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  1. Article ; Online: Always enough but never too much: the how and why of downregulating tissue oxygenation.

    Olson, Kenneth R

    American journal of physiology. Heart and circulatory physiology

    2023  Volume 325, Issue 4, Page(s) H888–H891

    Abstract: Cardiovascular regulation of tissue oxygenation is generally viewed as an anti-drop process that prevents tissue oxygen concentration from falling below some minimum. I propose that cardiovascular regulation is predominately an anti-rise process designed ...

    Abstract Cardiovascular regulation of tissue oxygenation is generally viewed as an anti-drop process that prevents tissue oxygen concentration from falling below some minimum. I propose that cardiovascular regulation is predominately an anti-rise process designed to downregulate oxygen delivery. This maintains an evolutionarily conserved, reduced intracellular environment to prevent oxidation of redox-sensitive regulatory protein thiols. A number of points support this hypothesis. First, oxygen is the only nutrient with a positive, fourfold diffusion gradient from the environment to systemic tissues, minimizing the likelihood that oxygen delivery is limited. Second, hemoglobin (Hb) retains oxygen unless offloading is absolutely necessary. The allosteric properties of Hb keep oxygen tightly bound until absolutely needed, and the Bohr shift, which favors offloading, is only transient and lost when metabolism is restored. Third, a myoglobin-like Hb (xHb) would offload all of its oxygen and could easily have evolved, but it did not. Fourth, oxygen-sensitive vasoconstrictors and hyperoxic-rarefaction prevent acute and chronic over perfusion. Fifth, Fåhraeus and Fåhraeus-Lindqvist effects reduce capillary hematocrit to minimize microcirculatory oxygen content. Sixth, venous blood remains 75% saturated, wasting 75% of cardiac output were an oxygen reserve not needed. Finally, xHb-containing red blood cells could be considerably smaller and thereby decrease Fåhraeus and Fåhraeus-Lindqvist effects and cardiac load. In summary, the capacity of the cardiovascular system to deliver oxygen to the tissues generally exceeds demand, and although maintenance of an oxygen delivery reserve is important, it is more important to prevent excess oxygen delivery.
    MeSH term(s) Humans ; Microcirculation ; Erythrocytes ; Heart ; Cachexia ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-08-25
    Publishing country United States
    Document type Editorial ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00449.2023
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article: A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism.

    Olson, Kenneth R

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 11

    Abstract: The ability to detect oxygen availability is a ubiquitous attribute of aerobic organisms. However, the mechanism(s) that transduce oxygen concentration or availability into appropriate physiological responses is less clear and often controversial. This ... ...

    Abstract The ability to detect oxygen availability is a ubiquitous attribute of aerobic organisms. However, the mechanism(s) that transduce oxygen concentration or availability into appropriate physiological responses is less clear and often controversial. This review will make the case for oxygen-dependent metabolism of hydrogen sulfide (H
    Language English
    Publishing date 2021-10-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10111650
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  3. Article ; Online: Transgenic Manipulation of Arthropod Vectors: Tools to Study Vector-Borne Diseases.

    Williams, Adeline E / Olson, Kenneth E

    Journal of visualized experiments : JoVE

    2023  , Issue 202

    MeSH term(s) Animals ; Arthropod Vectors/genetics ; Animals, Genetically Modified ; Vector Borne Diseases
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/64990
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  4. Article ; Online: Are Reactive Sulfur Species the New Reactive Oxygen Species?

    Olson, Kenneth R

    Antioxidants & redox signaling

    2020  Volume 33, Issue 16, Page(s) 1125–1142

    Abstract: Significance: ...

    Abstract Significance:
    MeSH term(s) Animals ; Antioxidants/metabolism ; Antioxidants/pharmacology ; Energy Metabolism/drug effects ; Homeostasis ; Humans ; Metabolic Networks and Pathways/drug effects ; Oxidation-Reduction ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects ; Sulfur/metabolism
    Chemical Substances Antioxidants ; Reactive Oxygen Species ; Sulfur (70FD1KFU70)
    Language English
    Publishing date 2020-08-05
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2020.8132
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5488: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Reactive oxygen species or reactive sulfur species: why we should consider the latter.

    Olson, Kenneth R

    The Journal of experimental biology

    2020  Volume 223, Issue Pt 4

    Abstract: The biological effects of oxidants, especially reactive oxygen species (ROS), include signaling functions (oxidative eustress), initiation of measures to reduce elevated ROS (oxidative stress), and a cascade of pathophysiological events that accompany ... ...

    Abstract The biological effects of oxidants, especially reactive oxygen species (ROS), include signaling functions (oxidative eustress), initiation of measures to reduce elevated ROS (oxidative stress), and a cascade of pathophysiological events that accompany excessive ROS (oxidative distress). Although these effects have long been studied in animal models with perturbed ROS, their actions under physiological conditions are less clear. I propose that some of the apparent uncertainty may be due to confusion of ROS with endogenously generated reactive sulfur species (RSS). ROS and RSS are chemically similar, but RSS are more reactive and versatile, and can be stored and reused. Both ROS and RSS signal via oxidation reactions with protein cysteine sulfur and they produce identical effector responses, but RSS appear to be more effective. RSS in the form of persulfidated cysteines (Cys-S-S) are produced endogenously and co-translationally introduced into proteins, and there is increasing evidence that many cellular proteins are persulfidated. A number of practical factors have contributed to confusion between ROS and RSS, and these are discussed herein. Furthermore, essentially all endogenous antioxidant enzymes appeared shortly after life began, some 3.8 billion years ago, when RSS metabolism dominated evolution. This was long before the rise in ROS, 600 million years ago, and I propose that these same enzymes, with only minor modifications, still effectively metabolize RSS in extant organisms. I am not suggesting that all ROS are RSS; however, I believe that the relative importance of ROS and RSS in biological systems needs further consideration.
    MeSH term(s) Antioxidants/metabolism ; Oxidation-Reduction ; Oxidative Stress/physiology ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Sulfur Compounds/metabolism
    Chemical Substances Antioxidants ; Reactive Oxygen Species ; Sulfur Compounds
    Language English
    Publishing date 2020-02-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 218085-6
    ISSN 1477-9145 ; 0022-0949
    ISSN (online) 1477-9145
    ISSN 0022-0949
    DOI 10.1242/jeb.196352
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2629: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: The biological legacy of sulfur: A roadmap to the future.

    Olson, Kenneth R

    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

    2020  Volume 252, Page(s) 110824

    Abstract: Nothing in biology makes sense except in the light of evolution" (Theodosius Dobzhansky) and "For such a large number of problems there will be some animal of choice, or a few such animals, on which it can be most conveniently studied" (August Krogh); ... ...

    Abstract "Nothing in biology makes sense except in the light of evolution" (Theodosius Dobzhansky) and "For such a large number of problems there will be some animal of choice, or a few such animals, on which it can be most conveniently studied" (August Krogh); dictums that can be used to illustrate the past and provide a guide to the future. Although sulfur was integral in the origin of life, and nearly seven-eights of subsequent evolution, its physiological importance is largely overlooked because much of contemporary life it is based on oxygen and the adherent problems associated with oxygen deficit (hypoxia) or excess (oxidative stress). This graphical review will summarize sulfur's role in evolution and make a case that many of the regulatory activities attributed to oxygen and reactive oxygen species (ROS) can also be ascribed to reactive sulfur species (RSS). ROS and RSS are chemically similar and signal via identical cysteine residues on regulatory proteins and have identical downstream effector responses. Antioxidant mechanisms, generally attributed to the advent of an oxic existence, actually appeared over 2 billion years prior, in sulfur metabolizing organisms. Recent evidence suggests they are active in sulfur metabolism to this day. Understanding these aspects of ROS and RSS suggests that alternative mechanisms for oxidant/antioxidant pathways and therapies must be considered. As oxygen and reduced sulfur do not coexist, either in cells or the environment, it is also important to design and conduct experiments in oxygen levels that are physiologically relevant. For every experiment there are optimal conditions under which it must be studied.
    MeSH term(s) Oxygen/metabolism ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Sulfur/metabolism
    Chemical Substances Reactive Oxygen Species ; Sulfur (70FD1KFU70) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2020-10-30
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 121246-1
    ISSN 1531-4332 ; 0300-9629 ; 1095-6433
    ISSN (online) 1531-4332
    ISSN 0300-9629 ; 1095-6433
    DOI 10.1016/j.cbpa.2020.110824
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 44/A: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: Hydrogen sulfide, reactive sulfur species and coping with reactive oxygen species.

    Olson, Kenneth R

    Free radical biology & medicine

    2019  Volume 140, Page(s) 74–83

    Abstract: Life began in a ferruginous (anoxic and ... ...

    Abstract Life began in a ferruginous (anoxic and Fe
    MeSH term(s) Adaptation, Psychological ; Antioxidants/metabolism ; Hydrogen Sulfide/metabolism ; Oxygen/metabolism ; Photosynthesis ; Reactive Oxygen Species/metabolism ; Sulfur/metabolism
    Chemical Substances Antioxidants ; Reactive Oxygen Species ; Sulfur (70FD1KFU70) ; Oxygen (S88TT14065) ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2019-01-28
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2019.01.020
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2109: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism

    Olson, Kenneth R.

    Antioxidants. 2021 Oct. 21, v. 10, no. 11

    2021  

    Abstract: The ability to detect oxygen availability is a ubiquitous attribute of aerobic organisms. However, the mechanism(s) that transduce oxygen concentration or availability into appropriate physiological responses is less clear and often controversial. This ... ...

    Abstract The ability to detect oxygen availability is a ubiquitous attribute of aerobic organisms. However, the mechanism(s) that transduce oxygen concentration or availability into appropriate physiological responses is less clear and often controversial. This review will make the case for oxygen-dependent metabolism of hydrogen sulfide (H₂S) and polysulfides, collectively referred to as reactive sulfur species (RSS) as a physiologically relevant O₂ sensing mechanism. This hypothesis is based on observations that H₂S and RSS metabolism is inversely correlated with O₂ tension, exogenous H₂S elicits physiological responses identical to those produced by hypoxia, factors that affect H₂S production or catabolism also affect tissue responses to hypoxia, and that RSS efficiently regulate downstream effectors of the hypoxic response in a manner consistent with a decrease in O₂. H₂S-mediated O₂ sensing is then compared to the more generally accepted reactive oxygen species (ROS) mediated O₂ sensing mechanism and a number of reasons are offered to resolve some of the confusion between the two.
    Keywords catabolism ; hydrogen sulfide ; hypoxia ; oxygen ; reactive oxygen species ; sulfur
    Language English
    Dates of publication 2021-1021
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10111650
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: The biological legacy of sulfur: A roadmap to the future

    Olson, Kenneth R

    Comparative biochemistry and physiology. 2021 Feb., v. 252

    2021  

    Abstract: Nothing in biology makes sense except in the light of evolution” (Theodosius Dobzhansky) and “For such a large number of problems there will be some animal of choice, or a few such animals, on which it can be most conveniently studied” (August Krogh); ... ...

    Abstract “Nothing in biology makes sense except in the light of evolution” (Theodosius Dobzhansky) and “For such a large number of problems there will be some animal of choice, or a few such animals, on which it can be most conveniently studied” (August Krogh); dictums that can be used to illustrate the past and provide a guide to the future. Although sulfur was integral in the origin of life, and nearly seven-eights of subsequent evolution, its physiological importance is largely overlooked because much of contemporary life it is based on oxygen and the adherent problems associated with oxygen deficit (hypoxia) or excess (oxidative stress). This graphical review will summarize sulfur's role in evolution and make a case that many of the regulatory activities attributed to oxygen and reactive oxygen species (ROS) can also be ascribed to reactive sulfur species (RSS). ROS and RSS are chemically similar and signal via identical cysteine residues on regulatory proteins and have identical downstream effector responses. Antioxidant mechanisms, generally attributed to the advent of an oxic existence, actually appeared over 2 billion years prior, in sulfur metabolizing organisms. Recent evidence suggests they are active in sulfur metabolism to this day. Understanding these aspects of ROS and RSS suggests that alternative mechanisms for oxidant/antioxidant pathways and therapies must be considered. As oxygen and reduced sulfur do not coexist, either in cells or the environment, it is also important to design and conduct experiments in oxygen levels that are physiologically relevant. For every experiment there are optimal conditions under which it must be studied.
    Keywords animals ; cysteine ; evolution ; hypoxia ; metabolism ; oxidants ; oxidative stress ; oxygen ; reactive oxygen species ; sulfur
    Language English
    Dates of publication 2021-02
    Publishing place Elsevier Inc.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 121246-1
    ISSN 1531-4332 ; 0300-9629 ; 1095-6433
    ISSN (online) 1531-4332
    ISSN 0300-9629 ; 1095-6433
    DOI 10.1016/j.cbpa.2020.110824
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    In stock of ZB MED Bonn / Germany

    Z 71/715: Show issues

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  10. Article ; Online: H

    Olson, Kenneth R

    Biochemical pharmacology

    2017  Volume 149, Page(s) 77–90

    Abstract: It is now well established that hydrogen sulfide ( ... ...

    Abstract It is now well established that hydrogen sulfide (H
    MeSH term(s) Animals ; Gasotransmitters/metabolism ; Humans ; Hydrogen Sulfide/metabolism ; Metabolic Networks and Pathways/physiology ; Oxidation-Reduction ; Sulfides/metabolism
    Chemical Substances Gasotransmitters ; Sulfides ; polysulfide (9080-49-3) ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2017-12-14
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2017.12.010
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 19: Show issues Location:
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