Article: Expanding the human gut microbiome atlas of Africa.
bioRxiv : the preprint server for biology
2024
Abstract: Population studies are crucial in understanding the complex interplay between the gut microbiome and geographical, lifestyle, genetic, and environmental factors. However, populations from low- and middle-income countries, which represent ~84% of the ... ...
| Abstract | Population studies are crucial in understanding the complex interplay between the gut microbiome and geographical, lifestyle, genetic, and environmental factors. However, populations from low- and middle-income countries, which represent ~84% of the world population, have been excluded from large-scale gut microbiome research. Here, we present the AWI-Gen 2 Microbiome Project, a cross-sectional gut microbiome study sampling 1,803 women from Burkina Faso, Ghana, Kenya, and South Africa. By intensively engaging with communities that range from rural and horticultural to urban informal settlements and post-industrial, we capture population diversity that represents a far greater breadth of the world's population. Using shotgun metagenomic sequencing, we find that study site explains substantially more microbial variation than disease status. We identify taxa with strong geographic and lifestyle associations, including loss of |
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| Language | English |
| Publishing date | 2024-03-14 |
| Publishing country | United States |
| Document type | Preprint |
| DOI | 10.1101/2024.03.13.584859 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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