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  1. Book ; Online ; E-Book: Viruses, plagues, and history

    Oldstone, Michael B. A.

    past, present, and future

    2020  

    Author's details Michael B. A. Oldstone
    Keywords Virus diseases/History
    Subject code 614.57
    Language English
    Size 1 Online-Ressource (xxii, 485 Seiten), Illustrationen, Diagramme
    Edition Second edition
    Publisher Oxford University Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020556721
    ISBN 978-0-19-005679-7 ; 978-0-19-005680-3 ; 9780190056780 ; 0-19-005679-7 ; 0-19-005680-0 ; 0190056789
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Ebola's curse

    Oldstone, Michael B. A. / Oldstone, Madeleine R.

    2013-2016 outbreak in West Africa : origin, spread and heroes

    2017  

    Author's details Michael B. A. Oldstone, Madeleine R. Oldstone
    Keywords Ebola virus disease ; Africa, West ; Electronic books
    Language English
    Size 1 Online-Ressource (xviii, 108 Seiten), Illustrationen
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020404964
    ISBN 978-0-12-813889-2 ; 9780128138885 ; 0-12-813889-0 ; 0128138882
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: History of Virology

    Oldstone, M.B.A.

    Encyclopedia of Microbiology

    Abstract: The history of virology can be traced as the personalities involved have described their concepts and published their experimental results. Although infections we now know as, e.g., rabies, yellow fever, smallpox, etc. were clinically evident in early ... ...

    Abstract The history of virology can be traced as the personalities involved have described their concepts and published their experimental results. Although infections we now know as, e.g., rabies, yellow fever, smallpox, etc. were clinically evident in early human history, the initial isolation of individual viruses and their assignment to specific diseases did not occur until about 1898, 120 years ago, a proverbial drop in the bucket of time. Just one lifetime ago, Peter Medawar, awarded the Nobel Prize in Medicine and Physiology in 1960, defined viruses as a piece of nucleic acid surrounded by bad news.
    Keywords covid19
    Publisher Elsevier; PMC
    Document type Article ; Online
    DOI 10.1016/b978-0-12-801238-3.00078-7
    Database COVID19

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  4. Article ; Online: The game's afoot: seeking viruses that cause chronic and degenerative neurologic and psychiatric disorder.

    Oldstone, M B A

    Molecular psychiatry

    2012  Volume 17, Issue 5, Page(s) 472–473

    MeSH term(s) Bipolar Disorder/virology ; Borna disease virus/immunology ; Depressive Disorder, Major/virology ; Female ; Humans ; Male ; Schizophrenia/virology
    Language English
    Publishing date 2012-05
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/mp.2012.5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4812: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: History of Virology

    Oldstone, M.B.A.

    Encyclopedia of Microbiology

    Abstract: Abstract The history of virology can be traced as the personalities involved have described their concepts and published their experimental results. Although infections we now know as, e.g., rabies, yellow fever, smallpox, etc. were clinically evident in ...

    Abstract Abstract The history of virology can be traced as the personalities involved have described their concepts and published their experimental results. Although infections we now know as, e.g., rabies, yellow fever, smallpox, etc. were clinically evident in early human history, the initial isolation of individual viruses and their assignment to specific diseases did not occur until about 1898, 120 years ago, a proverbial drop in the bucket of time. Just one lifetime ago, Peter Medawar, awarded the Nobel Prize in Medicine and Physiology in 1960, defined viruses as a piece of nucleic acid surrounded by bad news.
    Keywords covid19
    Publisher Elsevier; PMC
    Document type Article ; Online
    DOI 10.1016/b978-0-12-801238-3.00078-7
    Database COVID19

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  6. Article: Modeling subacute sclerosing panencephalitis in a transgenic mouse system: uncoding pathogenesis of disease and illuminating components of immune control.

    Oldstone, M B A

    Current topics in microbiology and immunology

    2008  Volume 330, Page(s) 31–54

    Abstract: Subacute sclerosing panencephalitis (SSPE) is a chronic neurodegenerative disease of the central nervous system (CNS) that afflicts eight to 20 individuals per one million of those who become infected with measles virus (MV). The six cardinal elements of ...

    Abstract Subacute sclerosing panencephalitis (SSPE) is a chronic neurodegenerative disease of the central nervous system (CNS) that afflicts eight to 20 individuals per one million of those who become infected with measles virus (MV). The six cardinal elements of SSPE are: (1) progressive fatal CNS disease developing several years after MV infection begins; (2) replication of MV in neurons; (3) defective nonreplicating MV in the CNS that is recoverable by co-cultivation with permissive tissue culture cells; (4) biased hypermutation of the MV recovered from the CNS with massive A to G (U to C) base changes primarily in the M gene of the virus; (5) high titers of antibody to MV; and (6) infiltration of B and T cells into the CNS. All these parameters can be mimicked in a transgenic (tg) mouse model that expresses the MV receptor, thus enabling infection of a usually uninfectable mouse in which the immune system is or is not manipulated. Utilization and analysis of such mice have illuminated how chronic measles virus infection of neurons can be initiated and maintained, leading to the SSPE phenotype. Further, an active role in prolonging MV replication while inhibiting its spread in the CNS can be mapped to a direct affect of the biased hypermutations (A to G changes) of the MV M gene in vivo.
    MeSH term(s) Animals ; Disease Models, Animal ; Humans ; Measles virus/genetics ; Measles virus/pathogenicity ; Measles virus/physiology ; Mice ; Mice, Transgenic ; Mutation ; Subacute Sclerosing Panencephalitis/immunology ; Subacute Sclerosing Panencephalitis/pathology ; Subacute Sclerosing Panencephalitis/virology ; Viral Matrix Proteins/genetics ; Viral Matrix Proteins/immunology ; Virus Replication
    Chemical Substances Viral Matrix Proteins
    Language English
    Publishing date 2008-12-30
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ISSN 0070-217X
    ISSN 0070-217X
    DOI 10.1007/978-3-540-70617-5_2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Molecular mimicry, microbial infection, and autoimmune disease: evolution of the concept.

    Oldstone, M B A

    Current topics in microbiology and immunology

    2005  Volume 296, Page(s) 1–17

    Abstract: Molecular mimicry is defined as similar structures shared by molecules from dissimilar genes or by their protein products. Either several linear amino acids or their conformational fit may be shared, even though their origins are separate. Hence, during ... ...

    Abstract Molecular mimicry is defined as similar structures shared by molecules from dissimilar genes or by their protein products. Either several linear amino acids or their conformational fit may be shared, even though their origins are separate. Hence, during a viral or microbe infection, if that organism shares cross-reactive epitopes for B or T cells with the host, then the response to the infecting agent will also attack the host, causing autoimmune disease. A variation on this theme is when a second, third, or repeated infection(s) shares cross-reactive B or T cell epitopes with the first (initiating) virus but not necessarily the host. In this instance, the secondary infectious agents increase the number of antiviral/antihost effector antibodies or T cells that potentiate or precipitate the autoimmune assault. The formation of this concept initially via study of monoclonal antibody or clone T cell cross-recognition in vitro through its evolution to in vivo animal models and to selected human diseases is explored in this mini-review.
    MeSH term(s) Amino Acid Sequence ; Animals ; Autoantibodies/biosynthesis ; Autoantigens/genetics ; Autoimmune Diseases/etiology ; Autoimmune Diseases/immunology ; Autoimmune Diseases/microbiology ; Disease Models, Animal ; Epitopes/genetics ; Humans ; Infections/immunology ; Models, Immunological ; Molecular Mimicry/immunology ; Molecular Sequence Data ; T-Lymphocytes/immunology
    Chemical Substances Autoantibodies ; Autoantigens ; Epitopes
    Keywords covid19
    Language English
    Publishing date 2005-11-28
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ISSN 0070-217X
    ISSN 0070-217X
    DOI 10.1007/3-540-30791-5_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Molecular and cellular mechanisms, pathogenesis, and treatment of insulin-dependent diabetes obtained through study of a transgenic model of molecular mimicry.

    Oldstone, M B A

    Current topics in microbiology and immunology

    2005  Volume 296, Page(s) 65–87

    Abstract: The portrait of autoimmune diabetes mellitus or type I diabetes can be copied by a transgenic model in which either the nucleoprotein (NP) or glycoprotein (GP) of lymphocytic choriomeningitis virus (LCMV) is expressed in beta cells of the islets of ... ...

    Abstract The portrait of autoimmune diabetes mellitus or type I diabetes can be copied by a transgenic model in which either the nucleoprotein (NP) or glycoprotein (GP) of lymphocytic choriomeningitis virus (LCMV) is expressed in beta cells of the islets of Langerhans. In the absence of further environmental insult, diabetes does not occur. However, when LCMV or a dissimilar virus that shares cross-reactive T cell epitopes with LCMV initiates infection, diabetes ensues. If the self "viral" transgene is expressed only in the beta cells, then diabetes occurs acutely within 8 to 12 days. Specific antiviral (self) CD8 T cells are mandatory for disease, but CD4 T cells are not. In this instance, diabetes can occur in the absence of infection if interferon gamma or B7.1 molecules are also expressed in the islets but not when IL-2, IL-4, IL-10, or IL-12 is similarly expressed. In contrast, both CD8 and CD4 antiviral (self) specific T cells are required when the self "viral" transgene is expressed concomitantly in beta cells and in the thymus. In this instance, infection by LCMV or cross-reacting virus is essential to cause diabetes. Further, the time from onset of infection until disease depends, in part, on the host's MHC background and its quantitative influence on negative selection of high-avidity antiviral (self) T cells. Knowledge of the cells, their numbers, and the molecules required to cause diabetes allows the design of successful strategies to treat and prevent the autoimmune disease.
    MeSH term(s) Amino Acid Sequence ; Animals ; Autoantigens/genetics ; Cytokines/biosynthesis ; Diabetes Mellitus, Type 1/etiology ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/immunology ; Diabetes Mellitus, Type 1/therapy ; Disease Models, Animal ; Humans ; Insulin/genetics ; Lymphocytic choriomeningitis virus/genetics ; Lymphocytic choriomeningitis virus/immunology ; Mice ; Mice, Transgenic ; Molecular Mimicry/genetics ; Molecular Mimicry/immunology ; Promoter Regions, Genetic ; Rats ; T-Lymphocytes/immunology
    Chemical Substances Autoantigens ; Cytokines ; Insulin
    Language English
    Publishing date 2005-11-18
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ISSN 0070-217X
    ISSN 0070-217X
    DOI 10.1007/3-540-30791-5_5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Biology and pathogenesis of lymphocytic choriomeningitis virus infection.

    Oldstone, M B A

    Current topics in microbiology and immunology

    2002  Volume 263, Page(s) 83–117

    MeSH term(s) Animals ; Disease Models, Animal ; Humans ; Lymphocytic Choriomeningitis/immunology ; Lymphocytic Choriomeningitis/physiopathology ; Lymphocytic Choriomeningitis/virology ; Lymphocytic choriomeningitis virus/pathogenicity ; Lymphocytic choriomeningitis virus/physiology ; Mice
    Language English
    Publishing date 2002-04-01
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
    ISSN 0070-217X
    ISSN 0070-217X
    DOI 10.1007/978-3-642-56055-2_6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Type I interferon during viral infections: multiple triggers for a multifunctional mediator.

    Zuniga, E I / Hahm, B / Oldstone, M B A

    Current topics in microbiology and immunology

    2007  Volume 316, Page(s) 337–357

    Abstract: Type I interferons (IFN-I) orchestrate numerous biological and cellular processes and are essential elements during host antiviral defense. After recognition of highly conserved virus signatures, a complex network of signaling events is rapidly initiated ...

    Abstract Type I interferons (IFN-I) orchestrate numerous biological and cellular processes and are essential elements during host antiviral defense. After recognition of highly conserved virus signatures, a complex network of signaling events is rapidly initiated and leads to IFN-I synthesis. These cytokines directly induce a strong antiviral state and exert several immune-regulatory actions aimed at preventing virus spread. On the other hand, viruses evolved to evade or subvert the IFN-I system for their own benefit. In the present article, we review selective aspects of IFN-I induction and functions during several viral infections and discuss the beneficial and detrimental roles of IFN-I illustrated during lymphocytic choriomeningitis virus (LCMV) infection in its natural host, the mouse.
    MeSH term(s) Animals ; Autoimmunity/immunology ; Disease Models, Animal ; Humans ; Interferon Type I/immunology ; Lymphocytic Choriomeningitis/immunology ; Lymphocytic Choriomeningitis/virology ; Lymphocytic choriomeningitis virus/immunology ; Mice ; Toll-Like Receptors/immunology
    Chemical Substances Interferon Type I ; Toll-Like Receptors
    Language English
    Publishing date 2007-09-01
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ISSN 0070-217X
    ISSN 0070-217X
    DOI 10.1007/978-3-540-71329-6_16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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