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  1. AU="Olivier Lortholary"
  2. AU="Lisnic, Vanda Juranic"
  3. AU="Seabloom, Eric W"
  4. AU="Odvina, Clarita V"
  5. AU="Singh, Inderbir"
  6. AU="Wonoh Lee"
  7. AU="Nelson, Warrick"
  8. AU="Douglas, David N"
  9. AU="King, Gary"
  10. AU="Barbera, Lauren"
  11. AU="Carlino, Antonio"
  12. AU="Shan, Qing-Hua"
  13. AU="Starko, S"
  14. AU="Lievre, Loïc"
  15. AU=Cammack N
  16. AU="Xia, Qin"
  17. AU="Ong, Ju Lynn"
  18. AU="Cullin, Christophe"
  19. AU="Georg K.S. Andersson"
  20. AU="Jeannel, Gaël-François"
  21. AU="Stuart Woods"
  22. AU="Shchegolev, A."
  23. AU="Nadeau, Pierre-Louis"
  24. AU="Gordon, David E A"
  25. AU="Shahid Mahmood"
  26. AU="Rosenblatt, Karin"
  27. AU="Dasgupta, Suvankar"
  28. AU=Nguyen Sylvain AU=Nguyen Sylvain

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  1. Article ; Online: Cryptococcus gattii in Patients with Lymphoid Neoplasms

    Olivier Paccoud / Marie-Elisabeth Bougnoux / Marie Desnos-Ollivier / Bruno Varet / Olivier Lortholary / Fanny Lanternier

    Journal of Fungi, Vol 7, Iss 212, p

    An Illustration of Evolutive Host–Fungus Interactions

    2021  Volume 212

    Abstract: Recent outbreaks of Cryptococcus gattii (CG) infections in North America have sparked renewed interest in the pathogenic potential of CG, and have underscored notable differences with Cryptococcus neoformans in terms of geographic distribution, pathogen ... ...

    Abstract Recent outbreaks of Cryptococcus gattii (CG) infections in North America have sparked renewed interest in the pathogenic potential of CG, and have underscored notable differences with Cryptococcus neoformans in terms of geographic distribution, pathogen virulence, and host susceptibility. While cases of CG are increasingly reported in patients with a wide variety of underlying conditions, only very few have been reported in patients with lymphoid neoplasms. Herein, we report a case of autochthonous CG meningitis in a patient receiving ibrutinib for chronic lymphocytic leukemia in France, and review available data on the clinical epidemiology of CG infections in patients with lymphoid neoplasms. We also summarise recent data on the host responses to CG infection, as well as the potential management pitfalls associated with its treatment in the haematological setting. The clinical epidemiology, clinical presentation, and course of disease during infections caused by CG involve complex interactions between environmental exposure to CG, infecting genotype, pathogen virulence factors, host susceptibility, and host immune responses. Future treatment guidelines should address the challenges associated with the management of antifungal treatments in the onco-haematological setting and the potential drug-drug interactions.
    Keywords Cryptococcus gattii ; cryptococcosis ; haematological malignancy ; lymphoid neoplasms ; chronic lymphocytic leukemia ; ibrutinib ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Recent advances in understanding and managing infectious diseases in solid organ transplant recipients [version 1; referees

    Claire Aguilar / Shahid Husain / Olivier Lortholary

    F1000Research, Vol

    3 approved]

    2018  Volume 7

    Abstract: Background: Undergoing solid organ transplantation (SOT) exposes the recipient to various infectious risks, including possible transmission of pathogen by the transplanted organ, post-surgical infections, reactivation of latent pathogens, or novel ... ...

    Abstract Background: Undergoing solid organ transplantation (SOT) exposes the recipient to various infectious risks, including possible transmission of pathogen by the transplanted organ, post-surgical infections, reactivation of latent pathogens, or novel infections. Recent advances: In the last few years, the emergence of Zika virus has raised concerns in the transplant community. Few cases have been described in SOT patients, and these were associated mainly with moderate disease and favorable outcome; the notable exception is a recent case of fatal meningo-encephalopathy in a heart transplant recipient. Because of the advances in treating hepatitis C, several teams recently started to use organs from hepatitis C-positive donors. The worldwide increasing incidence of multidrug-resistant pathogens, as well as the increasing incidence of Clostridioides difficile infection, is of particular concern in SOT patients. In the field of mycology, the main recent therapeutic advance is the availability of isavuconazole for the treatment of invasive aspergillosis and mucormycosis. This drug has the advantage of minimal interaction with calcineurin inhibitors. Regarding the viral reactivations occurring after transplant, cytomegalovirus (CMV) infection is still a significant issue in SOT patients. The management of resistant CMV remains particularly difficult. The approval of letermovir, albeit in bone marrow transplantation, and the therapeutic trial of maribavir bring a ray of hope. Another advancement in management of post-transplant infections is the development of in vitro tests evaluating pathogen-specific immune response, such as immunodiagnostics for CMV and, more recently, tests for monitoring immunity against BK virus. Conclusion: The increasing number of organ transplantations, the use of newer immunosuppressive drugs, and high-risk donors continue to define the landscape of transplant infectious diseases in the current era.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2018-05-01T00:00:00Z
    Publisher F1000 Research Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Recent advances in the understanding and management of mucormycosis [version 1; referees

    Benoit Pilmis / Alexandre Alanio / Olivier Lortholary / Fanny Lanternier

    F1000Research, Vol

    2 approved]

    2018  Volume 7

    Abstract: Mucormycoses were difficult-to-manage infections owing to limited diagnostic tools and therapeutic options. We review here advances in pathology understanding, diagnostic tools including computed tomography, and serum polymerase chain reaction and ... ...

    Abstract Mucormycoses were difficult-to-manage infections owing to limited diagnostic tools and therapeutic options. We review here advances in pathology understanding, diagnostic tools including computed tomography, and serum polymerase chain reaction and therapeutic options.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2018-09-01T00:00:00Z
    Publisher F1000 Research Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: 9th Trends in Medical Mycology Held on 11–14 October 2019, Nice, France, Organized under the Auspices of EORTC-IDG and ECMM

    Jean-Pierre Gangneux / Olivier Lortholary / Oliver A. Cornely / Livio Pagano

    Journal of Fungi, Vol 5, Iss 4, p

    2019  Volume 95

    Abstract: Dear Friends and Colleagues, It is a great honor and pleasure for us to invite you cordially to participate in the 9th Congress on Trends in Medical Mycology (TIMM-9) [.] ...

    Abstract Dear Friends and Colleagues, It is a great honor and pleasure for us to invite you cordially to participate in the 9th Congress on Trends in Medical Mycology (TIMM-9) [.]
    Keywords n/a ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2019-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Invasive Mold Infections in Solid Organ Transplant Recipients

    Yoann Crabol / Olivier Lortholary

    Scientifica, Vol

    2014  Volume 2014

    Keywords Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Invasive Mold Infections in Solid Organ Transplant Recipients

    Yoann Crabol / Olivier Lortholary

    Scientifica, Vol

    2014  Volume 2014

    Abstract: Invasive mold infections represent an increasing source of morbidity and mortality in solid organ transplant recipients. Whereas there is a large literature regarding invasive molds infections in hematopoietic stem cell transplants, data in solid organ ... ...

    Abstract Invasive mold infections represent an increasing source of morbidity and mortality in solid organ transplant recipients. Whereas there is a large literature regarding invasive molds infections in hematopoietic stem cell transplants, data in solid organ transplants are scarcer. In this comprehensive review, we focused on invasive mold infection in the specific population of solid organ transplant. We highlighted epidemiology and specific risk factors for these infections and we assessed the main clinical and imaging findings by fungi and by type of solid organ transplant. Finally, we attempted to summarize the diagnostic strategy for detection of these fungi and tried to give an overview of the current prophylaxis treatments and outcomes of these infections in solid organ transplant recipients.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: What Is New in Pulmonary Mucormycosis?

    François Danion / Anne Coste / Coralie Le Hyaric / Clea Melenotte / Frederic Lamoth / Thierry Calandra / Dea Garcia-Hermoso / Vishukumar Aimanianda / Fanny Lanternier / Olivier Lortholary

    Journal of Fungi, Vol 9, Iss 307, p

    2023  Volume 307

    Abstract: Mucormycosis is a rare but life-threatening fungal infection due to molds of the order Mucorales. The incidence has been increasing over recent decades. Worldwide, pulmonary mucormycosis (PM) presents in the lungs, which are the third main location for ... ...

    Abstract Mucormycosis is a rare but life-threatening fungal infection due to molds of the order Mucorales. The incidence has been increasing over recent decades. Worldwide, pulmonary mucormycosis (PM) presents in the lungs, which are the third main location for the infection after the rhino-orbito-cerebral (ROC) areas and the skin. The main risk factors for PM include hematological malignancies and solid organ transplantation, whereas ROC infections classically are classically favored by diabetes mellitus. The differences between the ROC and pulmonary locations are possibly explained by the activation of different mammalian receptors—GRP78 in nasal epithelial cells and integrin β1 in alveolar epithelial cells—in response to Mucorales. Alveolar macrophages and neutrophils play a key role in the host defense against Mucorales. The diagnosis of PM relies on CT scans, cultures, PCR tests, and histology. The reversed halo sign is an early, but very suggestive, sign of PM in neutropenic patients. Recently, the serum PCR test showed a very encouraging performance for the diagnosis and follow-up of mucormycosis. Liposomal amphotericin B is the drug of choice for first-line therapy, together with correction of underlying disease and surgery when feasible. After a stable or partial response, the step-down treatment includes oral isavuconazole or posaconazole delayed release tablets until a complete response is achieved. Secondary prophylaxis should be discussed when there is any risk of relapse, such as the persistence of neutropenia or the prolonged use of high-dose immunosuppressive therapy. Despite these novelties, the mortality rate from PM remains higher than 50%. Therefore, future research must define the place for combination therapy and adjunctive treatments, while the development of new treatments is necessary.
    Keywords pulmonary mucormycosis ; Mucorales ; review ; Epidemiology ; treatment ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Diagnostic and therapeutic strategies in cryptococcosis

    Timothée Boyer Chammard / Elvis Temfack / Olivier Lortholary / Alexandre Alanio

    Memórias do Instituto Oswaldo Cruz., Vol 113, Iss

    impact on outcome

    2018  Volume 7

    Abstract: Cryptococcosis diagnosis has been recently improved by the use of rapid cryptococcal antigen testing with lateral flow assays, which have proved sensitive and specific. Using “test and treat” screening strategies for cryptococcal disease with these tests ...

    Abstract Cryptococcosis diagnosis has been recently improved by the use of rapid cryptococcal antigen testing with lateral flow assays, which have proved sensitive and specific. Using “test and treat” screening strategies for cryptococcal disease with these tests has been showed effective in reducing cryptococcal meningitis (CM) in HIV-infected patients. Recommended induction, consolidation, and maintenance therapeutic strategy for CM is widely unavailable and/or expensive in low and middle-income settings. New therapeutic strategies, mostly using reduced duration, have recently shown acceptable outcome or are currently tested. Diagnostic and therapeutic guidelines for cryptococcal disease in limited resources countries are undergoing a paradigmatic shift.
    Keywords Cryptococcus neoformans ; cryptococcal meningo-encephalitis ; cryptococcal antigen ; HIV infection ; advanced AIDS disease ; screening ; Arctic medicine. Tropical medicine ; RC955-962 ; Microbiology ; QR1-502
    Subject code 610
    Language English
    Publishing date 2018-05-01T00:00:00Z
    Publisher Instituto Oswaldo Cruz, Ministério da Saúde
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Recent advances in managing HIV-associated cryptococcal meningitis [version 1; peer review

    Timothée Boyer-Chammard / Elvis Temfack / Alexandre Alanio / Joseph N. Jarvis / Thomas S. Harrison / Olivier Lortholary

    F1000Research, Vol

    2 approved]

    2019  Volume 8

    Abstract: The recent development of highly sensitive and specific point-of-care tests has made it possible to diagnose HIV-associated cryptococcal meningitis within minutes. However, diagnostic advances have not been matched by new antifungal drugs and treatment ... ...

    Abstract The recent development of highly sensitive and specific point-of-care tests has made it possible to diagnose HIV-associated cryptococcal meningitis within minutes. However, diagnostic advances have not been matched by new antifungal drugs and treatment still relies on old off-patent drugs: amphotericin B, flucytosine and fluconazole. Cryptococcal meningitis treatment is divided in three phases: induction, consolidation and maintenance. The induction phase, aimed at drastically reducing cerebrospinal fluid fungal burden, is key for patient survival. The major challenge in cryptococcal meningitis management has been the optimisation of induction phase treatment using the limited number of available medications, and major progress has recently been made. In this review, we summarise data from key trials which form the basis of current treatment recommendations for HIV-associated cryptococcal meningitis.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2019-05-01T00:00:00Z
    Publisher F1000 Research Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Aspergillus felis in Patient with Chronic Granulomatous Disease

    Olivier Paccoud / Romain Guery / Sylvain Poirée / Grégory Jouvion / Marie Elisabeth Bougnoux / Emilie Catherinot / Olivier Hermine / Olivier Lortholary / Fanny Lanternier

    Emerging Infectious Diseases, Vol 25, Iss 12, Pp 2319-

    2019  Volume 2321

    Abstract: We report a case of Aspergillus felis infection in a patient with chronic granulomatous disease who had overlapping features of invasive pulmonary aspergillosis and allergic bronchopulmonary aspergillosis. Identifying the species responsible for ... ...

    Abstract We report a case of Aspergillus felis infection in a patient with chronic granulomatous disease who had overlapping features of invasive pulmonary aspergillosis and allergic bronchopulmonary aspergillosis. Identifying the species responsible for aspergillosis by molecular methods can be crucial for directing patient management and selection of appropriate antifungal agents.
    Keywords Aspergillus felis ; invasive pulmonary aspergillosis ; allergic bronchopulmonary aspergillosis ; chronic granulomatous disease ; fungi ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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