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  1. Article ; Online: Melanocortin-1 Receptor (MC1R) Gene Variants are Not Associated With Vascular Brain Alterations.

    Candrea, E / Podlipnik, S / Oleaga, L / Puig, S

    Actas dermo-sifiliograficas

    2022  

    Title translation [Artículo traducido] Las variantes del gen receptor de melanocortina-1 (MC1R) no están asociadas a las enfermedades vasculares cerebrales.
    Language Spanish
    Publishing date 2022-11-09
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 390255-9
    ISSN 1578-2190 ; 0001-7310 ; 1138-8196
    ISSN (online) 1578-2190
    ISSN 0001-7310 ; 1138-8196
    DOI 10.1016/j.ad.2021.07.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: [No title information]

    Candrea, E / Podlipnik, S / Oleaga, L / Puig, S

    Actas dermo-sifiliograficas

    2022  

    Title translation Melanocortin-1 receptor (MC1R) gene variants are not associated with vascular brain alterations.
    Language Spanish
    Publishing date 2022-07-14
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 390255-9
    ISSN 1578-2190 ; 0001-7310 ; 1138-8196
    ISSN (online) 1578-2190
    ISSN 0001-7310 ; 1138-8196
    DOI 10.1016/j.ad.2021.07.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Radiomic-based nonlinear supervised learning classifiers on non-contrast CT to predict functional prognosis in patients with spontaneous intracerebral hematoma.

    Serrano, E / Moreno, J / Llull, L / Rodríguez, A / Zwanzger, C / Amaro, S / Oleaga, L / López-Rueda, A

    Radiologia

    2023  Volume 65, Issue 6, Page(s) 519–530

    Abstract: Purpose: To evaluate if nonlinear supervised learning classifiers based on non-contrast CT can predict functional prognosis at discharge in patients with spontaneous intracerebral hematoma.: Methods: Retrospective, single-center, observational ... ...

    Abstract Purpose: To evaluate if nonlinear supervised learning classifiers based on non-contrast CT can predict functional prognosis at discharge in patients with spontaneous intracerebral hematoma.
    Methods: Retrospective, single-center, observational analysis of patients with a diagnosis of spontaneous intracerebral hematoma confirmed by non-contrast CT between January 2016 and April 2018. Patients with HIE > 18 years and with TCCSC performed within the first 24 h of symptom onset were included. Patients with secondary spontaneous intracerebral hematoma and in whom radiomic variables were not available were excluded. Clinical, demographic and admission variables were collected. Patients were classified according to the Modified Rankin Scale (mRS) at discharge into good (mRS 0-2) and poor prognosis (mRS 3-6). After manual segmentation of each spontaneous intracerebral hematoma, the radiomics variables were obtained. The sample was divided into a training and testing cohort and a validation cohort (70-30% respectively). Different methods of variable selection and dimensionality reduction were used, and different algorithms were used for model construction. Stratified 10-fold cross-validation were performed on the training and testing cohort and the mean area under the curve (AUC) were calculated. Once the models were trained, the sensitivity of each was calculated to predict functional prognosis at discharge in the validation cohort.
    Results: 105 patients with spontaneous intracerebral hematoma were analyzed. 105 radiomic variables were evaluated for each patient. P-SVM, KNN-E and RF-10 algorithms, in combination with the ANOVA variable selection method, were the best performing classifiers in the training and testing cohort (AUC 0.798, 0.752 and 0.742 respectively). The predictions of these models, in the validation cohort, had a sensitivity of 0.897 (0.778-1;95%CI), with a false-negative rate of 0% for predicting poor functional prognosis at discharge.
    Conclusion: The use of radiomics-based nonlinear supervised learning classifiers are a promising diagnostic tool for predicting functional outcome at discharge in HIE patients, with a low false negative rate, although larger and balanced samples are still needed to develop and improve their performance.
    MeSH term(s) Humans ; Cerebral Hemorrhage/diagnostic imaging ; Hematoma/diagnostic imaging ; Prognosis ; Retrospective Studies ; Supervised Machine Learning ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2023-11-15
    Publishing country Spain
    Document type Journal Article ; Observational Study
    ISSN 2173-5107
    ISSN (online) 2173-5107
    DOI 10.1016/j.rxeng.2023.08.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Conference proceedings: Automatisierte Auswertung von Freitextantworten mittels Natural Language Processing – eine Machbarkeitsstudie auf Basis des EDiR-Examens.

    Stöhr, F / Kämpgen, B / Junquero, V / Merino, C / Mildenberger, P / Oleaga, L / Kloeckner, R

    RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren

    2023  Volume 195, Issue S 01

    Event/congress RÖKO 2023, RheinMain CongressCenter (RMCC) in Wiesbaden, 2023-05-17
    Language German
    Publishing date 2023-04-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 554830-5
    ISSN 1438-9010 ; 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
    ISSN (online) 1438-9010
    ISSN 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
    DOI 10.1055/s-0043-1763165
    Database Thieme publisher's database

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  5. Article: Análisis de la función cardíaca: métodos de imagen, indicaciones y limitaciones.

    Oleaga, L

    Radiologia

    2007  Volume 49, Issue 3, Page(s) 157–164

    Abstract: Cardiac function analysis is critical in the management of patients with cardiovascular diseases. The two most common non-invasive techniques used nowadays to evaluate cardiac function are ultrasonography and magnetic resonance imaging (MR). The ... ...

    Title translation Diagnostic imaging techniques for analyzing heart function: indications and limitations.
    Abstract Cardiac function analysis is critical in the management of patients with cardiovascular diseases. The two most common non-invasive techniques used nowadays to evaluate cardiac function are ultrasonography and magnetic resonance imaging (MR). The parameters to be determined with both techniques include the systolic volume of the left ventricle, the cardiac mass, myocardial thickness and ejection fraction. Ultrasound images have high resolution and they do not need any cardiac or respiratory gating. It has limitations in obese patients, patients with pulmonary obstructive disease or patients after thoracic surgery. MR has a high spatial and temporal resolution. There are different sequences we can use to determine cardiac function parameters, Gradient Echo sequences are used to analyze the ventricular volume and the ejection fraction. Myocardial tagging sequences are used to quantify the myocardial wall motion. Computed Tomography constitutes other alternative that can be used in patients with claustrophobia or pace markers to evaluate cardiac function.
    MeSH term(s) Echocardiography ; Heart Function Tests/methods ; Humans ; Magnetic Resonance Imaging ; Ventricular Function, Left
    Language Spanish
    Publishing date 2007-05-22
    Publishing country Spain
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 731840-6
    ISSN 0033-8338
    ISSN 0033-8338
    DOI 10.1016/s0033-8338(07)73744-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Laryngeal EBV-positive Inflammatory Follicular Dendritic cell/fibroblastic Reticular cell Tumour.

    Gil, Alex / Castrejon-de-Anta, Natalia / Vilaseca, Isabel / Frigola, Gerard / Campo, Elias / Oleaga, Laura

    Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

    2023  Volume 75, Issue 4, Page(s) 3941–3944

    Abstract: Epstein-Barr virus-positive Inflammatory follicular dendritic cell/fibroblastic reticular cell tumour (EBV-IFDC/FRCT) is a rare neoplasm that occurs almost exclusively in the liver or spleen. Extra-hepatosplenic presentation is infrequent and exceptional ...

    Abstract Epstein-Barr virus-positive Inflammatory follicular dendritic cell/fibroblastic reticular cell tumour (EBV-IFDC/FRCT) is a rare neoplasm that occurs almost exclusively in the liver or spleen. Extra-hepatosplenic presentation is infrequent and exceptional cases have been described arising in the gastrointestinal tract or in the pharynx. However, EBV-IFDC/FRCT cases have not been previously reported in the larynx. This report describes a case of a 32-year-old woman who arrived to the emergency department due to progressive dyspnea with associated inspiratory stridor and non-productive cough. Direct laryngoscopy showed a nodular tumour arising on the left posterior subglottic mucosa obstructing 90% of the airway. A preoperative dual energy contrast enhanced computed tomography (CECT) was performed demonstrating a low attenuation lesion on virtual non-contrast (VNC) images and vivid iodine uptake on the iodine map. The tumour was excised and the histopathological analysis led to the diagnosis of an EBV-IFDC/FRCT. A fibre-optic laryngoscopy six months after the surgery did not show any abnormalities. Although the vast majority of EBV-IFDC/FRCT occur in the liver or spleen, some extra hepatosplenic tumours have been reported affecting the head and neck region. We describe here the first case arising in the larynx, as well as the usefulness of preoperative dual energy imaging techniques to assess these lesions, thus providing information that could have management implications.
    Language English
    Publishing date 2023-06-20
    Publishing country India
    Document type Journal Article
    ZDB-ID 1471137-0
    ISSN 0973-7707 ; 2231-3796 ; 0019-5421
    ISSN (online) 0973-7707
    ISSN 2231-3796 ; 0019-5421
    DOI 10.1007/s12070-023-03937-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Prophylaxis against postcontrast acute kidney injury (PC-AKI): updates in the ESUR guidelines 10.0 and critical review.

    Sebastià, C / Nicolau, C / Martín de Francisco, Á L / Poch, E / Oleaga, L

    Radiologia

    2020  Volume 62, Issue 4, Page(s) 292–297

    Abstract: The European Society of Urogenital Radiology (ESUR) updated its guidelines for prophylaxis against postcontrast acute kidney injury (PC-AKI) in 2018 (ESUR 10.0). These guidelines drastically reduce the indications for prophylaxis against PC-AKI after ... ...

    Title translation Profilaxis de la lesión renal aguda poscontraste (LRA-PC). Actualización según la guía clínica ESUR 10.0 y revisión crítica.
    Abstract The European Society of Urogenital Radiology (ESUR) updated its guidelines for prophylaxis against postcontrast acute kidney injury (PC-AKI) in 2018 (ESUR 10.0). These guidelines drastically reduce the indications for prophylaxis against PC-AKI after iodine-based contrast administration, lowering the cutoff for administering prophylaxis to glomerular filtration rates <30ml/min/1.73m
    MeSH term(s) Acute Kidney Injury/chemically induced ; Acute Kidney Injury/prevention & control ; Contrast Media/adverse effects ; Humans
    Chemical Substances Contrast Media
    Language Spanish
    Publishing date 2020-02-03
    Publishing country Spain
    Document type Journal Article ; Practice Guideline
    ISSN 2173-5107
    ISSN (online) 2173-5107
    DOI 10.1016/j.rx.2019.12.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Metastasis asintomaticas de la base craneal: evolucion clinica y alternativas terapeuticas.

    Vargas, A / Paulazo, C / Oleaga, L / Verger, E

    Revista de neurologia

    2017  Volume 64, Issue 5, Page(s) 201–204

    Abstract: Introduction: Skull base metastases (SBM) are an infrequent and late type of cancer progression that are associated to poor prognosis. Its clinical manifestations may be grouped in five clinical syndromes and radiotherapy is its more frequent treatment. ...

    Title translation Asymptomatic skull base metastases: clinical course and therapeutic alternatives.
    Abstract Introduction: Skull base metastases (SBM) are an infrequent and late type of cancer progression that are associated to poor prognosis. Its clinical manifestations may be grouped in five clinical syndromes and radiotherapy is its more frequent treatment. Because of the improvement in imaging tests and the close follow up of cancer patients, SBM can be diagnosed incidentally. In this group the best option of treatment has not been established.
    Aim: To analyze the clinical features and outcomes of patients with SBM diagnosed incidentally.
    Patients and methods: Between January 2012 and December 2015, 31 patients with diagnoses of SBM from solid primary tumor were reviewed.
    Results: SBM were diagnosed due to skull base syndromes (n = 24) or incidentally (n = 7). Symptomatic patients were treated with radiotherapy. Patients diagnosed incidentally remained without symptoms of craneal base involvement during the follow up, although they frequently had other types of intracranial progression. A statistically significant difference in survival was observed between symptomatic and asymptomatic patients (p = 0.001).
    Conclusions: The incidentally diagnosed SBM were frequently associated to other types of intracranial progression, limiting the options of treatment.
    Language Spanish
    Publishing date 2017-03-01
    Publishing country Spain
    Document type English Abstract ; Journal Article
    ZDB-ID 1468278-3
    ISSN 1576-6578 ; 0210-0010
    ISSN (online) 1576-6578
    ISSN 0210-0010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Optimizing the Definition of Ischemic Core in CT Perfusion: Influence of Infarct Growth and Tissue-Specific Thresholds.

    Rodríguez-Vázquez, A / Laredo, C / Renú, A / Rudilosso, S / Llull, L / Amaro, S / Obach, V / Vera, V / Páez, A / Oleaga, L / Urra, X / Chamorro, Á

    AJNR. American journal of neuroradiology

    2022  Volume 43, Issue 9, Page(s) 1265–1270

    Abstract: Background and purpose: CTP allows estimating ischemic core in patients with acute stroke. However, these estimations have limited accuracy compared with MR imaging. We studied the effect of applying WM- and GM-specific thresholds and analyzed the ... ...

    Abstract Background and purpose: CTP allows estimating ischemic core in patients with acute stroke. However, these estimations have limited accuracy compared with MR imaging. We studied the effect of applying WM- and GM-specific thresholds and analyzed the infarct growth from baseline imaging to reperfusion.
    Materials and methods: This was a single-center cohort of consecutive patients (
    Results: The fixed threshold underestimated lesions in GM and overestimated them in WM. Double GM- and WM-specific thresholds of relative CBF were superior to fixed thresholds in predicting infarcted voxels. The closest estimations of the infarct on DWI were based on a relative CBF of 25% for a single threshold, 35% for GM, and 20% for WM, and they decreased when correcting for infarct growth: 20% for a single threshold, 25% for GM, and 15% for WM. The combination of 25% for GM and 15% for WM yielded the best prediction.
    Conclusions: GM- and WM-specific thresholds result in different estimations of ischemic core in CTP and increase the global accuracy. More restrictive thresholds better estimate the actual extent of the infarcted tissue.
    MeSH term(s) Humans ; Stroke/pathology ; Magnetic Resonance Imaging ; Infarction/diagnostic imaging ; Cerebrovascular Circulation ; Perfusion Imaging/methods ; Tomography, X-Ray Computed/methods ; Perfusion ; Brain Ischemia/diagnostic imaging ; Brain Ischemia/pathology
    Language English
    Publishing date 2022-08-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
    DOI 10.3174/ajnr.A7601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Effectiveness of the clinical decision support tool ESR eGUIDE for teaching medical students the appropriate selection of imaging tests: randomized cross-over evaluation.

    Diekhoff, Torsten / Kainberger, Franz / Oleaga, Laura / Dewey, Marc / Zimmermann, Elke

    European radiology

    2020  Volume 30, Issue 10, Page(s) 5684–5689

    Abstract: Objectives: To evaluate ESR eGUIDE-the European Society of Radiology (ESR) e-Learning tool for appropriate use of diagnostic imaging modalities-for learning purposes in different clinical scenarios.: Methods: This anonymized evaluation was performed ... ...

    Abstract Objectives: To evaluate ESR eGUIDE-the European Society of Radiology (ESR) e-Learning tool for appropriate use of diagnostic imaging modalities-for learning purposes in different clinical scenarios.
    Methods: This anonymized evaluation was performed after approval of ESR Education on Demand leadership. Forty clinical scenarios were developed in which at least one imaging modality was clinically most appropriate, and the scenarios were divided into sets 1 and 2. These sets were provided to medical students randomly assigned to group A or B to select the most appropriate imaging test for each scenario. Statistical comparisons were made within and across groups.
    Results: Overall, 40 medical students participated, and 31 medical students (78%) answered both sets. The number of correctly chosen imaging methods per set in these 31 paired samples was significantly higher when answered with versus without use of ESR eGUIDE (13.7 ± 2.6 questions vs. 12.1 ± 3.2, p = 0.012). Among the students in group A, who first answered set 1 without ESR eGUIDE (11.1 ± 3.2), there was significant improvement when set 2 was answered with ESR eGUIDE (14.3 ± 2.5, p = 0.013). The number of correct answers in group B did not drop when set 2 was answered without ESR eGUIDE (12.4 ± 2.6) after having answered set 1 first with ESR eGUIDE (13.0 ± 2.7, p = 0.66).
    Conclusion: The clinical decision support tool ESR eGUIDE is suitable for training medical students in choosing the best radiological imaging modality in typical scenarios, and its use in teaching radiology can thus be recommended.
    Key points: • ESR eGUIDE improved the number of appropriately selected imaging modalities among medical students. • This improvement was also seen in the group of students which first selected imaging tests without ESR eGUIDE. • In the student group which used ESR eGUIDE first, appropriate selection remained stable even without the teaching tool.
    MeSH term(s) Cross-Over Studies ; Decision Support Systems, Clinical ; Diagnostic Imaging ; Education, Medical, Undergraduate/methods ; Educational Measurement/methods ; Europe ; Humans ; Learning ; Radiography ; Radiology/education ; Students, Medical ; Teaching ; User-Computer Interface
    Language English
    Publishing date 2020-05-20
    Publishing country Germany
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-020-06942-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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