LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 5 of total 5

Search options

  1. Article ; Online: Bacterial-induced or passively administered interferon gamma conditions the lung for early control of SARS-CoV-2.

    Hilligan, Kerry L / Namasivayam, Sivaranjani / Clancy, Chad S / Baker, Paul J / Old, Samuel I / Peluf, Victoria / Amaral, Eduardo P / Oland, Sandra D / O'Mard, Danielle / Laux, Julie / Cohen, Melanie / Garza, Nicole L / Lafont, Bernard A P / Johnson, Reed F / Feng, Carl G / Jankovic, Dragana / Lamiable, Olivier / Mayer-Barber, Katrin D / Sher, Alan

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 8229

    Abstract: Type-1 and type-3 interferons (IFNs) are important for control of viral replication; however, less is known about the role of Type-2 IFN (IFNγ) in anti-viral immunity. We previously observed that lung infection with Mycobacterium bovis BCG achieved ... ...

    Abstract Type-1 and type-3 interferons (IFNs) are important for control of viral replication; however, less is known about the role of Type-2 IFN (IFNγ) in anti-viral immunity. We previously observed that lung infection with Mycobacterium bovis BCG achieved though intravenous (iv) administration provides strong protection against SARS-CoV-2 in mice yet drives low levels of type-1 IFNs but robust IFNγ. Here we examine the role of ongoing IFNγ responses to pre-established bacterial infection on SARS-CoV-2 disease outcomes in two murine models. We report that IFNγ is required for iv BCG induced reduction in pulmonary viral loads, an outcome dependent on IFNγ receptor expression by non-hematopoietic cells. Importantly, we show that BCG infection prompts pulmonary epithelial cells to upregulate IFN-stimulated genes with reported anti-viral activity in an IFNγ-dependent manner, suggesting a possible mechanism for the observed protection. Finally, we confirm the anti-viral properties of IFNγ by demonstrating that the recombinant cytokine itself provides strong protection against SARS-CoV-2 challenge when administered intranasally. Together, our data show that a pre-established IFNγ response within the lung is protective against SARS-CoV-2 infection, suggesting that concurrent or recent infections that drive IFNγ may limit the pathogenesis of SARS-CoV-2 and supporting possible prophylactic uses of IFNγ in COVID-19 management.
    MeSH term(s) Animals ; Mice ; SARS-CoV-2 ; Interferon-gamma ; COVID-19/prevention & control ; Lung ; Interferon Type I/pharmacology
    Chemical Substances Interferon-gamma (82115-62-6) ; Interferon Type I
    Language English
    Publishing date 2023-12-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-43447-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Pre-existing interferon gamma conditions the lung to mediate early control of SARS-CoV-2

    Hilligan, Kerry L. / Namasivayam, Sivaranjani / Clancy, Chad S. / Baker, Paul J. / Old, Samuel I. / Peluf, Victoria / Amaral, Eduardo P. / Oland, Sandra D. / O’Mard, Danielle / Laux, Julie / Cohen, Melanie / Garza, Nicole L. / Lafont, Bernard A. P. / Johnson, Reed F. / Feng, Carl G. / Jankovic, Dragana / Lamiable, Olivier / Mayer-Barber, Katrin D. / Sher, Alan

    bioRxiv

    Abstract: Interferons (IFNs) are critical for anti-viral host defence. Type-1 and type-3 IFNs are typically associated with early control of viral replication and promotion of inflammatory immune responses; however, less is known about the role of IFNγ in anti- ... ...

    Abstract Interferons (IFNs) are critical for anti-viral host defence. Type-1 and type-3 IFNs are typically associated with early control of viral replication and promotion of inflammatory immune responses; however, less is known about the role of IFNγ in anti-viral immunity, particularly in the context of SARS-CoV-2. We have previously observed that lung infection with attenuated bacteria Mycobacterium bovis BCG achieved though intravenous (iv) administration provides strong protection against SARS-CoV-2 (SCV2) infection and disease in two mouse models. Assessment of the pulmonary cytokine milieu revealed that iv BCG induces a robust IFNγ response and low levels of IFNβ. Here we examined the role of ongoing IFNγ responses due to pre-established bacterial infection on SCV2 disease outcomes in two murine models. We report that IFNγ is required for iv BCG induced reduction in pulmonary viral loads and that this outcome is dependent on IFNγ receptor expression by non-hematopoietic cells. Further analysis revealed that BCG infection promotes the upregulation of interferon-stimulated genes (ISGs) with reported anti-viral activity by pneumocytes and bronchial epithelial cells in an IFNγ-dependent manner, suggesting a possible mechanism for the observed protection. Finally, we confirmed the importance of IFNγ in these anti-viral effects by demonstrating that the recombinant cytokine itself provides strong protection against SCV2 challenge when administered intranasally. Together, our data show that a pre-established IFNγ response within the lung is protective against SCV2 infection, suggesting that concurrent or recent infections that drive IFNγ may limit the pathogenesis of SCV2 and supporting possible prophylactic uses of IFNγ in COVID-19 management.
    Keywords covid19
    Language English
    Publishing date 2023-07-17
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2023.07.15.549135
    Database COVID19

    Full text online

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Author Correction: Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote T

    Mayer, Johannes U / Hilligan, Kerry L / Chandler, Jodie S / Eccles, David A / Old, Samuel I / Domingues, Rita G / Yang, Jianping / Webb, Greta R / Munoz-Erazo, Luis / Hyde, Evelyn J / Wakelin, Kirsty A / Tang, Shiau-Choot / Chappell, Sally C / von Daake, Sventja / Brombacher, Frank / Mackay, Charles R / Sher, Alan / Tussiwand, Roxane / Connor, Lisa M /
    Gallego-Ortega, David / Jankovic, Dragana / Le Gros, Graham / Hepworth, Matthew R / Lamiable, Olivier / Ronchese, Franca

    Nature immunology

    2022  Volume 23, Issue 6, Page(s) 985

    Language English
    Publishing date 2022-04-13
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-022-01203-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5294: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 42: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote T

    Mayer, Johannes U / Hilligan, Kerry L / Chandler, Jodie S / Eccles, David A / Old, Samuel I / Domingues, Rita G / Yang, Jianping / Webb, Greta R / Munoz-Erazo, Luis / Hyde, Evelyn J / Wakelin, Kirsty A / Tang, Shiau-Choot / Chappell, Sally C / von Daake, Sventja / Brombacher, Frank / Mackay, Charles R / Sher, Alan / Tussiwand, Roxane / Connor, Lisa M /
    Gallego-Ortega, David / Jankovic, Dragana / Le Gros, Graham / Hepworth, Matthew R / Lamiable, Olivier / Ronchese, Franca

    Nature immunology

    2021  Volume 22, Issue 12, Page(s) 1538–1550

    Abstract: The signals driving the adaptation of type 2 dendritic cells (DC2s) to diverse peripheral environments remain mostly undefined. We show that differentiation of ... ...

    Abstract The signals driving the adaptation of type 2 dendritic cells (DC2s) to diverse peripheral environments remain mostly undefined. We show that differentiation of CD11b
    MeSH term(s) Allergens/pharmacology ; Animals ; CD11b Antigen/genetics ; CD11b Antigen/metabolism ; Cell Communication ; Cell Differentiation ; Cells, Cultured ; Databases, Genetic ; Humans ; Interleukin-13/genetics ; Interleukin-13/metabolism ; Langerhans Cells/drug effects ; Langerhans Cells/immunology ; Langerhans Cells/metabolism ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Phenotype ; STAT6 Transcription Factor/genetics ; STAT6 Transcription Factor/metabolism ; Signal Transduction ; Skin/cytology ; Skin/drug effects ; Skin/immunology ; Skin/metabolism ; Th17 Cells/drug effects ; Th17 Cells/immunology ; Th17 Cells/metabolism ; Th2 Cells/drug effects ; Th2 Cells/immunology ; Th2 Cells/metabolism ; Transcriptome ; Mice
    Chemical Substances Allergens ; CD11b Antigen ; IL13 protein, human ; ITGAM protein, human ; Interleukin-13 ; Itgam protein, mouse ; STAT6 Transcription Factor ; STAT6 protein, human ; Stat6 protein, mouse
    Language English
    Publishing date 2021-11-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-021-01067-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5294: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 42: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Th2 responses are primed by skin dendritic cells with distinct transcriptional profiles.

    Connor, Lisa M / Tang, Shiau-Choot / Cognard, Emmanuelle / Ochiai, Sotaro / Hilligan, Kerry L / Old, Samuel I / Pellefigues, Christophe / White, Ruby F / Patel, Deepa / Smith, Adam Alexander T / Eccles, David A / Lamiable, Olivier / McConnell, Melanie J / Ronchese, Franca

    The Journal of experimental medicine

    2017  Volume 214, Issue 1, Page(s) 125–142

    Abstract: The dendritic cell signals required for the in vivo priming of IL-4-producing T cells are unknown. We used RNA sequencing to characterize DCs from skin LN of mice exposed to two different Th2 stimuli: the helminth parasite Nippostrongylus brasiliensis ( ... ...

    Abstract The dendritic cell signals required for the in vivo priming of IL-4-producing T cells are unknown. We used RNA sequencing to characterize DCs from skin LN of mice exposed to two different Th2 stimuli: the helminth parasite Nippostrongylus brasiliensis (Nb) and the contact sensitizer dibutyl phthalate (DBP)-FITC. Both Nb and DBP-FITC induced extensive transcriptional changes that involved multiple DC subsets. Surprisingly, these transcriptional changes were highly distinct in the two models, with only a small number of genes being similarly regulated in both conditions. Pathway analysis of expressed genes identified no shared pathways between Nb and DBP-FITC, but revealed a type-I IFN (IFN-I) signature unique to DCs from Nb-primed mice. Blocking the IFN-I receptor at the time of Nb treatment had little effect on DC migration and antigen transport to the LN, but inhibited the up-regulation of IFN-I-induced markers on DCs and effectively blunted Th2 development. In contrast, the response to DBP-FITC was not affected by IFN-I receptor blockade, a finding consistent with the known dependence of this response on the innate cytokine TSLP. Thus, the priming of Th2 responses is associated with distinct transcriptional signatures in DCs in vivo, reflecting the diverse environments in which Th2 immune responses are initiated.
    MeSH term(s) Animals ; Dendritic Cells/immunology ; Immunoglobulins/physiology ; Interferon Type I/physiology ; Mice ; Mice, Inbred C57BL ; Nippostrongylus/immunology ; Receptor, Interferon alpha-beta/physiology ; Receptors, Cytokine/physiology ; Skin/immunology ; Th2 Cells/immunology ; Transcription, Genetic
    Chemical Substances Ifnar1 protein, mouse ; Immunoglobulins ; Interferon Type I ; Receptors, Cytokine ; Tslpr protein, mouse ; Receptor, Interferon alpha-beta (156986-95-7)
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20160470
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.107: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 45: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top