LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 90

Search options

  1. Article: Influence of Adhesive Incise Drape Use on Surgical Site Infection Rates in Contaminated and Dirty Abdominal Operations.

    Adeleke, A A / Olasehinde, O / Adisa, A O

    West African journal of medicine

    2024  Volume 41, Issue 1, Page(s) 42–47

    Abstract: Background: Surgical Site Infection (SSI) remains the most common cause of Healthcare-Associated Infections (HCAIs). In particular, contaminated and dirty abdominal wounds are attended by a high rate of SSI which in turn is associated with a huge burden ...

    Abstract Background: Surgical Site Infection (SSI) remains the most common cause of Healthcare-Associated Infections (HCAIs). In particular, contaminated and dirty abdominal wounds are attended by a high rate of SSI which in turn is associated with a huge burden on patients, caregivers and the entire health care system.
    Objective: To compare SSI rates following the use of iodine-impregnated adhesive incise drapes (Ioban) with routine conventional drapes in contaminated and dirty abdominal surgical wounds in a Nigerian tertiary hospital.
    Methodology: Consecutive, consenting adult patients who underwent laparotomy for cases classified as contaminated and dirty were prospectively enrolled in the study. Patients in the investigation arm had in addition to conventional drapes, iodine-impregnated adhesive incise drapes (Ioban) applied on the skin of the abdomen through which incisions were made, while patients in the control arm only had routine conventional drapes applied. All patients were followed up to 30 days after the operation. Surgical site infection rates were compared between the two groups.
    Results: Sixty-two consecutive patients were enrolled into this study, of which 55 completed the 30-day follow-up. The mean ages of patients in the two groups were 37.96 ± 19.59 years and 36.74 ± 16.93 years (p=0.81). Males were 36 (65.5%) and females were 19 (34.5%). Overall, 30 (54.5%) patients had surgical site infection (SSI) in this study. Thirteen (46.4%) patients had SSI in iodine iodine-impregnated adhesive incise drape group while 17 (63%) patients had SSI in the conventional drape group, a difference that was not statistically significant (p=0.22). The most commonly isolated organism from infected wounds was Klebsiella species.
    Conclusion: The use of iodine-impregnated surgical incise drapes was associated with a lower, though non-statistically significant SSI rates compared to the use of conventional drapes. This marginal benefit will require a larger population study to examine its potential cost-effectiveness in our setting.
    MeSH term(s) Male ; Adult ; Female ; Humans ; Adolescent ; Young Adult ; Middle Aged ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/prevention & control ; Adhesives ; Surgical Drapes ; Iodine ; Skin
    Chemical Substances Adhesives ; Iodine (9679TC07X4)
    Language English
    Publishing date 2024-02-27
    Publishing country Nigeria
    Document type Journal Article
    ZDB-ID 1132088-6
    ISSN 0189-160X
    ISSN 0189-160X
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Neuroinflammatory Response and Redox-regulation Activity of Hyperoside in Manganese-induced Neurotoxicity Model of Wistar Rats.

    Ogunro, Olalekan / Olasehinde, Oluwaseun

    Current aging science

    2024  

    Abstract: Background: Excessive manganese exposure can lead to neurotoxicity with detrimental effects on the brain. Neuroinflammatory responses and redox regulation play pivotal roles in this process. Exploring the impact of hyperoside in a Wistar rat model ... ...

    Abstract Background: Excessive manganese exposure can lead to neurotoxicity with detrimental effects on the brain. Neuroinflammatory responses and redox regulation play pivotal roles in this process. Exploring the impact of hyperoside in a Wistar rat model offers insights into potential neuroprotective strategies against manganese-induced neurotoxicity.
    Objective: The study investigated the neuroprotective efficacy of hyperoside isolated from the ethanol leaf extract of Gongronema latifolium (HELEGL), in the brain tissue of Wistar rats following 15 consecutive days of exposure to 30 mg/L of MnCl2.
    Methods: Control animals in Group 1 had access to regular drinking water, while animals in groups 2-4 were exposed to MnCl2 in their drinking water. Groups 3 and 4 also received additional HELEGL at doses of 100 mg/kg and 200 mg/kg of body weight, respectively. In Group 5, HELEGL at a dose of 100 mg/kg of body weight was administered alone. Treatment with HELEGL commenced on day 8 via oral administration.
    Results: HELEGL effectively mitigated MnCl2-induced memory impairment, organ-body weight discrepancies, and fluid intake deficits. Exposure to MnCl2 increased the activities or levels of various markers such as acyl peptide hydrolase, tumour necrosis factor-α, dipeptidyl peptidase IV, nitric oxide, IL-1β, prolyl oligopeptidase, caspase-3, myeloperoxidase, H2O2, and malondialdehyde, while it decreased the activities or levels of others, including AChE, BChE, DOPA, serotonin, epinephrine, norepinephrine, GST, GPx, CAT, SOD, GSH, and T-SH (p < 0.05). In contrast, HELEGL effectively counteracted the adverse effects of MnCl2 by alleviating oxidative stress, inflammation, apoptosis, mitochondrial dysfunction, cognitive deficits, and bolstering the antioxidant status. Moreover, HELEGL restored the normal histoarchitecture of the brain, which had been distorted by MnCl2.
    Conclusion: In summary, HELEGL reversed the causative factors of neurodegenerative diseases induced by MnCl2 exposure, suggesting its potential for further exploration as a prospective therapeutic agent in the management of Alzheimer's disease and related forms of dementia.
    Language English
    Publishing date 2024-03-15
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1874-6128
    ISSN (online) 1874-6128
    DOI 10.2174/0118746098277166231204103616
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Effect of sprouted whole pearl millet on growth performance, intestinal development, bacterial count, and blood indices of broiler chickens.

    Olasehinde, Oluwakemi / Aderemi, Foluke

    Translational animal science

    2023  Volume 7, Issue 1, Page(s) txad045

    Abstract: This study investigated the effects of varying levels of sprouted whole grain pearl millet (SPM) on growth performance, intestinal morphology, microbial count, and blood indices of broiler chickens. A maize-soybean meal basal diet was formulated and fed ... ...

    Abstract This study investigated the effects of varying levels of sprouted whole grain pearl millet (SPM) on growth performance, intestinal morphology, microbial count, and blood indices of broiler chickens. A maize-soybean meal basal diet was formulated and fed to broiler chickens as starter (0 to 21 d) and finisher (22 to 42 d) diets. The diets comprised of 0%, 25%, 50%, 75%, and 100% of SPM incorporated as whole grain. On 0 d, 180 unsexed broiler chickens were allocated to experimental diets in a completely randomized design. Each treatment was replicated three times; each replicate had 12 chicks. All diets were isonitrogenous and isocaloric to meet the nutrient requirements of broiler chickens. Diets and water were provided ad libitum for 42 d. Results showed that the body weight gain (BWG) of broiler chickens on SPM compared favorably with those on the control diet. BWG showed trends in increment (
    Language English
    Publishing date 2023-05-08
    Publishing country England
    Document type Journal Article
    ISSN 2573-2102
    ISSN (online) 2573-2102
    DOI 10.1093/tas/txad045
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article: Effect of Fascia Closure with Triclosan-Coated Polydioxanone Suture on Surgical Site Infection in Open Appendectomy Wounds: A Comparative Study.

    Aderounmu, Adewale A / Olasehinde, Olalekan / Wuraola, Funmilola O / Adisa, Adewale O / Lawal, Oladejo O

    Journal of the West African College of Surgeons

    2024  Volume 14, Issue 2, Page(s) 154–158

    Abstract: Background: Interest in surgical site infections (SSI) has been sustained over the years because its occurrence may be ruinous to the overall success of surgical operations. The use of antimicrobial suture has been associated with a reduction in SSI, ... ...

    Abstract Background: Interest in surgical site infections (SSI) has been sustained over the years because its occurrence may be ruinous to the overall success of surgical operations. The use of antimicrobial suture has been associated with a reduction in SSI, but its role in open appendectomy has not been evaluated.
    Objective: This study compared the effect of fascia closure with triclosan-coated polydioxanone (PDS) with plain PDS on SSI in appendectomy wounds.
    Materials and methods: Ninety-three consecutive patients who had open appendectomy for uncomplicated acute appendicitis were randomised to either have fascia closure with triclosan-coated PDS (TCS) or plain PDS. Post-operative wound infection rates were compared.
    Results: SSI occurred in three of the 93 patients (3.2%), two of these occurred in the plain suture group, while one occurred in the TCS group (4.2% vs. 2.2%,
    Conclusion: The use of triclosan-coated polydioxanone for fascia closure in open appendectomy did not significantly affect the rate or severity of SSI. Further studies, perhaps evaluating the use of TCS in a different anatomical plane or complicated appendicitis are recommended.
    Language English
    Publishing date 2024-02-22
    Publishing country India
    Document type Journal Article
    ISSN 2276-6944
    ISSN 2276-6944
    DOI 10.4103/jwas.jwas_25_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article: Awareness and Knowledge of Breast Cancer and Breast Examination amongst Undergraduate Students. Mixed Method Approach.

    Makinde, O Y / Wuraola, F O / Aderounmu, A A / Ugalahi, T O / Olasehinde, O / Adisa, A O

    West African journal of medicine

    2023  Volume 40, Issue 8, Page(s) 857–862

    Abstract: Introduction: Breast cancer is the most common cause of cancer death amongst women, and the stage at presentation has been found to be an important prognostic index. The study aims to assess breast cancer awareness, including breast cancer education and ...

    Abstract Introduction: Breast cancer is the most common cause of cancer death amongst women, and the stage at presentation has been found to be an important prognostic index. The study aims to assess breast cancer awareness, including breast cancer education and knowledge of breast self-examination, among undergraduate students with the hope of improving their knowledge of breast cancer.
    Methods: The study used the mixed method approach, to evaluate during breast cancer awareness month. All consenting participants completed a pre-test questionnaire before a breast health seminar, after which the post-test questionnaire was filled out. Consenting participants also had clinical breast examinations performed on them. The data were analyzed using IBM SPSS version 24.
    Results: One hundred and thirteen participants filled out the pre-test questionnaire while 127 participants filled out the post-test. There was a significant change following the seminar. About 87.9% of respondents knew about breast cancer but had poor knowledge of the predisposing factors (11.3%). Most participants (94.3%) knew about self-breast examination (SBE), however, only 46% examined themselves in the past with only 21% aware of the correct timing for SBE. Clinical breast exams were conducted on 80 participants, six (7.5%) breast lumps were found and two had excision biopsies with histopathology diagnosis of fibroadenoma.
    Conclusion: Breast education is important, as knowledge about breast cancer is still low, even among undergraduate students. Continuous breast education should be encouraged.
    MeSH term(s) Female ; Humans ; Breast Neoplasms/diagnosis ; Students ; Biopsy ; Health Education
    Language English
    Publishing date 2023-08-28
    Publishing country Nigeria
    Document type Journal Article
    ZDB-ID 1132088-6
    ISSN 0189-160X
    ISSN 0189-160X
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article: Audit of Preoperative Fasting for Elective General Surgeries in the Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.

    Adesunkanmi, A O / Ubom, A E / Ndegbu, C U / Olugbami, A M / Aaron, O I / Wuraola, F O / Olasehinde, O

    West African journal of medicine

    2023  Volume 40, Issue 8, Page(s) 786–791

    Abstract: Background: Despite overwhelming evidence in favour of a relaxed fasting protocol, the traditional practice of keeping patients nil per oral from midnight before the day of surgery for all elective operations still appears to hold sway in many practices. ...

    Abstract Background: Despite overwhelming evidence in favour of a relaxed fasting protocol, the traditional practice of keeping patients nil per oral from midnight before the day of surgery for all elective operations still appears to hold sway in many practices.
    Methods: A prospective study to evaluate the pattern of preoperative fasting among patients undergoing elective general surgical operations in the Department of Surgery, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria, was conducted between June and December 2020. Data obtained was analysed using the IBM SPSS Statistics for Windows, version 24, and presented as descriptive statistics in the form of frequencies and percentages.
    Results: The mean prescribed fasting duration was 11.2 ± 2.4 hours. The mean actual fasting duration of 17.6 ± 13.1 hours was significantly longer than the mean prescribed fasting duration (p= <0.001). Eighty-nine percent of patients fasted for >12 hours before their surgical operations. Bowel surgeries had the longest actual fasting duration of 34.9 ± 27.5 hours, while ventral hernia repairs and superficial mass excisions had the shortest duration of 13.5 ± 0.7 hours. Surgeries performed after noon had the longest actual fasting duration compared to those performed before noon (21.5 ± 18.7 hours vs. 15.6 ± 8.6 hours). Ninety percent of respondents reported hunger score of>4 while fasting.
    Conclusion: Preoperative fasting duration in our surgical unit remains long and conventional. The potential implications of this practice on patients' physiological status and surgical outcomes are strong enough to motivate a change.
    MeSH term(s) Humans ; Nigeria ; Prospective Studies ; Universities ; Hospitals, Teaching ; Fasting
    Language English
    Publishing date 2023-08-28
    Publishing country Nigeria
    Document type Journal Article
    ZDB-ID 1132088-6
    ISSN 0189-160X
    ISSN 0189-160X
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article: Breast Cancer Stage at Diagnosis in a Nigerian Hospital: Trend over a Decade.

    Olasehinde, O / Aderounmu, A / Wuraola, F / Omisore, A / Akinkuolie, A / Towoju, A / Mohammed, T / Mango, V / Kingham, P T / Adisa, A / Alatise, O

    West African journal of medicine

    2024  Volume 40, Issue 12, Page(s) 1298–1303

    Abstract: Background: Breast cancer outcomes are poor in Nigeria, partly due to late-stage diagnosis. To assess the impact of past and present interventions, a review of an institutional data base was performed to determine the trend with respect to stage at ... ...

    Abstract Background: Breast cancer outcomes are poor in Nigeria, partly due to late-stage diagnosis. To assess the impact of past and present interventions, a review of an institutional data base was performed to determine the trend with respect to stage at diagnosis over a decade.
    Methods: A retrospective analysis of an institutional data base was performed over a decade. The review period was divided into segments (2013-2015, 2016-2018 and 2019-2022). The latter period (2019-2022), corresponds to a time of more intense community interventions aimed at promoting early diagnosis and treatment around the locality of the teaching hospital. The stage at diagnosis within these periods were compared. The relationship between stage and sociodemographic variables (age, religion, marital status, menopausal status, and level of education) was assessed.
    Results: There were 910 patients, 144 within the first period (2013-2015), 318 in the second (2016-2018) and 454 in the third period (2019-2022). The majority presented with stage 3 disease (73.8%). There was a significant decline in the proportion of metastatic cases and a concomitant increase in early cases in the latter part of the review. The proportion of metastatic cases reduced from 23.6% (2013-2015), to 15.7% (2016-2018) and 9.3% (2019-2022) (p=0.001). Level of education was significantly associated with stage (p=0.001).
    Conclusion: This study shows a trend towards downstaging of breast cancer in our locality. This trend corresponds to the period of more intense community interventions, justifying the need to further interrogate the direct impact of each of the interventions. This will provide a firm basis for sustaining or improving on current efforts to achieve more robust gains.
    MeSH term(s) Female ; Humans ; Black People/statistics & numerical data ; Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Hospitals, Teaching/statistics & numerical data ; Retrospective Studies ; Early Detection of Cancer/statistics & numerical data ; Early Detection of Cancer/trends ; Databases, Factual/statistics & numerical data ; Databases, Factual/trends ; Nigeria/epidemiology ; Health Promotion/statistics & numerical data ; Health Promotion/trends ; Educational Status ; Community-Institutional Relations/trends
    Language English
    Publishing date 2024-01-23
    Publishing country Nigeria
    Document type Journal Article
    ZDB-ID 1132088-6
    ISSN 0189-160X
    ISSN 0189-160X
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: Effectiveness of Triclosan Coated Suture for Subcutaneous Wound Closure in Preventing Surgical Site Infection following Mesh Repair of Inguinal Hernia: A Pilot Study.

    Olasehinde, O / Aderounmu, A / Etonyeaku, A C / Mosanya, A O / Wuraola, F O / Agbakwuru, E A

    West African journal of medicine

    2021  Volume 38, Issue 6, Page(s) 566–570

    Abstract: Background: The role of prophylactic antibiotics in mesh repair of inguinal hernia is controversial and often based on institutional policies. Surgical site infection rate from earlier studies in Nigeria justifies the continued use of prophylactic ... ...

    Abstract Background: The role of prophylactic antibiotics in mesh repair of inguinal hernia is controversial and often based on institutional policies. Surgical site infection rate from earlier studies in Nigeria justifies the continued use of prophylactic antibiotics during hernia repair. With increased use of antibiotics comes the challenge of antibiotic resistance and toxicity. The use of antimicrobial coated suture may help avoid these challenges but its efficacy needs to be tested.
    Objective: To compare Triclosan coated suture with intravenous antibiotics for the repair of inguinal hernia with mesh.
    Methods: Patients with uncomplicated inguinal hernia undergoing mesh repair were randomized to either have intravenous antibiotics administered for prophylaxis or to have wound closure with Triclosan coated Vicryl 2/0 suture. Post operatively, wound infection rates were compared between the two groups. Follow up was for 1 year.
    Results: We studied 49 patients with 59 hernias with a mean age of 53 years. Hernias were solitary in 75% of cases, the majority of which were right sided, while 25% were bilateral. There were 25 patients with 32 hernias in the Intravenous antibiotic group (Group A) and 24 patients with 27 hernias in the Triclosan suture group (Group B). Wound grades were similar between the two groups with one patient in the Triclosan group confirmed to have wound infection (4.2%) and none in the Intravenous antibiotics group (p=0.27). Wound infection was of the superficial type which resolved with wound care within 1 month.
    Conclusion: Triclosan coated suture may be safely used as an alternative to intravenous antibiotics for the mesh repair of inguinal hernia. Further studies are required to validate this finding.
    MeSH term(s) Antibiotic Prophylaxis ; Hernia, Inguinal ; Humans ; Middle Aged ; Nigeria ; Pilot Projects ; Surgical Mesh ; Surgical Wound Infection ; Sutures ; Triclosan
    Chemical Substances Triclosan (4NM5039Y5X)
    Language English
    Publishing date 2021-04-14
    Publishing country Nigeria
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1132088-6
    ISSN 0189-160X
    ISSN 0189-160X
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article: Unveiling research training gaps in oncology: Evaluating a research capacity-building effort among Nigerian physicians.

    Owoade, I A / Wuraola, F / Olasehinde, O / Akinyemi, P A / Randolph, K / Dare, A J / Kingham, T P / Alatise, O I

    Nigerian journal of clinical practice

    2022  Volume 25, Issue 7, Page(s) 1038–1045

    Abstract: Background: Cancers are a disease of growing public health importance in Africa, but cancer research capacity in the region is underdeveloped. The quest to foster and promote locally conceptualized and conducted oncology research in Africa have informed ...

    Abstract Background: Cancers are a disease of growing public health importance in Africa, but cancer research capacity in the region is underdeveloped. The quest to foster and promote locally conceptualized and conducted oncology research in Africa have informed the African Research Group for Oncology's (ARGO) research capacity-building efforts in Nigeria.
    Aim: To evaluate the effectiveness of oncology research capacity-building initiatives among Nigerian senior trainees and junior faculty physicians.
    Subjects and methods: Panel study design was employed to study Nigerian senior trainees and junior faculty physicians who participated in two research capacity-building symposia. Data were collected pre-and immediate post-symposia, and 3-month post-first symposium. Changes in knowledge were assessed using the Chi-square test and confidence levels using the Wilcoxon signed rank test. A P value of <0.05 was considered statistically significant.
    Results: : In the first symposium, the participants' pass rate in the knowledge-based questions improved from 9.8% to 46.7% to 81.5% at the baseline, immediate post-symposium, and 3-month post-symposium, respectively (P < 0.001). Likewise, the participants' confidence level in carrying out certain research-related activities increased after the second symposium (P < 0.001).
    Conclusion: The study concludes that building capacity for oncology research in low- and middle-income countries is possible with focused symposia and educational programs.
    MeSH term(s) Capacity Building ; Faculty ; Humans ; Nigeria ; Physicians
    Language English
    Publishing date 2022-06-30
    Publishing country India
    Document type Journal Article
    ZDB-ID 1458330-6
    ISSN 1119-3077
    ISSN 1119-3077
    DOI 10.4103/njcp.njcp_1461_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Zinc Ameliorates Cadmium-Induced Immunotoxicity by Modulating Splenic Immunosuppressive Indoleamine 2,3-Dioxygenase Activity, Hematological Indices, and CD4

    Ebokaiwe, Azubuike Peter / Olasehinde, Olusanya / Chimezie, Iyiagwor P / Odobi, Ushang R / Nvene, Chiamaka / Faith, Ekoh

    Biological trace element research

    2023  Volume 202, Issue 3, Page(s) 1140–1149

    Abstract: Cadmium (Cd)-induced immunotoxicity has become a matter of public health concern owing to its prevalence in the environment consequently, great potential for human exposure. Zinc (Zn) has been known to possess antioxidant, anti-inflammatory, and immune- ... ...

    Abstract Cadmium (Cd)-induced immunotoxicity has become a matter of public health concern owing to its prevalence in the environment consequently, great potential for human exposure. Zinc (Zn) has been known to possess antioxidant, anti-inflammatory, and immune-boosting properties. However, the ameliorating influence of Zn against Cd-induced immunotoxicity connecting the IDO pathway is lacking. Adult male Wistar rats were exposed to normal drinking water with no metal contaminants (group 1), group 2 received drinking water containing 200 μg/L of Cd, group 3 received drinking water containing 200 μg/L of Zn, and group 4 received Cd and Zn as above in drinking water for 42 days. Cd exposure alone significantly triggered the splenic oxidative-inflammatory stress, increased activities of immunosuppressive tryptophan 2,3-dioxygenase (TDO), indoleamine 2,3-dioxygenases (IDO) activities/protein expression, and decreased CD4
    MeSH term(s) Rats ; Male ; Humans ; Animals ; Rats, Wistar ; Zinc/pharmacology ; Zinc/metabolism ; Cadmium/pharmacology ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Indoleamine-Pyrrole 2,3,-Dioxygenase/pharmacology ; Spleen/metabolism ; Drinking Water ; Oxidative Stress ; T-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes
    Chemical Substances Zinc (J41CSQ7QDS) ; Cadmium (00BH33GNGH) ; Indoleamine-Pyrrole 2,3,-Dioxygenase ; Drinking Water
    Language English
    Publishing date 2023-07-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 445336-0
    ISSN 1559-0720 ; 0163-4984
    ISSN (online) 1559-0720
    ISSN 0163-4984
    DOI 10.1007/s12011-023-03752-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top