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Article: Depersonalizatsionnye depressii u patsientok molodogo vozrasta.

Oleichik, I V / Moreva, A S / Baranov, P A

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

2023 Volume 123, Issue 11. Vyp. 2, Page(s) 68–73

Abstract: Objective: To study psychopathological structure characteristics of depersonalization depression in young women and nonsuicidal autoaggressive and suicidal behavior characteristics in these states.: Material and methods: We studied 36 adolescent ... ...

Title translation	Depersonalization depression in young female patients.
Abstract	Objective: To study psychopathological structure characteristics of depersonalization depression in young women and nonsuicidal autoaggressive and suicidal behavior characteristics in these states. Material and methods: We studied 36 adolescent female patients (16-25 years) with endogenous depression (F31.3-4; F34.0; F21.3-4+F31.3-4; F60.X+F31.3-4), whose clinical picture was dominated by depersonalization disorders represented by their auto-, allo-, and somatopsychic forms or combinations. Results: Depersonalization depressions in young female patients are characterized by the following features: the dominance of the manifestations of the sensory («hysterical») form of depersonalization (83.3%; Conclusions: Depersonalization depression in young female patients is characterized by the clinical specificity manifested both in depersonalization symptomatology and spectrum of comorbid disorders and in the specificity of motives and methods of suicide attempts and nonsuicidal self-harm.
MeSH term(s)	Adolescent ; Humans ; Female ; Depression/diagnosis ; Depression/epidemiology ; Depersonalization ; Depressive Disorder ; Suicide, Attempted ; Psychotic Disorders
Language	Russian
Publishing date	2023-12-21
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	1201462-x
ISSN	2309-4729 ; 1997-7298 ; 0044-4588
ISSN (online)	2309-4729
ISSN	1997-7298 ; 0044-4588
DOI	10.17116/jnevro202312311268
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Article: Effektivnost', bezopasnost' i priverzhennost' terapii preparatom Elitseya Ku-Tab v real'noi klinicheskoi praktike.

Oleichik, I V / Shishkovskaia, T I / Baranov, P A

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

2023 Volume 123, Issue 11. Vyp. 2, Page(s) 46–54

Abstract: Objective: To evaluate the effectiveness and safety of escitalopram in the form of oral dispersible tablets (Elicea Q-Tab) in real-life clinical practice in patients with depressive and anxiety disorders.: Material and methods: The study included 1 ... ...

Title translation	Effectiveness, safety and adherence to therapy with Elicea Q-Tab in real clinical practice.
Abstract	Objective: To evaluate the effectiveness and safety of escitalopram in the form of oral dispersible tablets (Elicea Q-Tab) in real-life clinical practice in patients with depressive and anxiety disorders. Material and methods: The study included 1.892 outpatient patients, 1.860 of whom completed participation in accordance with the protocol and entered the statistical analysis. Most patients were diagnosed with depressive and anxiety disorders of varying severity, as a rule, these diagnoses were established for the first time. The drug was most often prescribed at a dosage of 10 mg/day. The patients were monitored for 90 days and at each of the 3 visits, scales were used to assess the clinical condition (CGI-S and CGI-I), scales «Interaction with people, maintaining relationships (social functioning)» and «Availability of work, task completion, school attendance (professional functioning)», scales satisfaction with the convenience of admission/appointment and the effectiveness of treatment, various indicators of quality of life (autonomy, social and professional functioning, hobbies and hobbies), as well as the severity of cognitive disorders were measured. Results: Patients treated with escitalopram in the form of oral tablets dispersible in the oral cavity (Elicea Q-Tab) showed an improvement in their clinical condition (a decrease in CGI-S scores from 3.65 at visit 1 to 2.63 by visit 3, by 28%; a decrease in CGI-I scores from 2.39 at visit 1 to 1.57 to visit 3, by 34%), as well as improving the quality of life, social (from 2.74 points on 1 visit to 4.32 on 2 visits, by 58%) and professional functioning (from 2.81 on 1 visit to 4.35 on 2 visits, by 55%), the level of concentration (from 3.28 points on 1 visit up to 4.5 on 3 visits, by 37%). Doctors and patients noted high satisfaction with the effectiveness and convenience of using the drug, the frequency of adverse events was low. Conclusion: The study showed that escitalopram in the form of oral tablets dispersible in the oral cavity (Elicea Q-Tab) is an efficient and safe treatment for depressive and anxiety disorders in real-world clinical settings. Patients and physicians have evaluated the drug positively and it can be considered as an effective agent in psychiatric practice.
MeSH term(s)	Humans ; Escitalopram ; Quality of Life ; Depressive Disorder, Major/drug therapy ; Treatment Outcome ; Anxiety Disorders/drug therapy ; Citalopram/therapeutic use ; Citalopram/adverse effects
Chemical Substances	Escitalopram (4O4S742ANY) ; Citalopram (0DHU5B8D6V)
Language	Russian
Publishing date	2023-12-21
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	1201462-x
ISSN	2309-4729 ; 1997-7298 ; 0044-4588
ISSN (online)	2309-4729
ISSN	1997-7298 ; 0044-4588
DOI	10.17116/jnevro202312311246
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Article: Kliniko-psikhopatologicheskie osobennosti endogennykh depressii u patsientok molodogo vozrasta.

Levchenko, N S / Oleichik, I V

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

2021 Volume 121, Issue 5. Vyp. 2, Page(s) 27–34

Abstract: Objective: To study the features of psychopatological structure of endogenous depression in young women and to identify correlations between various clinical types of depression and their nosological affilation.: Material and methods: The results of ... ...

Title translation	Clinical and psychopatological features of endogenous depressions in young women.
Abstract	Objective: To study the features of psychopatological structure of endogenous depression in young women and to identify correlations between various clinical types of depression and their nosological affilation. Material and methods: The results of clinical/psychopathological examination of 107 female patients, aged 16 to 25 years, with endogenous depression with one of the following ICD-10 diagnosis: (F34.0; F31.3-F31.5; F21.3-F.21.4+F31.3-F31.5; F60.X+F31.3-F31.5) were analyzed. Results: Several types of endogenous depression were identified: 1) hysterical depression with hysterical-conversions, and also the phenomena of delusional fantasies; 2) dysmorphic depression with predominance of over-valued ideas of physical disability, self-inferiority and eating disorder; 3) depersonalization depression with depersonalization-derealization symptoms; 4) psychopath-like depression with exaggerated behavior, opposition and impulsivity; 5) existential depression with a feeling of losing the life meaning and often pessimistic worldview; 6) psychasthenic depression with the low self-esteem and exaggerated introspection combined with obsessive-phobic disorder; 7) anxious-melancholic depression with anxiety, melancholy and ideas of self-accusation and self-inferiority; 8) depression with symptoms of adolescent asthenic insolvency with difficulties of understanding information, increasing intellectual exhaustion. We revealed differences in motives for committing non-suicidal self-harm behavior and suicidal behavior in typological variants of depressions. Conclusion: Hysteroform and psychopathic depressions prevail in personality disorders, while psychosthenic-like, anxious-melancholic and existential depressions are more frequent in affective disorders. Depersonalization depressions are more common in schizotypal disorder. When comparing the types of depressions in boys as reported in previous research with those in girls, the prevalence of hysteroform and anxious-melancholic variants in girls is revealed.
MeSH term(s)	Adolescent ; Anxiety ; Anxiety Disorders ; Depression/diagnosis ; Depression/epidemiology ; Depressive Disorder/diagnosis ; Depressive Disorder/epidemiology ; Female ; Humans ; Male ; Phobic Disorders
Language	Russian
Publishing date	2021-08-17
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	1201462-x
ISSN	2309-4729 ; 1997-7298 ; 0044-4588
ISSN (online)	2309-4729
ISSN	1997-7298 ; 0044-4588
DOI	10.17116/jnevro202112105227
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Article ; Online: Hemostasis System in Patients with Schizophrenia and Schizophrenia Spectrum Disorders.

Karpova, N S / Brusov, O S / Oleichik, I V / Stolyarov, S A / Klyushnik, T P

Bulletin of experimental biology and medicine

2024 Volume 176, Issue 3, Page(s) 390–393

Abstract: Hemostasis system in patients with schizophrenia and schizophrenia spectrum disorders was examined using "Fibrinodynamics" technology that allows evaluating the overal coagulation, fibrinolysis, and hemostasis potentials. All indices, except for the ... ...

Abstract	Hemostasis system in patients with schizophrenia and schizophrenia spectrum disorders was examined using "Fibrinodynamics" technology that allows evaluating the overal coagulation, fibrinolysis, and hemostasis potentials. All indices, except for the parameter characterizing the hemostasis balance, were statistically higher (p<0.0001) in patients than in healthy volunteers (control). In most patients, the hemostasis system remained balanced despite changes in individual coagulation and fibrinolysis parameters. The obtained results have a fundamental importance, expand the understanding of the pathogenesis of endogenous mental disorders, and are useful for the development of personalized approaches to the treatment of these patients.
MeSH term(s)	Humans ; Schizophrenia ; Hemostasis ; Blood Coagulation ; Fibrinolysis
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	390407-6
ISSN	1573-8221 ; 0007-4888 ; 0365-9615
ISSN (online)	1573-8221
ISSN	0007-4888 ; 0365-9615
DOI	10.1007/s10517-024-06030-1
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Article: EEG-korrelyaty suitsidal'nykh namerenii u bol'nykh depressiei, bolevshikh i ne bolevshikh COVID-19.

Iznak, A F / Iznak, E V / Damyanovich, E V / Oleichik, I V

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

2023 Volume 123, Issue 11. Vyp. 2, Page(s) 92–95

Abstract: Objective: To search for EEG correlates of suicidal intentions in young depressive patients who survived and have not been ill with COVID-19.: Material and methods: We studied 46 female patients, aged 16-25 years, with depressive disorders who had ... ...

Title translation	EEG correlates of suicidal intentions in depressive patients who survived and have not been ill with COVID-19.
Abstract	Objective: To search for EEG correlates of suicidal intentions in young depressive patients who survived and have not been ill with COVID-19. Material and methods: We studied 46 female patients, aged 16-25 years, with depressive disorders who had previously had a mild or asymptomatic coronavirus infection («COVID» group) and 40 female patients with depressive disorders matched in age, syndromic structure of disorders and the initial severity of depression to patients of the «COVID» group but who are known not to have COVID-19 («non-COVID» group). The severity of suicidal intentions was assessed by the number of points of item 3 of HDRS-17. In all patients, pre-treatment multichannel background EEG was recorded with spectral power analysis in narrow frequency sub-bands. Results: In patients of the «COVID» group, the mean number of points of item 3 of HDRS-17 was slightly higher (at the trend level) than in the «non-COVID» group (2.1±1.5 and 1.8±1.6 points, respectively), and positively correlated ( Conclusion: Suicidal intentions increased in depressive patients survived from COVID-19, and their severity is associated with EEG signs of a reduced functional state of the cerebral cortex.
MeSH term(s)	Humans ; Female ; Suicidal Ideation ; Intention ; COVID-19 ; Electroencephalography
Language	Russian
Publishing date	2023-12-21
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	1201462-x
ISSN	2309-4729 ; 1997-7298 ; 0044-4588
ISSN (online)	2309-4729
ISSN	1997-7298 ; 0044-4588
DOI	10.17116/jnevro202312311292
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Article: Osobennosti neirokognitivnogo profilya bol'nykh s zatyazhnymi i khronicheskimi endogennymi maniakal'nymi i maniakal'no-bredovymi sostoyaniyami.

Rumyantseva, E B / Shevchenko, O P / Oleichik, I V / Sizov, S V

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

2023 Volume 123, Issue 8, Page(s) 82–89

Abstract: Objective: To study the neurocognitive profile of patients with protracted and chronic endogenous manic and manic-delusional states (EMDS).: Material and methods: Thirty-two female patients, aged 18 to 55 years (mean age 36.2±10.2 years), with ... ...

Title translation	Features of the neurocognitive profile of patients with protracted and chronic endogenous manic and manic-delusional states.
Abstract	Objective: To study the neurocognitive profile of patients with protracted and chronic endogenous manic and manic-delusional states (EMDS). Material and methods: Thirty-two female patients, aged 18 to 55 years (mean age 36.2±10.2 years), with protracted and chronic EMDS were studied. Based on the clinical typology of EMDS, patients were divided into 4 groups of 8 patients each: group 1 - «acute» subtype, group 2 - «chronified» subtype, group 3 - «developing» subtype and group 4 - subtype «double mania». Neuropsychological, clinical-psychopathological and statistical methods were used. Results: Disturbances of regulatory and executive functions and a decrease in neurodynamic indicators of mental activity in patients with EMDS are significantly more pronounced compared with the control group ( Conclusion: The most characteristic of EMBS are cognitive impairments associated with a decrease in the parameters of the neurodynamics of mental activity related to the first functional block, as well as with deficiency of executive functions, impaired planning and organization of cognitive activity, due to the weakness of the structures of the third functional block.
MeSH term(s)	Humans ; Female ; Adult ; Middle Aged ; Mania ; Cognitive Dysfunction ; Executive Function ; Patients ; Psychopathology
Language	Russian
Publishing date	2023-09-01
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	1201462-x
ISSN	2309-4729 ; 1997-7298 ; 0044-4588
ISSN (online)	2309-4729
ISSN	1997-7298 ; 0044-4588
DOI	10.17116/jnevro202312308182
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Article ; Online: Clinical-Immunological Correlates in Post-COVID-19 Endogenous Psychoses.

Zozulya, S A / Sizov, S V / Oleichik, I V / Klyushnik, T P

Neuroscience and behavioral physiology

2023 Volume 53, Issue 2, Page(s) 174–179

Abstract: ... ...

Abstract	Objectives
Language	English
Publishing date	2023-03-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	121550-4
ISSN	1573-899X ; 0097-0549
ISSN (online)	1573-899X
ISSN	0097-0549
DOI	10.1007/s11055-023-01405-9
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Article: Kliniko-immunologicheskie korrelyaty pri endogennykh psikhozakh, razvivshikhsya posle perenesennogo COVID-19.

Zozulya, S A / Sizov, S V / Oleichik, I V / Klyushnik, T P

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

2022 Volume 122, Issue 6. Vyp. 2, Page(s) 71–77

Abstract: Objective: The clinical and immunological study of the potential impact of coronavirus infection on the course of endogenous psychosis.: Material and methods: Thirty-three female patients, aged 16 to 48 years, with depressive-delusional conditions ( ... ...

Title translation	Clinical and immunological correlates in endogenous psychoses developed after COVID-19.
Abstract	Objective: The clinical and immunological study of the potential impact of coronavirus infection on the course of endogenous psychosis. Material and methods: Thirty-three female patients, aged 16 to 48 years, with depressive-delusional conditions (ICD-10 F20.01, F21, F31) developed after coronavirus infection, of whom 15 people (group 1) had depressive-delusional states 1-2 months after COVID-19 and 18 people (group 2), who developed similar psychoses in later periods (2-6 months). The severity of the psychopathologic symptoms was evaluated with PANSS and HDRS-21 scales. The activity of inflammatory markers - leukocyte elastase (LE) and α1-proteinase inhibitor (α1-PI) in the blood was determined. The absolute neutrophil count, the absolute lymphocyte count and the neutrophil/lymphocyte ratio were calculated. As a control, we used standard values of indicators of age - and sex-matched healthy donors. Results: The endogenous psychosis that developed later after a coronavirus infection (group 2) is associated with a "typical" inflammatory reaction with an increase in the activity of acute phase proteins (according to α1-PI) and degranulation activity of neutrophils (according to LE), which is associated with the development of depressive-delusional states in patients with the dominance of manifestations of positive affectivity (anxiety, melancholy) and the extended nature of delusional disorders, which were predominantly incongruent to affect. On the contrary, the development of endogenous psychosis during the first two months after COVID-19 (group 1) is characterized by a spectrum of inflammatory biomarkers with a decrease in the number of neutrophils and low activity of LE. This immunological profile is associated with the predominance of manifestations of negative affectivity (apathy, asthenia, adynamia) in the structure of depressive-delusional states and the relatively undeveloped nature of delusional disorders, which were predominantly congruent to affect. Conclusion: The clinical and biological correlates presumably indicate the modulating effect of the coronavirus infection (COVID-19) on neuroinflammation and the structure of endogenous psychosis.
MeSH term(s)	Asthenia ; Biomarkers ; COVID-19 ; Female ; Humans ; Leukocyte Elastase/metabolism ; Psychotic Disorders/etiology ; alpha 1-Antitrypsin
Chemical Substances	Biomarkers ; alpha 1-Antitrypsin ; Leukocyte Elastase (EC 3.4.21.37)
Language	Russian
Publishing date	2022-07-07
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	1201462-x
ISSN	2309-4729 ; 1997-7298 ; 0044-4588
ISSN (online)	2309-4729
ISSN	1997-7298 ; 0044-4588
DOI	10.17116/jnevro202212206271
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Article: Kliniko-neirofiziologicheskie korrelyatsii u patsientok molodogo vozrasta s geboidnoi depressiei.

Iznak, A F / Iznak, E V / Damyanovich, E V / Oleichik, I V

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

2022 Volume 122, Issue 6. Vyp. 2, Page(s) 30–35

Abstract: Objective: To determine EEG markers of depression severity and clarify the brain mechanisms of heboid depression by identifying relationships between clinical and neurophysiological parameters in female adolescents with heboid depression.: Material ... ...

Title translation	Clinical-neurophysiological correlations in female adolescents with heboid depression.
Abstract	Objective: To determine EEG markers of depression severity and clarify the brain mechanisms of heboid depression by identifying relationships between clinical and neurophysiological parameters in female adolescents with heboid depression. Material and methods: A clinical-neurophysiological study of 25 female adolescents, aged 16-25 years, mean age 18.7±2.6 years, with heboid depression (ICD-10 items F31.3-F31.4, F34.0) was carried out. The severity of depressive disorders during hospitalization varied from mild to severe - the HDRS-17 total score ranged from 12 to 37 points (average 26.4±6.5 points). To assess the functional state of the brain, a multichannel EEG recording was performed in a state of calm wakefulness with closed eyes (for 2-3 minutes). EEG was recorded in 16 leads: F7, F3, F4, F8, T3, C3, Cz, C4, T4, T5, P3, Pz, P4, T6, O1 and O2. Data analysis was carried out using descriptive and nonparametric statistics programs from the IBM SPSS Statistics, v.22 package. Results: Differences in the EEG of patients from the norm were detected in the alpha frequency range, SpM values of the alpha2 subrange (9-11 Hz) were statistically significantly lower in the frontal areas (in the left frontal lead F3 Conclusion: In patients with heboid depression, there is a functional «uncoupling» of the frontal-central-anterior-temporal areas of the right and left hemispheres of the brain. It is possible that such a «dissociation» and a relatively large activation of the anterior parts of the left rather than the right hemisphere play a role in the weak control of impulsive delinquent behavior in patients with heboid depression. The identified atypical features of the EEG spatial organization and correlations of the EEG frequency structure with clinical parameters are consistent with the atypical clinical picture of heboid depression.
MeSH term(s)	Adolescent ; Adult ; Brain ; Depression/diagnosis ; Electroencephalography ; Emotions ; Female ; Frontal Lobe ; Humans ; Young Adult
Language	Russian
Publishing date	2022-07-07
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	1201462-x
ISSN	2309-4729 ; 1997-7298 ; 0044-4588
ISSN (online)	2309-4729
ISSN	1997-7298 ; 0044-4588
DOI	10.17116/jnevro202212206230
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Article: Isteroformnye depressii u patsientok molodogo vozrasta.

Oleichik, I V / Baranov, P A / Yunilaynen, O A / Khoang, S Z

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

2022 Volume 122, Issue 6. Vyp. 2, Page(s) 12–16

Abstract: Objective: To study the features of the psychopathological structure of depression in young women with hysteroform symptoms, as well as the features of auto-aggressive non-suicidal and suicidal behavior in these conditions.: Material and methods: The ...

Title translation	Hysteroform depressions in young female patients.
Abstract	Objective: To study the features of the psychopathological structure of depression in young women with hysteroform symptoms, as well as the features of auto-aggressive non-suicidal and suicidal behavior in these conditions. Material and methods: The results of a clinical/psychopathological examination of 50 female adolescent patients, aged 16 to 25 years, with endogenous depressions with one of the following ICD-10 diagnosis: (F31.3-4, F34.0, F21.3-4 + F31.3-4, F60.X + F31.3-4) and prevail of hysteroform symptoms in the form of conversion/dissociative disorders in their clinical picture were analyzed. Results: Depression was characterized by an acute onset due to a traumatic situation represented by difficulties in personal or family relationships (36%, Conclusion: Hysteroform depressions in girls are characterized by polymorphism of the psychopathological structure, erosion of the depressive triad, originality of the clinical picture of dissociative disorders, presence of comorbid disorders, and frequent, but with a low danger to life suicidal attempts.
MeSH term(s)	Adolescent ; Anxiety/diagnosis ; Anxiety Disorders ; Depression/diagnosis ; Depression/epidemiology ; Depressive Disorder, Major ; Female ; Humans ; Phobic Disorders/diagnosis
Language	Russian
Publishing date	2022-07-07
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	1201462-x
ISSN	2309-4729 ; 1997-7298 ; 0044-4588
ISSN (online)	2309-4729
ISSN	1997-7298 ; 0044-4588
DOI	10.17116/jnevro202212206212
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