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  1. Article ; Online: Central hypersomnia and chronic insomnia: expanding the spectrum of sleep disorders in long COVID syndrome - a prospective cohort study.

    Moura, Alissa Elen Formiga / Oliveira, Danilo Nunes / Torres, Danielle Mesquista / Tavares-Júnior, José Wagner Leonel / Nóbrega, Paulo Ribeiro / Braga-Neto, Pedro / Sobreira-Neto, Manoel Alves

    BMC neurology

    2022  Volume 22, Issue 1, Page(s) 417

    Abstract: Introduction: Long-onset COVID syndrome has been described in patients with COVID-19 infection with persistence of symptoms or development of sequelae beyond 4 weeks after the onset of acute symptoms, a medium- and long-term consequence of COVID-19. ... ...

    Abstract Introduction: Long-onset COVID syndrome has been described in patients with COVID-19 infection with persistence of symptoms or development of sequelae beyond 4 weeks after the onset of acute symptoms, a medium- and long-term consequence of COVID-19. This syndrome can affect up to 32% of affected individuals, with symptoms of fatigue, dyspnea, chest pain, cognitive disorders, insomnia, and psychiatric disorders. The present study aimed to characterize and evaluate the prevalence of sleep symptoms in patients with long COVID syndrome.
    Methodology: A total of 207 patients with post-COVID symptoms were evaluated through clinical evaluation with a neurologist and specific exams in the subgroup complaining of excessive sleepiness.
    Results: Among 189 patients included in the long COVID sample, 48 (25.3%) had sleep-related symptoms. Insomnia was reported by 42 patients (22.2%), and excessive sleepiness (ES) was reported by 6 patients (3.17%). Four patients with ES were evaluated with polysomnography and test, multiple sleep latencies test, and actigraphic data. Two patients had a diagnosis of central hypersomnia, and one had narcolepsy. A history of steroid use was related to sleep complaints (insomnia and excessive sleepiness), whereas depression was related to excessive sleepiness. We observed a high prevalence of cognitive complaints in these patients.
    Conclusion: Complaints related to sleep, such as insomnia and excessive sleepiness, seem to be part of the clinical post-acute syndrome (long COVID syndrome), composing part of its clinical spectrum, relating to some clinical data.
    MeSH term(s) Humans ; Sleep Initiation and Maintenance Disorders/epidemiology ; COVID-19/complications ; COVID-19/epidemiology ; Prospective Studies ; Sleepiness ; Disorders of Excessive Somnolence/diagnosis ; Disorders of Excessive Somnolence/epidemiology ; Sleep Wake Disorders/epidemiology ; Syndrome
    Language English
    Publishing date 2022-11-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041347-6
    ISSN 1471-2377 ; 1471-2377
    ISSN (online) 1471-2377
    ISSN 1471-2377
    DOI 10.1186/s12883-022-02940-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Post-COVID-19 Cognitive Decline and Apoe Polymorphism: Towards a Possible Link?

    Tavares-Júnior, José Wagner Leonel / Oliveira, Danilo Nunes / da Silva, Jean Breno Silveira / Queiroz Feitosa, Werbety Lucas / Sousa, Artur Victor Menezes / Marinho, Samuel Cavalcante / Cunha, Letícia Chaves Vieira / Gaspar, Safira de Brito / Gomes, Carmem Meyve Pereira / de Oliveira, Laís Lacerda Brasil / Moreira-Nunes, Caroline Aquino / Sobreira, Emmanuelle Silva Tavares / Moraes, Maria Elisabete Amaral de / Sobreira-Neto, Manoel Alves / Montenegro, Raquel Carvalho / Braga-Neto, Pedro

    Brain sciences

    2023  Volume 13, Issue 12

    Abstract: ... ...

    Abstract APOE
    Language English
    Publishing date 2023-11-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci13121611
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Covid-19 post-infectious acute transverse myelitis responsive to corticosteroid therapy: report of two clinical cases.

    Vasconcelos, Thaís de Maria Frota / Oliveira, Danilo Nunes / Ferreira, Glauber de Menezes / Torres, Fabrícia Carneiro / Castro, José Daniel Vieira de / Braga-Neto, Pedro / Sobreira-Neto, Manoel Alves

    Journal of neurovirology

    2021  Volume 27, Issue 5, Page(s) 791–796

    Abstract: SARS-COV-2 infection has affected millions of individuals with a wide range of clinical manifestations, including central and peripheral nervous systems through several mechanisms. A rare but potentially severe manifestation of this virus is transverse ... ...

    Abstract SARS-COV-2 infection has affected millions of individuals with a wide range of clinical manifestations, including central and peripheral nervous systems through several mechanisms. A rare but potentially severe manifestation of this virus is transverse myelitis. Herein, we report on two patients who developed paraparesis, sensory deficit, and autonomic changes on the tenth day after infection by COVID-19. A 27-year-old man, previously healthy, had symptoms of COVID-19 confirmed by oropharyngeal and nasopharyngeal swab tests. On the tenth day of symptoms, the patient started to experience acute paraparesis, urinary retention, constipation, and hypoesthesia up to the T4 level. The second patient is a 50-year-old man, previously healthy, who had symptoms of the flu-like syndrome. The diagnosis of COVID-19 infection was confirmed by oropharyngeal and nasopharyngeal swab tests. On the tenth day of symptoms, the patient started to experience paraparesis, urinary incontinence, and hypoesthesia up to the T6 level. The neuroimaging and cerebrospinal fluid (CSF) analysis of both patients confirmed acute transverse myelitis after COVID-19 infection. High-dose corticosteroid therapy was started, and both patients showed rapid recovery from their deficits. Although rare, post-infectious transverse myelitis may be related to SARS-COV-2 infection and should be quickly recognized. Although controlled studies are needed, treatment with corticosteroid therapy in high doses was effective in these patients.
    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Adult ; COVID-19/complications ; Humans ; Male ; Middle Aged ; Myelitis, Transverse/drug therapy ; Myelitis, Transverse/virology ; SARS-CoV-2
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2021-08-27
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1283265-0
    ISSN 1538-2443 ; 1355-0284
    ISSN (online) 1538-2443
    ISSN 1355-0284
    DOI 10.1007/s13365-021-01010-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Long-covid cognitive impairment: Cognitive assessment and apolipoprotein E (APOE) genotyping correlation in a Brazilian cohort.

    Tavares-Júnior, José Wagner Leonel / Oliveira, Danilo Nunes / da Silva, Jean Breno Silveira / Feitosa, Werbety Lucas Queiroz / Sousa, Artur Victor Menezes / Cunha, Letícia Chaves Vieira / Gaspar, Safira de Brito / Gomes, Carmem Meyve Pereira / de Oliveira, Laís Lacerda Brasil / Moreira-Nunes, Caroline Aquino / Montenegro, Raquel Carvalho / Sobreira-Neto, Manoel Alves / Braga-Neto, Pedro

    Frontiers in psychiatry

    2022  Volume 13, Page(s) 947583

    Abstract: Introduction: Few studies have objectively evaluated cognitive deficits after the acute phase of COVID-19 disease. Moreover, the role of apolipoprotein E (APOE) genotypes in cognitive decline in patients with COVID-19 has not been evaluated yet.: ... ...

    Abstract Introduction: Few studies have objectively evaluated cognitive deficits after the acute phase of COVID-19 disease. Moreover, the role of apolipoprotein E (APOE) genotypes in cognitive decline in patients with COVID-19 has not been evaluated yet.
    Methods: This cross-sectional study was conducted in confirmed cases of COVID-19 patients with neurological symptoms that persisted for more than 3 months from the onset. We determined APOE genotypes.
    Results: The final sample consisted of 141 patients. The most frequent APOE genotype was E3/E3 (
    Discussion: Hospitalized patients had more severe infection with a greater possibility of systemic complications, greater inflammatory response, and prolonged hospitalization, which could impact cognitive performance. Cognitive impairment in patients with COVID-19 does not necessarily involve specific APOE polymorphisms. However, psychiatric disorders may also be responsible for cognitive complaints. Cognitive complaints are frequent in patients with COVID-19, even after the acute phase of the disease and in mild cases. Hospitalized participants and depressed patients may have a higher risk of cognitive impairment. APOE genotypes or haplotypes may not significantly play a role in COVID-19 cognitive impairment.
    Language English
    Publishing date 2022-08-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2022.947583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Characterization of Headache in COVID-19: a Retrospective Multicenter Study.

    Dos Anjos de Paula, Rafael César / de Maria Frota Vasconcelos, Thaís / da Costa, Francisco Bruno Santana / de Brito, Lara Albuquerque / Torres, Danielle Mesquita / Moura, Alissa Elen Formiga / Oliveira, Danilo Nunes / de Lima Henn, Guilherme Alves / Rodrigues, Pedro Gustavo Barros / de Sousa Pereira, Isabelle / Braga, Ianna Lacerda Sampaio / Rocha, Felipe Araújo / Frota, Norberto Anízio Ferreira / Carvalho, Fernanda Martins Maia / Pitombeira, Milena Sales / Tavares-Junior, José Wagner Leonel / Montenegro, Raquel Carvalho / Braga-Neto, Pedro / Nóbrega, Paulo Ribeiro /
    Sobreira-Neto, Manoel Alves

    Molecular neurobiology

    2021  Volume 58, Issue 9, Page(s) 4487–4494

    Abstract: Headache is the most common neurological symptom in COVID-19, reported in 6.5 to 34% of patients. Few studies have analyzed its characteristics, and some of them included cases without laboratory confirmation or reported only critical patients. We aimed ... ...

    Abstract Headache is the most common neurological symptom in COVID-19, reported in 6.5 to 34% of patients. Few studies have analyzed its characteristics, and some of them included cases without laboratory confirmation or reported only critical patients. We aimed to analyze the clinical characteristics of COVID-19 associated headache in laboratory-confirmed cases. We conducted a retrospective evaluation of patients with COVID-19 and neurological symptoms. Patients who reported headache answered an interview about its clinical characteristics. Twenty-four patients with COVID-19 associated headache completed the interview. Mean age of patients was 53.8 (standard deviation-17.44), and 14 out of 24 (58.3%) were male. The majority (75%) had no previous history of headache. Fever was documented in 19 out of the 24 patients (79.1%). Headache was predominantly bifrontal or holocranial, in pressure, during hours, worsening with cough or physical activity. COVID-19 headache tends to appear in the first days of symptoms, be either frontal or holocranial and last for days. The quality of pain in pressure and the worsening with cough or physical activity were reported in most cases. We have not found any characteristic that could differentiate COVID-19 associated headache from other causes of headache, possibly because of its multifactorial mechanism.
    MeSH term(s) Adolescent ; Adult ; Antihypertensive Agents/therapeutic use ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Testing ; Comorbidity ; Cytokines/physiology ; Endothelium, Vascular/physiopathology ; Endothelium, Vascular/virology ; Female ; Fever/etiology ; Headache/etiology ; Headache/physiopathology ; Humans ; Inflammation ; Male ; Models, Biological ; Neoplasms/epidemiology ; Retrospective Studies ; SARS-CoV-2 ; Symptom Assessment ; Trigeminal Nerve/virology ; Young Adult
    Chemical Substances Antihypertensive Agents ; Cytokines
    Language English
    Publishing date 2021-05-25
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-021-02430-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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