosin / Nwaozuru, Ucheoma / Calvin, Colvin / Musa, Zaidat / Idigbe, Ifeoma / Nwakwo, Chioma / Odejobi, Yemi / Aifah, Angela / Kanneh, Nafesa / Mishra, Shivani / Onakomaiya, Deborah / Iwelunmor, Juliet / Ogedegbe, Olugbenga / Ezechi, Oliver

BMC health services research

2023 Volume 23, Issue 1, Page(s) 673

Abstract: Background: With improved access to anti-retroviral drugs, persons living with HIV/AIDS (PLWHA) are living longer but with attendant increased risks of non-communicable diseases (NCDs). The increasing burden of NCDs, especially hypertension, could ... ...

Abstract	Background: With improved access to anti-retroviral drugs, persons living with HIV/AIDS (PLWHA) are living longer but with attendant increased risks of non-communicable diseases (NCDs). The increasing burden of NCDs, especially hypertension, could reverse gains attributed to HIV care. Nurses and Community Health Officers (CHO) in Nigeria are cardinal in delivering primary health care. A task-strengthening strategy could enable them to manage hypertension in HIV care settings. This study aimed to assess their knowledge and practice of hypertension management among Healthcare workers (HCWs) and to explore the challenges involved in conducting onsite training during pandemics. Methods: Nurses and CHOs in the employment of the Lagos State Primary Health Care Board (LSPHCB), Lagos State, Nigeria, were recruited. They were trained through hybrid (virtual and onsite) modules before study implementation and a series of refresher trainings. A pre-and post-training test survey was administered, followed by qualitative interviews to assess skills and knowledge uptake, the potential barriers and facilitators of task-sharing in hypertension management in HIV clinics, and the lessons learned. Results: Sixty HCWs participated in the two-day training at baseline. There was a significant improvement in the trainees' knowledge of hypertension management and control. The average score during the pre-test and post-test was 59% and 67.6%, respectively. While about 75% of the participants had a good knowledge of hypertension, its cause, symptoms, and management, 20% had moderate knowledge, and 5% had poor knowledge at baseline. There was also an increase in the mean score between the pre-test and post-test of the refresher training using paired t-tests (P < 0.05). Role-playing and multimedia video use improved the participants' uptake of the training. The primary barrier and facilitator of task sharing strategy in hypertension management reported were poor delineation of duties among HCWs and the existing task shifting at the Primary Healthcare Centres (PHC) level, respectively. Conclusions: The task strengthening strategy is relevant in managing hypertension in HIV clinics in Nigeria. The capacity development training for the nurses and CHOs involved in the Integration of Hypertension Management into HIV Care in Nigeria: A Task Strengthening Strategy (TASSH-Nigeria) study yielded the requisite improvement in knowledge uptake, which is a reassurance of the delivery of the project outcomes at the PHCs.
MeSH term(s)	Humans ; Nigeria ; Hypertension/therapy ; Health Personnel ; Palliative Care ; HIV Infections/complications ; HIV Infections/therapy
Language	English
Publishing date	2023-06-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2050434-2
ISSN	1472-6963 ; 1472-6963
ISSN (online)	1472-6963
ISSN	1472-6963
DOI	10.1186/s12913-023-09603-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Self-reported use of and access to personal protective equipment among healthcare workers during the COVID-19 outbreak in Nigeria

Oladele, David Ayoola / Idigbe, Ifeoma Eugenia / Musa, Adesola Zaidat / Gbaja-Biamila, Titilola / Bamidele, Tajudeen / Ohihoin, Aigbe Gregory / Salako, Abideen / Odubela, Tosin / Aina, Oluwagbemiga / Ohihoin, Esther / David, Agatha / Ezechi, Oliver / Odunukwe, Nkiruka / Salako, Babatunde Lawal

Heliyon. 2021 May, v. 7, no. 5

2021

Abstract: The SARS-CoV-2 virus is highly infectious resulting in increased infection and death among the front-line Healthcare Workers (HCW) because of limited access to personal protective equipment (PPE). This study assesses the availability and self-reported ... ...

Abstract	The SARS-CoV-2 virus is highly infectious resulting in increased infection and death among the front-line Healthcare Workers (HCW) because of limited access to personal protective equipment (PPE). This study assesses the availability and self-reported use of PPE amongst HCW during the COVID-19 pandemic in Nigeria. A mixed-method study was conducted through a cross-sectional survey and in-depth interviews amongst HCW. Quantitative data analysis was done using SPSS version 26 and thematic analysis was done for the in-depth interview. A total of 258 HCW completed the survey while 15 HCW took part in the in-depth interview. The mean age was 40 (±8.6) years, 67.4% were female and 83.3% were married. 49% were Doctors, 21.1% were Nurses, 28.7% were other allied HCW and 62.2% had at least 10 years of practice experience. Only 22.1% of HCWs had regular access to PPE and only 20.6% had access to N-95 facemask compare to other PPEs. Male HCWs and those working at secondary or tertiary facilities had access to N-95 facemask (p-value 0.025 and 0.010 respectively). The facilitator of PPE use is leadership quality of hospital head and donation of PPE to the facilities while the barriers to PPE use include a limited supply of PPE, as well as facility's infrastructural and operational challenges. The study reported limited access to essential PPE with varying perspectives on its use. Therefore, access, knowledge, and appropriate use of PPE need urgent attention with improved implementation of infection control policy at the facility level.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; cross-sectional studies ; death ; disease control ; females ; head ; health services ; hospitals ; issues and policy ; leadership ; males ; safety equipment ; surveys ; viruses ; Nigeria
Language	English
Dates of publication	2021-05
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2021.e07100
Database	NAL-Catalogue (AGRICOLA)

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Article: Self-reported use of and access to personal protective equipment among healthcare workers during the COVID-19 outbreak in Nigeria.

Heliyon

2021 Volume 7, Issue 5, Page(s) e07100

Abstract	The SARS-CoV-2 virus is highly infectious resulting in increased infection and death among the front-line Healthcare Workers (HCW) because of limited access to personal protective equipment (PPE). This study assesses the availability and self-reported use of PPE amongst HCW during the COVID-19 pandemic in Nigeria. A mixed-method study was conducted through a cross-sectional survey and in-depth interviews amongst HCW. Quantitative data analysis was done using SPSS version 26 and thematic analysis was done for the in-depth interview. A total of 258 HCW completed the survey while 15 HCW took part in the in-depth interview. The mean age was 40 (±8.6) years, 67.4% were female and 83.3% were married. 49% were Doctors, 21.1% were Nurses, 28.7% were other allied HCW and 62.2% had at least 10 years of practice experience. Only 22.1% of HCWs had regular access to PPE and only 20.6% had access to N-95 facemask compare to other PPEs. Male HCWs and those working at secondary or tertiary facilities had access to N-95 facemask (p-value 0.025 and 0.010 respectively). The facilitator of PPE use is leadership quality of hospital head and donation of PPE to the facilities while the barriers to PPE use include a limited supply of PPE, as well as facility's infrastructural and operational challenges. The study reported limited access to essential PPE with varying perspectives on its use. Therefore, access, knowledge, and appropriate use of PPE need urgent attention with improved implementation of infection control policy at the facility level.
Language	English
Publishing date	2021-05-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2021.e07100
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: COVID-19 vaccine breakthrough infections among fully vaccinated Health Care Workers in Lagos, Nigeria

Oladele, David Ayoola / Salako, Abideen / Ayorinde, James / Onwuamah, Chika / Usman, Olagoke / Abubakar, Rufai / Liboro, Gideon / Odubela, Oluwatosin / Mogaji, Sunday / Ige, Fehintola / Ohihoin, Gregory / Ezechi, Oliver / Audu, Rosemary / Adegbola, Richard A. / Dada, Adedamola / Salako, Tunde

medRxiv

Abstract: Background Access to vaccines has contributed to the control of COVID-19. However, evaluation of the effectiveness of the vaccines in a setting where the vaccines were not originally tested is critically important. This study evaluates the clinical and ... ...

Abstract	Background Access to vaccines has contributed to the control of COVID-19. However, evaluation of the effectiveness of the vaccines in a setting where the vaccines were not originally tested is critically important. This study evaluates the clinical and laboratory characteristics of COVID-19 vaccine breakthrough infections among healthcare workers (HCWs). Methods A multicentre prospective study among HCWs who had two doses of the Oxford/AstraZeneca ChAdOx1-S [recombinant] (AZD1222) vaccine were followed up 24 weeks. Nasopharyngeal and oropharyngeal specimens were tested using RT-PCR for SARS-CoV-2 and positive samples were subjected to whole genome sequencing for variant assignment. Result A total of 369 HCWs were enrolled; of which 24 (6.5%) had breakthrough infections. There was equal sex distribution among the breakthrough cases. The majority were aged between 30 to 39years (37.5%), and had mild symptoms of cough, fever, headache, and nausea/vomiting (58%), with no hospitalization. Among the 24 breakthrough cases whose whole genomes were successfully sequenced, three were confirmed to be Delta B.1.617.2 variant during the 3 rd wave and an additional three were confirmed as omicron B.1.1.529 variant during the 4 th wave. Conclusion We reported vaccine breakthrough cases among fully vaccinated HCWs with the majority presenting with mild illness. Both delta and omicron variants were identified during the different epidemiologic spectrums of SARS-CoV-2. Therefore, there is a need to scale up vaccination for all front-line health workers and high-risk populations in developing countries.
Keywords	covid19
Language	English
Publishing date	2022-06-22
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2022.06.22.22276765
Database	COVID19

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Article ; Online: Pattern, challenges and correlates of condom use among Nigerians living with HIV infection.

Oladele David Ayoola / Gab-Okafor Chidinma Victoria / Oke Bamidele / Kalejaiye Olufunto Olufela / Somefun Esther Oluwatosin / Ezeobi Paschal Mbaneifo / Gbajabiamila Titilola / Adu Rosemary Adagu / Onwujekwe Dan Ifeanyi / Ohwodo Harry / Odubela Oluwatosin / Odunukwe Nkiru Nonyelum / David Nkiruka / Ezechi Oliver Chukwujekwu

Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss S1, Pp S198-S

2014 Volume 203

Abstract: Objective: To determine the pattern, challenges and correlates of condom use among Nigerians living with HIV Infection. Methods: A cross sectional questionnaire study among HIV positive adults attending an HIV treatment centre in Lagos, Nigeria. Data ... ...

Abstract	Objective: To determine the pattern, challenges and correlates of condom use among Nigerians living with HIV Infection. Methods: A cross sectional questionnaire study among HIV positive adults attending an HIV treatment centre in Lagos, Nigeria. Data entry and analysis were done with Epi-info version 3.5.1. Results: The mean age of respondents was 35 (SD=7.7; range: 17–58 years) and mean age at sexual debut was 20 years old (range: 7–37 years). Majority were women (66.6%), had at least secondary school education(91.1%), married (68.2%)), on ART (50.7%) and knew their partners HIV status(60.9%). The rate of condom use at last sex act was 65.9%, but only 48.8% used condom consistently. Factors associated with condom use were male gender (OR=2.43, CI=1.35–4.33, P=0.002), less than secondary school education (OR=3.12, CI=1.04–9.28, P=0.05) and Not knowing partner's HIV status (OR=1.90, CI=1.04–3.80, P=0.04). Refusal to use condom (28.4%) were as a result of pregnancy intention, undesirability of condom in marriage and decreased sexual pleasure. Conclusion: There is low consistent condom use rate of 48.8% among this cohort despite their exposure to behavioural change messages. A review of the present counselling strategy and combination prevention is therefore advocated.
Keywords	Condom use ; HIV ; Nigeria ; Positive prevention ; Arctic medicine. Tropical medicine ; RC955-962 ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2014-05-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Risks of cardio-vascular diseases among highly active antiretroviral therapy (HAART) treated HIV seropositive volunteers at a treatment centre in Lagos, Nigeria.

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Article ; Online: An Unstructured Supplementary Service Data System to Verify HIV Self-Testing Among Nigerian Youths: Mixed Methods Analysis of Usability and Feasibility.

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Article ; Online: Training primary healthcare workers on a task-strengthening strategy for integrating hypertension management into HIV care in Nigeria: implementation strategies, knowledge uptake, and lessons learned.

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Article: Self-reported use of and access to personal protective equipment among healthcare workers during the COVID-19 outbreak in Nigeria

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Article: Self-reported use of and access to personal protective equipment among healthcare workers during the COVID-19 outbreak in Nigeria.

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Article ; Online: COVID-19 vaccine breakthrough infections among fully vaccinated Health Care Workers in Lagos, Nigeria

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Article ; Online: Pattern, challenges and correlates of condom use among Nigerians living with HIV infection.

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