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Article ; Online: 1:2 entrainment is not a device-induced artefact, except when it is.

Sermon, James J / Benjaber, Moaad / Duchet, Benoit / Anso, Juan / Olaru, Maria / Starr, Philip A / Denison, Timothy

2024 Volume 17, Issue 2, Page(s) 149–151

MeSH term(s)	Humans ; Artifacts ; Electroencephalography/instrumentation ; Electroencephalography/methods
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Letter
ZDB-ID	2394410-9
ISSN	1876-4754 ; 1935-861X
ISSN (online)	1876-4754
ISSN	1935-861X
DOI	10.1016/j.brs.2024.01.010
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Article ; Online: A quantitative approach for measuring laterality in clinical fMRI for preoperative language mapping.

Olaru, Maria / Nillo, Ryan M / Mukherjee, Pratik / Sugrue, Leo P

Neuroradiology

2021 Volume 63, Issue 9, Page(s) 1489–1500

Abstract: Purpose: fMRI is increasingly used for presurgical language mapping, but lack of standard methodology has made it difficult to combine/compare data across institutions or determine the relative efficacy of different approaches. Here, we describe a ... ...

Abstract	Purpose: fMRI is increasingly used for presurgical language mapping, but lack of standard methodology has made it difficult to combine/compare data across institutions or determine the relative efficacy of different approaches. Here, we describe a quantitative analytic framework for determining language laterality in clinical fMRI that addresses these concerns. Methods: We retrospectively analyzed fMRI data from 59 patients who underwent presurgical language mapping at our institution with identical imaging and behavioral protocols. First, we compared the efficacy of different regional masks in capturing language activations. Then, we systematically explored how laterality indices (LIs) computed from these masks vary as a function of task and activation threshold. Finally, we determined the percentile threshold that maximized the correlation between the results of our LI approach and the laterality assessments from the original clinical radiology reports. Results: First, we found that a regional mask derived from a meta-analysis of the fMRI literature better captured language task activations than masks based on anatomically defined language areas. Then, we showed that an LI approach based on this functional mask and percentile thresholding of subject activation can quantify the relative ability of different language tasks to lateralize language function at the population level. Finally, we determined that the 92nd percentile of subject-level activation provides the optimal LI threshold with which to reproduce the original clinical reports. Conclusion: A quantitative framework for determining language laterality that uses a functionally-derived language mask and percentile thresholding of subject activation can combine/compare results across tasks and patients and reproduce clinical assessments of language laterality.
MeSH term(s)	Brain Mapping ; Functional Laterality ; Humans ; Language ; Magnetic Resonance Imaging ; Retrospective Studies
Language	English
Publishing date	2021-03-26
Publishing country	Germany
Document type	Journal Article ; Meta-Analysis
ZDB-ID	123305-1
ISSN	1432-1920 ; 0028-3940
ISSN (online)	1432-1920
ISSN	0028-3940
DOI	10.1007/s00234-021-02685-z
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Article ; Online: Motor network gamma oscillations in chronic home recordings predict dyskinesia in Parkinson's disease.

Olaru, Maria / Cernera, Stephanie / Hahn, Amelia / Wozny, Thomas A / Anso, Juan / de Hemptinne, Coralie / Little, Simon / Neumann, Wolf-Julian / Abbasi-Asl, Reza / Starr, Philip A

Brain : a journal of neurology

2024

Abstract: In Parkinson's disease, imbalances between "antikinetic" and "prokinetic" patterns of neuronal oscillatory activity are related to motor dysfunction. Invasive brain recordings from the motor network have suggested that medical or surgical therapy can ... ...

Abstract	In Parkinson's disease, imbalances between "antikinetic" and "prokinetic" patterns of neuronal oscillatory activity are related to motor dysfunction. Invasive brain recordings from the motor network have suggested that medical or surgical therapy can promote a prokinetic state by inducing narrowband gamma rhythms (65-90 Hz). Excessive narrowband gamma in the motor cortex promotes dyskinesia in rodent models, but the relationship between narrowband gamma and dyskinesia in humans has not been well established. To assess this relationship, we used a sensing-enabled deep brain stimulator system, attached to both motor cortex and basal ganglia (subthalamic or pallidal) leads, paired with wearable devices that continuously tracked motor signs in the contralateral upper limbs. We recorded 984 hours of multisite field potentials in 30 hemispheres of 16 subjects with Parkinson's disease (2/16 female, mean age 57 ± 12 years) while at home on usual antiparkinsonian medications. Recordings were done two to four weeks after implantation, prior to starting therapeutic stimulation. Narrowband gamma was detected in the precentral gyrus, subthalamic nucleus, or both structures on at least one side of 92% of subjects with a clinical history of dyskinesia. Narrowband gamma was not detected in the globus pallidus. Narrowband gamma spectral power in both structures co-fluctuated similarly with contralateral wearable dyskinesia scores (mean correlation coefficient of ρ=0.48 with a range of 0.12-0.82 for cortex, ρ=0.53 with a range of 0.5-0.77 for subthalamic nucleus). Stratification analysis showed the correlations were not driven by outlier values, and narrowband gamma could distinguish "on" periods with dyskinesia from "on" periods without dyskinesia. Time lag comparisons confirmed that gamma oscillations herald dyskinesia onset without a time lag in either structure when using 2-minute epochs. A linear model incorporating the three oscillatory bands (beta, theta/alpha, and narrowband gamma) increased the predictive power of dyskinesia for several subject hemispheres. We further identified spectrally distinct oscillations in the low gamma range (40-60 Hz) in three subjects, but the relationship of low gamma oscillations to dyskinesia was variable. Our findings support the hypothesis that excessive oscillatory activity at 65-90 Hz in the motor network tracks with dyskinesia similarly across both structures, without a detectable time lag. This rhythm may serve as a promising control signal for closed-loop deep brain stimulation using either cortical or subthalamic detection.
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article
ZDB-ID	80072-7
ISSN	1460-2156 ; 0006-8950
ISSN (online)	1460-2156
ISSN	0006-8950
DOI	10.1093/brain/awae004
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Book ; Online ; Thesis: Dynamic NMR of nano- and microstructured materials

Olaru, Maria Alexandra

(Berichte aus der Physik)

2013

Author's details	Maria Alexandra Olaru
Series title	Berichte aus der Physik
Language	English
Size	Online-Ressource
Publisher	Shaker
Publishing place	Aachen
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	Techn. Hochsch., Diss.--Aachen, 2012
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Online ; Thesis: Dynamic NMR of nano- and microstructured materials

Olaru, Maria Alexandra

(Berichte aus der Physik)

2013

Author's details	Maria Alexandra Olaru
Series title	Berichte aus der Physik
Language	English
Size	Online-Ressource
Publisher	Shaker
Publishing place	Aachen
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	Techn. Hochsch., Diss.--Aachen, 2012
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Book ; Thesis: Dynamic NMR of nano- and microstructured materials

Olaru, Maria Alexandra

(Berichte aus der Physik)

2013

Title variant	nanostructured
Author's details	Maria Alexandra Olaru
Series title	Berichte aus der Physik
Keywords	DNMR-Spektroskopie ; Poröser Stoff
Language	English
Size	VIII, 149 S, Ill., graph. Darst, 21 cm, 246 g
Publisher	Shaker
Publishing place	Aachen
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Techn. Hochsch., Diss.--Aachen, 2012
Note	Literaturverz. S. 135 - 138
ISBN	9783844022575 ; 3844022570
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Sub-harmonic entrainment of cortical gamma oscillations to deep brain stimulation in Parkinson's disease: Model based predictions and validation in three human subjects.

Sermon, James J / Olaru, Maria / Ansó, Juan / Cernera, Stephanie / Little, Simon / Shcherbakova, Maria / Bogacz, Rafal / Starr, Philip A / Denison, Timothy / Duchet, Benoit

Brain stimulation

2023 Volume 16, Issue 5, Page(s) 1412–1424

Abstract: Objectives: The exact mechanisms of deep brain stimulation (DBS) are still an active area of investigation, in spite of its clinical successes. This is due in part to the lack of understanding of the effects of stimulation on neuronal rhythms. ... ...

Abstract	Objectives: The exact mechanisms of deep brain stimulation (DBS) are still an active area of investigation, in spite of its clinical successes. This is due in part to the lack of understanding of the effects of stimulation on neuronal rhythms. Entrainment of brain oscillations has been hypothesised as a potential mechanism of neuromodulation. A better understanding of entrainment might further inform existing methods of continuous DBS, and help refine algorithms for adaptive methods. The purpose of this study is to develop and test a theoretical framework to predict entrainment of cortical rhythms to DBS across a wide range of stimulation parameters. Materials and methods: We fit a model of interacting neural populations to selected features characterising PD patients' off-stimulation finely-tuned gamma rhythm recorded through electrocorticography. Using the fitted models, we predict basal ganglia DBS parameters that would result in 1:2 entrainment, a special case of sub-harmonic entrainment observed in patients and predicted by theory. Results: We show that the neural circuit models fitted to patient data exhibit 1:2 entrainment when stimulation is provided across a range of stimulation parameters. Furthermore, we verify key features of the region of 1:2 entrainment in the stimulation frequency/amplitude space with follow-up recordings from the same patients, such as the loss of 1:2 entrainment above certain stimulation amplitudes. Conclusion: Our results reveal that continuous, constant frequency DBS in patients may lead to nonlinear patterns of neuronal entrainment across stimulation parameters, and that these responses can be predicted by modelling. Should entrainment prove to be an important mechanism of therapeutic stimulation, our modelling framework may reduce the parameter space that clinicians must consider when programming devices for optimal benefit.
MeSH term(s)	Humans ; Parkinson Disease/therapy ; Deep Brain Stimulation/methods ; Basal Ganglia ; Physical Therapy Modalities ; Electrocorticography
Language	English
Publishing date	2023-09-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2394410-9
ISSN	1876-4754 ; 1935-861X
ISSN (online)	1876-4754
ISSN	1935-861X
DOI	10.1016/j.brs.2023.08.026
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Article ; Online: Metabolic and bone profile in postmenopausal women with and without type 2 diabetes

Dumitru Nicoleta / Carsote Mara / Cocolos Andra / Petrova Eugenia / Olaru Maria / Caragheorgheopol Andra / Dumitrache Constantin / Ghemigian Adina

Romanian Journal of Internal Medicine, Vol 57, Iss 1, Pp 61-

a cross-sectional study

2019 Volume 67

Abstract: Introduction. Current studies support the implication of metabolic changes associated with type 2 diabetes in altering bone metabolism, structure and resistance. ...

Abstract	Introduction. Current studies support the implication of metabolic changes associated with type 2 diabetes in altering bone metabolism, structure and resistance.
Keywords	type 2 diabetes mellitus ; diabetic bone disease ; trabecular bone score ; osteocalcin ; bone density ; Internal medicine ; RC31-1245
Language	English
Publishing date	2019-03-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bias and Precision in Magnetic Resonance Imaging-Based Estimates of Renal Blood Flow: Assessment by Triangulation.

Alhummiany, Bashair A / Shelley, David / Saysell, Margaret / Olaru, Maria-Alexandra / Kühn, Bernd / Buckley, David L / Bailey, Julie / Wroe, Kelly / Coupland, Cherry / Mansfield, Michael W / Sourbron, Steven P / Sharma, Kanishka

Journal of magnetic resonance imaging : JMRI

2021 Volume 55, Issue 4, Page(s) 1241–1250

Abstract: Background: Renal blood flow (RBF) can be measured with dynamic contrast enhanced-MRI (DCE-MRI) and arterial spin labeling (ASL). Unfortunately, individual estimates from both methods vary and reference-standard methods are not available. A potential ... ...

Abstract	Background: Renal blood flow (RBF) can be measured with dynamic contrast enhanced-MRI (DCE-MRI) and arterial spin labeling (ASL). Unfortunately, individual estimates from both methods vary and reference-standard methods are not available. A potential solution is to include a third, arbitrating MRI method in the comparison. Purpose: To compare RBF estimates between ASL, DCE, and phase contrast (PC)-MRI. Study type: Prospective. Population: Twenty-five patients with type-2 diabetes (36% female) and five healthy volunteers (HV, 80% female). Field strength/sequences: A 3 T; gradient-echo 2D-DCE, pseudo-continuous ASL (pCASL) and cine 2D-PC. Assessment: ASL, DCE, and PC were acquired once in all patients. ASL and PC were acquired four times in each HV. RBF was estimated and split-RBF was derived as (right kidney RBF)/total RBF. Repeatability error (RE) was calculated for each HV, RE = 1.96 × SD, where SD is the standard deviation of repeat scans. Statistical tests: Paired t-tests and one-way analysis of variance (ANOVA) were used for statistical analysis. The 95% confidence interval (CI) for difference between ASL/PC and DCE/PC was assessed using two-sample F-test for variances. Statistical significance level was P < 0.05. Influential outliers were assessed with Cook's distance (D Results: In patients, the mean RBF (mL/min/1.73m Conclusions: ASL, DCE, and PC RBF show poor agreement in individual subjects but agree well on average. Triangulation with PC suggests that the accuracy of ASL and DCE is comparable. Evidence level: 2 TECHNICAL EFFICACY: Stage 2.
MeSH term(s)	Contrast Media ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Prospective Studies ; Renal Circulation/physiology ; Reproducibility of Results ; Spin Labels
Chemical Substances	Contrast Media ; Spin Labels
Language	English
Publishing date	2021-08-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.27888
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Article ; Online: Metabolic and bone profile in postmenopausal women with and without type 2 diabetes: a cross-sectional study.

Dumitru, Nicoleta / Carsote, Mara / Cocolos, Andra / Petrova, Eugenia / Olaru, Maria / Caragheorgheopol, Andra / Dumitrache, Constantin / Ghemigian, Adina

Romanian journal of internal medicine = Revue roumaine de medecine interne

2018 Volume 57, Issue 1, Page(s) 61–67

Abstract: Introduction: Current studies support the implication of metabolic changes associated with type 2 diabetes in altering bone metabolism, structure and resistance.: Objective: We conducted a cross-sectional study on postmenopausal women aimed to ... ...

Abstract	Introduction: Current studies support the implication of metabolic changes associated with type 2 diabetes in altering bone metabolism, structure and resistance. Objective: We conducted a cross-sectional study on postmenopausal women aimed to analyze the differences in metabolic and bone profile in patients with and without type 2 diabetes Methods. We analyzed the metabolic and bone profile in postmenopausal women with and without type 2 diabetes (T2DM). Clinical, metabolic, hormonal parameters, along with lumbar, hip and femoral bone mineral density (BMD) and trabecular bone score (TBS) were evaluated. Results: 56 women with T2DM(63.57±8.97 years) and 83 non-T2DM (60.21±8.77 years) were included. T2DM patients presented a higher value of body mass index (BMI) and BMD vs. control group (p = 0.001; p = 0.03-lumbar level, p = 0.07-femoral neck and p = 0.001-total hip). Also, BMI correlated positively with lumbar-BMD and glycated hemoglobin (HbA1c) (r = 0.348, p = 0.01; r = 0.269, p = 0.04), correlation maintained even after age and estimated glomerular filtration rate (eGFR) adjustment (r = 0.383, p = 0.005; r = 0.237, p = 0.08). Diabetic patients recorded lower levels of 25(OH)D(p = 0.05), bone markers (p ≤ 0.05) and TBS(p = 0.07). For the entire patient group we found a negative correlation between HbA1c level and bone markers: r = -0.358, p = 0.0005-osteocalcin, r = -0.40, p = 0.0005-P1NP, r = -0.258, p = 0.005-crosslaps. Conclusions: Our results indicate the presence of altered bone microarchitecture in T2DZ patients according to the TBS score, combined with lower levels of bone markers, with a statistically significant negative correlation between HbA1c level and bone markers.
MeSH term(s)	25-Hydroxyvitamin D 2/metabolism ; Aged ; Biomarkers/metabolism ; Body Mass Index ; Bone Density ; Bone Resorption ; Bone and Bones/metabolism ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/metabolism ; Female ; Glycated Hemoglobin A/metabolism ; Humans ; Middle Aged ; Obesity/metabolism ; Osteocalcin/metabolism ; Peptide Fragments/metabolism ; Postmenopause/metabolism ; Procollagen/metabolism
Chemical Substances	Biomarkers ; Glycated Hemoglobin A ; Peptide Fragments ; Procollagen ; hemoglobin A1c protein, human ; procollagen Type I N-terminal peptide ; Osteocalcin (104982-03-8) ; 25-Hydroxyvitamin D 2 (21343-40-8)
Language	English
Publishing date	2018-12-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2015966-3
ISSN	2501-062X ; 0035-3973 ; 1582-3296
ISSN (online)	2501-062X
ISSN	0035-3973 ; 1582-3296
DOI	10.2478/rjim-2018-0036
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