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Article ; Online: Biological activities of African medicinal plants in the treatment of erectile dysfunction: a mechanistic perspective.

Babalola, Olorunfemi Oyewole / Iwaloye, Opeyemi / Ottu, Paul Olamide / Aturamu, Precious Olayinka / Olawale, Femi

Hormone molecular biology and clinical investigation

2024 Volume 44, Issue 4, Page(s) 357–370

Abstract: The global incidence of erectile dysfunction is increasingly becoming a significant health concern, as its frequency demonstrates a consistent upward trajectory each year. In recent years, FDA-approved drugs like sildenafil among others has been approved ...

Abstract	The global incidence of erectile dysfunction is increasingly becoming a significant health concern, as its frequency demonstrates a consistent upward trajectory each year. In recent years, FDA-approved drugs like sildenafil among others has been approved to treat this disorder however the drug is not without its own side effects. In a bid to develop alternative therapeutic option, scientists have now turned to traditional medicine in search of a treatment regimen. Africa is blessed with numerous medicinal plants used in the treatment and management of several diseases including erectile dysfunction. Due to limited access to modern medicine and high-quality medical facilities, a significant number of individuals in Africa continue to depend on traditional medicine as a means of addressing critical health issues. Perhaps one of the grossly explored medicinal properties of plants in Africa is for erectile function. Through years of extensive research in medicinal plants, several plants indigenous to Africa have been identified to show profound ability to mitigate erectile dysfunction. While previous reports have indeed corroborated the ability of this plant to abate erectile dysfunction, there is still a dearth of information regarding the mechanistic aspect of these plants. Hence, the current review aims to provide a comprehensive mechanistic perspective to the major African medicinal plant which have been reported to be effective in the treatment of erectile dysfunction.
MeSH term(s)	Male ; Humans ; Plants, Medicinal ; Erectile Dysfunction/drug therapy ; Erectile Dysfunction/etiology ; Sildenafil Citrate/therapeutic use
Chemical Substances	Sildenafil Citrate (BW9B0ZE037)
Language	English
Publishing date	2024-01-16
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2536635-X
ISSN	1868-1891 ; 1868-1883
ISSN (online)	1868-1891
ISSN	1868-1883
DOI	10.1515/hmbci-2022-0090
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Probing the bioactive compounds of

Olofinsan, Kolawole / Olawale, Femi / Karigidi, Kayode / Shityakov, Sergey / Iwaloye, Opeyemi

Journal of biomolecular structure & dynamics

2023 Volume 41, Issue 22, Page(s) 12838–12862

Abstract: Tumor Necrosis Factor Alpha Converting Enzyme (TACE) mediates inflammatory disorder and contributes to the pathophysiology of a variety of illnesses, such as chronic inflammation and cancer. This study identified metabolites in solvent extracts ... ...

Abstract	Tumor Necrosis Factor Alpha Converting Enzyme (TACE) mediates inflammatory disorder and contributes to the pathophysiology of a variety of illnesses, such as chronic inflammation and cancer. This study identified metabolites in solvent extracts of
MeSH term(s)	Humans ; ADAM17 Protein ; Chromatography, High Pressure Liquid ; Gas Chromatography-Mass Spectrometry ; Spectroscopy, Fourier Transform Infrared ; Molecular Dynamics Simulation ; Inflammation ; Molecular Docking Simulation
Chemical Substances	ADAM17 Protein (EC 3.4.24.86)
Language	English
Publishing date	2023-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2023.2168758
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Article: Biological activities of Chromolaena odorata: A mechanistic review

Olawale, Femi / Olofinsan, Kolawole / Iwaloye, Opeyemi

SAAB South African journal of botany. 2022 Jan., v. 144

2022

Abstract: Chromolaena odorata is a perennial shrub that grows abundantly in Asia and sub-Saharan Africa, where it has been used in the treatment of many ailments and disease conditions such as diabetes, malaria, wounds, inflammation and fever. Several studies have ...

Abstract	Chromolaena odorata is a perennial shrub that grows abundantly in Asia and sub-Saharan Africa, where it has been used in the treatment of many ailments and disease conditions such as diabetes, malaria, wounds, inflammation and fever. Several studies have investigated the different biological activities of C. odorata intending to validate its purported medicinal property and identify chemical components of the plants responsible for such properties. Despite the studies carried out on the plant, there is still a dearth of knowledge regarding the mechanism by which C. odorata constituents bring about the different biological activity of the plant. The present review collated scientific reports on the antidiabetic, anticancer, anti-inflammatory, antimicrobial, antiparasitic, antinociceptive, antipyretic and wound healing activities of C. odorata from Scopus, PubMed, Google Scholar and Web of Science database. Interestingly, findings from these reports suggest that C. odorata contains bioactive compounds such as flavonoids, fatty acids, saponins, and alkaloids, which can act singly or synergistically to mediate different biological properties. Moreover, the bioactive compounds act by modulating critical proteins of signalling pathways involved in the different health conditions. The current review discusses the critical aspect of C. odorata biological activity, the likely mechanism involved and possible roadmap for better outcomes in future research. Collectively, the mechanisms covered in this article reveal biochemical pathways that may provide insight into potential targets that could be explored in disease management.
Keywords	Chromolaena odorata ; antiparasitic agents ; databases ; diabetes ; disease control ; fever ; flavonoids ; inflammation ; malaria ; medicinal properties ; saponins ; shrubs ; Asia ; Sub-Saharan Africa
Language	English
Dates of publication	2022-01
Size	p. 44-57.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2126918-X
ISSN	0254-6299
ISSN	0254-6299
DOI	10.1016/j.sajb.2021.09.001
Database	NAL-Catalogue (AGRICOLA)

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Article: Biogenic Synthesis of Silver-Core Selenium-Shell Nanoparticles Using

Olawale, Femi / Ariatti, Mario / Singh, Moganavelli

Nanomaterials (Basel, Switzerland)

2021 Volume 11, Issue 10

Abstract: Bimetallic nanoparticles (BNPs) have shown better biological potential compared to their monometallic counterparts owing to the synergistic effect produced by these alloys. In this study, selenium-capped silver nanoparticles (Ag@Se NPs) were synthesized ... ...

Abstract	Bimetallic nanoparticles (BNPs) have shown better biological potential compared to their monometallic counterparts owing to the synergistic effect produced by these alloys. In this study, selenium-capped silver nanoparticles (Ag@Se NPs) were synthesized using an
Language	English
Publishing date	2021-09-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano11102516
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Article ; Online: Virtual screening of natural compounds as selective inhibitors of polo-like kinase-1 at C-terminal polo box and N-terminal catalytic domain.

Olawale, Femi / Iwaloye, Opeyemi / Elekofehinti, Olusola Olalekan

Journal of biomolecular structure & dynamics

2021 Volume 40, Issue 24, Page(s) 13606–13624

Abstract: The over-expression of Polo-like kinase-1 (PLK1) is associated with cancer prognosis due to its pivotal role in cell proliferation. The N-terminal catalytic domain (NCD) and C-terminal polo box domain (PBD) of PLK1 are critical for the activity of the ... ...

Abstract	The over-expression of Polo-like kinase-1 (PLK1) is associated with cancer prognosis due to its pivotal role in cell proliferation. The N-terminal catalytic domain (NCD) and C-terminal polo box domain (PBD) of PLK1 are critical for the activity of the protein. Drugs that inhibit PLK1 by targeting these domains are on clinical trials, but so far, none has been approved by FDA. Thus, this study targets the two domains of PLK1 to identify compounds with inhibitory potential. Four validated e-pharmacophore models from NCD (PDB ID: 2OU7 and 4J52) and PBD (PDB ID: 5NEI and 5NN2) were used to screen over 26,000 natural compounds from NPASS database. Hits were identified after the well-fitted compounds were subjected to molecular docking study and ADME prediction. The pIC50 and electronic behaviour of the identified hits selectively targeting NCD and PBD of PLK1 were predicted via an externally validated QSAR model and quantum mechanics. The results showed that CAA180504, CAA197326, CAA74619, CAA328856 modulating PLK1 at NCD, and CBB130581, CBB230713, CBB206123, CBB12656 and CBB267117 modulating PLK1 at PBD had better molecular docking scores, pharmacokinetics and drug-like properties than NCD (volasertib) and PBD (purpurogallin) reference inhibitors. The compounds all had satisfactory inhibitory (pIC50) values which range from 6.187 to 7.157. The electronic behaviours of understudied compounds using HOMO/LUMO and global descriptive parameters revealed the atomic portion of the compounds prone to donating and accepting electrons. In conclusion, the hit compounds identified from the library of natural compounds are worthy of further experimental validation.Communicated by Ramaswamy H. Sarma.
MeSH term(s)	Humans ; Molecular Docking Simulation ; Catalytic Domain ; Noncommunicable Diseases ; Cell Cycle Proteins ; Protein Domains ; Cell Proliferation ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/metabolism
Chemical Substances	Cell Cycle Proteins ; Protein Kinase Inhibitors
Language	English
Publishing date	2021-10-20
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2021.1991476
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Article: Picralima nitida leaf extract ameliorates oxidative stress and modulates insulin signaling pathway in high fat-diet/STZ induced diabetic rats

Folorunso, Ibukun Mary / Olawale, Femi / Olofinsan, Kolawole / Iwaloye, Opeyemi

South African journal of botany. 2022 Aug., v. 148

2022

Abstract: The aqueous leaf extract of Picralima nitida has been shown to produce antipyretic and anti-inflammatory effects in the management of several disease conditions, including diabetes. This study examined the ameliorative effect of aqueous seed extract of ... ...

Abstract	The aqueous leaf extract of Picralima nitida has been shown to produce antipyretic and anti-inflammatory effects in the management of several disease conditions, including diabetes. This study examined the ameliorative effect of aqueous seed extract of Picralima nitida on elevated liver enzymes, oxidative stress parameters, and impaired insulin pathway in high fat-fed streptozotocin-induced diabetic rats. Experimental rats (8 weeks old) were fed a control diet or a high-fat diet for 30 days, followed by a one-time intraperitoneal (i.p.) injection of streptozotocin (45 mg/kg). P. nitida (50, 100, and 150 mg/kg dose) and metformin (50 mg/kg dose) were administered orally to the rats for 21 days. The liver enzymes, antioxidant enzyme markers as well as certain metabolic genes implicated in the insulin signaling system, were also evaluated. When compared to the conventional antidiabetic drug metformin, P. nitida at 150 mg/kg causes a significant decrease in blood glucose and ameliorated liver damage in diabetic rats. Treatment with P. nitida at 150 mg/kg also showed a significant increase in the level of superoxide dismutase (SOD) and catalase (CAT) but a significant decrease in the level of malonaldehyde (MDA) in the diabetic rats. Furthermore, at all experimental doses assayed, P. nitida strongly raised the mRNA expression of Nrf2, PI3K, AKT, and mTOR, but dramatically downregulated the mRNA expression of Keap1 and PTEN. The study has thus far shown that P. nitida holds significant promise in mitigating liver damage, oxidative stress, and aberrations in insulin signaling pathway associated with high-fat diet streptozotocin-induced diabetes.
Keywords	antioxidant enzymes ; blood glucose ; botany ; catalase ; diabetes ; gene expression ; high fat diet ; insulin ; leaf extracts ; liver ; malondialdehyde ; metformin ; oxidative stress ; phosphatidylinositol 3-kinase ; seed extracts ; streptozotocin
Language	English
Dates of publication	2022-08
Size	p. 268-282.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2126918-X
ISSN	0254-6299
ISSN	0254-6299
DOI	10.1016/j.sajb.2022.04.048
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Article ; Online: Saponins in Cancer Treatment: Current Progress and Future Prospects.

Elekofehinti, Olusola Olalekan / Iwaloye, Opeyemi / Olawale, Femi / Ariyo, Esther Opeyemi

Pathophysiology : the official journal of the International Society for Pathophysiology

2021 Volume 28, Issue 2, Page(s) 250–272

Abstract: Saponins are steroidal or triterpenoid glycoside that is distinguished by the soap-forming nature. Different saponins have been characterized and purified and are gaining attention in cancer chemotherapy. Saponins possess high structural diversity, which ...

Abstract	Saponins are steroidal or triterpenoid glycoside that is distinguished by the soap-forming nature. Different saponins have been characterized and purified and are gaining attention in cancer chemotherapy. Saponins possess high structural diversity, which is linked to the anticancer activities. Several studies have reported the role of saponins in cancer and the mechanism of actions, including cell-cycle arrest, antioxidant activity, cellular invasion inhibition, induction of apoptosis and autophagy. Despite the extensive research and significant anticancer effects of saponins, there are currently no known FDA-approved saponin-based anticancer drugs. This can be attributed to a number of limitations, including toxicities and drug-likeness properties. Recent studies have explored options such as combination therapy and drug delivery systems to ensure increased efficacy and decreased toxicity in saponin. This review discusses the current knowledge on different saponins, their anticancer activity and mechanisms of action, as well as promising research within the last two decades and recommendations for future studies.
Language	English
Publishing date	2021-06-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1212740-1
ISSN	1873-149X ; 0928-4680
ISSN (online)	1873-149X
ISSN	0928-4680
DOI	10.3390/pathophysiology28020017
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Article: Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer.

Adetunji, Tomi Lois / Olawale, Femi / Olisah, Chijioke / Adetunji, Ademola Emmanuel / Aremu, Adeyemi Oladapo

Frontiers in oncology

2022 Volume 12, Page(s) 908487

Abstract: Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is one of the most important natural products in the ... ...

Abstract	Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is one of the most important natural products in the genus
Language	English
Publishing date	2022-07-13
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.908487
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Article: The genus Aloe: A bibliometric analysis of global research outputs (2001–2020) and summary of recent research reports on its biological activities

Adetunji, Tomi Lois / Olisah, Chijioke / Adegbaju, Oluwafunmilayo Dorcas / Olawale, Femi / Adetunji, Ademola Emmanuel / Siebert, Frances / Siebert, Stefan

SAAB South African journal of botany. 2022 Jan. 22,

2022

Abstract: The genus Aloe has attracted considerable research attention in the last two decades owing to its ethnomedicinal, nutraceutical, pharmaceutical, and cosmeceutical importance. This review aimed to evaluate the performance of research outputs, identify ... ...

Abstract	The genus Aloe has attracted considerable research attention in the last two decades owing to its ethnomedicinal, nutraceutical, pharmaceutical, and cosmeceutical importance. This review aimed to evaluate the performance of research outputs, identify evolving trends and research hotspots, and present a detailed summary of recent research reports on the biological and clinical activities of Aloe species of the last two decades. Two databases (Scopus and Web of Science Core Collection) were searched to identify relevant literature on Aloe species spanning 2001 to 2020. The search and retrieval approaches were TITLE-ABS-KEY (Aloe) and TS (Biological AND Activit*). RStudio Inc. 1.1.463 and VOSviewer 1.6.15 were used to analyze the main bibliometric indicators such as annual publication evolution and trend, contributing authors, articles, countries, journals, collaborative network, and thematic domains. Information on biological and clinical activities was retrieved from relevant articles from January 2001 to September 2021 from different databases. A total of 8192 documents were retrieved. The number of publications in the study period showed an increasing trend, with a mean annual growth rate of 5%. India was the most productive country and had the greatest collaborative strength on Aloe research. Articles were predominantly published in the Journal of Ethnopharmacology. Gideon F. Smith made the most significant contributions to Aloe research. Three thematic research domains were identified: (i) pharmacological/toxicological studies, (ii) traditional/medicinal uses, and (iii) nutraceutical and cosmetic studies. Recent biological investigations were mainly in vitro and in vivo and focused on antimicrobial, anti-inflammatory, anti-diabetic, anti-cancer, wound-healing, antimalarial, antioxidant, analgesic, laxative, anti-erythema, and anti-skin wrinkling effects. The majority of human clinical investigations in the last two decades have been conducted using A. vera leaf gel. The results from the biological activities confirm that Aloe is indeed a promising medicinal genus. However, there is a need for more clinical trials to be conducted on different species and isolated bioactive compounds in this genus.
Keywords	analgesics ; antimalarials ; antioxidants ; bibliometric analysis ; cosmetics ; dietary supplements ; evolution ; gels ; humans ; leaves ; toxicology ; traditional medicine ; India
Language	English
Dates of publication	2022-0122
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	2126918-X
ISSN	0254-6299
ISSN	0254-6299
DOI	10.1016/j.sajb.2022.01.030
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Article: Newly designed compounds from scaffolds of known actives as inhibitors of survivin: computational analysis from the perspective of fragment-based drug design.

Elekofehinti, Olusola Olalekan / Iwaloye, Opeyemi / Olawale, Femi / Chukwuemeka, Prosper Obed / Folorunso, Ibukun Mary

In silico pharmacology

2021 Volume 9, Issue 1, Page(s) 47

Abstract: Survivin is an apoptosis suppressing protein linked to different forms of cancer. As it stands, there are no approved drugs for the inhibition of survivin in cancer cells despite a number of promising compounds in clinical trials. This study designed a ... ...

Abstract	Survivin is an apoptosis suppressing protein linked to different forms of cancer. As it stands, there are no approved drugs for the inhibition of survivin in cancer cells despite a number of promising compounds in clinical trials. This study designed a new set of compounds from fragments of active survivin inhibitors to potentiate their binding with survivin at BIR domain. Three hundred and five (305) fragments made from eight potent inhibitors of survivin were reconstructed to form a new set of compounds. The compounds were optimized using R group enumeration and bioisostere replacement after extensive docking analysis. The optimised compounds were filtered by a validated pharmacophore model to reveal how well they are aligned to the pharmacophore sites. Molecular docking of the well aligned compounds revealed the top-scoring compounds; and these compounds were compared with the eight inhibitors used as template for fragment-based design on the basis of binding affinity (rigid and flexible docking), predicted pIC50 and intermolecular interactions. The electronic behaviours (global descriptors, HOMO/LUMO, molecular electrostatic potential and Fukui functions) of newly designed compounds were calculated to investigate their reactivity and atomic sites prone to neutrophilic/electrophilic attack. The nine newly designed compounds had better rigid and flexible docking scores, free energy of binding and intermolecular interactions with survivin at BIR domain than the eight active inhibitors. Based on frontier molecular orbitals, OPE-3 was found to be the most reactive and less stable compound (0.13194 eV), followed by OPE-4 and OPE-9. The global descriptive parameters showed that OPE-3 had highest softness value (7.5245 eV) while OPE-8 recorded the maximum hardness value (0.08486 eV). The well-validated QSAR model also showed that OPE-3, OPE-7 and OPE-8 had the most significant bioactivity of all the inhibitors. This study thus provides new insight into the design of compounds capable of modulating the activity of survivin. Supplementary information: The online version contains supplementary material available at 10.1007/s40203-021-00108-8.
Language	English
Publishing date	2021-07-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2702993-1
ISSN	2193-9616
ISSN	2193-9616
DOI	10.1007/s40203-021-00108-8
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