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  1. Book: Pulmonale Hypertonie

    Olschewski, Horst / Olschewski, Andrea

    2011  

    Author's details [Horst Olschewski ; Andrea Olschewski]
    Keywords Hypertension, Pulmonary / prevention & control ; Pulmonary Circulation / physiology ; Pulmonale Hypertonie
    Subject Lungenhochdruck ; Pulmonale hypertension ; Pulmonal-arterielle Hypertonie ; PAH
    Subject code 616.24
    Language German
    Size 156 S. : Ill., graph. Darst.
    Edition 2. Aufl.
    Publisher UNI-MED-Verl
    Publishing place Bremen u.a.
    Publishing country Germany
    Document type Book
    Note Literaturangaben
    HBZ-ID HT017852165
    ISBN 978-3-8374-2211-5 ; 3-8374-2211-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 1015 available for loan (reading room) Lesesaal EG

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  2. Article: Succinate at the Crossroad of Metabolism and Angiogenesis: Roles of SDH, HIF1α and SUCNR1.

    Atallah, Reham / Olschewski, Andrea / Heinemann, Akos

    Biomedicines

    2022  Volume 10, Issue 12

    Abstract: Angiogenesis is an essential process by which new blood vessels develop from existing ones. While adequate angiogenesis is a physiological process during, for example, tissue repair, insufficient and excessive angiogenesis stands on the pathological side. ...

    Abstract Angiogenesis is an essential process by which new blood vessels develop from existing ones. While adequate angiogenesis is a physiological process during, for example, tissue repair, insufficient and excessive angiogenesis stands on the pathological side. Fine balance between pro- and anti-angiogenic factors in the tissue environment regulates angiogenesis. Identification of these factors and how they function is a pressing topic to develop angiogenesis-targeted therapeutics. During the last decade, exciting data highlighted non-metabolic functions of intermediates of the mitochondrial Krebs cycle including succinate. Among these functions is the contribution of succinate to angiogenesis in various contexts and through different mechanisms. As the concept of targeting metabolism to treat a wide range of diseases is rising, in this review we summarize the mechanisms by which succinate regulates angiogenesis in normal and pathological settings. Gaining a comprehensive insight into how this metabolite functions as an angiogenic signal will provide a useful approach to understand diseases with aberrant or excessive angiogenic background, and may provide strategies to tackle them.
    Language English
    Publishing date 2022-12-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10123089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Let's Talk About Respiratory Swings!

    Olschewski, Horst / Zeder, Katarina / Douschan, Philipp / Sassmann, Teresa / Foris, Vasile / Olschewski, Andrea / Kovacs, Gabor

    American journal of respiratory and critical care medicine

    2023  Volume 208, Issue 12, Page(s) 1338–1340

    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Letter
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202309-1637LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.80: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Blocking potassium channels: a new principle for treating restenosis?

    Olschewski, Andrea

    Cardiovascular research

    2011  Volume 89, Issue 2, Page(s) 255–257

    MeSH term(s) Animals ; Arterial Occlusive Diseases/drug therapy ; Arterial Occlusive Diseases/metabolism ; Arterial Occlusive Diseases/pathology ; Cardiovascular Agents/therapeutic use ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Constriction, Pathologic ; Humans ; Hyperplasia ; Kv1.3 Potassium Channel/antagonists & inhibitors ; Kv1.3 Potassium Channel/metabolism ; Mice ; Muscle, Smooth, Vascular/drug effects ; Muscle, Smooth, Vascular/metabolism ; Muscle, Smooth, Vascular/pathology ; Myocytes, Smooth Muscle/drug effects ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/pathology ; Potassium Channel Blockers/therapeutic use ; Recurrence ; Tunica Intima/drug effects ; Tunica Intima/metabolism ; Tunica Intima/pathology
    Chemical Substances Cardiovascular Agents ; Kv1.3 Potassium Channel ; Potassium Channel Blockers
    Language English
    Publishing date 2011-02-01
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvq388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Targeting TASK-1 channels as a therapeutic approach.

    Olschewski, Andrea

    Advances in experimental medicine and biology

    2010  Volume 661, Page(s) 459–473

    Abstract: The voltage-independent background two-pore domain K(+) channel TASK-1 sets the resting membrane potential in excitable cells and renders these cells sensitive to a variety of vasoactive factors. There is clear evidence for TASK-1 in human pulmonary ... ...

    Abstract The voltage-independent background two-pore domain K(+) channel TASK-1 sets the resting membrane potential in excitable cells and renders these cells sensitive to a variety of vasoactive factors. There is clear evidence for TASK-1 in human pulmonary artery smooth muscle cells and TASK-1 channels are likely to regulate the pulmonary vascular tone through their regulation by hypoxia, pH, inhaled anesthetics, and G protein-coupled pathways. Furthermore, TASK-1 is a strong candidate to play a role in hypoxic pulmonary vasoconstriction. On the other hand, consistent with the activation of TASK-1 channels by volatile anesthetics, TASK-1 contributes to the anesthetic-induced pulmonary vasodilation. TASK-1 channels are unique among K(+) channels because they are regulated by both, increases and decreases from physiological pH, thus contributing to their protective effect on the pulmonary arteries. Moreover, TASK-1 may also have a critical role in mediating the vasoactive response of G protein-coupled pathways in resistance arteries which can offer promising therapeutic solutions to target diseases of the pulmonary circulation.
    MeSH term(s) Anesthetics, Inhalation/metabolism ; Animals ; Endothelin-1/metabolism ; Humans ; Hydrogen-Ion Concentration ; Hypoxia/metabolism ; Muscle, Smooth, Vascular/cytology ; Myocytes, Smooth Muscle/cytology ; Myocytes, Smooth Muscle/physiology ; Nerve Tissue Proteins/chemistry ; Nerve Tissue Proteins/classification ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Phylogeny ; Potassium Channels, Tandem Pore Domain/chemistry ; Potassium Channels, Tandem Pore Domain/classification ; Potassium Channels, Tandem Pore Domain/genetics ; Potassium Channels, Tandem Pore Domain/metabolism ; Protein Isoforms/chemistry ; Protein Isoforms/classification ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Pulmonary Artery/cytology ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction/physiology ; Vasoconstriction/physiology
    Chemical Substances Anesthetics, Inhalation ; Endothelin-1 ; Nerve Tissue Proteins ; Potassium Channels, Tandem Pore Domain ; Protein Isoforms ; Receptors, G-Protein-Coupled ; potassium channel subfamily K member 3
    Language English
    Publishing date 2010
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-1-60761-500-2_30
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Apelin-17 to diagnose idiopathic pulmonary arterial hypertension: A biomarker study.

    Foris, Vasile / Kovacs, Gabor / Avian, Alexander / Bálint, Zoltán / Douschan, Philipp / Ghanim, Bahil / Klepetko, Walter / Olschewski, Andrea / Olschewski, Horst

    Frontiers in physiology

    2023  Volume 13, Page(s) 986295

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.986295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Endotyping COPD: hypoxia-inducible factor-2 as a molecular "switch" between the vascular and airway phenotypes?

    Myronenko, Oleh / Foris, Vasile / Crnkovic, Slaven / Olschewski, Andrea / Rocha, Sonia / Nicolls, Mark R / Olschewski, Horst

    European respiratory review : an official journal of the European Respiratory Society

    2023  Volume 32, Issue 167

    Abstract: COPD is a heterogeneous disease with multiple clinical phenotypes. COPD endotypes can be determined by different expressions of hypoxia-inducible factors (HIFs), which, in combination with individual susceptibility and environmental factors, may cause ... ...

    Abstract COPD is a heterogeneous disease with multiple clinical phenotypes. COPD endotypes can be determined by different expressions of hypoxia-inducible factors (HIFs), which, in combination with individual susceptibility and environmental factors, may cause predominant airway or vascular changes in the lung. The pulmonary vascular phenotype is relatively rare among COPD patients and characterised by out-of-proportion pulmonary hypertension (PH) and low diffusing capacity of the lung for carbon monoxide, but only mild-to-moderate airway obstruction. Its histologic feature, severe remodelling of the small pulmonary arteries, can be mediated by HIF-2 overexpression in experimental PH models. HIF-2 is not only involved in the vascular remodelling but also in the parenchyma destruction. Endothelial cells from human emphysema lungs express reduced HIF-2α levels, and the deletion of pulmonary endothelial
    MeSH term(s) Animals ; Humans ; Mice ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Emphysema/metabolism ; Emphysema/pathology ; Endothelial Cells/pathology ; Hypertension, Pulmonary/genetics ; Hypertension, Pulmonary/metabolism ; Hypoxia ; Pulmonary Disease, Chronic Obstructive/genetics ; Pulmonary Disease, Chronic Obstructive/metabolism ; Pulmonary Disease, Chronic Obstructive/pathology ; Pulmonary Emphysema/genetics ; Pulmonary Emphysema/metabolism
    Chemical Substances Basic Helix-Loop-Helix Transcription Factors ; endothelial PAS domain-containing protein 1 (1B37H0967P)
    Language English
    Publishing date 2023-01-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0173-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3265: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Compartment-specific remodeling patterns in end-stage chronic obstructive pulmonary disease with and without severe pulmonary hypertension.

    Zeder, Katarina / Marsh, Leigh M / Avian, Alexander / Brcic, Luka / Birnhuber, Anna / Douschan, Philipp / Foris, Vasile / Sassmann, Teresa / Hoetzenecker, Konrad / Boehm, Panja M / Kwapiszewska, Grazyna / Olschewski, Andrea / Olschewski, Horst / Kovacs, Gabor

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2024  

    Abstract: Background: In patients with end-stage chronic obstructive pulmonary disease (COPD), severe pulmonary hypertension (PH) is frequently associated with less severe airway obstruction as compared to mild or no PH. However, the histologic correlate of this ... ...

    Abstract Background: In patients with end-stage chronic obstructive pulmonary disease (COPD), severe pulmonary hypertension (PH) is frequently associated with less severe airway obstruction as compared to mild or no PH. However, the histologic correlate of this finding is not clear. We aimed to quantify remodeling of pulmonary arteries, airways, and parenchyma in random samples of explanted end-stage COPD lungs.
    Methods: We quantified remodeling of small pulmonary arteries, small airways, and the degree of emphysema (mean interseptal distance [MID]) with dedicated software. As primary objective, we compared COPD patients with severe PH (SevPH-COPD) with age- and sex-matched MildPH-COPD. For comparison, we also investigated COPD lungs with no PH (NoPH-COPD), idiopathic PAH (IPAH), and healthy donors.
    Results: We included n = 17 SevPH-COPD (mPAP = 43 [39-45]mm Hg), n = 17 MildPH-COPD (mPAP = 28 [24-31]mm Hg), n = 5 NoPH-COPD (mPAP = 18 [16-19]mm Hg), n = 10 IPAH (mPAP = 72 [65-91]mm Hg), and n = 10 healthy donor lungs. SevPH-COPD versus MildPH-COPD was characterized by better preserved forced vital capacity (51% vs 40% predicted, p < 0.05), less emphysema (MID 169 µm vs 279 µm, p < 0.001), and less PAS-positive and CD45-positive mucosa cells (15% vs 22%, p = 0.063% and 5% vs 7%, p = 0.058) suggesting less airway inflammation. In COPD patients, intimal and medial thickening were strongly correlated with mPAP (r = 0.676, p < 0.001 and r = 0.595, p < 0.001). MID was negatively correlated with mPAP (r = -0.556, p < 0.001) and was highest in NoPH-COPD (mean 281 µm), suggesting that emphysema per se is not associated with PH.
    Conclusions: End-stage COPD with severe PH is characterized by pronounced pulmonary vascular remodeling, less inflammation of small airways, and less emphysema as compared to COPD with mild PH or no PH, suggesting that COPD with severe PH may represent a unique phenotype of COPD.
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2024.02.1044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2056: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Revisiting the Large-Conductance Calcium-Activated Potassium (BKCa) Channels in the Pulmonary Circulation.

    Guntur, Divya / Olschewski, Horst / Enyedi, Péter / Csáki, Réka / Olschewski, Andrea / Nagaraj, Chandran

    Biomolecules

    2021  Volume 11, Issue 11

    Abstract: Potassium ion concentrations, controlled by ion pumps and potassium channels, predominantly govern a cell's membrane potential and the tone in the vessels. Calcium-activated potassium channels respond to two different stimuli-changes in voltage and/or ... ...

    Abstract Potassium ion concentrations, controlled by ion pumps and potassium channels, predominantly govern a cell's membrane potential and the tone in the vessels. Calcium-activated potassium channels respond to two different stimuli-changes in voltage and/or changes in intracellular free calcium. Large conductance calcium-activated potassium (BKCa) channels assemble from pore forming and various modulatory and auxiliary subunits. They are of vital significance due to their very high unitary conductance and hence their ability to rapidly cause extreme changes in the membrane potential. The pathophysiology of lung diseases in general and pulmonary hypertension, in particular, show the implication of either decreased expression and partial inactivation of BKCa channel and its subunits or mutations in the genes encoding different subunits of the channel. Signaling molecules, circulating humoral molecules, vasorelaxant agents, etc., have an influence on the open probability of the channel in pulmonary arterial vascular cells. BKCa channel is a possible therapeutic target, aimed to cause vasodilation in constricted or chronically stiffened vessels, as shown in various animal models. This review is a comprehensive collation of studies on BKCa channels in the pulmonary circulation under hypoxia (hypoxic pulmonary vasoconstriction; HPV), lung pathology, and fetal to neonatal transition, emphasising pharmacological interventions as viable therapeutic options.
    MeSH term(s) Calcium ; Large-Conductance Calcium-Activated Potassium Channels ; Pulmonary Circulation
    Chemical Substances Large-Conductance Calcium-Activated Potassium Channels ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-11-03
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom11111629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Potassium Channels in the Transition from Fetal to the Neonatal Pulmonary Circulation.

    Nagaraj, Chandran / Li, Yingji / Tang, Bi / Bordag, Natalie / Guntur, Divya / Enyedi, Péter / Olschewski, Horst / Olschewski, Andrea

    International journal of molecular sciences

    2022  Volume 23, Issue 9

    Abstract: The transition from the fetal to the neonatal circulation includes dilatation of the pulmonary arteries (PA) and closure of the Ductus Arteriosus Botalli (DAB). The resting membrane potential and various potassium channel activities in smooth muscle ... ...

    Abstract The transition from the fetal to the neonatal circulation includes dilatation of the pulmonary arteries (PA) and closure of the Ductus Arteriosus Botalli (DAB). The resting membrane potential and various potassium channel activities in smooth muscle cells (SMC) from fetal and neonatal PA and DAB obtained from the same species has not been systematically analyzed. The key issue addressed in this paper is how the resting membrane potential and the whole-cell potassium current (IK) change when PASMC or DABSMC are transitioned from hypoxia, reflecting the fetal state, to normoxia, reflecting the post-partal state. Patch-clamp measurements were employed to characterize whole-cell K
    MeSH term(s) Animals ; Ductus Arteriosus/metabolism ; Fetal Development/physiology ; Humans ; Infant, Newborn ; Muscle, Smooth, Vascular/metabolism ; Potassium Channels/metabolism ; Pulmonary Artery/metabolism ; Pulmonary Circulation/physiology ; Rats
    Chemical Substances Potassium Channels
    Language English
    Publishing date 2022-04-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23094681
    Database MEDical Literature Analysis and Retrieval System OnLINE

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