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Article ; Online: Abrogation of neutrophil inflammatory pathways and potential reduction of neutrophil-related factors in COVID-19 by intravenous immunoglobulin.

Masso-Silva, Jorge Adrian / Sakoulas, George / Olay, Jarod / Groysberg, Victoria / Geriak, Matthew / Nizet, Victor / Crotty Alexander, Laura E / Meier, Angela

Frontiers in immunology

2022 Volume 13, Page(s) 993720

Abstract: Pathogenesis of lung injury in COVID-19 is not completely understood, leaving gaps in understanding how current treatments modulate the course of COVID-19. Neutrophil numbers and activation state in circulation have been found to correlate with COVID-19 ... ...

Abstract	Pathogenesis of lung injury in COVID-19 is not completely understood, leaving gaps in understanding how current treatments modulate the course of COVID-19. Neutrophil numbers and activation state in circulation have been found to correlate with COVID-19 severity, and neutrophil extracellular traps (NETs) have been found in the lung parenchyma of patients with acute respiratory distress syndrome (ARDS) in COVID-19. Targeting the pro-inflammatory functions of neutrophils may diminish lung injury in COVID-19 and ARDS. Neutrophils were isolated from peripheral blood of healthy donors, treated
MeSH term(s)	Humans ; Neutrophils/metabolism ; Immunoglobulins, Intravenous/therapeutic use ; Immunoglobulins, Intravenous/pharmacology ; Leukocyte Elastase/metabolism ; Lung Injury/metabolism ; Respiratory Distress Syndrome ; Cell-Free Nucleic Acids/metabolism ; Dexamethasone ; COVID-19 Drug Treatment
Chemical Substances	Immunoglobulins, Intravenous ; Leukocyte Elastase (EC 3.4.21.37) ; Cell-Free Nucleic Acids ; Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2022-10-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.993720
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Article ; Online: Dual use of e-cigarettes with conventional tobacco is associated with increased sleep latency in cross-sectional Study.

Advani, Ira / Gunge, Deepti / Boddu, Shreyes / Mehta, Sagar / Park, Kenneth / Perera, Samantha / Pham, Josephine / Nilaad, Sedtavut / Olay, Jarod / Ma, Lauren / Masso-Silva, Jorge / Sun, Xiaoying / Jain, Sonia / Malhotra, Atul / Crotty Alexander, Laura E

Scientific reports

2022 Volume 12, Issue 1, Page(s) 2536

Abstract: The health effects of e-cigarettes remain relatively unknown, including their impact on sleep quality. We previously showed in a pilot study that females who smoke both conventional tobacco and vape e-cigarettes (dual users) had decreased sleep quality ( ... ...

Abstract	The health effects of e-cigarettes remain relatively unknown, including their impact on sleep quality. We previously showed in a pilot study that females who smoke both conventional tobacco and vape e-cigarettes (dual users) had decreased sleep quality (measurement of how well an individual is sleeping) and increased sleep latency (amount of time to fall asleep), suggesting an influence by gender. Cough is also known to adversely impact sleep quality and may be caused by inhalant use. As a result, we undertook this study to assess the impact of e-cigarette, conventional tobacco, and dual use on sleep quality, sleep latency, cough, and drug use. Participants (n = 1198) were recruited through online surveys posted to social media sites with a monetary incentive. Participants were grouped by inhalant use, with 8% e-cigarette users, 12% conventional tobacco users, 30% dual users, and 51% non-smokers/non-vapers. Dual use of e-cigarettes and conventional tobacco was associated with increased sleep latency relative to non-smokers/non-vapers by multivariable linear regression (mean difference of 4.08; 95% CI: 1.12 to 7.05, raw p = 0.007, adjusted p = 0.042); however, dual usage was not significantly associated with sleep quality relative to non-smokers/non-vapers (mean difference 0.22, 95%CI: (-0.36, 0.80), raw p = 0.452, adjust p = 0.542). Dual use was also associated with a higher reporting of cough (p = 0.038), as well as increased marijuana (p < 0.001) and cocaine (p < 0.001) usage. This study demonstrates that dual use is associated with longer sleep latency, and suggests that the shared component of nicotine may be a driver. Because sleep broadly impacts multiple aspects of human health, defining the associations of e-cigarettes and vaping devices on sleep is critical to furthering our understanding of their influence on the body.
MeSH term(s)	Adolescent ; Adult ; Cross-Sectional Studies ; Electronic Nicotine Delivery Systems ; Female ; Humans ; Male ; Sleep Latency ; Tobacco Smoking ; Young Adult
Language	English
Publishing date	2022-02-15
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-06445-8
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Article: Chronic E-Cigarette Aerosol Inhalation Alters the Immune State of the Lungs and Increases ACE2 Expression, Raising Concern for Altered Response and Susceptibility to SARS-CoV-2.

Masso-Silva, Jorge A / Moshensky, Alexander / Shin, John / Olay, Jarod / Nilaad, Sedtavut / Advani, Ira / Bojanowski, Christine M / Crotty, Shane / Li, Wei Tse / Ongkeko, Weg M / Singla, Sunit / Crotty Alexander, Laura E

Frontiers in physiology

2021 Volume 12, Page(s) 649604

Abstract: Conventional smoking is known to both increase susceptibility to infection and drive inflammation within the lungs. Recently, smokers have been found to be at higher risk of developing severe forms of coronavirus disease 2019 (COVID-19). E-cigarette ... ...

Abstract	Conventional smoking is known to both increase susceptibility to infection and drive inflammation within the lungs. Recently, smokers have been found to be at higher risk of developing severe forms of coronavirus disease 2019 (COVID-19). E-cigarette aerosol inhalation (vaping) has been associated with several inflammatory lung disorders, including the recent e-cigarette or vaping product use-associated lung injury (EVALI) epidemic, and recent studies have suggested that vaping alters host susceptibility to pathogens such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To assess the impact of vaping on lung inflammatory pathways, including the angiotensin-converting enzyme 2 (ACE2) receptor known to be involved in SARS-CoV-2 infection, mice were exposed to e-cigarette aerosols for 60 min daily for 1-6 months and underwent gene expression analysis. Hierarchical clustering revealed extensive gene expression changes occurred in the lungs of both inbred C57BL/6 mice and outbred CD1 mice, with 2,933 gene expression changes in C57BL/6 mice, and 2,818 gene expression changes in CD1 mice (>abs 1.25-fold change). Particularly, large reductions in IgA and CD4 were identified, indicating impairment of host responses to pathogens
Language	English
Publishing date	2021-05-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2021.649604
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Article: Vaping-induced metabolomic signatures in the circulation of mice are driven by device type, e-liquid, exposure duration and sex.

ERJ open research

2021 Volume 7, Issue 3

Abstract: Each type of vaping device (vape pen, box Mod and JUUL), as well as nicotine and flavourings, induces a disparate metabolite profile or signature, such that each device and liquid is likely to lead to its own set of health ... ...

Abstract	Each type of vaping device (vape pen, box Mod and JUUL), as well as nicotine and flavourings, induces a disparate metabolite profile or signature, such that each device and liquid is likely to lead to its own set of health effects
Language	English
Publishing date	2021-07-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2827830-6
ISSN	2312-0541
ISSN	2312-0541
DOI	10.1183/23120541.00229-2021
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Article ; Online: Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice.

Moshensky, Alex / Brand, Cameron S / Alhaddad, Hasan / Shin, John / Masso-Silva, Jorge A / Advani, Ira / Gunge, Deepti / Sharma, Aditi / Mehta, Sagar / Jahan, Arya / Nilaad, Sedtavut / Olay, Jarod / Gu, Wanjun / Simonson, Tatum / Almarghalani, Daniyah / Pham, Josephine / Perera, Samantha / Park, Kenneth / Al-Kolla, Rita /

Moon, Hoyoung / Das, Soumita / Byun, Min Kwang / Shah, Zahoor / Sari, Youssef / Heller Brown, Joan / Crotty Alexander, Laura E

eLife

2022 Volume 11

Abstract: While health effects of conventional tobacco are well defined, data on vaping devices, including one of the most popular e-cigarettes which have high nicotine levels, are less established. Prior acute e-cigarette studies have demonstrated inflammatory ... ...

Abstract	While health effects of conventional tobacco are well defined, data on vaping devices, including one of the most popular e-cigarettes which have high nicotine levels, are less established. Prior acute e-cigarette studies have demonstrated inflammatory and cardiopulmonary physiology changes while chronic studies have demonstrated extra-pulmonary effects, including neurotransmitter alterations in reward pathways. In this study we investigated the impact of inhalation of aerosols produced from pod-based, flavored e-cigarettes (JUUL) aerosols three times daily for 3 months on inflammatory markers in the brain, lung, heart, and colon. JUUL aerosol exposure induced upregulation of cytokine and chemokine gene expression and increased HMGB1 and RAGE in the nucleus accumbens in the central nervous system. Inflammatory gene expression increased in the colon, while gene expression was more broadly altered by e-cigarette aerosol inhalation in the lung. Cardiopulmonary inflammatory responses to acute lung injury with lipopolysaccharide were exacerbated in the heart. Flavor-specific findings were detected across these studies. Our findings suggest that daily e-cigarette use may cause neuroinflammation, which may contribute to behavioral changes and mood disorders. In addition, e-cigarette use may cause gut inflammation, which has been tied to poor systemic health, and cardiac inflammation, which leads to cardiovascular disease.
MeSH term(s)	Aerosols ; Animals ; Brain ; Colon ; Electronic Nicotine Delivery Systems ; Inflammation ; Lung ; Mangifera ; Mentha ; Mice
Chemical Substances	Aerosols
Language	English
Publishing date	2022-04-12
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.67621
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Article ; Online: Correction to: Increased Peripheral Blood Neutrophil Activation Phenotypes and Neutrophil Extracellular Trap Formation in Critically Ill Coronavirus Disease 2019 Patients: A Case Series and Review of the Literature.

Masso-Silva, Jorge A / Moshensky, Alexander / Lam, Michael T Y / Odish, Mazen / Patel, Arjun / Xu, Le / Hansen, Emily / Trescott, Samantha / Nguyen, Celina / Kim, Roy / Perofsky, Katherine / Perera, Samantha / Ma, Lauren / Pham, Josephine / Rolfsen, Mark / Olay, Jarod / Shin, John / Dan, Jennifer M / Abbott, Robert /

Ramirez, Sydney / Alexander, Thomas H / Lin, Grace Y / Fuentes, Ana Lucia / Advani, Ira / Gunge, Deepti / Pretorius, Victor / Malhotra, Atul / Sun, Xin / Duran, Jason / Hepokoski, Mark / Crotty, Shane / Coufal, Nicole G / Meier, Angela / Crotty Alexander, Laura E

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2022 Volume 74, Issue 10, Page(s) 1889–1890

Language	English
Publishing date	2022-04-13
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciac216
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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Increased Peripheral Blood Neutrophil Activation Phenotypes and Neutrophil Extracellular Trap Formation in Critically Ill Coronavirus Disease 2019 (COVID-19) Patients: A Case Series and Review of the Literature.

Masso-Silva, Jorge A / Moshensky, Alexander / Lam, Michael T Y / Odish, Mazen F / Patel, Arjun / Xu, Le / Hansen, Emily / Trescott, Samantha / Nguyen, Celina / Kim, Roy / Perofsky, Katherine / Perera, Samantha / Ma, Lauren / Pham, Josephine / Rolfsen, Mark / Olay, Jarod / Shin, John / Dan, Jennifer M / Abbott, Robert K /

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2020 Volume 74, Issue 3, Page(s) 479–489

Abstract: Background: Increased inflammation has been well defined in coronavirus disease 2019 (COVID-19), while definitive pathways driving severe forms of this disease remain uncertain. Neutrophils are known to contribute to immunopathology in infections, ... ...

Abstract	Background: Increased inflammation has been well defined in coronavirus disease 2019 (COVID-19), while definitive pathways driving severe forms of this disease remain uncertain. Neutrophils are known to contribute to immunopathology in infections, inflammatory diseases, and acute respiratory distress syndrome, a primary cause of morbidity and mortality in COVID-19. Changes in neutrophil function in COVID-19 may give insight into disease pathogenesis and identify therapeutic targets. Methods: Blood was obtained serially from critically ill COVID-19 patients for 11 days. Neutrophil extracellular trap formation (NETosis), oxidative burst, phagocytosis, and cytokine levels were assessed. Lung tissue was obtained immediately postmortem for immunostaining. PubMed searches for neutrophils, lung, and COVID-19 yielded 10 peer-reviewed research articles in English. Results: Elevations in neutrophil-associated cytokines interleukin 8 (IL-8) and interleukin 6, and general inflammatory cytokines IFN-inducible protien-19, granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin 1β, interleukin 10, and tumor necrosis factor, were identified both at first measurement and across hospitalization (P < .0001). COVID-19 neutrophils had exaggerated oxidative burst (P < .0001), NETosis (P < .0001), and phagocytosis (P < .0001) relative to controls. Increased NETosis correlated with leukocytosis and neutrophilia, and neutrophils and NETs were identified within airways and alveoli in lung parenchyma of 40% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected lungs available for examination (2 of 5). While elevations in IL-8 and absolute neutrophil count correlated with disease severity, plasma IL-8 levels alone correlated with death. Conclusions: Literature to date demonstrates compelling evidence of increased neutrophils in the circulation and lungs of COVID-19 patients. Importantly, neutrophil quantity and activation correlates with severity of disease. Similarly, our data show that circulating neutrophils in COVID-19 exhibit an activated phenotype with enhanced NETosis and oxidative burst.
MeSH term(s)	COVID-19 ; Critical Illness ; Extracellular Traps ; Humans ; Neutrophil Activation ; Neutrophils ; Phenotype ; SARS-CoV-2
Language	English
Publishing date	2020-10-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciab437
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Article ; Online: Increased peripheral blood neutrophil activation phenotypes and NETosis in critically ill COVID-19 patients

Masso-Silva, Jorge A. / Moshensky, Alexander / Lam, Michael T. Y. / Odish, Mazen / Patel, Arjun / Xu, Le / Hansen, Emily / Trescott, Samantha / Nguyen, Celina / Kim, Roy / Perofsky, Katherine / Perera, Samantha / Ma, Lauren / Pham, Josephine / Rolfsen, Mark / Olay, Jarod / Shin, John / Dan, Jennifer M. / Abbott, Robert /

Ramirez, Sydney / Alexander, Thomas H. / Lin, Grace Y. / Fuentes, Ana Lucia / Advani, Ira N. / Gunge, Deepti / Pretorius, Victor / Malhotra, Atul / Sun, Xin / Duran, Jason / Crotty, Shane / Coufal, Nicole G. / Meier, Angela / Crotty Alexander, Laura E.

medRxiv

Abstract: Background: Increased inflammation is a hallmark of COVID-19, with pulmonary and systemic inflammation identified in multiple cohorts of patients. Definitive cellular and molecular pathways driving severe forms of this disease remain uncertain. ... ...

Abstract	Background: Increased inflammation is a hallmark of COVID-19, with pulmonary and systemic inflammation identified in multiple cohorts of patients. Definitive cellular and molecular pathways driving severe forms of this disease remain uncertain. Neutrophils, the most numerous leukocytes in blood circulation, can contribute to immunopathology in infections, inflammatory diseases and acute respiratory distress syndrome (ARDS), a primary cause of morbidity and mortality in COVID-19. Changes in multiple neutrophil functions and circulating cytokine levels over time during COVID-19 may help define disease severity and guide care and decision making. Methods: Blood was obtained serially from critically ill COVID-19 patients for 11 days. Neutrophil oxidative burst, neutrophil extracellular trap formation (NETosis), phagocytosis and cytokine levels were assessed ex vivo. Lung tissue was obtained immediately post-mortem for immunostaining. Results: Elevations in neutrophil-associated cytokines IL-8 and IL-6, and general inflammatory cytokines IP-10, GM-CSF, IL-1b, IL-10 and TNF, were identified in COVID-19 plasma both at the first measurement and at multiple timepoints across hospitalization (p < 0.0001). Neutrophils had exaggerated oxidative burst (p < 0.0001), NETosis (p < 0.0001) and phagocytosis (p < 0.0001) relative to controls. Increased NETosis correlated with both leukocytosis and neutrophilia. Neutrophils and NETs were identified within airways and alveoli in the lung parenchyma of 40% of SARS-CoV-2 infected lungs. While elevations in IL-8 and ANC correlated to COVID-19 disease severity, plasma IL-8 levels alone correlated with death. Conclusions: Circulating neutrophils in COVID-19 exhibit an activated phenotype with increased oxidative burst, NETosis and phagocytosis. Readily accessible and dynamic, plasma IL-8 and circulating neutrophil function may be potential COVID-19 disease biomarkers.
Keywords	covid19
Language	English
Publishing date	2021-01-15
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2021.01.14.21249831
Database	COVID19

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Article ; Online: Increased IL-8, Neutrophil Activation Phenotypes and NETosis in Critically Ill COVID-19 Patients

Masso-Silva, Jorge A. / Moshensky, Alexander / Lam, Micheal T.Y. / Odish, Mazen / Patel, Arjun / Xu, Le / Hansen, Emily / Trescott, Samantha / Nguyen, Celina / Kim, Roy / Perofsky, Katherine / Perera, Samantha / Ma, Lauren / Pham, Josephine / Rolfsen, Mark / Olay, Jarod / Shin, John / Dan, Jennifer M. / Abbott, Robert /

Ramirez, Sydney / Alexander, Thomas H. / Lin, Grace Y. / Fuentes, Ana Lucia / Pretorius, Victor / Malhotra, Atul / Sun, Xin / Duran, Jason / Crotty, Shane / Coufal, Nicole G. / Meier, Angela / Alexander, Laura Crotty

SSRN Electronic Journal ; ISSN 1556-5068

2020

Keywords	covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.2139/ssrn.3705291
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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