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  1. Article ; Online: Chronic incretin-based therapy in cystic fibrosis-related diabetes: A tale of 3 patients treated with sitagliptin for over 5 years.

    Olatunbosun, Samuel T

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2021  Volume 20, Issue 6, Page(s) e124–e128

    Abstract: Cystic fibrosis-related diabetes (CFRD) affects 40-50% of adult patients with cystic fibrosis. Insulin therapy is recommended but there are therapeutic challenges, particularly risk of hypoglycemia and aversion of some patients to injectables. An oral ... ...

    Abstract Cystic fibrosis-related diabetes (CFRD) affects 40-50% of adult patients with cystic fibrosis. Insulin therapy is recommended but there are therapeutic challenges, particularly risk of hypoglycemia and aversion of some patients to injectables. An oral incretin-based therapy using a DPP-4i (dipeptidyl peptidase-4 inhibitor), may be a reasonable option, especially in the early stage of the disease. The effect of chronic incretin-based therapy on CFRD is unknown. Here is a report of 3 cases of CFRD patients treated with sitagliptin and the response to therapy over a period of 5-10 years. An effective glycemic control was demonstrated in all the patients, at least during the first 5 years of sitagliptin treatment, and the benefit persisted for a decade in two of them. The secondary failure of the DPP-4i occurred in a CFRD patient with a phenotype resembling type 2 diabetes. A DPP-4i may have an important role in the management of CFRD.
    MeSH term(s) Adult ; Cystic Fibrosis/complications ; Diabetes Mellitus, Type 2/drug therapy ; Glycemic Control ; Humans ; Hypoglycemic Agents/therapeutic use ; Incretins/therapeutic use ; Male ; Sitagliptin Phosphate/therapeutic use
    Chemical Substances Hypoglycemic Agents ; Incretins ; Sitagliptin Phosphate (TS63EW8X6F)
    Language English
    Publishing date 2021-03-02
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2084724-5
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2021.02.005
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    Zs.A 6028: Show issues Location:
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    Zs.MO 459: Show issues

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  2. Article: Bempedoic Acid, an Inhibitor of Cholesterol Biosynthesis, Reduces Cardiovascular Events.

    Jialal, Ishwarlal / Olatunbosun, Samuel

    Journal of clinical medicine

    2023  Volume 12, Issue 10

    Abstract: An elevated low-density lipoprotein cholesterol (LDL-C) is a major risk factor for premature atherosclerotic cardiovascular diseases (ASCVD) [ ... ]. ...

    Abstract An elevated low-density lipoprotein cholesterol (LDL-C) is a major risk factor for premature atherosclerotic cardiovascular diseases (ASCVD) [...].
    Language English
    Publishing date 2023-05-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12103463
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  3. Article ; Online: Multiple endocrine neoplasia type 2: diagnostic challenges of a medullary thyroid carcinoma nodule.

    Olatunbosun, Samuel T / Huddleston, Brent J

    Internal medicine journal

    2021  Volume 51, Issue 7, Page(s) 1188–1190

    MeSH term(s) Carcinoma, Neuroendocrine/diagnostic imaging ; Humans ; Multiple Endocrine Neoplasia ; Multiple Endocrine Neoplasia Type 2a/diagnostic imaging ; Thyroid Neoplasms/diagnostic imaging
    Language English
    Publishing date 2021-07-19
    Publishing country Australia
    Document type Letter
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/imj.15417
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    Zs.A 792: Show issues Location:
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    Zs.MO 424: Show issues

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  4. Article ; Online: Diagnosis of Resistance to Thyroid Hormone due to a Rare Mutation in the Thyroid Hormone Receptor Beta Gene in a Patient Previously Presumed to Have Graves' Disease.

    Olatunbosun, Samuel T / Kluesner, Joseph K / Clerc, Philip G / Prasad, Shalvin S

    Military medicine

    2023  Volume 189, Issue 1-2, Page(s) e439–e442

    Abstract: Clinicians may confuse an impaired sensitivity to thyroid hormone with hyperthyroidism and offer an inappropriate treatment. We report a diagnosis of resistance to thyroid hormone (RTH) caused by a rare mutation in the thyroid hormone receptor beta gene ... ...

    Abstract Clinicians may confuse an impaired sensitivity to thyroid hormone with hyperthyroidism and offer an inappropriate treatment. We report a diagnosis of resistance to thyroid hormone (RTH) caused by a rare mutation in the thyroid hormone receptor beta gene in a patient previously presumed to have Graves' disease. We have found only one published case of a novel point mutation, c.749T>C (p.Ile250Thr variant) associated with 50% reduction in thyroid hormone receptor binding affinity for triiodothyronine in the I250T mutant; it was found in this patient. A 66-year-old male veteran, with a history of non-ischemic cardiomyopathy and arrhythmias, was referred by a cardiologist with concerns for a possible thyrotropin (TSH) adenoma on account of elevated TSH and free thyroxine (FT4) levels. Pituitary imaging was negative. He was previously treated with radioiodine for presumptive Graves' disease in the civilian sector. Examination revealed a goiter with no nodules. Repeat TSH and FT4 levels were elevated and also free triiodothyronine (FT3) and reverse triiodothyronine. These findings and other test results were consistent with RTH, which was confirmed by genetic testing. Mutation analysis showed the patient to be heterozygous for the p.Ile250Thr variant. He later developed hypothyroidism. Resistance to thyroid hormone can be misdiagnosed as hyperthyroidism with consequent inappropriate treatment. Treatment is not needed in most RTH-beta patients. Thyroid ablation should generally be avoided. Clinicians must be cautious whenever they encounter concurrent elevation of TSH, FT4, and FT3. This RTH-beta patient has a rare I250T mutant of the thyroid hormone receptor beta gene, the second reported case in the literature.
    MeSH term(s) Male ; Humans ; Aged ; Triiodothyronine ; Thyroid Hormone Receptors beta/genetics ; Iodine Radioisotopes ; Thyroid Hormones ; Graves Disease/diagnosis ; Graves Disease/genetics ; Graves Disease/complications ; Thyrotropin ; Mutation ; Hyperthyroidism/genetics ; Hyperthyroidism/complications ; Thyroid Hormone Resistance Syndrome/diagnosis ; Thyroid Hormone Resistance Syndrome/genetics ; Thyroid Hormone Resistance Syndrome/complications
    Chemical Substances Triiodothyronine (06LU7C9H1V) ; Thyroid Hormone Receptors beta ; Iodine Radioisotopes ; Thyroid Hormones ; Thyrotropin (9002-71-5)
    Language English
    Publishing date 2023-07-31
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 391061-1
    ISSN 1930-613X ; 0026-4075
    ISSN (online) 1930-613X
    ISSN 0026-4075
    DOI 10.1093/milmed/usad283
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    Un I Zs.546: Show issues Location:
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  5. Article: Visual Vignette.

    Kluesner, Joseph K / Whang, S Charles / Viswanathan, Lavanya / Olatunbosun, Samuel T

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

    2020  Volume 26, Issue 7, Page(s) 799

    MeSH term(s) Aged ; Fanconi Syndrome/complications ; Female ; Humans ; Osteomalacia/diagnostic imaging ; Osteomalacia/etiology
    Language English
    Publishing date 2020-11-24
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1473503-9
    ISSN 1530-891X
    ISSN 1530-891X
    DOI 10.4158/EP-2019-0433
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    Zs.A 5034: Show issues Location:
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    Zs.MO 508: Show issues

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  6. Article ; Online: Diagnostic Evaluation of Hypoglycemia Due To an Insulinoma in a Deployed Infantryman: Significance of Neuroglycopenia and the Role of the Military Health System.

    Olatunbosun, Samuel T / Alaketu, Ayodeji F / McDermott, Joseph H / Elsayed von Bayreuth, Al M

    Military medicine

    2021  

    Abstract: Insulinoma, the prototype of endogenous hyperinsulinemic hypoglycemia, is a very rare condition, with an incidence of four cases per million person-years. Its rate of occurrence in the U.S. military population is unknown. Two cases of insulinomas ... ...

    Abstract Insulinoma, the prototype of endogenous hyperinsulinemic hypoglycemia, is a very rare condition, with an incidence of four cases per million person-years. Its rate of occurrence in the U.S. military population is unknown. Two cases of insulinomas involving active duty service members have been published. However, there has been no reported case of an insulinoma in a deployed service member. We report the case of a 21-year-old infantryman with clinical hypoglycemia of insidious onset, manifesting with overt neuroglycopenic symptoms during his deployment as a combatant soldier, and the ultimate diagnosis of an insulinoma as the underlying cause. The series of multiple clinical evaluations and the unique circumstances leading to the formal evaluation of the patient's hypoglycemia and treatment are chronicled. The significance of neuroglycopenia and the diagnostic approach to any suspected case of hypoglycemia, the potential challenges and opportunities, and educational aspects of evaluation and management of the insulinoma are elaborated. The potential role of the Military Health System in facilitating the detection and treatment of this rare condition in the service member is discussed as well.
    Language English
    Publishing date 2021-07-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 391061-1
    ISSN 1930-613X ; 0026-4075
    ISSN (online) 1930-613X
    ISSN 0026-4075
    DOI 10.1093/milmed/usab261
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  7. Article: Central Obesity in Africans: Anthropometric Assessment of Abdominal Adiposity and its Predictors in Urban Nigerians.

    Olatunbosun, Samuel T / Kaufman, Jay S / Bella, Andrew F

    Journal of the National Medical Association

    2018  Volume 110, Issue 5, Page(s) 519–527

    Abstract: Objective: To assess the occurrence of central obesity and identify its predictors in urban Africans using anthropometric tools. Another objective was to evaluate the anthropometric indices and their interaction with various cardiovascular risk factors.! ...

    Abstract Objective: To assess the occurrence of central obesity and identify its predictors in urban Africans using anthropometric tools. Another objective was to evaluate the anthropometric indices and their interaction with various cardiovascular risk factors.
    Methods: In an obesity survey in a major Nigerian city, we measured the prevalence of central obesity in 998 randomly selected men and women using the IDF (International Diabetes Federation) criteria. Normalized values of three anthropometric indices, waist circumference (WC), WHR (waist-to-hip ratio) and WHtR (waist-to-height ratio) were also employed in assessing central adiposity and its predictors in the population.
    Results: Most (61%) female participants had central obesity compared with 9% of the males based on the IDF waist criteria. Higher income level and physical inactivity were associated with central obesity (p < 0.001). In multivariate analyses, older participants and women were more likely to have central obesity (p < 0.001), but men had higher WHR than women at the same body mass index. WC was a stronger predictor of glucose intolerance than WHR, whereas WHR was more predictive of hypertension than WC. WHR showed a strong relationship with hypertension but not with glucose intolerance. WHtR was predictive of plasma glucose and diastolic blood pressure. WC showed strongest correlation with other indices.
    Conclusions: Central obesity was highly prevalent among women in this sample. It was associated with age, gender, socioeconomic status, physical inactivity, and it predicted glucose intolerance and hypertension. WC was a major determinant of both cardiovascular risk factors. It showed best correlation with other anthropometric indices.
    MeSH term(s) Adiposity ; Adult ; Analysis of Variance ; Anthropometry ; Cardiovascular Diseases ; Female ; Government Employees ; Health Surveys ; Humans ; Male ; Nigeria/epidemiology ; Obesity, Abdominal/epidemiology ; Prevalence ; Risk Factors ; Sedentary Behavior ; Sex Factors ; Social Class ; Urban Population ; Waist Circumference
    Language English
    Publishing date 2018-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 419737-9
    ISSN 0027-9684
    ISSN 0027-9684
    DOI 10.1016/j.jnma.2018.01.001
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