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Article: La rete assistenziale per lo scompenso cardiaco cronico.

Oliviero, Ugo

Giornale italiano di cardiologia (2006)

2013 Volume 14, Issue 3 Suppl 1, Page(s) 57–59

Abstract: Chronic heart failure (CHF) is one of the leading causes of disability in the older population. In addition, the management of older CHF patients is particularly complex not only in cases of exacerbations, usually treated in the emergency department, but ...

Title translation	Healthcare networks for chronic heart failure management.
Abstract	Chronic heart failure (CHF) is one of the leading causes of disability in the older population. In addition, the management of older CHF patients is particularly complex not only in cases of exacerbations, usually treated in the emergency department, but also in daily clinical practice, where a large commitment from the family and the presence of an accessible competent healthcare district are required. The management of CHF should include a network providing adequate follow-up of older patients and implement the continuity of care from hospital to territory. An adequate integration between hospital and territory can be obtained with a multilevel system made by a first territorial level (outpatient cardiologists and general practitioners), a second level for the treatment of exacerbations (day-hospital or full hospitalization), and a third level, characterized by the availability of comprehensive means for complex examinations and advanced treatments (academic or high-level specialized hospitals). The three levels identified should operate as a single, integrated unit in which all staff members operate synergistically, along common diagnostic and therapeutic pathways, established and shared according to the current guidelines for the treatment of older CHF patients.
MeSH term(s)	Chronic Disease ; Disease Management ; Emergency Service, Hospital ; Heart Failure/therapy ; Hospitalization ; Humans
Language	Italian
Publishing date	2013-03
Publishing country	Italy
Document type	English Abstract ; Journal Article
ZDB-ID	2272414-X
ISSN	1972-6481 ; 1827-6806
ISSN (online)	1972-6481
ISSN	1827-6806
DOI	10.1714/1261.13942
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Article ; Online: Echocardiographic assessment of aortic pulse wave velocity for left ventricular diastolic dysfunction.

Bosso, Giorgio / DE Luca, Mariarosaria / Oliviero, Ugo

Minerva cardiology and angiology

2020 Volume 69, Issue 1, Page(s) 9–11

MeSH term(s)	Echocardiography ; Humans ; Prognosis ; Pulse Wave Analysis ; Ventricular Dysfunction, Left/diagnostic imaging
Language	English
Publishing date	2020-05-29
Publishing country	Italy
Document type	Journal Article ; Comment
ZDB-ID	3059238-0
ISSN	2724-5772
ISSN (online)	2724-5772
DOI	10.23736/S2724-5683.20.05314-1
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Article ; Online: High prevalence of cardiac post-acute sequelae in patients recovered from Covid-19. Results from the ARCA post-COVID study.

Antoncecchi, Valeria / Antoncecchi, Ettore / Orsini, Enrico / D'Ascenzo, Giuseppe / Oliviero, Ugo / Savino, Ketty / Aloisio, Angelo / Casalino, Laura / Lillo, Adele / Chiuini, Emilia / Santoro, Giosuè / Manfrè, Vincenzo / Rizzo, Valeria / Zito, Giovanni Battista

International journal of cardiology. Cardiovascular risk and prevention

2024 Volume 21, Page(s) 200267

Abstract: Background: Many data were published about Long-Covid prevalence, very few about the findings of new cardiac alterations (NCA) in COVID-19-recovered people. : Results: The median age was 56 years (IQR 44-67); women were 52.19%; in the acute phase 24 ... ...

Abstract	Background: Many data were published about Long-Covid prevalence, very few about the findings of new cardiac alterations (NCA) in COVID-19-recovered people. Results: The median age was 56 years (IQR 44-67); women were 52.19%; in the acute phase 24.1% of patients were treated in a medical department, 7.2% in the ICU and the others at home. At the visit, 389 patients (77.49%) complained of a broad range of symptoms. We reported patients' characteristics according to the course of the disease and the persistence of symptoms. NCA were found in 138 patients (27.49%): among them 60 cases (11.95%) of pericardial effusion. Patients with NCA were older (median 60y, IQR: 47-72, vs median 56y, IQR 42-65), had a higher prevalence of smokers (27% vs 17%; p0.014), CAD (11% vs 6%; p0.048) and stroke/TIA (3.6% vs 0.3%; p0.002) and a lower prevalence of hypercholesterolemia (18% vs 30%; p0.007). The prevalence of NCA seems constant with different subtypes of the virus. Conclusion: the prevalence of NCA in patients who recovered from COVID-19 is high and constant since the beginning of the pandemic; it is predictable based on hospitalization and long-lasting symptoms (9.64%-42.52%). Patients with one of these characteristics should undergo cardiological screening.
Language	English
Publishing date	2024-04-05
Publishing country	Netherlands
Document type	Journal Article
ISSN	2772-4875
ISSN (online)	2772-4875
DOI	10.1016/j.ijcrp.2024.200267
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Article ; Online: Clinical outcomes of newly diagnosed, stable angina patients managed according to current guidelines. The ARCA (Arca Registry for Chronic Angina) Registry: A prospective, observational, nationwide study.

Orsini, Enrico / Marzilli, Mario / Zito, Giovanni Battista / Carbone, Vincenzo / Latina, Loredana / Oliviero, Ugo / Rizzo, Umberto

International journal of cardiology

2022 Volume 352, Page(s) 9–18

Abstract: Background: Clinical outcomes of stable angina patients treated according to guidelines recommendations (medical therapy first, selective revascularization in high risk or unresponsive patients) are not fully known.: Methods and results: Eight ... ...

Abstract	Background: Clinical outcomes of stable angina patients treated according to guidelines recommendations (medical therapy first, selective revascularization in high risk or unresponsive patients) are not fully known. Methods and results: Eight hundred thirty-three patients with newly diagnosed, stable angina were enrolled in a prospective, observational, nationwide registry and followed for 1 year. Symptoms and quality of life were evaluated with the CCS angina grading, with a self-assessment scale and with the SAQ-7. A composite end-point of MACEs (all-cause death, non-fatal myocardial infarction, non-fatal stroke or hospitalization for unstable angina) at 1 year was considered. Upon enrollment, all patients were prescribed guidelines directed medical therapy. After one month of therapy, angina relieved or improved in 47% of the overall population. Patients in CCS class I significantly increased from 28.4% at enrollment to 67.1% at 12 months, and the SAQ-7 score from 58.4 ± 20 to 85.9 ± 14. The rate of MACEs was low (2.9%) in the overall population. After one month of medical therapy, 40.6% of patients were referred for coronary angiography and revascularization for resistant symptoms (invasive strategy). Among these, 38.2% had normal coronary arteries and 47% actually underwent revascularization. No difference between invasive and medical groups was found at 12 months in symptoms, quality of life and MACEs, except for a greater improvement in self-assessed symptoms in the invasive group. Combined medical and invasive strategies left 28.5% of patients still symptomatic at the end of the study. Conclusions: The study confirms the efficacy and safety of a tailored approach to stable angina, as recommended by guidelines, with medical therapy first followed by selective revascularization when needed.
MeSH term(s)	Angina, Stable ; Coronary Angiography ; Humans ; Myocardial Infarction/therapy ; Prospective Studies ; Quality of Life ; Registries ; Treatment Outcome
Language	English
Publishing date	2022-02-01
Publishing country	Netherlands
Document type	Journal Article ; Observational Study
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2022.01.056
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Article ; Online: Effects of three-months folate supplementation on early vascular abnormalities in hyperhomocysteinemic patients with epilepsy.

De Luca, Mariarosaria / Valvano, Antonio / Striano, Pasquale / Bosso, Giorgio / Pirone, Daniela / Trinchillo, Assunta / Bilo, Leonilda / Oliviero, Ugo

Seizure

2022 Volume 103, Page(s) 120–125

Abstract: Background: Epilepsy has been associated with an increased risk of cardiovascular events. Anti-seizure medication (ASM) may contribute to vascular risk by several mechanisms, including increased homocysteine levels. This study aims to assess the global ... ...

Abstract	Background: Epilepsy has been associated with an increased risk of cardiovascular events. Anti-seizure medication (ASM) may contribute to vascular risk by several mechanisms, including increased homocysteine levels. This study aims to assess the global vascular burden in hyperhomocysteinemic people with epilepsy (PWE) on long-term ASM before and after folic acid supplementation and in subgroups of PWE treated with single enzyme-inducing or single non-enzyme inducing ASM. Methods: One hundred and seventy-four hyperhomocysteinemic (HHcy) PWE who met the inclusion criteria were enrolled. Carotid Doppler ultrasonography, FMD and ultrasound assessment of the brachial artery properties at the baseline and after 90 days of folic acid supplementation were performed. The vascular biomarkers MMP-9 and TIMP-1 were also detected. Results: After folic acid supplementation, in HHcy patients homocysteine levels reduced from 26.8 ± 10.5 to 20.2 ± 5.3 μmol/L, carotid Intima-Media-Thickness reduced from 0.83+0.06 mm to 0.79±0.05 mm, and FMD, distensibility coefficient and β-stiffness improved (p < 0.05). Moreover, MMP-9 and TIMP-1 reduced after supplementation (p < 0.05). PWE treated with a single enzyme-inducing ASM showed an impairment of vascular parameters compared to patients treated with non-enzyme inducing ASM. Conclusions: The results highlight the importance of assessing homocysteine levels and estimating the cardiovascular risk of PWE, preferring non-enzyme inducing ASM in high cardiovascular-risk patients. An adequate correction of homocysteine levels with folate supplementation should be considered to improve the cardiovascular profile.
MeSH term(s)	Humans ; Tissue Inhibitor of Metalloproteinase-1 ; Matrix Metalloproteinase 9 ; Epilepsy/complications ; Epilepsy/drug therapy ; Dietary Supplements ; Homocysteine ; Folic Acid/therapeutic use
Chemical Substances	Tissue Inhibitor of Metalloproteinase-1 ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Homocysteine (0LVT1QZ0BA) ; Folic Acid (935E97BOY8)
Language	English
Publishing date	2022-11-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1137610-7
ISSN	1532-2688 ; 1059-1311
ISSN (online)	1532-2688
ISSN	1059-1311
DOI	10.1016/j.seizure.2022.11.009
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Article ; Online: Alert-LDL-2: adherence to guidelines and goals attainment in the treatment of diabetic patients with dyslipidemia.

DE Luca, Mariarosaria / Bosso, Giorgio / Alma, Giovanni / Carbone, Vincenzo / Ferrara, Ferdinando / Fimiani, Biagio / Guarnaccia, Franco / Iandolo, Alessandro / Murolo, Sabato / Olivares, Maurizio / Romeo, Emanuele / Santoro, Giosuè / Valvano, Antonio / Zito, Giovanni / Oliviero, Ugo

Minerva cardiology and angiology

2023 Volume 71, Issue 3, Page(s) 249–256

Abstract: Background: Type 2 diabetes mellitus is associated with a cluster of lipid and apolipoprotein abnormalities which increase the risk for atherosclerotic cardiovascular disease. The aim of this study was to evaluate the adherence to guidelines-oriented ... ...

Abstract	Background: Type 2 diabetes mellitus is associated with a cluster of lipid and apolipoprotein abnormalities which increase the risk for atherosclerotic cardiovascular disease. The aim of this study was to evaluate the adherence to guidelines-oriented dyslipidemia treatment in diabetic patients and to assess the efficacy of a territorial goal-oriented program. Methods: One thousand seventy-one diabetic patients at very high cardiovascular risk were enrolled in this prospective study. They performed a clinical-laboratory follow-up program, received lifestyle recommendations and optimization of their antihyperlipidemic therapies. At the beginning and the 3-month follow-up visit, LDL-c data were collected, and further therapies were prescribed to the patients that did not reach the target. After 12 month follow-up, LDL-c data were collected again. Results: Diabetic patients significantly improved mean LDL cholesterol levels during one-year follow-up (LDLc mean value 135 mg/dL at baseline, 60 mg/dL at the end of the study), obtaining a greater reduction compared to non-diabetic patients participating in the same program. Accordingly, the percentage of patients that reached the lipid target was significantly higher in diabetic patients after 3-months and 12- follow-ups (P<0.05). Diabetic patients assuming statins, both in monotherapy and in combination with ezetimibe, increased during the follow-up (74.1% at the enrolment vs. 88.2% one year later). GLP1ra-treated patients achieved the greatest reduction in cholesterol levels compared to baseline. Conclusions: The results of the study recommend encouraging strategies and appropriate treatments to achieve a targeted lipid profile in diabetic patients at very high cardiovascular risk.
MeSH term(s)	Humans ; Goals ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Cholesterol, LDL ; Prospective Studies ; Dyslipidemias/drug therapy ; Dyslipidemias/epidemiology
Chemical Substances	Cholesterol, LDL
Language	English
Publishing date	2023-01-13
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3059238-0
ISSN	2724-5772
ISSN (online)	2724-5772
DOI	10.23736/S2724-5683.22.06189-0
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Article ; Online: Can pulse wave velocity (PWV) alone express arterial stiffness? A neglected tool for vascular function assessment.

De Luca, Mariarosaria / Iacono, Olimpia / Valente, Valeria / Giardino, Federica / Crisci, Giulia / Lettieri, Maddalena / Marra, Alberto / Giallauria, Francesco / Oliviero, Ugo

Journal of basic and clinical physiology and pharmacology

2021 Volume 33, Issue 4, Page(s) 373–379

Abstract: Arterial stiffness, defined as the rigidity of the arterial wall, is the consequence of vascular aging and is associated with the full spectrum of cardiovascular diseases. Carotid-femoral pulse wave velocity (cf-PWV) is the gold standard method for ... ...

Abstract	Arterial stiffness, defined as the rigidity of the arterial wall, is the consequence of vascular aging and is associated with the full spectrum of cardiovascular diseases. Carotid-femoral pulse wave velocity (cf-PWV) is the gold standard method for arterial stiffness evaluation: it measures the velocity of the arterial pulse along the thoracic and abdominal aorta alongside arterial distensibility. Its value rises as stiffness progresses. Cf-PWV is helpful to assess residual cardiovascular risk (CVR) in hypertension (HT). In fact, an increase in pulsatility and arterial stiffness predicts CVR in patients affected by arterial HT, independently of other risk factors. Arterial stiffness can predict cardiovascular events in several other clinical conditions such as heart failure, diabetes, and pulmonary HT. However, cf-PWV has not been yet included in routine clinical practice so far. A possible reason might be its methodological and theoretical limitations (inaccuracy in the traveled distance, intra and interindividual variability, lack of well-defined references values, and age- and blood pressure-independent cutoff). To exceed these limits a strict adherence to guidelines, use of analytical approaches, and possibility of integrating the results with other stiffness examinations are essential approaches.
MeSH term(s)	Aging ; Blood Pressure ; Humans ; Hypertension ; Pulse Wave Analysis ; Vascular Stiffness
Language	English
Publishing date	2021-07-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1071737-7
ISSN	2191-0286 ; 0792-6855 ; 0334-1534
ISSN (online)	2191-0286
ISSN	0792-6855 ; 0334-1534
DOI	10.1515/jbcpp-2021-0193
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Article ; Online: Atorvastatin-linked rhabdomyolysis caused by the simultaneous intake of amoxicillin clavulanic acid.

De Luca, Mariarosaria / Iacono, Olimpia / Lucci, Rosa / Guardasole, Vincenzo / Bosso, Giorgio / Cittadini, Antonio / Oliviero, Ugo

Journal of basic and clinical physiology and pharmacology

2020

Abstract: Objectives Rhabdomyolysis is a rare syndrome in which a serious muscle damage suddenly appears, with the possible occurrence of severe complications such as kidney failure, electrolyte imbalances and death, and represents the most severe form of statin- ... ...

Abstract	Objectives Rhabdomyolysis is a rare syndrome in which a serious muscle damage suddenly appears, with the possible occurrence of severe complications such as kidney failure, electrolyte imbalances and death, and represents the most severe form of statin-induced muscle injury. Case presentation Here we present the case of a 55-year-old woman who started therapy with amoxicillin clavulanic acid on a background of atorvastatin therapy, resulting in rhabdomyolysis. Conclusions This case highlights the importance of evaluating potential drug interactions in patients taking statin and the need of monitoring clinical and laboratory findings suggestive of rhabdomyolysis.
Language	English
Publishing date	2020-09-08
Publishing country	Germany
Document type	Case Reports
ZDB-ID	1071737-7
ISSN	2191-0286 ; 0792-6855 ; 0334-1534
ISSN (online)	2191-0286
ISSN	0792-6855 ; 0334-1534
DOI	10.1515/jbcpp-2020-0108
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Article ; Online: Adherence to guidelines in the management of patients with chronic heart failure follow-up: role of periodic echocardiographic examinations.

Bosso, Giorgio / Valvano, Antonio / Guarnaccia, Franco / Fimiani, Biagio / Carbone, Vincenzo / Cittadini, Antonio / Zito, Giovanni Battista / Oliviero, Ugo

Journal of cardiovascular medicine (Hagerstown, Md.)

2020 Volume 21, Issue 3, Page(s) 216–222

Abstract: Background and aim: The Adherence to Guidelines in the Treatment of patients with Chronic Heart Failure trial showed a poor adherence to the current therapeutic guidelines in 660 chronic heart failure (CHF) patients. The second phase, Adherence to ... ...

Abstract	Background and aim: The Adherence to Guidelines in the Treatment of patients with Chronic Heart Failure trial showed a poor adherence to the current therapeutic guidelines in 660 chronic heart failure (CHF) patients. The second phase, Adherence to Guidelines in the Treatment of patients with Chronic Heart Failure follow-up, was aimed to determine if periodic echocardiographic evaluations could improve the prognosis of CHF patients and/or increase the adherence to the guidelines. Material and methods: Among 528 CHF patients with reduced ejection fraction from the ALERT registry, 436 patients accepted to participate in the second phase of the study between February and September 2013 and completed the 3-year follow-up phase between February and September 2016. They were randomized into two groups: Group A (n = 218) followed by clinical evaluation and ECG every 3 months, and echocardiography every 6 months and Group B (n = 218) monitored only with clinical evaluation and ECG every 3 months. Results: The number of vascular events that occurred resulted as similar in both the groups: there were 78 hospitalizations (37 in Group A vs. 41 in Group B); 9 home-treated vascular events (4 in Group A and five in Group B); and 16 cardiovascular deaths (9 and 7, respectively). The adherence to the guidelines at the end of the trial resulted as significantly improved in both the groups in comparison with the basal evaluation, without differences between the two groups. Conclusion: A strict follow-up of CHF patients was associated with a lower number of events and an improvement in the adherence to the guidelines. Periodic echocardiography does not modify these results.
MeSH term(s)	Aged ; Aged, 80 and over ; Chronic Disease ; Echocardiography/trends ; Electrocardiography/trends ; Female ; Guideline Adherence/trends ; Heart Failure/diagnostic imaging ; Heart Failure/mortality ; Heart Failure/physiopathology ; Heart Failure/therapy ; Home Care Services/trends ; Hospitalization/trends ; Humans ; Italy ; Male ; Practice Guidelines as Topic ; Practice Patterns, Physicians'/trends ; Predictive Value of Tests ; Registries ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2020-01-30
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	2223461-5
ISSN	1558-2035 ; 1558-2027
ISSN (online)	1558-2035
ISSN	1558-2027
DOI	10.2459/JCM.0000000000000940
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Article ; Online: Peripheral Vascular Function in Dilated Cardiomyopathy of Different Etiology.

Bosso, Giorgio / Valvano, Antonio / Apuzzi, Valentina / Mercurio, Valentina / Di Simone, Valeria / Cittadini, Antonio / Napoli, Raffaele / Oliviero, Ugo

Angiology

2020 Volume 71, Issue 8, Page(s) 726–733

Abstract: Vascular function in dilated cardiomyopathy of different etiology has been poorly investigated. Moreover, reference values of flow-mediated dilation (FMD) in chronic heart failure (CHF) need to be updated according to the new standardized protocols. We ... ...

Abstract	Vascular function in dilated cardiomyopathy of different etiology has been poorly investigated. Moreover, reference values of flow-mediated dilation (FMD) in chronic heart failure (CHF) need to be updated according to the new standardized protocols. We characterized the vascular impairment in different stages of post-ischemic dilated cardiomyopathy (PI-DC) or idiopathic dilated cardiomyopathy (I-DC). Eighty consecutive outpatients with CHF in different New York Heart Association (NYHA) classes (45 PI-DC, 35 I-DC) and 50 control subjects underwent FMD and brachial distensibility coefficient measurement. Patients with CHF showed a marked impairment in FMD compared with controls that worsened from classes NYHA I-II to III-IV, independently of etiology (
MeSH term(s)	Aged ; Brachial Artery/diagnostic imaging ; Brachial Artery/physiopathology ; Cardiomyopathy, Dilated/diagnostic imaging ; Cardiomyopathy, Dilated/etiology ; Cardiomyopathy, Dilated/physiopathology ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Myocardial Ischemia/complications ; Myocardial Ischemia/diagnosis ; Myocardial Ischemia/physiopathology ; Prognosis ; Risk Assessment ; Risk Factors ; Vascular Stiffness ; Vasodilation
Language	English
Publishing date	2020-06-17
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	80040-5
ISSN	1940-1574 ; 0003-3197
ISSN (online)	1940-1574
ISSN	0003-3197
DOI	10.1177/0003319720932803
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