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  1. AU="Oliveira, Giuliana S"
  2. AU="Maria Cecilia Jocson"
  3. AU="Tollman, Stephen"
  4. AU="Cherry, Katie E."
  5. AU="Nazet, Ute"
  6. AU="Kranzer, K"
  7. AU="Avelino, Samuel"
  8. AU="Sun, Xiang-Dong"
  9. AU="Vogl, Thomas J."
  10. AU="Johnson, C R"
  11. AU="Gil-Pérez, Pablo"
  12. AU="Donno, Federica"
  13. AU="Vom Saal, Frederick S."
  14. AU="Gazzana, S"
  15. AU="Viswanadha, Vijaya P"
  16. AU="Anastasi, G A"
  17. AU="Romerosa, Antonio"
  18. AU=Gupta Gaorav P
  19. AU="Fernández-Susavila, Héctor"

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  1. Artikel: Pneumococcal Vaccines: Past Findings, Present Work, and Future Strategies.

    Oliveira, Giuliana S / Oliveira, Maria Leonor S / Miyaji, Eliane N / Rodrigues, Tasson C

    Vaccines

    2021  Band 9, Heft 11

    Abstract: The importance ... ...

    Abstract The importance of
    Sprache Englisch
    Erscheinungsdatum 2021-11-17
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines9111338
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Efficacy of a Protein Vaccine and a Conjugate Vaccine Against Co-colonization with Vaccine-type and Non-vaccine Type Pneumococci in Mice.

    Colichio, Gabriela Bc / Oliveira, Giuliana S / Rodrigues, Tasson C / Oliveira, Maria Leonor S / Miyaji, Eliane N

    Pathogens (Basel, Switzerland)

    2020  Band 9, Heft 4

    Abstract: Widespread use of pneumococcal conjugate vaccines (PCVs) has led to substitution of vaccine-type (VT) strains by non-vaccine type (NVT) strains in nasopharyngeal carriage. We compared the efficacy of PCV13 and a nasal protein formulation containing ... ...

    Abstract Widespread use of pneumococcal conjugate vaccines (PCVs) has led to substitution of vaccine-type (VT) strains by non-vaccine type (NVT) strains in nasopharyngeal carriage. We compared the efficacy of PCV13 and a nasal protein formulation containing pneumococcal surface protein A (PspA) adjuvanted with the whole-cell pertussis vaccine (wP) in the protection against co-colonization challenge models in mice with VT and NVT strains expressing different PspAs. Immunized mice were challenged with two different mixtures: i. VT4 (PspA3) + NVT33 (PspA1) and ii. VT23F (PspA2) + NVT15B/C (PspA4). Results from the first mixture showed a reduction in loads of VT4 strain in the nasopharynx of mice immunized with PCV13. A statistical difference between the loads of the VT and NVT strains was observed, indicating a competitive advantage for the NVT strain in PCV13-immunized animals. In the second mixture, no reduction was observed for the VT23F strain, probably due to low levels of anti-23F polysaccharide IgG induced by PCV13. Interestingly, a combination of the PspA formulation containing wP with PCV13 led to a reduction in colonization with both strains of the two mixtures tested, similar to the groups immunized nasally with wP or PspA plus wP. These results indicate that a combination of vaccines may be a useful strategy to overcome pneumococcal serotype replacement.
    Sprache Englisch
    Erscheinungsdatum 2020-04-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens9040278
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Correction: Evaluation of inactivated Bordetella pertussis as a delivery system for the immunization of mice with Pneumococcal Surface Antigen A.

    Castro, Julia T / Oliveira, Giuliana S / Nishigasako, Melissa A / Debrie, Anne-Sophie / Miyaji, Eliane N / Soares-Schanoski, Alessandra / Akamatsu, Milena A / Locht, Camille / Ho, Paulo L / Mielcarek, Nathalie / Oliveira, Maria Leonor S

    PloS one

    2020  Band 15, Heft 2, Seite(n) e0229050

    Abstract: This corrects the article DOI: 10.1371/journal.pone.0228055.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pone.0228055.].
    Sprache Englisch
    Erscheinungsdatum 2020-02-05
    Erscheinungsland United States
    Dokumenttyp Published Erratum
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0229050
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Evaluation of inactivated Bordetella pertussis as a delivery system for the immunization of mice with Pneumococcal Surface Antigen A.

    Castro, Julia T / Oliveira, Giuliana S / Nishigasako, Melissa A / Debrie, Anne-Sophie / Miyaji, Eliane N / Soares-Schanoski, Alessandra / Akamatsu, Milena A / Locht, Camille / Ho, Paulo L / Mielcarek, Nathalie / Oliveira, Maria Leonor S

    PloS one

    2020  Band 15, Heft 1, Seite(n) e0228055

    Abstract: Pneumococcal Surface Protein A (PspA) has been successfully tested as vaccine candidate against Streptococcus pneumoniae infections. Vaccines able to induce PspA-specific antibodies and Th1 cytokines usually provide protection in mice. We have shown that ...

    Abstract Pneumococcal Surface Protein A (PspA) has been successfully tested as vaccine candidate against Streptococcus pneumoniae infections. Vaccines able to induce PspA-specific antibodies and Th1 cytokines usually provide protection in mice. We have shown that the whole cell pertussis vaccine (wP) or components from acellular pertussis vaccines, such as Pertussis Toxin or Filamentous Hemagglutinin (FHA), are good adjuvants to PspA, suggesting that combined pertussis-PspA vaccines would be interesting strategies against the two infections. Here, we evaluated the potential of wP as a delivery vector to PspA. Bordetella pertussis strains producing a PspA from clade 4 (PspA4Pro) fused to the N-terminal region of FHA (Fha44) were constructed and inactivated with formaldehyde for the production of wPPspA4Pro. Subcutaneous immunization of mice with wPPspA4Pro induced low levels of anti-PspA4 IgG, even after 3 doses, and did not protect against a lethal pneumococcal challenge. Prime-boost strategies using wPPspA4Pro and PspA4Pro showed that there was no advantage in using the wPPspA4Pro vaccine. Immunization of mice with purified PspA4Pro induced higher levels of antibodies and protection against pneumococcal infection than the prime-boost strategies. Finally, purified Fha44:PspA4Pro induced high levels of anti-PspA4Pro IgG, but no protection, suggesting that the antibodies induced by the fusion protein were not directed to protective epitopes.
    Mesh-Begriff(e) Adhesins, Bacterial/administration & dosage ; Adjuvants, Immunologic/administration & dosage ; Animals ; Antigens, Bacterial/pharmacology ; Antigens, Surface/pharmacology ; Bacterial Proteins/pharmacology ; Drug Carriers/administration & dosage ; Female ; Mice ; Mice, Inbred BALB C ; Pertussis Vaccine/administration & dosage ; Pneumococcal Infections/prevention & control ; Vaccination ; Virulence Factors, Bordetella/administration & dosage
    Chemische Substanzen Adhesins, Bacterial ; Adjuvants, Immunologic ; Antigens, Bacterial ; Antigens, Surface ; Bacterial Proteins ; Drug Carriers ; Pertussis Vaccine ; Virulence Factors, Bordetella ; filamentous hemagglutinin adhesin, Bordetella pertussis ; pneumococcal surface protein A
    Sprache Englisch
    Erscheinungsdatum 2020-01-16
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0228055
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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