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  1. Book ; Online: Advances in Liver Inflammation and Fibrosis due to Infectious Diseases

    Victoria Delpino, M. / Hernán Giambartolomei, Guillermo / Quarleri, Jorge / Oliveira, Sergio C. / Splitter, Gary

    2020  

    Keywords Medicine ; Immunology ; Liver Fibrosis ; Liver immune response ; Bacteria and liver ; Parasite and liver ; Virus and liver
    Size 1 electronic resource (107 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230640
    ISBN 9782889661664 ; 2889661660
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Host Immune Responses and Pathogenesis to

    Oliveira, Sergio C

    Pathogens (Basel, Switzerland)

    2021  Volume 10, Issue 3

    Abstract: Brucellosis, caused by the facultative intracellular ... ...

    Abstract Brucellosis, caused by the facultative intracellular bacteria
    Language English
    Publishing date 2021-03-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10030288
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Host Immune Responses and Pathogenesis to Brucella spp. Infection

    Oliveira, Sergio C

    Pathogens. 2021 Mar. 03, v. 10, no. 3

    2021  

    Abstract: Brucellosis, caused by the facultative intracellular bacteria Brucella species, is one the most prevalent zoonoses worldwide [ ... ] ...

    Abstract Brucellosis, caused by the facultative intracellular bacteria Brucella species, is one the most prevalent zoonoses worldwide [...]
    Keywords Brucella ; brucellosis ; pathogenesis ; zoonoses
    Language English
    Dates of publication 2021-0303
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10030288
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: How the crosstalk between innate immune sensors and metabolic pathways affect the outcome of

    Oliveira, Sergio C / Guimarães, Erika S

    Frontiers in microbiology

    2022  Volume 13, Page(s) 995219

    Language English
    Publishing date 2022-08-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.995219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Guanylate-binding protein-5 is involved in inflammasome activation by bacterial DNA but only the cooperation of multiple GBPs accounts for control of

    Marinho, Fabio V / Brito, Camila / de Araujo, Ana Carolina V S C / Oliveira, Sergio C

    Frontiers in immunology

    2024  Volume 15, Page(s) 1341464

    Abstract: Introduction: Guanylate-binding proteins (GBPs) are produced in response to pro-inflammatory signals, mainly interferons. The most studied cluster of GBPs in mice is on chromosome 3. It comprises the genes for GBP1-to-3, GBP5 and GBP7. In humans, all ... ...

    Abstract Introduction: Guanylate-binding proteins (GBPs) are produced in response to pro-inflammatory signals, mainly interferons. The most studied cluster of GBPs in mice is on chromosome 3. It comprises the genes for GBP1-to-3, GBP5 and GBP7. In humans, all GBPs are present in a single cluster on chromosome 1. Brucella abortus is a Gram-negative bacterium known to cause brucellosis, a debilitating disease that affects both humans and animals. Our group demonstrated previously that GBPs present on murine chromosome 3 (GBPchr3) is important to disrupt Brucella-containing vacuole and GBP5 itself is important to Brucella intracellular LPS recognition. In this work, we investigated further the role of GBPs during B. abortus infection.
    Methods and results: We observed that all GBPs from murine chromosome 3 are significantly upregulated in response to B. abortus infection in mouse bone marrow-derived macrophages. Of note, GBP5 presents the highest expression level in all time points evaluated. However, only GBPchr3-/- cells presented increased bacterial burden compared to wild-type macrophages. Brucella DNA is an important Pathogen-Associated Molecular Pattern that could be available for inflammasome activation after BCV disruption mediated by GBPs. In this regard, we observed reduced IL-1β production in the absence of GBP2 or GBP5, as well as in GBPchr3-/- murine macrophages. Similar result was showed by THP-1 macrophages with downregulation of GBP2 and GBP5 mediated by siRNA. Furthermore, significant reduction on caspase-1 p20 levels, LDH release and Gasdermin-D conversion into its mature form (p30 N-terminal subunit) was observed only in GBPchr3-/- macrophages. In an
    Discussion/conclusion: Altogether, these results demonstrate that although GBP5 presents a high expression pattern and is involved in inflammasome activation by bacterial DNA in macrophages, the cooperation of multiple GBPs from murine chromosome 3 is necessary for full control of Brucella abortus infection.
    MeSH term(s) Animals ; Mice ; Brucella abortus/genetics ; Brucellosis/microbiology ; Carrier Proteins/metabolism ; DNA, Bacterial ; Inflammasomes/genetics ; Inflammasomes/metabolism ; GTP-Binding Proteins/genetics
    Chemical Substances Carrier Proteins ; DNA, Bacterial ; Inflammasomes ; Gbp5 protein, mouse (EC 3.6.1.-) ; GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 2024-02-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1341464
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Neutrophils and schistosomiasis: a missing piece in pathology.

    Sanches, Rodrigo C O / Mambelli, Fábio / Oliveira, Sergio C

    Parasite immunology

    2022  Volume 44, Issue 6, Page(s) e12916

    Abstract: Schistosomiasis is a chronic human parasitic disease that causes serious health problems worldwide. The disease-associated liver pathology is one of the hallmarks of infections by Schistosoma mansoni and Schistosoma japonicum, and is accountable for the ... ...

    Abstract Schistosomiasis is a chronic human parasitic disease that causes serious health problems worldwide. The disease-associated liver pathology is one of the hallmarks of infections by Schistosoma mansoni and Schistosoma japonicum, and is accountable for the debilitating condition found in infected patients. In the past few years, investigative studies have highlighted the key role played by neutrophils and the influence of inflammasome signalling pathway in different pathological conditions. However, it is noteworthy that the study of inflammasome activation in neutrophils has been overlooked by reports concerning macrophages and monocytes. This interplay between neutrophils and inflammasomes is much more poorly investigated during schistosomiasis. Herein, we reviewed the role of neutrophils during schistosomiasis and addressed the potential connection between these cells and inflammasome activation in this context.
    MeSH term(s) Animals ; Humans ; Inflammasomes/metabolism ; Liver Diseases ; Neutrophils/metabolism ; Schistosoma japonicum/physiology ; Schistosoma mansoni ; Schistosomiasis
    Chemical Substances Inflammasomes
    Language English
    Publishing date 2022-04-05
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 424444-8
    ISSN 1365-3024 ; 0141-9838
    ISSN (online) 1365-3024
    ISSN 0141-9838
    DOI 10.1111/pim.12916
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1509: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Caspase-8 but not caspase-7 influences inflammasome activation to act in control of

    Santos, Raiany A / Cerqueira, Daiane M / Zamboni, Dario S / Oliveira, Sergio C

    Frontiers in microbiology

    2022  Volume 13, Page(s) 1086925

    Abstract: Programmed cell death (PCD) is an important mechanism of innate immunity against bacterial pathogens. The innate immune PCD pathway involves the molecules caspase-7 and caspase-8, among others. ...

    Abstract Programmed cell death (PCD) is an important mechanism of innate immunity against bacterial pathogens. The innate immune PCD pathway involves the molecules caspase-7 and caspase-8, among others.
    Language English
    Publishing date 2022-12-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.1086925
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Validation of 3-day rainfall forecast at the regional scale.

    Melo, Raquel / Oliveira, Sandra / Tomé, Ricardo / Ramos, Alexandre M / Oliveira, Sérgio C

    MethodsX

    2023  Volume 10, Page(s) 102071

    Abstract: Nearly half of the natural disasters in the world are due to hydro-geomorphological hazards. Therefore, rainfall forecast is a key parameter for the implementation of landslides and flash-floods early warning systems. In this work we developed a routine ... ...

    Abstract Nearly half of the natural disasters in the world are due to hydro-geomorphological hazards. Therefore, rainfall forecast is a key parameter for the implementation of landslides and flash-floods early warning systems. In this work we developed a routine in R software that enables the validation of a 3-day rainfall forecast by comparison with the daily rainfall data recorded in 101 automatic meteorological stations available in mainland Portugal. The routine integrates the pre-processing of base data, the matching between the 3-day rainfall forecast and the daily rainfall registered in the automatic meteorological stations based on sequence of days, the estimation of the difference between the forecasted and the real rainfall values and the computation of error measures, such as the bias, the mean absolute error, the mean absolute percentage error and the root mean square error. The results from the error measures, estimated for the 101 automatic meteorological stations, are then exported to an excel file. The routine is implemented for mainland Portugal and tested using data from February 2015, however, the spatial and temporal data can be easily updated for other regions.•A routine to validate the rainfall forecast at the regional scale using R programming language is implemented.•The automated routine can be easily updated and adapted with different spatial and temporal scales.
    Language English
    Publishing date 2023-02-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2830212-6
    ISSN 2215-0161
    ISSN 2215-0161
    DOI 10.1016/j.mex.2023.102071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Innate immune sensing of nucleic acids from pathogens.

    Oliveira, Sergio C

    Microbes and infection

    2014  Volume 16, Issue 12, Page(s) 977–978

    Abstract: The innate immune system is important as the first line of defense to sense invading pathogens. Nucleic acids represent critical pathogen signatures that trigger a host proinflammatory immune response. Much progress has been made in understanding how DNA ...

    Abstract The innate immune system is important as the first line of defense to sense invading pathogens. Nucleic acids represent critical pathogen signatures that trigger a host proinflammatory immune response. Much progress has been made in understanding how DNA and RNA trigger host defense countermeasures, however, several aspects of how cytosolic nucleic acids are sensed remain unclear. This special issue reviews how the host innate immune system senses nucleic acids from Brucella abortus, Mycobacterium sp and Legionella pneumophila, viral DNA, the role of STING in DNA sensing and inflammatory diseases and the mechanism of viral RNA recognition by the small interfering RNA pathway in Drosophila melanogaster.
    MeSH term(s) Animals ; DNA, Bacterial/immunology ; DNA, Viral/immunology ; Host-Pathogen Interactions ; Humans ; Immunity, Innate/physiology ; Nucleic Acids/immunology ; RNA, Bacterial/immunology ; RNA, Viral/immunology
    Chemical Substances DNA, Bacterial ; DNA, Viral ; Nucleic Acids ; RNA, Bacterial ; RNA, Viral
    Language English
    Publishing date 2014-12
    Publishing country France
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1465093-9
    ISSN 1769-714X ; 1286-4579
    ISSN (online) 1769-714X
    ISSN 1286-4579
    DOI 10.1016/j.micinf.2014.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5014: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Schistosoma antigens as activators of inflammasome pathway: from an unexpected stimulus to an intriguing role.

    Sanches, Rodrigo C O / Souza, Cláudia / Oliveira, Sergio C

    Microbes and infection

    2020  Volume 22, Issue 10, Page(s) 534–539

    Abstract: Parasites of the genus Schistosoma are organisms capable of living for decades within the definitive host. They interfere with the immune response by interacting with host's receptors. In this review, we discuss from the first reports to the most recent ... ...

    Abstract Parasites of the genus Schistosoma are organisms capable of living for decades within the definitive host. They interfere with the immune response by interacting with host's receptors. In this review, we discuss from the first reports to the most recent discoveries regarding the ability of Schistosoma antigens in triggering intracellular receptors and inducing inflammasome activation.
    MeSH term(s) Animals ; Antigens, Helminth/metabolism ; Dendritic Cells/metabolism ; Hepatic Stellate Cells/metabolism ; Inflammasomes/metabolism ; Interleukin-1beta/metabolism ; Macrophages/metabolism ; NLR Proteins/metabolism ; Ovum ; Pyroptosis ; Schistosoma/immunology ; Schistosoma/metabolism ; Schistosomiasis/metabolism ; Schistosomiasis/parasitology
    Chemical Substances Antigens, Helminth ; Inflammasomes ; Interleukin-1beta ; NLR Proteins
    Language English
    Publishing date 2020-08-22
    Publishing country France
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1465093-9
    ISSN 1769-714X ; 1286-4579
    ISSN (online) 1769-714X
    ISSN 1286-4579
    DOI 10.1016/j.micinf.2020.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5014: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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