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Article ; Online: Contraceptive uptake among gender-expansive individuals in the HER Salt Lake Contraceptive Initiative.

Lazaris, E / Sanders, J N / Carter, G / Olsen, J / Gero, A / Gawron, L M

2024 , Page(s) 110446

Abstract: Objectives: We examined differences in contraceptive uptake and discontinuation between gender-expansive individuals and cis-women in the HER Salt Lake Contraceptive Initiative.: Study design: We used self-reported survey data to assess associations ... ...

Abstract	Objectives: We examined differences in contraceptive uptake and discontinuation between gender-expansive individuals and cis-women in the HER Salt Lake Contraceptive Initiative. Study design: We used self-reported survey data to assess associations between gender identity, contraceptive uptake, and discontinuation. Results: Of participants (n=4,289), 178/4289(4%) identified as gender-expansive with 157/178(88%) reporting recent sexual activity with men. Selection of IUD or Implant was most common, with 109/178(61%) of gender-expansive individuals choosing these options. We observed similar methods selected (p=0.2) and discontinuation rates at three years between participants (OR: 0.93, p=0.8). Conclusion: Gender-expansive individuals had similar method selection and discontinuation rates as cis-women.
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	80106-9
ISSN	1879-0518 ; 0010-7824
ISSN (online)	1879-0518
ISSN	0010-7824
DOI	10.1016/j.contraception.2024.110446
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Article ; Online: A relativistic configuration interaction method with general expansions and initial applications to electronic g-factors.

Nyvang, Andreas / Olsen, Jeppe

The Journal of chemical physics

2023 Volume 159, Issue 4

Abstract: A new implementation of the orbital-based two-component relativistic configuration interaction approach is reported and applied to calculations of the electronic g-shifts of three diatomic radicals: AlO, HgF, and PdH. The new implementation augments ... ...

Abstract	A new implementation of the orbital-based two-component relativistic configuration interaction approach is reported and applied to calculations of the electronic g-shifts of three diatomic radicals: AlO, HgF, and PdH. The new implementation augments efficient routines for the calculation of nonrelativistic Hamiltonians with new vectorized routines for the calculation of the action of the one-electron spin-orbit operator and allows efficient calculations for the expansion of generalized active space type. The program makes full use of double group as well as time-reversal symmetry. Particle-hole reorganization of the operators is used to improve the efficiency for expansions with nearly fully occupied orbital spaces. The flexibility of the algorithm and program is used to investigate the convergence of electronic g-shifts for the three diatomic radicals as functions of the active space, states included in the orbital optimization, and excitation levels. It was possible to converge to the valence limits within a few percent using expansions containing up to quadruple excitations. However, when excitations from the core orbitals were added, it was not possible to demonstrate convergence to within a few percent with expansions containing at most 10 × 109 determinants.
Language	English
Publishing date	2023-07-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/5.0152655
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Article ; Online: Effectiveness of lapatinib for enhancing 5-aminolevulinic acid-mediated protoporphyrin IX fluorescence and photodynamic therapy in human cancer cell lines with varied ABCG2 activities.

Howley, Richard / Olsen, Jordyn / Chen, Bin

Photochemistry and photobiology

2024

Abstract: 5-Aminolevulinic acid (ALA) is a prodrug for protoporphyrin IX (PpIX)-mediated photodynamic therapy (PDT) and fluorescence-guided tumor surgery. We previously reported that lapatinib, a repurposed ABCG2 inhibitor, enhanced ALA-induced PpIX fluorescence ... ...

Abstract	5-Aminolevulinic acid (ALA) is a prodrug for protoporphyrin IX (PpIX)-mediated photodynamic therapy (PDT) and fluorescence-guided tumor surgery. We previously reported that lapatinib, a repurposed ABCG2 inhibitor, enhanced ALA-induced PpIX fluorescence and PDT by blocking ABCG2-mediated PpIX efflux. In the present study, we evaluated how the variation in ABCG2 activities/protein levels affected tumor cell response to the enhancement of PpIX/PDT by lapatinib and Ko143, an ABCG2 tool inhibitor. ABCG2 activities and protein levels were determined in a panel of human cancer cell lines. Effects of lapatinib and Ko143 on enhancing ALA-PpIX fluorescence and PDT were evaluated and correlated with tumor cell ABCG2 activities. We found that both lapatinib and Ko143 enhanced ALA-PpIX fluorescence and PDT in a dose-dependent manner, although lapatinib exhibited lower efficacy and potency than Ko143 in nearly all cancer cell lines. The EC
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	123540-0
ISSN	1751-1097 ; 0031-8655
ISSN (online)	1751-1097
ISSN	0031-8655
DOI	10.1111/php.13936
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Article ; Online: Interpretation of Oxygen Saturation in Congenital Heart Disease: Fact and Fallacy.

Olsen, Jillian / Puri, Kriti

Pediatrics in review

2022 Volume 43, Issue 8, Page(s) 436–448

Abstract: Oxygen saturation is the percentage of hemoglobin that is saturated with oxygen, converting it to oxyhemoglobin. Oxygen saturation is a critical part of the physical examination of children with congenital heart disease (CHD). The expected oxygen ... ...

Abstract	Oxygen saturation is the percentage of hemoglobin that is saturated with oxygen, converting it to oxyhemoglobin. Oxygen saturation is a critical part of the physical examination of children with congenital heart disease (CHD). The expected oxygen saturation of a patient with CHD depends on their anatomical lesion, their previous surgeries, and any additional pulmonary or systemic pathology that may derange their saturation. Oxygen saturation can be noninvasively measured using pulse oximetry. Pulse oximetry is based on the differential absorption of infrared and red light by oxyhemoglobin and deoxyhemoglobin, with the former absorbing more infrared than the latter. Pulse oximetry readings may be inaccurate in settings of low cardiac output, peripheral vasoconstriction, arrhythmia, hypothermia, and venous pulsations. The use of pulse oximetry in the care of a child with CHD begins with the newborn critical CHD screen. A failed screen indicates a need for further investigation, such as repeated pulse oximetry or echocardiography. The oxyhemoglobin dissociation curve may be used to estimate the partial pressure of oxygen in the blood at various oxygen saturations. It is also a marker of the affinity of hemoglobin for oxygen, with a right-shifted curve indicating a higher oxygen tension needed to saturate hemoglobin. This is a helpful adaptation of the body to situations of stress such as fever, acidosis, and hypercapnia. An understanding of these concepts is paramount for providers caring for patients with known or potential CHD in any setting to appropriately interpret and respond to abnormal saturations for each child.
MeSH term(s)	Child ; Heart Defects, Congenital/diagnosis ; Hemoglobins/analysis ; Humans ; Infant, Newborn ; Oximetry ; Oxygen ; Oxygen Saturation ; Oxyhemoglobins/analysis ; Oxyhemoglobins/metabolism
Chemical Substances	Hemoglobins ; Oxyhemoglobins ; Oxygen (S88TT14065)
Language	English
Publishing date	2022-08-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	774515-1
ISSN	1526-3347 ; 0191-9601
ISSN (online)	1526-3347
ISSN	0191-9601
DOI	10.1542/pir.2020-005364
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Article ; Online: Barriers to adoption of a local anesthesia program for inguinal hernia repair: authors' reply.

Olsen, J H H / Rosenberg, J

Hernia : the journal of hernias and abdominal wall surgery

2022 Volume 27, Issue 1, Page(s) 203–204

MeSH term(s)	Humans ; Anesthesia, Local ; Hernia, Inguinal/surgery ; Herniorrhaphy ; Anesthesia, General ; Anesthesia, Spinal
Language	English
Publishing date	2022-10-19
Publishing country	France
Document type	Letter ; Comment
ZDB-ID	1388125-5
ISSN	1248-9204 ; 1265-4906
ISSN (online)	1248-9204
ISSN	1265-4906
DOI	10.1007/s10029-022-02697-5
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Article ; Online: Does Trans-radial Longitudinal Compression Influence Myoelectric Control?

Olsen, J / Day, S / Dupan, S / Nazarpour, K / Dyson, M

Canadian prosthetics & orthotics journal

2022 Volume 5, Issue 2, Page(s) 37963

Abstract: Background: Existing trans-radial prosthetic socket designs are not optimised to facilitate reliable myoelectric control. Many socket designs pre-date the introduction of myoelectric devices. However, socket designs featuring improved biomechanical ... ...

Abstract	Background: Existing trans-radial prosthetic socket designs are not optimised to facilitate reliable myoelectric control. Many socket designs pre-date the introduction of myoelectric devices. However, socket designs featuring improved biomechanical stability, notably longitudinal compression sockets, have emerged in more recent years. Neither the subsequent effects, if any, of stabilising the limb on myoelectric control nor in which arrangement to apply the compression have been reported. Methodology: Twelve able-bodied participants completed two tasks whilst wearing a longitudinal compression socket simulator in three different configurations: 1) compressed, where the compression strut was placed on top of the muscle of interest, 2) relief, where the compression struts were placed either side of the muscle being recorded and 3) uncompressed, with no external compression. The tasks were 1) a single-channel myoelectric target tracking exercise, followed by 2), a high-intensity grasping task. The wearers' accuracy during the tracking task, the pressure at opposing sides of the simulator during contractions and the rate at which the limb fatigued were observed. Findings: No significant difference between the tracking-task accuracy scores or rate of fatigue was observed for the different compression configurations. Pressure recordings from the compressed configuration showed that pressure was maintained at opposing sides of the simulator during muscle contractions. Conclusion: Longitudinal compression does not inhibit single-channel EMG control, nor improve fatigue performance. Longitudinal compression sockets have the potential to improve the reliability of multi-channel EMG control due to the maintenance of pressure during muscle contractions.
Language	English
Publishing date	2022-07-20
Publishing country	Canada
Document type	Journal Article
ISSN	2561-987X
ISSN (online)	2561-987X
DOI	10.33137/cpoj.v5i2.37963
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Article ; Online: Cost of illness of HER2-positive and metastatic and recurrent HER2-positive breast cancer - a Danish register-based study from 2005 to 2016.

Spanggaard, M / Olsen, J / Jensen, K F / Anderson, M

BMC health services research

2022 Volume 22, Issue 1, Page(s) 745

Abstract: Background: Information and knowledge about cost of illness and labour productivity in patients with HER2-positive early-stage and metastatic breast cancer treated with trastuzumab is limited. The aim of this study was to estimate the direct and ... ...

Abstract	Background: Information and knowledge about cost of illness and labour productivity in patients with HER2-positive early-stage and metastatic breast cancer treated with trastuzumab is limited. The aim of this study was to estimate the direct and indirect costs associated with treatment of HER2-positive breast cancer among patients with early-stage and metastatic breast cancer, treated with trastuzumab, in a 10-year period after diagnosis. Materials and methods: This study included all Danish HER2-positive breast cancer patients (≥ 18 years) treated with trastuzumab between 2005 and 2016 identified in The Danish Patient Register and the Danish Cancer Register. Furthermore, we identified patients experiencing metastatic or recurrent breast cancer. For the study populations, we estimated total direct costs and indirect costs for one year prior to the breast cancer diagnosis and up to 10 years after diagnosis compared with a group of matched controls free of breast cancer. In addition to The Danish Patient Register and Cancer Register, we applied patient level data from The Civil Registration System, The National Pathology Register, National Health Service Register for Primary Care, Register of Medicinal Product Statistics, Register of Municipal Services, The DREAM database, and Population's Education Register. Results: We identified 4,153 HER2-positive breast cancer patients, whereof 27% were identified with metastatic or recurrent breast cancer. During the follow-up period of 10 years, we estimated excess direct costs of EUR 115,000 among the total study population compared to controls; EUR 211,000 among patients with metastases or recurrence; and EUR 89,000 among patients without metastases or recurrence. Direct costs were found to be highest in the first year after diagnosis and also peaked in the year after recurrence. Labour productivity was significantly lower among patients with recurrence 10 years after breast cancer diagnosis compared with controls. Conclusions: In this study, we estimated the direct and indirect cost associated with HER2-positive breast cancer. The costs were significantly higher during the 10 years after diagnosis compared to the control group, specifically among patients experiencing metastases or recurrence of breast cancer.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols ; Breast Neoplasms/drug therapy ; Cost of Illness ; Denmark/epidemiology ; Female ; Humans ; Neoplasm Recurrence, Local ; Receptor, ErbB-2/therapeutic use ; State Medicine ; Trastuzumab/therapeutic use
Chemical Substances	Receptor, ErbB-2 (EC 2.7.10.1) ; Trastuzumab (P188ANX8CK)
Language	English
Publishing date	2022-06-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2050434-2
ISSN	1472-6963 ; 1472-6963
ISSN (online)	1472-6963
ISSN	1472-6963
DOI	10.1186/s12913-022-08143-7
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Article ; Online: SuPAR in major depression: Association with 26 weeks antidepressant response and 10-year depression outcomes.

Haupt, T H / Elfving, B / Eugen-Olsen, J / Mors, O / Köhler-Forsberg, O

Brain, behavior, & immunity - health

2023 Volume 33, Page(s) 100685

Abstract: Introduction: Inflammation has been associated with depression and differential antidepressant (AD) treatment response. Soluble urokinase plasminogen activator receptor (suPAR) is a novel measure of chronic inflammation. We investigated whether suPAR is ...

Abstract	Introduction: Inflammation has been associated with depression and differential antidepressant (AD) treatment response. Soluble urokinase plasminogen activator receptor (suPAR) is a novel measure of chronic inflammation. We investigated whether suPAR is associated with depression severity and AD response. Methods: We included 90 patients with major depressive disorder (MDD) who participated in a part-randomized clinical trial of 26 weeks of treatment with escitalopram or nortriptyline. suPAR levels were measured in serum samples collected at baseline and after 8, 12 and 26 weeks. Mixed effects models for the association between suPAR levels and AD response were performed. By merging with Danish nationwide registers, we included information on psychiatric hospital contacts during ten years after the GENDEP trial. Cox regression analyses calculated the hazard rate ratios between suPAR levels and subsequent hospitalizations. Results: At baseline, higher suPAR levels were not associated with overall depression severity but with greater severity of neurovegetative depressive symptoms, specifically appetite and weight changes. 57 (63.3%) patients responded positively to treatment. Among 57 (63.3%) patients who achieved response, those who responded had significantly higher baseline suPAR levels levels, and response was associated with a significant decrease in suPAR during AD treatment. Remitters decreased from 3.1 ng/ml at baseline to 2.8 ng/ml after 26 weeks (p = 0.003) and responders from 3.0 to 2.8 ng/ml (p = 0.02), whereas non-remitters and non-responders showed unchanged suPAR levels. We found no correlation between a change in suPAR and a change in MADRS, but a lowering of suPAR correlated with a decrease in neurovegetative symptoms. We found no association between suPAR levels and 10-year risk for hospitalizations. Discussion: The present study suggests that an elevated level of chronic inflammation, measured as the suPAR level, is associated with better response to AD treatment.
Language	English
Publishing date	2023-09-07
Publishing country	United States
Document type	Journal Article
ISSN	2666-3546
ISSN (online)	2666-3546
DOI	10.1016/j.bbih.2023.100685
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Book ; Online: Whistling While They Work

Olsen, Jane / Brown, A. J. / Roberts, Peter

2011

Abstract: This guide sets out results from four years of research into how public sector organisations can better fulfil their missions, maintain their integrity and value their employees by adopting a current best-practice approach to the management of ... ...

Abstract	This guide sets out results from four years of research into how public sector organisations can better fulfil their missions, maintain their integrity and value their employees by adopting a current best-practice approach to the management of whistleblowing. This guide focuses on: the processes needed for public employees and employees of public contractors to be able to report concerns about wrongdoing in public agencies and programs; and managerial responsibilities for the support, protection and management of those who make disclosures about wrongdoing, as part of an integrated management approach.The guide is designed to assist with the special systems needed for managing 'public interest' whistleblowing-where the suspected or alleged wrongdoing affects more than the personal or private interests of the person making the disclosure. As the guide explains, however, an integrated approach requires having good systems for managing all types of reported wrongdoing-including personal, employment and workplace grievances-not least because these might often be interrelated with 'public interest' matters
Keywords	Political institutions and public administration (General)
Size	1 electronic resource (124 p.)
Publisher	ANU Press
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT020087614
ISBN	9781921862304 ; 1921862300
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Preventing Ventilator-Associated Tracheitis in the Pediatric Cardiac Intensive Care Unit.

Olsen, Jessica / Finley, Krista / McNary, Caitlyn

Critical care nurse

2023 Volume 43, Issue 4, Page(s) 80–83

MeSH term(s)	Child ; Humans ; Tracheitis/prevention & control ; Ventilators, Mechanical ; Intensive Care Units, Pediatric ; Pneumonia, Ventilator-Associated/prevention & control ; Respiration, Artificial/adverse effects
Language	English
Publishing date	2023-08-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	632663-8
ISSN	1940-8250 ; 0279-5442
ISSN (online)	1940-8250
ISSN	0279-5442
DOI	10.4037/ccn2023933
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