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  1. Article: The Repairing of the Recto-Neovaginal Fistula in a Male-to-Female Transgender Through Perineal Graciloplasty.

    Omarov, Nail / Tatar, Sedat

    Cureus

    2021  Volume 13, Issue 6, Page(s) e15784

    Abstract: Rectovaginal fistulas, which are abnormal epithelial-lined connections between the rectum and vagina, are challenging to treat. Treatment of recto-neovaginal fistulas is more complicated due to the altered perineal anatomy in individuals undergoing ... ...

    Abstract Rectovaginal fistulas, which are abnormal epithelial-lined connections between the rectum and vagina, are challenging to treat. Treatment of recto-neovaginal fistulas is more complicated due to the altered perineal anatomy in individuals undergoing gender reassignment surgery. We present a recto-neovaginal fistula that occurred after reassignment surgery male-to-female transgender case of a was successfully treated with restorative perineal graciloplasty.
    Language English
    Publishing date 2021-06-20
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.15784
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Different uses of the breast implant to prevent empty pelvic complications following pelvic exenteration.

    Omarov, Nail / Uymaz, Derya Salim / Bugra, Dursun

    BMJ case reports

    2022  Volume 15, Issue 3

    Abstract: Pelvic exenteration surgery is used as a standard procedure in recurrent pelvic cancers. Total pelvic exenteration (TPE) includes resection of the uterus, prostate, ureters, bladder and rectosigmoid colon from pelvic space. Empty pelvis syndrome is a ... ...

    Abstract Pelvic exenteration surgery is used as a standard procedure in recurrent pelvic cancers. Total pelvic exenteration (TPE) includes resection of the uterus, prostate, ureters, bladder and rectosigmoid colon from pelvic space. Empty pelvis syndrome is a complication of the TPE procedure. Following TPE, complications such as haematoma, abscess leading to permanent pus discharge and chronic infections can occur. Herein, we present the case of a man in his 50s who was referred for pelvic pain, foul-smelling discharge and non-functioning colostomy, and operated for distal rectal cancer 1.5 years ago and underwent low anterior resection. In this case, we performed TPE for the recurrent tumour. To prevent TPE complications, we used a breast implant for filling the pelvic cavity. The early and late postoperative course was uneventful.
    MeSH term(s) Breast Implants ; Female ; Humans ; Male ; Neoplasm Recurrence, Local/pathology ; Pelvic Exenteration/adverse effects ; Pelvic Exenteration/methods ; Pelvic Neoplasms/surgery ; Pelvis/pathology
    Language English
    Publishing date 2022-03-29
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-245630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Right paraduodenal hernia accompanying superior mesenteric vein thrombosis: a rare case.

    Omarov, Nail / Özata, İbrahim Halil / Balık, Emre

    BMJ case reports

    2021  Volume 14, Issue 6

    Abstract: A 59-year-old man with abdominal pain was admitted to the emergency department. Investigations had revealed a right-sided paraduodenal hernia and superior mesenteric vein (SMV) twisting around the superior mesenteric artery in rotation, the 'whirlpool ... ...

    Abstract A 59-year-old man with abdominal pain was admitted to the emergency department. Investigations had revealed a right-sided paraduodenal hernia and superior mesenteric vein (SMV) twisting around the superior mesenteric artery in rotation, the 'whirlpool sign'. Owing to the increasing severity of abdominal pain and the presence of SMV thrombosis complicated with strangulated paraduodenal herniation associated with high mortality rates, diagnostic laparoscopy was performed. Resection of the intestines was not needed and paraduodenal hernia was repaired. The patient was uneventfully discharged.
    MeSH term(s) Duodenal Diseases ; Hernia/complications ; Hernia/diagnostic imaging ; Humans ; Male ; Mesenteric Veins/diagnostic imaging ; Mesenteric Veins/surgery ; Middle Aged ; Paraduodenal Hernia ; Thrombosis
    Language English
    Publishing date 2021-06-04
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-241324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Comparison of neoadjuvant versus upfront surgery for treatment of locally advanced gastric cancer.

    Omarov, Nail / Uymaz, Derya Salim / Gurbuz, Bulent / Selcukbiricik, Fatih / Cigtaskin, Orhun / Yesilsoy, Mesut / Ozoran, Emre / Balik, Emre / Bugra, Dursun

    Annali italiani di chirurgia

    2023  Volume 94, Page(s) 569–579

    Abstract: Objective: In this study, we aimed to compare long term oncological outcomes of upfront surgery versus neoadjuvant treatment in patients with locally advanced gastric cancer.: Methods: A total of 183 patients who were operated for gastric cancer were ...

    Abstract Objective: In this study, we aimed to compare long term oncological outcomes of upfront surgery versus neoadjuvant treatment in patients with locally advanced gastric cancer.
    Methods: A total of 183 patients who were operated for gastric cancer were retrospectively analyzed. The patients received either standard gastrectomy or preoperative NACT + gastrectomy. Neoadjuvant therapy was administered with FLOT regimen (docetaxel, oxaliplatin, fluorouracil, and leucovorin) or DCF regimen (docetaxel, cisplatin, and 5-fluorouracil).
    Results: Of the patients receiving NACT, 33 received FLOT regimen and 14 received DCF regimen. The number of male patients was higher in both standard gastrectomy and NACT + gastrectomy groups (p=0.385). Leukopenia and neutropenia were the most common hematological toxicities, while anemia and nausea were the most frequent non-hematological side effects in the both of NACT group. The outcomes of the grades of postoperative complications according to the Clavien-Dindo classification is similar between groups. There was no statistically significant difference in the length of hospital stay after surgery between the groups (p=0,001). According to the disease stage, it was found no statistically significant difference in the OS and DFS between the NACT and standard gastrectomy groups.
    Conclusion: Although we found no significant difference between the patients undergoing standard gastrectomy and those undergoing NACT before gastrectomy, we believe that NACT may contribute to the favorable prognosis of patients with locally advanced disease with improved OS and DFS and this should be examined in future studies.
    Key words: FLOT, Gastric Cancer, Neoadjuvant Treatment.
    MeSH term(s) Humans ; Male ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/surgery ; Neoadjuvant Therapy ; Docetaxel/therapeutic use ; Retrospective Studies ; Treatment Outcome ; Adenocarcinoma/drug therapy ; Adenocarcinoma/surgery ; Fluorouracil ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
    Chemical Substances Docetaxel (15H5577CQD) ; Fluorouracil (U3P01618RT)
    Language English
    Publishing date 2023-09-19
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 418927-9
    ISSN 2239-253X ; 0003-469X
    ISSN (online) 2239-253X
    ISSN 0003-469X
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  5. Article ; Online: The Role of FDG Positron Emission Tomography/Contrast--Enhanced Computed Tomography in Preoperative Staging and Postoperative Follow-up in Rectal Cancer Surgery.

    Omarov, Nail / Uymaz, Derya Salim / Kulle, Cemil Burak / Ozkan, Zeynep Gozde / Azamat, Sena / Keskin, Metin / Bulut, Mehmet Turker

    Polski przeglad chirurgiczny

    2022  Volume 94, Issue 6, Page(s) 10–16

    Abstract: ... Introduction: ... F-18 fluorodeoxyglucose (F18-FDG) positron emission tomography-computed tomography (PET/CT) is a valuable functional imaging modality for the clinical diagnosis which provides physiological information based on the altered tissue ... ...

    Abstract Introduction: F-18 fluorodeoxyglucose (F18-FDG) positron emission tomography-computed tomography (PET/CT) is a valuable functional imaging modality for the clinical diagnosis which provides physiological information based on the altered tissue metabolism.

    Aim: This study aims to investigate the effectiveness of F-18 fluorodeoxyglucose (F18-FDG) positron emission tomography-computed tomography (PET/CT) in preoperative staging and postoperative local recurrence and distant metastases in patients with rectal cancer.

    Material and methods: The imaging of 726 patients with rectal cancer who were operated on at Istanbul University, Istanbul School of Medicine and had F18-FDG PET/CT, CT, and magnetic resonance imaging (MRI) scans between September 2005 and October 2016 were retrospectively analyzed. Of these patients, 170 who had pre- and postoperative PET/CT scans, had their CT scans included in the study. The sensitivity and specificity of PET/CT in preoperative staging and detection of postoperative local recurrence and distant metastases were analyzed.

    Results: Of the patients, 101 were males and 69 were females with a median age of 62.27 (range, 31 to 89) years. The sensitivity and specificity of preoperative PET/CT in detecting liver metastases were 100% (confidence interval [CI]: 66.37-100%) and 94.2% (CI: 89.72-100%), respectively (Cohen's kappa [κ]: 1.00; P < 0.001). The sensitivity and specificity of postoperative PET/ CT in diagnosing liver metastases were 100% (CI: 88.06-100%) and 98% (CI: 9-100%), respectively (Cohen's κ: 1.00; P < 0.001). The sensitivity and specificity of preoperative PET/CT in detecting lung metastases were 100% (CI: 66.37-100%) and 91.8% (CI: 89.72-100%), respectively (Cohen's κ: 1.00; P < 0.001). The sensitivity and specificity of postoperative PET/CT in detecting lung metastases were 100% (CI: 91.4-100%) and 96% (CI: 95.8-100%), respectively (Cohen's κ: 1.00; P < 0.001). The sensitivity and specificity of PET/CT in preoperative staging of pathological pelvic lymph nodes were 100% (CI: 63.06-100%) and 94.29% (CI: 80.84-99.3%), respectively (Cohen's κ: 0.860; P < 0.001). The sensitivity and specificity of postoperative PET/CT in detecting local recurrences were 100% (CI: 78.2-100%) and 76.74% (CI: 61.37-88.24%), respectively (Cohen's κ: 0.219; P < 0.08).

    Results: Given the fact that PET/CT can detect all primary rectal cancer in preoperative staging, it can be effectively used in selected cases, particularly in those suspected of local and advanced disease and with metastases (T3N0, T3N1, and/or T4N1). Due to a relatively low specificity in detecting local recurrences postoperatively, PET/CT can be combined with further modalities.
    MeSH term(s) Female ; Male ; Humans ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Fluorodeoxyglucose F18 ; Positron Emission Tomography Computed Tomography ; Follow-Up Studies ; Retrospective Studies ; Rectal Neoplasms/diagnostic imaging ; Rectal Neoplasms/surgery ; Positron-Emission Tomography ; Tomography, X-Ray Computed ; Lung Neoplasms ; Liver Neoplasms ; Recurrence
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2022-11-09
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 128732-1
    ISSN 2299-2847 ; 0032-373X
    ISSN (online) 2299-2847
    ISSN 0032-373X
    DOI 10.5604/01.3001.0015.7361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Multimodal assessment after total neoadjuvant therapy versus standard neoadjuvant chemoradiotherapy in locally advanced rectal cancer accurately predicts complete responders.

    Özoran, Emre / Özata, İbrahim Halil / Uymaz, Derya Salim / Omarov, Nail / Bozkurt, Emre / Tüfekçi, Tutku / Karahan, Salih Nafiz / Gürbüz, Bülent / Selçukbiricik, Fatih / Bölükbaşı, Yasemin / Taşkın, Orhun Çığ / Gürses, Bengi / Rencüzoğulları, Ahmet / Buğra, Dursun / Balık, Emre

    International journal of colorectal disease

    2023  Volume 38, Issue 1, Page(s) 229

    Abstract: Purpose: This study aimed to compare local regrowth rates after total neoadjuvant therapy (TNT) versus standard neoadjuvant chemoradiotherapy (SNCRT) in locally advanced rectal cancer (LARC) patients that were strictly selected and assessed with a ... ...

    Abstract Purpose: This study aimed to compare local regrowth rates after total neoadjuvant therapy (TNT) versus standard neoadjuvant chemoradiotherapy (SNCRT) in locally advanced rectal cancer (LARC) patients that were strictly selected and assessed with a multimodal approach. Secondary outcomes were 4-year disease-free (DFS) and overall survival (OS) rates.
    Methods: Locally advanced rectal cancer patients without distant metastases treated at Koç Healthcare Group between January 2014 and January 2021 were included. Patients were assessed for complete response with a combination of digital rectal exam, endoscopy, and magnetic resonance imaging with a dedicated rectum protocol. The systemic evaluation was performed with an upper abdomen MRI using intravenous hepatobiliary contrast agent and a thorax CT.
    Results: Of the 270 patients with LARC, 182 fulfilled the inclusion criteria. Ninety-seven (53.3%) underwent TNT, while 85 (46.7%) underwent SNCRT. A cumulative combination of pathological and sustained clinical complete response was significantly higher in the TNT group than in the SNCRT (45.4% vs. 20.0%, p < 0.0001). After a median follow-up of 48 months, seven patients in the W&W group had regrowth [TNT: 4 (10.8%) vs. SNCRT: 3 (23.1%), p = 0.357]. Based on pathological examination, complete/near complete mesorectum rates (p = 1.000) and circumferential resection margin positivity rates (p = 1.000) were similar between the groups. The 4-year DFS and OS rates were comparable. The patients with clinical or pathological complete response had significantly longer overall survival (p = 0.017) regardless of the type of neoadjuvant treatment.
    Conclusions: Multimodal assessment after TNT effectively detects complete responders, resulting in low local recurrence and increased cumulative complete response rates. However, these outcomes did not translate into a survival advantage.
    MeSH term(s) Humans ; Rectum ; Neoadjuvant Therapy ; Pelvis ; Abdominal Cavity ; Neoplasms, Second Primary ; Rectal Neoplasms/diagnostic imaging ; Rectal Neoplasms/therapy
    Language English
    Publishing date 2023-09-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 84975-3
    ISSN 1432-1262 ; 0179-1958
    ISSN (online) 1432-1262
    ISSN 0179-1958
    DOI 10.1007/s00384-023-04526-2
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  7. Article: The Role of Minimally Invasive Surgery in Gastric Cancer.

    Omarov, Nail / Uymaz, Derya / Azamat, Ibrahim F / Ozoran, Emre / Ozata, Ibrahim H / Bırıcık, Fatih S / Taskin, Orhun C / Balik, Emre

    Cureus

    2021  Volume 13, Issue 11, Page(s) e19563

    Abstract: Objective: This study aims to investigate the efficacy and safety of minimally invasive surgery (MIS) in gastric cancer and to compare MIS versus open gastrectomy (OG) in terms of early mortality and morbidity, long-term oncological outcomes, and ... ...

    Abstract Objective: This study aims to investigate the efficacy and safety of minimally invasive surgery (MIS) in gastric cancer and to compare MIS versus open gastrectomy (OG) in terms of early mortality and morbidity, long-term oncological outcomes, and recurrence rates.
    Methods: A total of 75 patients who underwent MIS or OG for gastric cancer at Koç University School of Medicine between December 2014 and December 2019 were retrospectively analyzed. Postoperative complications and disease-specific survival were compared between surgical approaches.
    Results: Of the patients, 44 were treated with MIS and 31 with OG. In the MIS group, 33 patients underwent laparoscopic surgery, and 11 patients underwent robotic gastrectomy. Duration of operation was significantly longer in the MIS group than in the OG group (p<0.0001). The median amount of blood loss was 142.5 (range, 110 to 180) mL in the MIS group and 180.4 (range, 145 to 230) mL in the OG group (p<0.706). The median number of lymph node dissection was 38.9 (range, 15 to 66) and 38.7 (range, 12 to 70) in the MIS and OG groups, respectively (p<0.736). The median length of hospitalization, twelve days in the OG group and nine days in the MIS group. Median follow-up was 19.1 (range, 2 to 61) months in the MIS group and 22.1 (range, 2 to 58) months in the OG group. The median OS and DFS rates were 56.8 months and 39.6 months in the MIS group, respectively (log-rank; p=0.004) and 31.6 months and 23.1 months in the OG group, respectively (log-rank; p=0.003).
    Conclusion: Our study results suggest that, despite its technical challenges, MIS is an effective and safe method in treating gastric cancer with favorable early mortality and morbidity rates and long-term oncological outcomes, and acceptable recurrence rates.
    Language English
    Publishing date 2021-11-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.19563
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  8. Article: Thyroid cancer incidence in simultaneous thyroidectomy with parathyroid surgery.

    Emirikçi, Selman / Özçınar, Beyza / Öner, Gizem / Omarov, Nail / Ağcaoğlu, Orhan / Soytaş, Yiğit / Aksakal, Nihat / Yanar, Fatih / Barbaros, Umut / Erbil, Yeşim

    Ulusal cerrahi dergisi

    2015  Volume 31, Issue 4, Page(s) 214–217

    Abstract: Objective: Primary hyperparathyroidism (PHPT) is often seen in conjunction with an underlying thyroid disorder. Imaging methods that are used to localize the parathyroid adenoma also detect associated thyroid nodules and thyroid cancer. The aim of this ... ...

    Abstract Objective: Primary hyperparathyroidism (PHPT) is often seen in conjunction with an underlying thyroid disorder. Imaging methods that are used to localize the parathyroid adenoma also detect associated thyroid nodules and thyroid cancer. The aim of this study was to detect the rate of thyroid cancer identified while performing parathyroidectomy and thyroidectomy in patients with PHPT.
    Material and methods: Files of all patients who were operated for PHPT and who underwent simultaneous thyroidectomy were analyzed. Data regarding parathyroid pathology, surgical procedures, indications of thyroid surgery, and pathology results were retrospectively recorded. The indications for thyroid surgery included presence of suspicious thyroid nodules in ultrasonography, increase in size of thyroid nodules in follow-up ultrasound, or presence of suspicious thyroid fine needle aspiration biopsy (FNAB) findings. Rates of thyroid cancer detection were investigated according to definite pathology reports.
    Results: Eighty-three patients who underwent parathyroidectomy with a diagnosis of PHPT with concurrent thyroidectomy in Department of General Surgery, İstanbul University İstanbul Faculty of Medicine were included in the study. Eighteen patients were male (22%) and 65 were female (78%). The median age was 53 (18-70) years. The primary indication for parathyroidectomy was primary hyperparathyroidism in all patients. The thyroid procedures applied in addition to parathyroidectomy were lobectomy + isthmusectomy in 29 patients (35%), bilateral subtotal thyroidectomy in 20 patients (24%), bilateral total thyroidectomy in 23 patients (28%), and total thyroidectomy on one side and near total thyroidectomy to the other side in 11 patients (13%). The only indication for thyroidectomy was the presence of thyroid nodules until 2000 (20 patients, 24%). Indications in the remaining 63 patients included the presence of multiple nodules that cannot be followed up by ultrasonography in 25 patients (30%), presence of a suspicious nodule on ultrasonography in 33 patients (40%), growth in nodule size in 2 patients (2%), and detection of suspicious findings on FNAB in 3 patients (4%). Five patients (6%) were diagnosed with papillary thyroid cancer, four of whom were micropapillary cancer.
    Conclusion: Imaging methods performed to localize the pathological parathyroid gland for a diagnosis of PHPT are useful in estimating other accompanying pathologies. Presence of thyroid nodules should be evaluated before all parathyroid procedures, and if the nodule has an indication for surgery, thyroid surgery should be considered at the same operation with parathyroid surgery.
    Language English
    Publishing date 2015-08-18
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 1394172-0
    ISSN 1300-0705
    ISSN 1300-0705
    DOI 10.5152/UCD.2015.2666
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  9. Article ; Online: Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago.

    Perrone, Gennaro / Giuffrida, Mario / Abu-Zidan, Fikri / Kruger, Vitor F / Livrini, Marco / Petracca, Gabriele Luciano / Rossi, Giorgio / Tarasconi, Antonio / Tian, Brian W C A / Bonati, Elena / Mentz, Ricardo / Mazzini, Federico N / Campana, Juan P / Gasser, Elisabeth / Kafka-Ritsch, Reinhold / Felsenreich, Daniel M / Dawoud, Christopher / Riss, Stefan / Gomes, Carlos Augusto /
    Gomes, Felipe Couto / Gonzaga, Ricardo Alessandro Teixeira / Canton, Cassio Alfred Brattig / Pereira, Bruno Monteiro / Fraga, Gustavo P / Zem, Leticia Gonçalves / Cordeiro-Fonseca, Vinicius / de Mesquita Tauil, Renato / Atanasov, Boyko / Belev, Nikolay / Kovachev, Nikola / Meléndez, L Juan José / Dimova, Ana / Dimov, Stefan / Zelić, Zdravko / Augustin, Goran / Bogdanić, Branko / Morić, Trpimir / Chouillard, Elie / Bajul, Melinda / De Simone, Belinda / Panis, Yves / Esposito, Francesco / Notarnicola, Margherita / Lauka, Lelde / Fabbri, Anna / Hentati, Hassen / Fnaiech, Iskander / Aurélien, Venara / Bougard, Marie / Roulet, Maxime / Demetrashvili, Zaza / Pipia, Irakli / Merabishvili, Giorgi / Bouliaris, Konstantinos / Koukoulis, Georgios / Doudakmanis, Christos / Xenaki, Sofia / Chrysos, Emmanuel / Kokkinakis, Stamatios / Vassiliu, Panteleimon / Michalopoulos, Nikolaos / Margaris, Ioannis / Kechagias, Aristotelis / Avgerinos, Konstantinos / Katunin, Jevgeni / Lostoridis, Eftychios / Nagorni, Eleni-Aikaterini / Pujante, Antonio / Mulita, Francesk / Maroulis, Ioannis / Vailas, Michail / Marinis, Athanasios / Siannis, Ioannis / Bourbouteli, Eirini / Manatakis, Dimitrios K / Tasis, Nikolaos / Acheimastos, Vasileios / Maria, Sotiropoulou / Stylianos, Kapiris / Kuzeridis, Harilaos / Korkolis, Dimitrios / Fradelos, Evangelos / Kavalieratos, George / Petropoulou, Thalia / Polydorou, Andreas / Papacostantinou, Ioannis / Triantafyllou, Tania / Kimpizi, Despina / Theodorou, Dimitrios / Toutouzas, Konstantinos / Chamzin, Alexandros / Frountzas, Maximos / Schizas, Dimitrios / Karavokyros, Ioannis / Syllaios, Athanasios / Charalabopoulos, Alexandros / Boura, Maria / Baili, Efstratia / Ioannidis, Orestis / Loutzidou, Lydia / Anestiadou, Elissavet / Tsouknidas, Ioannis / Petrakis, Georgios / Polenta, Eleni / Bains, Lovenish / Gupta, Rahul / Singh, Sudhir K / Khanduri, Archana / Bala, Miklosh / Kedar, Asaf / Pisano, Marcello / Podda, Mauro / Pisanu, Adolfo / Martines, Gennaro / Trigiante, Giuseppe / Lantone, Giuliano / Agrusa, Antonino / Di Buono, Giuseppe / Buscemi, Salvatore / Veroux, Massimiliano / Gioco, Rossella / Veroux, Gastone / Oragano, Luigi / Zonta, Sandro / Lovisetto, Federico / Feo, Carlo V / Pesce, Antonio / Fabbri, Nicolò / Lantone, Giulio / Marino, Fabio / Perrone, Fabrizio / Vincenti, Leonardo / Papagni, Vincenzo / Picciariello, Arcangelo / Rossi, Stefano / Picardi, Biagio / Del Monte, Simone Rossi / Visconti, Diego / Osella, Giulia / Petruzzelli, Luca / Pignata, Giusto / Andreuccetti, Jacopo / D'Alessio, Rossella / Buonfantino, Massimo / Guaitoli, Eleonora / Spinelli, Stefano / Sampietro, Gianluca Matteo / Corbellini, Carlo / Lorusso, Leonardo / Frontali, Alice / Pezzoli, Isabella / Bonomi, Alessandro / Chierici, Andrea / Cotsoglou, Christian / Manca, Giuseppe / Delvecchio, Antonella / Musa, Nicola / Casati, Massimiliano / Letizia, Laface / Abate, Emmanuele / Ercolani, Giorgio / D'Acapito, Fabrizio / Solaini, Leonardo / Guercioni, Gianluca / Cicconi, Simone / Sasia, Diego / Borghi, Felice / Giraudo, Giorgio / Sena, Giuseppe / Castaldo, Pasquale / Cardamone, Eugenia / Portale, Giuseppe / Zuin, Matteo / Spolverato, Ylenia / Esposito, Marialusia / Isernia, Roberta Maria / Di Salvo, Maria / Manunza, Romina / Esposito, Giuseppe / Agus, Marcello / Asti, Emanuele Luigi Giuseppe / Bernardi, Daniele Tiziano / Tonucci, Tommaso Panici / Luppi, Davide / Casadei, Massimiliano / Bonilauri, Stefano / Pezzolla, Angela / Panebianco, Annunziata / Laforgia, Rita / De Luca, Maurizio / Zese, Monica / Parini, Dario / Jovine, Elio / De Sario, Giuseppina / Lombardi, Raffaele / Aprea, Giovanni / Palomba, Giuseppe / Capuano, Marianna / Argenio, Giulio / Orio, Gianluca / Armellino, Mariano Fortunato / Troian, Marina / Guerra, Martina / Nagliati, Carlo / Biloslavo, Alan / Germani, Paola / Aizza, Giada / Monsellato, Igor / Chahrour, Ali Chaouki / Anania, Gabriele / Bombardini, Cristina / Bagolini, Francesco / Sganga, Gabriele / Fransvea, Pietro / Bianchi, Valentina / Boati, Paolo / Ferrara, Francesco / Palmieri, Francesco / Cianci, Pasquale / Gattulli, Domenico / Restini, Enrico / Cillara, Nicola / Cannavera, Alessandro / Nita, Gabriela Elisa / Sarnari, Jlenia / Roscio, Francesco / Clerici, Federico / Scandroglio, Ildo / Berti, Stefano / Cadeo, Alessandro / Filippelli, Alice / Conti, Luigi / Grassi, Carmine / Cattaneo, Gaetano Maria / Pighin, Marina / Papis, Davide / Gambino, Giovanni / Bertino, Vanessa / Schifano, Domenico / Prando, Daniela / Fogato, Luisella / Cavallo, Fabio / Ansaloni, Luca / Picheo, Roberto / Pontarolo, Nicholas / Depalma, Norma / Spampinato, Marcello / D'Ugo, Stefano / Lepre, Luca / Capponi, Michela Giulii / Campa, Rossella Domenica / Sarro, Giuliano / Dinuzzi, Vincenza Paola / Olmi, Stefano / Uccelli, Matteo / Ferrari, Davide / Inama, Marco / Moretto, Gianluigi / Fontana, Michele / Favi, Francesco / Picariello, Erika / Rampini, Alessia / Barberis, Andrea / Azzinnaro, Antonio / Oliva, Alba / Totaro, Luigi / Benzoni, Ilaria / Ranieri, Valerio / Capolupo, Gabriella Teresa / Carannante, Filippo / Caricato, Marco / Ronconi, Maurizio / Casiraghi, Silvia / Casole, Giovanni / Pantalone, Desire / Alemanno, Giovanni / Scheiterle, Maximilian / Ceresoli, Marco / Cereda, Marco / Fumagalli, Chiara / Zanzi, Federico / Bolzon, Stefano / Guerra, Enrico / Lecchi, Francesca / Cellerino, Paola / Ardito, Antonella / Scaramuzzo, Rosa / Balla, Andrea / Lepiane, Pasquale / Tartaglia, Nicola / Ambrosi, Antonio / Pavone, Giovanna / Palini, Gian Marco / Veneroni, Simone / Garulli, Gianluca / Ricci, Claudio / Torre, Beatrice / Russo, Iris Shari / Rottoli, Matteo / Tanzanu, Marta / Belvedere, Angela / Milone, Marco / Manigrasso, Michele / De Palma, Giovanni Domenico / Piccoli, Micaela / Pattacini, Gianmaria Casoni / Magnone, Stefano / Bertoli, Paolo / Pisano, Michele / Massucco, Paolo / Palisi, Marco / Luzzi, Andrea-Pierre / Fleres, Francesco / Clarizia, Guglielmo / Spolini, Alessandro / Kobe, Yoshiro / Toma, Takayuki / Shimamura, Fumihiko / Parker, Robert / Ranketi, Sinkeet / Mitei, Mercy / Svagzdys, Saulius / Pauzas, Henrikas / Zilinskas, Justas / Poskus, Tomas / Kryzauskas, Marius / Jakubauskas, Matas / Zakaria, Andee Dzulkarnaen / Zakaria, Zaidi / Wong, Michael Pak-Kai / Jusoh, Asri Che / Zakaria, Muhammad Nazreen / Cruz, Daniel Rios / Elizalde, Aurea Barbara Rodriguez / Reynaud, Alejandro Bañon / Hernandez, Edgard Efren Lozada / Monroy, Jose Maria Victor Palomo / Hinojosa-Ugarte, Diego / Quiodettis, Martha / Du Bois, María Esther / Latorraca, José / Major, Piotr / Pędziwiatr, Michał / Pisarska-Adamczyk, Magdalena / Walędziak, Maciej / Kwiatkowski, Andrzej / Czyżykowski, Łukasz / da Costa, Silvia Dantas / Pereira, Bela / Ferreira, Ana Rita Oliveira / Almeida, Filipe / Rocha, Ricardo / Carneiro, Carla / Perez, Diego Pita / Carvas, João / Rocha, Catarina / Ferreira, Cátia / Marques, Rita / Fernandes, Urânia / Leao, Pedro / Goulart, André / Pereira, Rita Gonçalves / Patrocínio, Sara Daniela Direito / de Mendonça, Nuno Gonçalo Gonçalves / Manso, Maria Isabel Cerqueira / Morais, Henrique Manuel Cardoso / Cardoso, Paulo Sebastião / Calu, Valentin / Miron, Adrian / Toma, Elena Adelina / Gachabayov, Mahir / Abdullaev, Abakar / Litvin, Andrey / Nechay, Taras / Tyagunov, Alexander / Yuldashev, Anvar / Bradley, Alison / Wilson, Michael / Panyko, Arpád / Látečková, Zuzana / Lacko, Vladimír / Lesko, Dusan / Soltes, Marek / Radonak, Jozef / Turrado-Rodriguez, Victor / Termes-Serra, Roser / Morales-Sevillano, Xavier / Lapolla, Pierfrancesco / Mingoli, Andrea / Brachini, Gioia / Degiuli, Maurizio / Sofia, Silvia / Reddavid, Rossella / de Manzoni Garberini, Andrea / Buffone, Angelica / Del Pozo, Eduardo Perea / Aparicio-Sánchez, Daniel / Dos Barbeito, Sandra / Estaire-Gómez, Mercedes / Vitón-Herrero, Rebeca / de Los Ángeles Gil Olarte-Marquez, Mª / Gil-Martínez, José / Alconchel, Felipe / Nicolás-López, Tatiana / Rahy-Martin, Aida Cristina / Pelloni, María / Bañolas-Suarez, Raquel / Mendoza-Moreno, Fernando / Nisa, Francisca García-Moreno / Díez-Alonso, Manuel / Rodas, María Elisa Valle / Agundez, María Carmona / Andrés, María Inmaculada Pérez / Moreira, Claudia Cristina Lopes / Perez, Aintzane Lizarazu / Ponce, Iñigo Augusto / González-Castillo, Ana María / Membrilla-Fernández, Estela / Salvans, Silvia / Serradilla-Martín, Mario / Pardo, Pablo Sancho / Rivera-Alonso, Daniel / Dziakova, Jana / Huguet, Jose Mugüerza / Valle, Naila Pagès / Ruiz, Enrique Colás / Valcárcel, Cristina Rey / Moreno, Cristina Ruiz / Salazar, Yeniffer Tatiana Moreno / García, Juan Jesús Rubio / Micó, Silvia Sevila / López, Joaquín Ruiz / Farré, Silvia Pérez / Gomez, Maite Santamaria / Petit, Nuria Mestres / Titos-García, Alberto / Aranda-Narváez, Jose Manuel / Romacho-López, Laura / Sánchez-Guillén, Luis / Aranaz-Ostariz, Veronica / Bosch-Ramírez, Marina / Martínez-Pérez, Aleix / Martínez-López, Elías / Sebastián-Tomás, Juan Carlos / Jimenez-Riera, Granada / Jimenez-Vega, Javier / Cuellar, Jose Aurelio Navas / Campos-Serra, Andrea / Muñoz-Campaña, Anna / Gràcia-Roman, Raquel / Alegre, Javier Martínez / Pinto, Francisca Lima / O'Sullivan, Sara Nuñez / Antona, Francisco Blanco / Jiménez, Beatriz Muñoz / López-Sánchez, Jaime / Carmona, Zahira Gómez / Fernández, Rocio Torres / Sierra, Isabel Blesa / de León, Laura Román García / Moreno, Verónica Polaino / Iglesias, Eva / Cumplido, Paola Lora / Bravo, Altea Arango / Simó, Ignacio Rey / Domínguez, Carlota López / Caamaño, Aloia Guerreiro / Lozano, Rafael Calleja / Martínez, Manuel Durán / Torres, Álvaro Naranjo / de Quiros, Javier Tomas Morales Bernaldo / Pellino, Gianluca / Cloquell, Miriam Moratal / Moller, Elsa García / Jalal-Eldin, Sami / Abdoun, Ahmed K / Hamid, Hytham K S / Lohsiriwat, Varut / Mongkhonsupphawan, Aitsariya / Baraket, Oussama / Ayed, Karim / Abbassi, Imed / Ali, Ali Ben / Ammar, Houssem / Kchaou, Ali / Tlili, Ahmed / Zribi, Imen / Colak, Elif / Polat, Suleyman / Koylu, Zehra Alan / Guner, Ali / Usta, Mehmet Arif / Reis, Murat Emre / Mantoglu, Baris / Gonullu, Emre / Akin, Emrah / Altintoprak, Fatih / Bayhan, Zulfu / Firat, Necattin / Isik, Arda / Memis, Ufuk / Bayrak, Mehmet / Altıntaş, Yasemin / Kara, Yasin / Bozkurt, Mehmet Abdussamet / Kocataş, Ali / Das, Koray / Seker, Ahmet / Ozer, Nazmi / Atici, Semra Demirli / Tuncer, Korhan / Kaya, Tayfun / Ozkan, Zeynep / Ilhan, Onur / Agackiran, Ibrahim / Uzunoglu, Mustafa Yener / Demirbas, Eren / Altinel, Yuksel / Meric, Serhat / Hacım, Nadir Adnan / Uymaz, Derya Salim / Omarov, Nail / Balık, Emre / Tebala, Giovanni D / Khalil, Hany / Rana, Mridul / Khan, Mansoor / Florence, Charlotte / Swaminathan, Christie / Leo, Cosimo Alex / Liasis, Lampros / Watfah, Josef / Trostchansky, Ivan / Delgado, Edward / Pontillo, Marcelo / Latifi, Rifat / Coimbra, Raul / Edwards, Sara / Lopez, Ana / Velmahos, George / Dorken, Ander / Gebran, Anthony / Palmer, Amanda / Oury, Jeffrey / Bardes, James M / Seng, Sirivan Suon / Coffua, Lauren S / Ratnasekera, Asanthi / Egodage, Tanya / Echeverria-Rosario, Karla / Armento, Isabella / Napolitano, Lena M / Sangji, Naveen F / Hemmila, Mark / Quick, Jacob A / Austin, Tyler R / Hyman, Theodore S / Curtiss, William / McClure, Amanda / Cairl, Nicholas / Biffl, Walter L / Truong, Hung P / Schaffer, Kathryn / Reames, Summer / Banchini, Filippo / Capelli, Patrizio / Coccolini, Federico / Sartelli, Massimo / Bravi, Francesca / Vallicelli, Carlo / Agnoletti, Vanni / Baiocchi, Gian Luca / Catena, Fausto

    World journal of emergency surgery : WJES

    2024  Volume 19, Issue 1, Page(s) 14

    Abstract: Background: Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann's procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute ... ...

    Abstract Background: Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann's procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute left-sided colonic emergencies and the factors that leading to the choice of treatment, comparing HP and RPA.
    Methods: This is a prospective, international, multicenter, observational study registered on ClinicalTrials.gov. A total 1215 patients with left-sided colonic emergencies who required surgery were included from 204 centers during the period of March 1, 2020, to May 31, 2020. with a 1-year follow-up.
    Results: 564 patients (43.1%) were females. The mean age was 65.9 ± 15.6 years. HP was performed in 697 (57.3%) patients and RPA in 384 (31.6%) cases. Complicated acute diverticulitis was the most common cause of left-sided colonic emergencies (40.2%), followed by colorectal malignancy (36.6%). Severe complications (Clavien-Dindo ≥ 3b) were higher in the HP group (P < 0.001). 30-day mortality was higher in HP patients (13.7%), especially in case of bowel perforation and diffused peritonitis. 1-year follow-up showed no differences on ostomy reversal rate between HP and RPA. (P = 0.127). A backward likelihood logistic regression model showed that RPA was preferred in younger patients, having low ASA score (≤ 3), in case of large bowel obstruction, absence of colonic ischemia, longer time from admission to surgery, operating early at the day working hours, by a surgeon who performed more than 50 colorectal resections.
    Conclusions: After 100 years since the first Hartmann's procedure, HP remains the most common treatment for left-sided colorectal emergencies. Treatment's choice depends on patient characteristics, the time of surgery and the experience of the surgeon. RPA should be considered as the gold standard for surgery, with HP being an exception.
    MeSH term(s) Female ; Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Male ; Emergencies ; Prospective Studies ; Postoperative Complications/etiology ; Anastomosis, Surgical/methods ; Colorectal Neoplasms/surgery
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Observational Study ; Multicenter Study ; Journal Article
    ZDB-ID 2233734-9
    ISSN 1749-7922 ; 1749-7922
    ISSN (online) 1749-7922
    ISSN 1749-7922
    DOI 10.1186/s13017-024-00543-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis?

    De Simone, Belinda / Abu-Zidan, Fikri M / Chouillard, Elie / Di Saverio, Salomone / Sartelli, Massimo / Podda, Mauro / Gomes, Carlos Augusto / Moore, Ernest E / Moug, Susan J / Ansaloni, Luca / Kluger, Yoram / Coccolini, Federico / Landaluce-Olavarria, Aitor / Estraviz-Mateos, Begoña / Uriguen-Etxeberria, Ana / Giordano, Alessio / Luna, Alfonso Palmieri / Amín, Luz Adriana Hernández / Hernández, Adriana María Palmieri /
    Shabana, Amanda / Dzulkarnaen, Zakaria Andee / Othman, Muhammad Asyraf / Sani, Mohamad Ikhwan / Balla, Andrea / Scaramuzzo, Rosa / Lepiane, Pasquale / Bottari, Andrea / Staderini, Fabio / Cianchi, Fabio / Cavallaro, Andrea / Zanghì, Antonio / Cappellani, Alessandro / Campagnacci, Roberto / Maurizi, Angela / Martinotti, Mario / Ruggieri, Annamaria / Jusoh, Asri Che / Rahman, Karim Abdul / Zulkifli, Anis Suraya M / Petronio, Barbara / Matías-García, Belén / Quiroga-Valcárcel, Ana / Mendoza-Moreno, Fernando / Atanasov, Boyko / Campanile, Fabio Cesare / Vecchioni, Ilaria / Cardinali, Luca / Travaglini, Grazia / Sebastiani, Elisa / Chooklin, Serge / Chuklin, Serhii / Cianci, Pasquale / Restini, Enrico / Capuzzolo, Sabino / Currò, Giuseppe / Filippo, Rosalinda / Rispoli, Michele / Aparicio-Sánchez, Daniel / Muñóz-Cruzado, Virginia Durán / Barbeito, Sandra Dios / Delibegovic, Samir / Kesetovic, Amar / Sasia, Diego / Borghi, Felice / Giraudo, Giorgio / Visconti, Diego / Doria, Emanuele / Santarelli, Mauro / Luppi, Davide / Bonilauri, Stefano / Grossi, Ugo / Zanus, Giacomo / Sartori, Alberto / Piatto, Giacomo / De Luca, Maurizio / Vita, Domenico / Conti, Luigi / Capelli, Patrizio / Cattaneo, Gaetano Maria / Marinis, Athanasios / Vederaki, Styliani-Aikaterini / Bayrak, Mehmet / Altıntas, Yasemin / Uzunoglu, Mustafa Yener / Demirbas, Iskender Eren / Altinel, Yuksel / Meric, Serhat / Aktimur, Yunus Emre / Uymaz, Derya Salim / Omarov, Nail / Azamat, Ibrahim / Lostoridis, Eftychios / Nagorni, Eleni-Aikaterini / Pujante, Antonio / Anania, Gabriele / Bombardini, Cristina / Bagolini, Francesco / Gonullu, Emre / Mantoglu, Baris / Capoglu, Recayi / Cappato, Stefano / Muzio, Elena / Colak, Elif / Polat, Suleyman / Koylu, Zehra Alan / Altintoprak, Fatih / Bayhan, Zülfü / Akin, Emrah / Andolfi, Enrico / Rezart, Sulce / Kim, Jae Il / Jung, Sung Won / Shin, Yong Chan / Enciu, Octavian / Toma, Elena Adelina / Medas, Fabio / Canu, Gian Luigi / Cappellacci, Federico / D'Acapito, Fabrizio / Ercolani, Giorgio / Solaini, Leonardo / Roscio, Francesco / Clerici, Federico / Gelmini, Roberta / Serra, Francesco / Rossi, Elena Giulia / Fleres, Francesco / Clarizia, Guglielmo / Spolini, Alessandro / Ferrara, Francesco / Nita, Gabriela / Sarnari, Jlenia / Gachabayov, Mahir / Abdullaev, Abakar / Poillucci, Gaetano / Palini, Gian Marco / Veneroni, Simone / Garulli, Gianluca / Piccoli, Micaela / Pattacini, Gianmaria Casoni / Pecchini, Francesca / Argenio, Giulio / Armellino, Mariano Fortunato / Brisinda, Giuseppe / Tedesco, Silvia / Fransvea, Pietro / Ietto, Giuseppe / Franchi, Caterina / Carcano, Giulio / Martines, Gennaro / Trigiante, Giuseppe / Negro, Giulia / Vega, Gustavo Machain / González, Agustín Rodríguez / Ojeda, Leonardo / Piccolo, Gaetano / Bondurri, Andrea / Maffioli, Anna / Guerci, Claudio / Sin, Boo Han / Zuhdi, Zamri / Azman, Azlanudin / Mousa, Hussam / Al Bahri, Shadi / Augustin, Goran / Romic, Ivan / Moric, Trpimir / Nikolopoulos, Ioannis / Andreuccetti, Jacopo / Pignata, Giusto / D'Alessio, Rossella / Kenig, Jakub / Skorus, Urszula / Fraga, Gustavo Pereira / Hirano, Elcio Shiyoiti / de Lima Bertuol, Jackson Vinícius / Isik, Arda / Kurnaz, Eray / Asghar, Mohammad Sohail / Afzal, Ameer / Akbar, Ali / Nikolouzakis, Taxiarchis Konstantinos / Lasithiotakis, Konstantinos / Chrysos, Emmanuel / Das, Koray / Özer, Nazmi / Seker, Ahmet / Ibrahim, Mohamed / Hamid, Hytham K S / Babiker, Ahmed / Bouliaris, Konstantinos / Koukoulis, George / Kolla, Chrysoula-Christina / Lucchi, Andrea / Agostinelli, Laura / Taddei, Antonio / Fortuna, Laura / Agostini, Carlotta / Licari, Leo / Viola, Simona / Callari, Cosimo / Laface, Letizia / Abate, Emmanuele / Casati, Massimiliano / Anastasi, Alessandro / Canonico, Giuseppe / Gabellini, Linda / Tosi, Lorenzo / Guariniello, Anna / Zanzi, Federico / Bains, Lovenish / Sydorchuk, Larysa / Iftoda, Oksana / Sydorchuk, Andrii / Malerba, Michele / Costanzo, Federico / Galleano, Raffaele / Monteleone, Michela / Costanzi, Andrea / Riva, Carlo / Walędziak, Maciej / Kwiatkowski, Andrzej / Czyżykowski, Łukasz / Major, Piotr / Strzałka, Marcin / Matyja, Maciej / Natkaniec, Michal / Valenti, Maria Rosaria / Di Vita, Maria Domenica Pia / Sotiropoulou, Maria / Kapiris, Stylianos / Massalou, Damien / Veroux, Massimiliano / Volpicelli, Alessio / Gioco, Rossella / Uccelli, Matteo / Bonaldi, Marta / Olmi, Stefano / Nardi, Matteo / Livadoti, Giada / Mesina, Cristian / Dumitrescu, Theodor Viorel / Ciorbagiu, Mihai Calin / Ammendola, Michele / Ammerata, Giorgio / Romano, Roberto / Slavchev, Mihail / Misiakos, Evangelos P / Pikoulis, Emmanouil / Papaconstantinou, Dimitrios / Elbahnasawy, Mohamed / Abdel-Elsalam, Sherief / Felsenreich, Daniel M / Jedamzik, Julia / Michalopoulos, Nikolaos V / Sidiropoulos, Theodoros A / Papadoliopoulou, Maria / Cillara, Nicola / Deserra, Antonello / Cannavera, Alessandro / Negoi, Ionuţ / Schizas, Dimitrios / Syllaios, Athanasios / Vagios, Ilias / Gourgiotis, Stavros / Dai, Nick / Gurung, Rekha / Norrey, Marcus / Pesce, Antonio / Feo, Carlo Vittorio / Fabbri, Nicolo' / Machairas, Nikolaos / Dorovinis, Panagiotis / Keramida, Myrto D / Mulita, Francesk / Verras, Georgios Ioannis / Vailas, Michail / Yalkin, Omer / Iflazoglu, Nidal / Yigit, Direnc / Baraket, Oussama / Ayed, Karim / Ghalloussi, Mohamed Hedi / Patias, Parmenion / Ntokos, Georgios / Rahim, Razrim / Bala, Miklosh / Kedar, Asaf / Sawyer, Robert G / Trinh, Anna / Miller, Kelsey / Sydorchuk, Ruslan / Knut, Ruslan / Plehutsa, Oleksandr / Liman, Rumeysa Kevser / Ozkan, Zeynep / Kader, Saleh Abdel / Gupta, Sanjay / Gureh, Monika / Saeidi, Sara / Aliakbarian, Mohsen / Dalili, Amin / Shoko, Tomohisa / Kojima, Mitsuaki / Nakamoto, Raira / Atici, Semra Demirli / Tuncer, Gizem Kilinc / Kaya, Tayfun / Delis, Spiros G / Rossi, Stefano / Picardi, Biagio / Del Monte, Simone Rossi / Triantafyllou, Tania / Theodorou, Dimitrios / Pintar, Tadeja / Salobir, Jure / Manatakis, Dimitrios K / Tasis, Nikolaos / Acheimastos, Vasileios / Ioannidis, Orestis / Loutzidou, Lydia / Symeonidis, Savvas / de Sá, Tiago Correia / Rocha, Mónica / Guagni, Tommaso / Pantalone, Desiré / Maltinti, Gherardo / Khokha, Vladimir / Abdel-Elsalam, Wafaa / Ghoneim, Basma / López-Ruiz, José Antonio / Kara, Yasin / Zainudin, Syaza / Hayati, Firdaus / Azizan, Nornazirah / Khei, Victoria Tan Phooi / Yi, Rebecca Choy Xin / Sellappan, Harivinthan / Demetrashvili, Zaza / Lekiashvili, Nika / Tvaladze, Ana / Froiio, Caterina / Bernardi, Daniele / Bonavina, Luigi / Gil-Olarte, Angeles / Grassia, Sebastiano / Romero-Vargas, Estela / Bianco, Francesco / Gumbs, Andrew A / Dogjani, Agron / Agresta, Ferdinando / Litvin, Andrey / Balogh, Zsolt J / Gendrikson, George / Martino, Costanza / Damaskos, Dimitrios / Pararas, Nikolaos / Kirkpatrick, Andrew / Kurtenkov, Mikhail / Gomes, Felipe Couto / Pisanu, Adolfo / Nardello, Oreste / Gambarini, Fabrizio / Aref, Hager / Angelis, Nicola De' / Agnoletti, Vanni / Biondi, Antonio / Vacante, Marco / Griggio, Giulia / Tutino, Roberta / Massani, Marco / Bisetto, Giovanni / Occhionorelli, Savino / Andreotti, Dario / Lacavalla, Domenico / Biffl, Walter L / Catena, Fausto

    World journal of emergency surgery : WJES

    2022  Volume 17, Issue 1, Page(s) 61

    Abstract: Background: The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis ... ...

    Abstract Background: The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not.
    Methods: Data were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not.
    Results: A total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p < 0.0001), diabetes (p < 0.0001), and severe chronic obstructive airway disease (p = 0.005) were significantly more frequent in the COVID-19 group. Markers of sepsis severity including ARDS (p < 0.0001), PIPAS score (p < 0.0001), WSES sepsis score (p < 0.0001), qSOFA (p < 0.0001), and Tokyo classification of severity of acute cholecystitis (p < 0.0001) were significantly higher in the COVID-19 group. The COVID-19 group had significantly higher postoperative complications (32.2% compared with 11.7%, p < 0.0001), longer mean hospital stay (13.21 compared with 6.51 days, p < 0.0001), and mortality rate (13.4% compared with 1.7%, p < 0.0001). The incidence of gangrenous cholecystitis was doubled in the COVID-19 group (40.7% compared with 22.3%). The mean wall thickness of the gallbladder was significantly higher in the COVID-19 group [6.32 (SD: 2.44) mm compared with 5.4 (SD: 3.45) mm; p < 0.0001].
    Conclusions: The incidence of gangrenous cholecystitis is higher in COVID patients compared with non-COVID patients admitted to the emergency department with acute cholecystitis. Gangrenous cholecystitis in COVID patients is associated with high-grade Clavien-Dindo postoperative complications, longer hospital stay and higher mortality rate. The open cholecystectomy rate is higher in COVID compared with non -COVID patients. It is recommended to delay the surgical treatment in COVID patients, when it is possible, to decrease morbidity and mortality rates. COVID-19 infection and gangrenous cholecystistis are not absolute contraindications to perform laparoscopic cholecystectomy, in a case by case evaluation, in expert hands.
    Language English
    Publishing date 2022-12-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2233734-9
    ISSN 1749-7922 ; 1749-7922
    ISSN (online) 1749-7922
    ISSN 1749-7922
    DOI 10.1186/s13017-022-00466-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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