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  1. Article ; Online: Cryptococcus gattii in Patients with Lymphoid Neoplasms

    Olivier Paccoud / Marie-Elisabeth Bougnoux / Marie Desnos-Ollivier / Bruno Varet / Olivier Lortholary / Fanny Lanternier

    Journal of Fungi, Vol 7, Iss 212, p

    An Illustration of Evolutive Host–Fungus Interactions

    2021  Volume 212

    Abstract: Recent outbreaks of Cryptococcus gattii (CG) infections in North America have sparked renewed interest in the pathogenic potential of CG, and have underscored notable differences with Cryptococcus neoformans in terms of geographic distribution, pathogen ... ...

    Abstract Recent outbreaks of Cryptococcus gattii (CG) infections in North America have sparked renewed interest in the pathogenic potential of CG, and have underscored notable differences with Cryptococcus neoformans in terms of geographic distribution, pathogen virulence, and host susceptibility. While cases of CG are increasingly reported in patients with a wide variety of underlying conditions, only very few have been reported in patients with lymphoid neoplasms. Herein, we report a case of autochthonous CG meningitis in a patient receiving ibrutinib for chronic lymphocytic leukemia in France, and review available data on the clinical epidemiology of CG infections in patients with lymphoid neoplasms. We also summarise recent data on the host responses to CG infection, as well as the potential management pitfalls associated with its treatment in the haematological setting. The clinical epidemiology, clinical presentation, and course of disease during infections caused by CG involve complex interactions between environmental exposure to CG, infecting genotype, pathogen virulence factors, host susceptibility, and host immune responses. Future treatment guidelines should address the challenges associated with the management of antifungal treatments in the onco-haematological setting and the potential drug-drug interactions.
    Keywords Cryptococcus gattii ; cryptococcosis ; haematological malignancy ; lymphoid neoplasms ; chronic lymphocytic leukemia ; ibrutinib ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Prevalence of Antimicrobial Resistance and Infectious Diseases in a Hospitalised Migrant Population in Paris, France, a Retrospective Study

    Sarah Stabler / Olivier Paccoud / Léa Duchesne / Marie-Aude Piot / Nadia Valin / Dominique Decré / Pierre-Marie Girard / Valérie Lalande / Karine Lacombe / Laure Surgers

    International Journal of Public Health, Vol

    2022  Volume 67

    Abstract: Objectives: The aim of this study was to estimate the prevalence of anti-microbial resistance (AMR) carriage and its risk factors in hospitalized migrants. Additionally, the prevalence of infectious diseases was evaluated, as well as symptoms of ... ...

    Abstract Objectives: The aim of this study was to estimate the prevalence of anti-microbial resistance (AMR) carriage and its risk factors in hospitalized migrants. Additionally, the prevalence of infectious diseases was evaluated, as well as symptoms of psychological trauma.Methods: We conducted a retrospective monocentric cross-sectional study including all migrant patients recently arrived and hospitalised over a one-year period.Results: Among 101 patients, seventy-nine percent originated from Sub-Saharan Africa. The overall AMR carriage rate was 20.7% [95% CI: 12.4; 28.9%]. We isolated 5/92 methicillin-resistant Staphylococcus aureus strains (5.4%) and 15/92 extended-spectrum beta-lactamase-producing Enterobacteriaceae (16.4%). AMR carriage was associated with older age, region of origin and length of migration. Rates of HIV, HBV, and HCV infection were 39.6%, 32.7%, and 5%, reflecting sampling bias linked to reasons for hospitalization. Eleven percent had serological evidence of treponemasis and 7.8% had Chlamydia trachomatis infection. Symptoms of depression or post-traumatic stress disorder were observed for more than half the patients.Conclusion: It appears essential to offer a systematic and comprehensive post-arrival screening of AMR carriage, infectious diseases and psychological trauma to subjects who experienced migration.
    Keywords migrants ; schistosomiasis ; psychological disorders ; AMR carriage ; ESBL-E ; sexual transmitted infections ; Public aspects of medicine ; RA1-1270
    Subject code 150
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Invasive Rhinosinusitis Caused by Alternaria infectoria in a Patient with Autosomal Recessive CARD9 Deficiency and a Review of the Literature

    Olivier Paccoud / Nicolas Vignier / Mohammed Boui / Mélanie Migaud / Pierre Vironneau / Romain Kania / Frédéric Méchaï / Sophie Brun / Alexandre Alanio / Arnault Tauziède-Espariat / Homa Adle-Biassette / Elise Ouedraogo / Jacinta Bustamante / Olivier Bouchaud / Jean-Laurent Casanova / Anne Puel / Fanny Lanternier

    Journal of Fungi, Vol 8, Iss 446, p

    2022  Volume 446

    Abstract: Phaeohyphomycoses comprise a heterogeneous group of fungal infections caused by dematiaceous fungi and have primarily been reported in patients with underlying acquired immunodeficiencies, such as hematological malignancies or solid-organ transplants. ... ...

    Abstract Phaeohyphomycoses comprise a heterogeneous group of fungal infections caused by dematiaceous fungi and have primarily been reported in patients with underlying acquired immunodeficiencies, such as hematological malignancies or solid-organ transplants. Over the past decade, a growing number of patients with phaeohyphomycosis but otherwise healthy were reported with autosomal recessive (AR) CARD9 deficiency. We report a 28-year-old woman who presented with invasive rhinosinusitis caused by Alternaria infectoria . Following a candidate gene sequencing approach, we identified a biallelic loss-of-function mutation of CARD9, thereby further broadening the spectrum of invasive fungal diseases found in patients with inherited CARD9 deficiency. In addition, we reviewed 17 other cases of phaeohyphomycosis associated with AR CARD9 deficiency. Physicians should maintain a high degree of suspicion for inborn errors of immunity, namely CARD9 deficiency, when caring for previously healthy patients with phaeohyphomycosis, regardless of age at first presentation.
    Keywords Alternaria infectoria ; CARD9 deficiency ; phaeohyphomycosis ; invasive fungal sinusitis ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Aspergillus felis in Patient with Chronic Granulomatous Disease

    Olivier Paccoud / Romain Guery / Sylvain Poirée / Grégory Jouvion / Marie Elisabeth Bougnoux / Emilie Catherinot / Olivier Hermine / Olivier Lortholary / Fanny Lanternier

    Emerging Infectious Diseases, Vol 25, Iss 12, Pp 2319-

    2019  Volume 2321

    Abstract: We report a case of Aspergillus felis infection in a patient with chronic granulomatous disease who had overlapping features of invasive pulmonary aspergillosis and allergic bronchopulmonary aspergillosis. Identifying the species responsible for ... ...

    Abstract We report a case of Aspergillus felis infection in a patient with chronic granulomatous disease who had overlapping features of invasive pulmonary aspergillosis and allergic bronchopulmonary aspergillosis. Identifying the species responsible for aspergillosis by molecular methods can be crucial for directing patient management and selection of appropriate antifungal agents.
    Keywords Aspergillus felis ; invasive pulmonary aspergillosis ; allergic bronchopulmonary aspergillosis ; chronic granulomatous disease ; fungi ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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