LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Olson, Jason C"
  2. AU="Buchholz, V."
  3. AU="Urquhart, Bradley L"
  4. AU="Ezaki, Kazune"
  5. AU="Choi, Jong Hyun"
  6. AU="Xie, Qiaowei"
  7. AU=Rojas-Marte G AU=Rojas-Marte G
  8. AU="Belli, A"
  9. AU="Moolman, M Charl"
  10. AU="Mazzoni, Stefania"
  11. AU=Stryjewski Martin E
  12. AU=Vallon Volker AU=Vallon Volker
  13. AU="Knowland, K E"
  14. AU="Beker, M. G."

Suchergebnis

Treffer 1 - 3 von insgesamt 3

Suchoptionen

  1. Artikel ; Online: Correction: Tim‑3 expression represents dysfunctional tumor infiltrating T cells in renal cell carcinoma.

    Cai, Chen / Xu, Yi-Fan / Wu, Zhen-Jie / Dong, Qin / Li, Min-Yu / Olson, Jason C / Rabinowitz, Yaron M / Wang, Lin-Hui / Sun, Yinghao

    World journal of urology

    2023  Band 41, Heft 7, Seite(n) 2001

    Sprache Englisch
    Erscheinungsdatum 2023-06-02
    Erscheinungsland Germany
    Dokumenttyp Published Erratum
    ZDB-ID 380333-8
    ISSN 1433-8726 ; 0724-4983
    ISSN (online) 1433-8726
    ISSN 0724-4983
    DOI 10.1007/s00345-023-04453-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  2. Artikel ; Online: Editorial Expression of Concern: Tim‑3 expression represents dysfunctional tumor infiltrating T cells in renal cell carcinoma.

    Cai, Chen / Xu, Yi-Fan / Wu, Zhen-Jie / Dong, Qin / Li, Min-Yu / Olson, Jason C / Rabinowitz, Yaron M / Wang, Lin-Hui / Sun, Yinghao

    World journal of urology

    2023  Band 41, Heft 2, Seite(n) 615

    Sprache Englisch
    Erscheinungsdatum 2023-01-23
    Erscheinungsland Germany
    Dokumenttyp Expression of Concern
    ZDB-ID 380333-8
    ISSN 1433-8726 ; 0724-4983
    ISSN (online) 1433-8726
    ISSN 0724-4983
    DOI 10.1007/s00345-023-04293-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  3. Artikel ; Online: Tim-3 expression represents dysfunctional tumor infiltrating T cells in renal cell carcinoma.

    Cai, Chen / Xu, Yi-Fan / Wu, Zhen-Jie / Dong, Qin / Li, Min-Yu / Olson, Jason C / Rabinowitz, Yaron M / Wang, Lin-Hui / Sun, Yinghao

    World journal of urology

    2015  Band 34, Heft 4, Seite(n) 561–567

    Abstract: Purpose: Renal cell carcinoma (RCC) is the most common cancer of kidney. Evidences have shown that RCC is sensitive to various immunotherapies. Tim-3 plays a role in suppressing Th1-mediated immune responses. However, no study has yet examined the ... ...

    Abstract Purpose: Renal cell carcinoma (RCC) is the most common cancer of kidney. Evidences have shown that RCC is sensitive to various immunotherapies. Tim-3 plays a role in suppressing Th1-mediated immune responses. However, no study has yet examined the effect of Tim-3 on tumor infiltrating lymphocytes (TILs) in RCC.
    Methods: We investigated the expression and function of Tim-3 on TIL CD4+ T cells and TIL CD8+ T cells from 30 RCC patients.
    Results: Levels of Tim-3 were significantly increased on both TIL CD4+ T cells and TIL CD8+ T cells and were associated with higher stages of the cancer. Also, GATA-3 and interferon gamma (IFN-γ) were down-regulated, whereas T-bet was up-regulated in TIL Tim-3+ T cells, indicating that Tim-3 expression defined a population of dysfunctional TIL Th1/Tc1 cells. Mechanism analyses showed that TIL Tim-3-expressing CD8+ T cells exhibited impaired Stat5 and p38 signaling pathway. Blocking the Tim-3 pathway restored cell proliferation and increased IFN-γ production in TIL CD4+ and CD8+ T cells of RCC.
    Conclusions: These results suggest that Tim-3 may be used as a novel target for increasing immune responses in RCC tumor microenvironment.
    Mesh-Begriff(e) Carcinoma, Renal Cell/diagnosis ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/metabolism ; Cell Proliferation ; Female ; Flow Cytometry ; Gene Expression Regulation, Neoplastic ; Hepatitis A Virus Cellular Receptor 2/biosynthesis ; Hepatitis A Virus Cellular Receptor 2/genetics ; Humans ; Kidney/metabolism ; Kidney/pathology ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/genetics ; Kidney Neoplasms/metabolism ; Lymphocytes, Tumor-Infiltrating/pathology ; Male ; Middle Aged ; Neoplasm Staging ; Polymerase Chain Reaction ; Prognosis ; RNA, Neoplasm/genetics
    Chemische Substanzen HAVCR2 protein, human ; Hepatitis A Virus Cellular Receptor 2 ; RNA, Neoplasm
    Sprache Englisch
    Erscheinungsdatum 2015-08-08
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 380333-8
    ISSN 1433-8726 ; 0724-4983
    ISSN (online) 1433-8726
    ISSN 0724-4983
    DOI 10.1007/s00345-015-1656-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

Zum Seitenanfang