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Book ; Online: Dementia in Parkinson's Disease

Zhang, Lin / Olichney, John M.

Everything you Need to Know

2022

Keywords	Neurology & clinical neurophysiology
Language	0\|e
Size	1 electronic resource (236 pages)
Publisher	IntechOpen
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021613493
ISBN	9781839688454 ; 1839688459
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: AMYLOID CLEARING IMMUNOTHERAPY FOR ALZHEIMER'S DISEASE AND THE RISK OF CEREBRAL AMYLOID ANGIOPATHY.

Kile, Shawn J / Olichney, John M

Alzheimer's disease research journal

2014 Volume 1, Issue 1-2, Page(s) 5–12

Abstract: Immunization strategies which aid in the clearance of beta-amyloid (Aβ) plaques have raised new hopes for the treatment of Alzheimer's disease (AD). Two particularly promising passive immunization therapies currently being investigated include ... ...

Abstract	Immunization strategies which aid in the clearance of beta-amyloid (Aβ) plaques have raised new hopes for the treatment of Alzheimer's disease (AD). Two particularly promising passive immunization therapies currently being investigated include intravenous immunoglobulins (IVIG) containing Aβ antibodies and specifically developed monoclonal antibodies for Aβ. These Aβ antibodies may reduce amyloid accumulation in the brain by binding to the amyloid peptide and drawing it in through the blood-brain barrier for subsequent removal from the capillaries. However, as this strategy aims at removing extracellular amyloid through cerebral vessels, a redistribution of amyloid pathology may manifest as increased cerebral amyloid angiopathy (CAA). CAA occurs when Aβ becomes embedded in the walls of cerebral vessels associated with weakening of the vessel walls. Antibody mediated Aβ clearance from the parenchyma could significantly increase the Aβ burden in the vessel lumen and wall, therefore increasing the risk of vessel rupture and hemorrhage. This chapter will review the current literature on Aβ immunotherapy for AD and explore the mechanisms as well as possible risks of amyloid clearance treatment, particularly cerebral amyloid angiopathy.
Language	English
Publishing date	2014-09-09
Publishing country	United States
Document type	Journal Article
ISSN	1935-2514
ISSN	1935-2514
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Article ; Online: The Role of Glutamate in Language and Language Disorders - Evidence from ERP and Pharmacologic Studies.

Li, Wentao / Kutas, Marta / Gray, John A / Hagerman, Randi H / Olichney, John M

Neuroscience and biobehavioral reviews

2020 Volume 119, Page(s) 217–241

Abstract: Current models of language processing do not address mechanisms at the neurotransmitter level, nor how pharmacologic agents may improve language function(s) in seemingly disparate disorders. L-Glutamate, the primary excitatory neurotransmitter in the ... ...

Abstract	Current models of language processing do not address mechanisms at the neurotransmitter level, nor how pharmacologic agents may improve language function(s) in seemingly disparate disorders. L-Glutamate, the primary excitatory neurotransmitter in the human brain, is extensively involved in various higher cortical functions. We postulate that the physiologic role of L-Glutamate neurotransmission extends to the regulation of language access, comprehension, and production, and that disorders in glutamatergic transmission and circuitry contribute to the pathogenesis of neurodegenerative diseases and sporadic-onset language disorders such as the aphasic stroke syndromes. We start with a review of basic science data pertaining to various glutamate receptors in the CNS and ways that they may influence the physiological processes of language access and comprehension. We then focus on the dysregulation of glutamate neurotransmission in three conditions in which language dysfunction is prominent: Alzheimer's Disease, Fragile X-associated Tremor/Ataxia Syndrome, and Aphasic Stroke Syndromes. Finally, we review the pharmacologic and electrophysiologic (event related brain potential or ERP) data pertaining to the role glutamate neurotransmission plays in language processing and disorders.
MeSH term(s)	Aphasia ; Fragile X Syndrome ; Glutamic Acid ; Humans ; Language ; Tremor
Chemical Substances	Glutamic Acid (3KX376GY7L)
Language	English
Publishing date	2020-10-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	282464-4
ISSN	1873-7528 ; 0149-7634
ISSN (online)	1873-7528
ISSN	0149-7634
DOI	10.1016/j.neubiorev.2020.09.023
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Article ; Online: Event-related potential and EEG oscillatory predictors of verbal memory in mild cognitive impairment.

Xia, Jiangyi / Mazaheri, Ali / Segaert, Katrien / Salmon, David P / Harvey, Danielle / Shapiro, Kim / Kutas, Marta / Olichney, John M

Brain communications

2020 Volume 2, Issue 2, Page(s) fcaa213

Abstract: Reliable biomarkers of memory decline are critical for the early detection of Alzheimer's disease. Previous work has found three EEG measures, namely the event-related brain potential P600, suppression of oscillatory activity in the alpha frequency range ...

Abstract	Reliable biomarkers of memory decline are critical for the early detection of Alzheimer's disease. Previous work has found three EEG measures, namely the event-related brain potential P600, suppression of oscillatory activity in the alpha frequency range (∼10 Hz) and cross-frequency coupling between low theta/high delta and alpha/beta activity, each of which correlates strongly with verbal learning and memory abilities in healthy elderly and patients with mild cognitive impairment or prodromal Alzheimer's disease. In the present study, we address the question of whether event-related or oscillatory measures, or a combination thereof, best predict the decline of verbal memory in mild cognitive impairment and Alzheimer's disease. Single-trial correlation analyses show that despite a similarity in their time courses and sensitivities to word repetition, the P600 and the alpha suppression components are minimally correlated with each other on a trial-by-trial basis (generally \|
Language	English
Publishing date	2020-12-10
Publishing country	England
Document type	Journal Article
ISSN	2632-1297
ISSN (online)	2632-1297
DOI	10.1093/braincomms/fcaa213
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Article ; Online: Cerebral white matter free water: A sensitive biomarker of cognition and function.

Maillard, Pauline / Fletcher, Evan / Singh, Baljeet / Martinez, Oliver / Johnson, David K / Olichney, John M / Farias, Sarah T / DeCarli, Charles

Neurology

2019 Volume 92, Issue 19, Page(s) e2221–e2231

Abstract: Objective: To determine whether free water (FW) content, initially developed to correct metrics derived from diffusion tensor imaging and recently found to be strongly associated with vascular risk factors, may constitute a sensitive biomarker of white ... ...

Abstract	Objective: To determine whether free water (FW) content, initially developed to correct metrics derived from diffusion tensor imaging and recently found to be strongly associated with vascular risk factors, may constitute a sensitive biomarker of white matter (WM) microstructural differences associated with cognitive performance but remains unknown. Methods: Five hundred thirty-six cognitively diverse individuals, aged 77 ± 8 years, received yearly comprehensive clinical evaluations and a baseline MRI examination of whom 224 underwent follow-up MRI. WM microstructural measures, including FW, fractional anisotropy, and mean diffusivity corrected for FW and WM hyperintensity burden were computed within WM voxels of each individual. Baseline and change in MRI metrics were then used as independent variables to explain baseline and change in episodic memory (EM), executive function (EF), and Clinical Dementia Rating (CDR) scores using linear, logistic, and Cox proportional-hazards regressions. Results: Higher baseline FW and WM hyperintensity were associated with lower baseline EM and EF, higher baseline CDR, accelerated EF and EM decline, and higher probability to transition to a more severe CDR stage ( Conclusions: This study finds cross-sectional and longitudinal associations between FW content and trajectory of cognitive and functional performance in a large sample of cognitively diverse individuals. It supports the need to investigate the pathophysiologic process that manifests increased FW, potentially leading to more severe WM territory injury and promoting cognitive and functional decline.
MeSH term(s)	Aged ; Aged, 80 and over ; Anisotropy ; Biomarkers/analysis ; Brain/diagnostic imaging ; Brain/physiology ; Cognition/physiology ; Cross-Sectional Studies ; Executive Function/physiology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuropsychological Tests ; Water/analysis ; White Matter/chemistry ; White Matter/diagnostic imaging ; White Matter/physiology
Chemical Substances	Biomarkers ; Water (059QF0KO0R)
Language	English
Publishing date	2019-04-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000007449
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Article: High-Density Lipoprotein Changes in Alzheimer's Disease Are

Hong, Brian V / Zheng, Jingyuan / Agus, Joanne K / Tang, Xinyu / Lebrilla, Carlito B / Jin, Lee-Way / Maezawa, Izumi / Erickson, Kelsey / Harvey, Danielle J / DeCarli, Charles S / Mungas, Dan M / Olichney, John M / Farias, Sarah T / Zivkovic, Angela M

Biomedicines

2022 Volume 10, Issue 7

Abstract: High-density lipoproteins (HDL) play a critical role in cholesterol homeostasis. Apolipoprotein E ( ...

Abstract	High-density lipoproteins (HDL) play a critical role in cholesterol homeostasis. Apolipoprotein E (
Language	English
Publishing date	2022-06-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10071495
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Article: From amnesia to dementia: ERP studies of memory and language.

Taylor, Jason R / Olichney, John M

Clinical EEG and neuroscience

2007 Volume 38, Issue 1, Page(s) 8–17

Abstract: Cognitive event-related potential (ERP) studies of memory and language impairments in amnesia and Alzheimer's disease (AD) are reviewed. Well-circumscribed lesions of the medial temporal lobe (MTL) or diencephalon causing an amnestic syndrome, an ... ...

Abstract	Cognitive event-related potential (ERP) studies of memory and language impairments in amnesia and Alzheimer's disease (AD) are reviewed. Well-circumscribed lesions of the medial temporal lobe (MTL) or diencephalon causing an amnestic syndrome, an inability to encode and retrieve episodic memories beyond the brief duration of working memory, appear to produce altered plasticity of the late positive P600 component, but usually spare P300 and N400 components. The neuropathology of AD affects MTL and extends to neocortical association areas, causing deficits of episodic and semantic memory. In AD dementia, the P300, N400, and P600 all commonly show abnormalities. ERP studies of individuals with mild cognitive impairment may reveal neurophysiological changes prior to the emergence of clinical deficits, which could advance the early detection and diagnosis of AD.
MeSH term(s)	Amnesia/physiopathology ; Brain/physiopathology ; Brain Mapping/methods ; Clinical Trials as Topic ; Dementia/physiopathology ; Electroencephalography/methods ; Evoked Potentials ; Humans ; Language ; Language Disorders/physiopathology ; Memory
Language	English
Publishing date	2007-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	2140201-2
ISSN	1550-0594 ; 0009-9155
ISSN	1550-0594 ; 0009-9155
DOI	10.1177/155005940703800106
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Article ; Online: Association of vascular brain injury, neurodegeneration, amyloid, and cognitive trajectory.

Han, Ji Won / Maillard, Pauline / Harvey, Danielle / Fletcher, Evan / Martinez, Oliver / Johnson, David K / Olichney, John M / Farias, Sarah T / Villeneuve, Sylvia / Jagust, William / Mungas, Dan / DeCarli, Charles

Neurology

2020 Volume 95, Issue 19, Page(s) e2622–e2634

Abstract: Objective: To determine whether vascular and neurodegenerative factors influence cognition before clinically relevant Alzheimer disease pathology, we analyzed MRI measures and amyloid imaging in an ethnoracially diverse cohort of cognitively normal ... ...

Abstract	Objective: To determine whether vascular and neurodegenerative factors influence cognition before clinically relevant Alzheimer disease pathology, we analyzed MRI measures and amyloid imaging in an ethnoracially diverse cohort of cognitively normal individuals older than 60 years. Methods: Participants (n = 154; mean age 74.15 ± 6.94; 50% female; 54% Caucasian, 22.1% Hispanic, 14.9% African American) were recruited from the University of California, Davis Alzheimer's Disease Research Center, who were cognitively normal at baseline, time of PET, and MRI, and received yearly cognitive assessment for 6.23 ± 4.16 years. Mixed model regression with random slope and intercept was calculated for episodic memory and executive function, adjusting for age, sex, education, and ethnicity. Results: Vascular burden score was associated with total white matter hyperintensity (WMH) volume (β, 0.171; 95% confidence interval [CI], 0.024-0.318). WMH volume was associated with low baseline executive function (-0.115; -0.226 to -0.003) and rate of change in memory (-0.029; -0.045 to -0.012). Hippocampal volume was associated with the rate of change in memory (0.040; 0.021-0.059) and executive function (0.024; 0.008-0.039). Continuous measures of amyloid status influenced change in memory (-0.026; -0.044 to -0.008) and executive function (-0.033; -0.046 to -0.021) independently of MRI measures. Conclusion: Vascular brain injury and neurodegeneration are associated with baseline cognitive performance and the rate of longitudinal change independent of amyloid status among community-dwelling, ethnicity diverse cognitively normal individuals, supporting the role of vascular diseases as risk factors for later-life dementia.
MeSH term(s)	Aged ; Aged, 80 and over ; Amyloid beta-Peptides/metabolism ; Aniline Compounds ; Brain/diagnostic imaging ; Brain/metabolism ; Cerebrovascular Disorders/physiopathology ; Cognition/physiology ; Cognitive Dysfunction/physiopathology ; Disease Progression ; Executive Function/physiology ; Female ; Hippocampus/diagnostic imaging ; Hippocampus/pathology ; Humans ; Independent Living ; Magnetic Resonance Imaging ; Male ; Memory Disorders/physiopathology ; Memory, Episodic ; Neuropsychological Tests ; Organ Size ; Plaque, Amyloid/diagnostic imaging ; Positron-Emission Tomography ; Thiazoles ; White Matter/diagnostic imaging ; White Matter/pathology
Chemical Substances	2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole ; Amyloid beta-Peptides ; Aniline Compounds ; Thiazoles
Language	English
Publishing date	2020-07-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000010531
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Article: Plasma biomarkers predict cognitive trajectories in an ethnoracially and clinically diverse cohort: Mediation with hippocampal volume.

Sapkota, Shraddha / Erickson, Kelsey / Harvey, Danielle / Tomaszewski-Farias, Sarah E / Olichney, John M / Johnson, David K / Dugger, Brittany N / Mungas, Dan M / Fletcher, Evan / Maillard, Pauline / Seshadri, Sudha / Satizabal, Claudia L / Kautz, Tiffany / Parent, Danielle / Tracy, Russell P / Maezawa, Izumi / Jin, Lee-Way / DeCarli, Charles

Alzheimer's & dementia (Amsterdam, Netherlands)

2022 Volume 14, Issue 1, Page(s) e12349

Abstract: Introduction: We examine whether the association between key plasma biomarkers (amyloid β [aβ] 42/40, total tau (t-tau), neurofilament light [NfL]) and cognitive trajectories (executive function [EF] and episodic memory [EM]) is mediated through ... ...

Abstract	Introduction: We examine whether the association between key plasma biomarkers (amyloid β [aβ] 42/40, total tau (t-tau), neurofilament light [NfL]) and cognitive trajectories (executive function [EF] and episodic memory [EM]) is mediated through neurodegeneration. Methods: All participants were recruited from the University of California, Davis-Alzheimer's Disease Research Center ( Results: HV differentially mediated the association aβ 42/40 and NfL on EF and EM level and change. Hippocampal volume (HV) did not mediate the association between t-tau and cognitive performance. Discussion: Neurodegeneration as represented with HV selectively mediates the association between key non-invasive plasma biomarkers and cognitive trajectories in an ethnoracially and clinically diverse community-based sample.
Language	English
Publishing date	2022-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2832898-X
ISSN	2352-8729
ISSN	2352-8729
DOI	10.1002/dad2.12349
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Article: Neurodegenerative disorders with diffuse cortical Lewy bodies.

Fleisher, Adam S / Olichney, John M

Advances in neurology

2005 Volume 96, Page(s) 148–165

MeSH term(s)	Cerebral Cortex/metabolism ; Cerebral Cortex/pathology ; Cerebral Cortex/physiopathology ; Cognition Disorders/metabolism ; Cognition Disorders/pathology ; Cognition Disorders/physiopathology ; Humans ; Incidence ; Lewy Bodies/pathology ; Lewy Body Disease/epidemiology ; Lewy Body Disease/metabolism ; Lewy Body Disease/pathology ; Lewy Body Disease/physiopathology ; Neurodegenerative Diseases/epidemiology ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Neurodegenerative Diseases/physiopathology ; Risk Factors ; Synucleins/metabolism
Chemical Substances	Synucleins
Language	English
Publishing date	2005
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ISSN	0091-3952
ISSN	0091-3952
Database	MEDical Literature Analysis and Retrieval System OnLINE

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