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  1. Article ; Online: Devices for osteoarthritis symptoms treatment: a patent review.

    Santos, Mariana Mendonça / Santos, Anamaria Mendonça / Carvalho Nascimento, José Adão / Santana, Cláudio Carvalho / Oliveira, Ana Maria Santos / Cezar, Silvia Vitoria Silva / Santos, Alcimary Bispo / Frank, Luiza Abrahão / Serafini, Mairim Russo

    Expert review of medical devices

    2024  Volume 21, Issue 1-2, Page(s) 91–107

    Abstract: Introduction: Osteoarthritis is a musculoskeletal disease that can lead to the loss and inability of those affected to perform normal daily functions, which leads to a decrease in quality of life. The main symptoms of osteoarthritis are tenderness, ... ...

    Abstract Introduction: Osteoarthritis is a musculoskeletal disease that can lead to the loss and inability of those affected to perform normal daily functions, which leads to a decrease in quality of life. The main symptoms of osteoarthritis are tenderness, joint pain, stiffness, crepitus, limited movement, and local inflammation.
    Areas covered: The selected patents were deposited from 2010 to April 2022 involving 57 documents that were in line with the study objective in the final selection. The patents were classified in years, country, and applicants. Also, the therapeutic fields that presented the most documents were electrical stimulation, phototherapy, and ultrasound, followed by magnetic, electromagnetic, and thermotherapy. Therefore, the most current therapies used in the documents are already on the market.
    Expert opinion: Although the OA is cureless, non-surgical treatments are classified as the primary management approach for this disease. The pharmacological and non-pharmacological therapies are employed to reduce its prevalence and ensure the effectiveness of treatments. A strategy for relieving OA symptoms is non-pharmacological treatment, which can be based on exercise and patient education, combined with other alternative therapies. These therapies are used as supplements to the main OA treatments, enhancing the effectiveness of treatment outcomes.
    MeSH term(s) Humans ; Quality of Life ; Osteoarthritis/therapy ; Hyperthermia, Induced ; Inflammation ; Exercise
    Language English
    Publishing date 2024-02-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2250857-0
    ISSN 1745-2422 ; 1743-4440
    ISSN (online) 1745-2422
    ISSN 1743-4440
    DOI 10.1080/17434440.2023.2298729
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The use of natural extracts with photoprotective activity: a 2015-2023 patent prospection.

    Oliveira, Ana Maria Santos / de Souza Batista, Daniel / de Castro, Tailaine Nascimento / Alves, Izabel Almeida / Souto, Ricardo Bizogne / Mota, Milleno Dantas / Serafini, Mairim Russo / Rajkumar, Gomathi / Cazedey, Edith Cristina Laignier

    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

    2024  

    Abstract: Synthetic sunscreen offers protection against excessive exposure to ultraviolet (UV) radiation from the sun, and protects the skin from possible damage. However, they have low efficacy against the formation of reactive oxygen species (ROS), which are ... ...

    Abstract Synthetic sunscreen offers protection against excessive exposure to ultraviolet (UV) radiation from the sun, and protects the skin from possible damage. However, they have low efficacy against the formation of reactive oxygen species (ROS), which are highly reactive molecules that can be generated in the skin when it is exposed to UV radiation, and are known to play a role in oxidative stress, which can contribute to skin aging and damage. Thus, there is an ongoing search for sunscreens that do not have these negative effects. One promising source for these is natural products. Therefore, the current patent review summarizes topical formulations made from natural compounds that have antioxidant properties and can be used as photoprotective or anti-aging agents, either using a single natural extract or a combination of extracts. The review reports basic patent information (applicant country, type of applicant, and year of filing) and gives details about the invention, including its chemical composition, and the in vitro and in vivo tests performed. These patents describe natural products that can be used to protect the skin and validate their efficacy, and safety, in addition to standardizing their formulations. The compositions described illustrate the consistent innovation in the use of natural products to protect against UV damage and photoaging disorders, a promising field which is receiving growing global recognition.
    Language English
    Publishing date 2024-04-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2072584-X
    ISSN 1474-9092 ; 1474-905X
    ISSN (online) 1474-9092
    ISSN 1474-905X
    DOI 10.1007/s43630-024-00559-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Pharmaceuticals agents for preventing NSAID-induced gastric ulcers: a patent review.

    Teixeira, Daiane Franco / Santos, Anamaria Mendonça / Oliveira, Ana Maria Santos / Nascimento Júnior, José Adão Carvalho / Frank, Luiza Abrahão / Santana Souza, Marilia Trindade De / Camargo, Enilton Aparecido / Serafini, Mairim Russo

    Expert review of clinical pharmacology

    2021  Volume 14, Issue 6, Page(s) 677–686

    Abstract: Introduction: Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of drugs widely used due to their pharmacological potential, demonstrating anti-inflammatory, analgesic, or antipyretic activity. However, prolonged use of these medications can ... ...

    Abstract Introduction: Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of drugs widely used due to their pharmacological potential, demonstrating anti-inflammatory, analgesic, or antipyretic activity. However, prolonged use of these medications can lead to the development of gastric ulcers in patients. This review aimed to find patents for drugs with an anti-inflammatory and gastroprotective character to treat NSAID-induced gastric ulcers.
    Areas covered: For the treatment of NSAID-induced gastric ulcers, formulations with different action mechanisms were found, including donors of nitric oxide, heterocyclic compounds, and natural products.
    Expert opinion: Many of the structures found have already been used in clinic settings and others, and according to the results found, they are promising for the treatment of gastric ulcers.
    MeSH term(s) Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Anti-Ulcer Agents/administration & dosage ; Anti-Ulcer Agents/pharmacology ; Biological Products/administration & dosage ; Biological Products/pharmacology ; Heterocyclic Compounds/administration & dosage ; Heterocyclic Compounds/pharmacology ; Humans ; Nitric Oxide Donors/administration & dosage ; Nitric Oxide Donors/pharmacology ; Patents as Topic ; Stomach Ulcer/chemically induced ; Stomach Ulcer/prevention & control
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Anti-Ulcer Agents ; Biological Products ; Heterocyclic Compounds ; Nitric Oxide Donors
    Language English
    Publishing date 2021-04-12
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1751-2441
    ISSN (online) 1751-2441
    DOI 10.1080/17512433.2021.1909475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Trends in MERS-CoV, SARS-CoV, and SARS-CoV-2 (COVID-19) Diagnosis Strategies: A Patent Review.

    Nascimento Junior, José Adão Carvalho / Santos, Anamaria Mendonça / Oliveira, Ana Maria Santos / Guimarães, Adriana Gibara / Quintans-Júnior, Lucindo José / Coutinho, Henrique Douglas Melo / Martins, Natália / Borges, Lysandro Pinto / Serafini, Mairim Russo

    Frontiers in public health

    2020  Volume 8, Page(s) 563095

    Abstract: The emergence of a new coronavirus (SARS-CoV-2) outbreak represents a challenge for the diagnostic laboratories responsible for developing test kits to identify those infected with SARS-CoV-2. Methods with rapid and accurate detection are essential to ... ...

    Abstract The emergence of a new coronavirus (SARS-CoV-2) outbreak represents a challenge for the diagnostic laboratories responsible for developing test kits to identify those infected with SARS-CoV-2. Methods with rapid and accurate detection are essential to control the sources of infection, to prevent the spread of the disease and to assist decision-making by public health managers. Currently, there is a wide variety of tests available with different detection methodologies, levels of specificity and sensitivity, detection time, and with an extensive range of prices. This review therefore aimed to conduct a patent search in relation to tests for the detection of SARS-CoV, MERS-CoV, and SARS-CoV-2. The greatest number of patents identified in the search were registered between 2003 and 2011, being mainly deposited by China, the Republic of Korea, and the United States. Most of the patents used the existing RT-PCR, ELISA, and isothermal amplification methods to develop simple, sensitive, precise, easy to use, low-cost tests that reduced false-negative or false-positive results. The findings of this patent search show that an increasing number of materials and diagnostic tests for the coronavirus are being produced to identify infected individuals and combat the growth of the current pandemic; however, there is still a question in relation to the reliability of the results of these tests.
    MeSH term(s) COVID-19 ; China ; Humans ; Middle East Respiratory Syndrome Coronavirus/genetics ; Reproducibility of Results ; Republic of Korea ; SARS-CoV-2 ; Sensitivity and Specificity
    Keywords covid19
    Language English
    Publishing date 2020-10-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2711781-9
    ISSN 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2020.563095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Evaluation of the Use of Compressive Stockings Impregnated With Hesperetin-Based Nanocapsules in the Healing of Venous Ulcers: A Case Report.

    Menezes, Paula Dos Passos / Gomes, Cristiane Vilaça Campos / de Carvalho, Yasmim Maria Barbosa Gomes / Santos, Nayara Gomes Lima / Andrade, Valléria Matos / Oliveira, Ana Maria Santos / de Lima, Cláudio Moreira / Araújo, Adriano Antunes de Souza

    Clinical medicine insights. Case reports

    2019  Volume 12, Page(s) 1179547619858977

    Abstract: Venous ulcers are a more severe complication of chronic venous insufficiency, significantly compromising patient quality of life (QoL). Compressive stockings are still the gold standard treatment method with alternative therapies currently being ... ...

    Abstract Venous ulcers are a more severe complication of chronic venous insufficiency, significantly compromising patient quality of life (QoL). Compressive stockings are still the gold standard treatment method with alternative therapies currently being evaluated. In this perspective, we investigate the influence of compressive stockings impregnated with hesperetin-based nanocapsules in the healing process of venous ulcers. Compressive stockings impregnated with hesperetin-based nanocapsules were applied to a consenting patient for 6 months following all relevant ethical principles for patient studies. The patient was evaluated at baseline (T0), 3 months (T3), and 6 months (T6), using photographic register (healing) probes to measure skin melanin, erythema and hydration parameters, and venous diameters, followed by questionnaires regarding QoL and pain perception. Healing was observed at the 3-month time point and with 91.6% and 93.1% of retraction area in larger ulcers of the right leg and lateral portion of the left leg, respectively. The deepest ulcer in a medial portion of the left leg healed 47.3%. A reduction of all measured skin parameters was observed, indicating a possible hesperetin effect. The scores of QoL and pain were, respectively, in the ranges of 91.6 to 31.2 and 7 to 0. Reduction in venous diameters also indicates healing function. These preliminary findings suggest that compressive stockings impregnated with hesperetin nanocapsules enhance venous ulcer healing. Further clinical trial controlled by placebo, involving a greater number of patients, is required to confirm the findings of this case report.
    Language English
    Publishing date 2019-07-18
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2580498-4
    ISSN 1179-5476
    ISSN 1179-5476
    DOI 10.1177/1179547619858977
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Trends in MERS-CoV, SARS-CoV, and SARS-CoV-2 (COVID-19) Diagnosis Strategies

    Nascimento Junior, José Adão Carvalho / Santos, Anamaria Mendonça / Oliveira, Ana Maria Santos / Guimarães, Adriana Gibara / Quintans-Júnior, Lucindo José / Coutinho, Henrique Douglas Melo / Martins, Natália / Borges, Lysandro Pinto / Serafini, Mairim Russo

    Frontiers in Public Health

    A Patent Review

    2020  Volume 8

    Keywords covid19
    Publisher Frontiers Media SA
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 2711781-9
    ISSN 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2020.563095
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Otoliths-composed gelatin/sodium alginate scaffolds for bone regeneration.

    Valido, Daisy Pereira / Júnior, Wilson Déda Gonçalves / de Andrade, Maria Eliane / Rezende, Allan Andrade / de Andrade de Carvalho, Felipe Mendes / de Lima, Renata / das Graças Gomes Trindade, Gabriela / de Alcântara Campos, Caio / Oliveira, Ana Maria Santos / de Souza, Eloísa Portugal Barros Silva Soares / Frank, Luiza Abrahão / Guterres, Silvia Stanisçuaski / Sussuchi, Eliana Midori / Matos, Charlene Regina Santos / Polloni, André / de Souza Araújo, Adriano Antunes / Padilha, Francine Ferreira / Severino, Patrícia / Souto, Eliana Barbosa /
    de Albuquerque Júnior, Ricardo Luiz Cavalcanti

    Drug delivery and translational research

    2020  Volume 10, Issue 6, Page(s) 1716–1728

    Abstract: Evidence that otoliths, mineral-rich limestone concrescences present in the inner ear of bone fishes, can accelerate bone formation in vivo has been previously reported. The goal of this work was the development, characterization, and evaluation of the ... ...

    Abstract Evidence that otoliths, mineral-rich limestone concrescences present in the inner ear of bone fishes, can accelerate bone formation in vivo has been previously reported. The goal of this work was the development, characterization, and evaluation of the cytocompatibility of otoliths-incorporated sodium alginate and gelatin scaffolds. Cynoscion acoupa-derived otoliths were characterized by X-ray fluorescence spectrometry (FRX), particle size, free lime, and weight loss by calcination. Furthermore, otoliths were incorporated into sodium alginate (ALG/OTL-s) or gelatin (GEL/OTL-s) scaffolds, previously developed by freeze-drying. Then, the scaffolds were characterized by thermogravimetric analysis (TGA/DTG), differential scanning calorimetry (DSC), infrared spectroscopy with Fourier transform (FTIR), swelling tests, and scanning electron microscopy (SEM). Cytotoxicity assays were run against J774.G8 macrophages and MC3T3-E1 osteoblasts. Data obtained from TGA/DTG, DSC, and FTIR analyses confirmed the interaction between otoliths and the polymeric scaffolds. SEM showed the homogeneous porous 3D structure rich in otolith micro-fragments in both scaffolds. Swelling of the GEL/OTL-s (63.54 ± 3.0%) was greater than of ALG/OTL-s (13.36 ± 9.9%) (p < 0.001). The viability of J774.G8 macrophages treated with both scaffolds was statistically similar to the group treated with DMEM only (p > 0.05) and significantly higher than that treated with Triton-X (p < 0.01) at 72 h. Both scaffolds showed approximately 100% growth of MC3T3-E1 osteoblasts by 24 h, similarly to control (p > 0.05). However, by 48 h, only ALG/OTL-s showed growth similar to control (p > 0.05), whereas GEL/OTL showed a significantly lower growth index (p < 0.05). In conclusion, the physicochemical profiles suggest proper interaction between the otoliths and the two developed polymeric 3D scaffolds. Moreover, both materials showed cytocompatibility with J774.G8 macrophages but the growth of MC3T3-E1 osteoblasts was higher when exposed to ALG/OTL-s. These data suggest that sodium alginate/otoliths scaffolds are potential biomaterials to be used in bone regeneration applications. Graphical abstract.
    MeSH term(s) 3T3 Cells ; Alginates ; Animals ; Biocompatible Materials ; Bone Regeneration ; Gelatin ; Mice ; Otolithic Membrane ; Porosity ; Spectroscopy, Fourier Transform Infrared ; Tissue Engineering ; Tissue Scaffolds
    Chemical Substances Alginates ; Biocompatible Materials ; Gelatin (9000-70-8)
    Keywords covid19
    Language English
    Publishing date 2020-09-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2590155-2
    ISSN 2190-3948 ; 2190-393X
    ISSN (online) 2190-3948
    ISSN 2190-393X
    DOI 10.1007/s13346-020-00845-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Otoliths-composed gelatin/sodium alginate scaffolds for bone regeneration

    Valido, Daisy Pereira / Júnior, Wilson Déda Gonçalves / de Andrade, Maria Eliane / Rezende, Allan Andrade / de Andrade de Carvalho, Felipe Mendes / de Lima, Renata / das Graças Gomes Trindade, Gabriela / de Alcântara Campos, Caio / Oliveira, Ana Maria Santos / de Souza, Eloísa Portugal Barros Silva Soares / Frank, Luiza Abrahão / Guterres, Silvia Stanisçuaski / Sussuchi, Eliana Midori / Matos, Charlene Regina Santos / Polloni, André / de Souza Araújo, Adriano Antunes / Padilha, Francine Ferreira / Severino, Patrícia / Souto, Eliana Barbosa /
    de Albuquerque Júnior, Ricardo Luiz Cavalcanti

    Drug deliv. transl. res. (Internet)

    Abstract: Evidence that otoliths, mineral-rich limestone concrescences present in the inner ear of bone fishes, can accelerate bone formation in vivo has been previously reported. The goal of this work was the development, characterization, and evaluation of the ... ...

    Abstract Evidence that otoliths, mineral-rich limestone concrescences present in the inner ear of bone fishes, can accelerate bone formation in vivo has been previously reported. The goal of this work was the development, characterization, and evaluation of the cytocompatibility of otoliths-incorporated sodium alginate and gelatin scaffolds. Cynoscion acoupa-derived otoliths were characterized by X-ray fluorescence spectrometry (FRX), particle size, free lime, and weight loss by calcination. Furthermore, otoliths were incorporated into sodium alginate (ALG/OTL-s) or gelatin (GEL/OTL-s) scaffolds, previously developed by freeze-drying. Then, the scaffolds were characterized by thermogravimetric analysis (TGA/DTG), differential scanning calorimetry (DSC), infrared spectroscopy with Fourier transform (FTIR), swelling tests, and scanning electron microscopy (SEM). Cytotoxicity assays were run against J774.G8 macrophages and MC3T3-E1 osteoblasts. Data obtained from TGA/DTG, DSC, and FTIR analyses confirmed the interaction between otoliths and the polymeric scaffolds. SEM showed the homogeneous porous 3D structure rich in otolith micro-fragments in both scaffolds. Swelling of the GEL/OTL-s (63.54 ± 3.0%) was greater than of ALG/OTL-s (13.36 ± 9.9%) (p < 0.001). The viability of J774.G8 macrophages treated with both scaffolds was statistically similar to the group treated with DMEM only (p > 0.05) and significantly higher than that treated with Triton-X (p < 0.01) at 72 h. Both scaffolds showed approximately 100% growth of MC3T3-E1 osteoblasts by 24 h, similarly to control (p > 0.05). However, by 48 h, only ALG/OTL-s showed growth similar to control (p > 0.05), whereas GEL/OTL showed a significantly lower growth index (p < 0.05). In conclusion, the physicochemical profiles suggest proper interaction between the otoliths and the two developed polymeric 3D scaffolds. Moreover, both materials showed cytocompatibility with J774.G8 macrophages but the growth of MC3T3-E1 osteoblasts was higher when exposed to ALG/OTL-s. These data suggest that sodium alginate/otoliths scaffolds are potential biomaterials to be used in bone regeneration applications. Graphical abstract.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32901369
    Database COVID19

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