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  1. Book ; Conference proceedings: Therapy for viral hepatitis and prevention of hepatocelluar carcinoma

    Omata, Masao

    the first single-topic conference on "Therapy of Viral Hepatitis and Prevention of Hepatocellular Carcinoma" was held November 14 -15, 2002, near Mt. Fuji

    2004  

    Institution Single Topic Conference on Therapy of Viral Hepatitis and Prevention of Hepatocellular Carcinoma
    Author's details M. Omata ...(ed.)
    Keywords Hepatitis, Viral, Human / therapy ; Carcinoma, Hepatocellular / prevention & control ; Virushepatitis ; Therapie ; Leberzellkrebs ; Prävention
    Subject Verhütung ; Vorbeugung ; Prophylaxe ; Vorsorge ; Leberzellkarzinom ; Hepatozelluläres Carcinom ; Hepatozelluläres Karzinom ; Primäres Leberzellkarzinom ; Malignes Hepatom ; Medizinische Behandlung ; Behandlung ; Krankenbehandlung
    Language English
    Size XI, 295 S. : Ill., graph. Darst., 24 cm
    Publisher Springer
    Publishing place Tokyo u.a.
    Publishing country Japan
    Document type Book ; Conference proceedings
    Note Literaturangaben
    HBZ-ID HT014001773
    ISBN 4-431-40280-2 ; 978-4-431-40280-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 1795 order for loan Magazin

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  2. Article ; Online: Nomograms should be noted.

    Obi, Shuntaro / Omata, Masao

    Hepatology international

    2024  Volume 18, Issue 2, Page(s) 420–421

    MeSH term(s) Humans ; Nomograms ; Prognosis
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 2270316-0
    ISSN 1936-0541 ; 1936-0533
    ISSN (online) 1936-0541
    ISSN 1936-0533
    DOI 10.1007/s12072-023-10612-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Genomic evidence for reinfection with different Omicron subvariants.

    Hirotsu, Yosuke / Omata, Masao

    The Journal of infection

    2023  Volume 86, Issue 3, Page(s) e61–e63

    MeSH term(s) Humans ; Reinfection ; Genomics
    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2023.01.010
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    Zs.A 1501: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 48: Show issues

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  4. Article ; Online: Effectiveness of the severe acute respiratory syndrome coronavirus 2 Omicron BA.5 bivalent vaccine on symptoms in healthcare workers with BA.5 infection.

    Hirotsu, Yosuke / Takatori, Mika / Mochizuki, Hitoshi / Omata, Masao

    Vaccine: X

    2024  Volume 17, Page(s) 100433

    Abstract: Background: The infection status of healthcare workers (HCWs) with coronavirus disease 2019 has become a major concern worldwide. In this study, we investigated the efficacy of the number of vaccine doses on symptoms after BA.5-adapted bivalent ... ...

    Abstract Background: The infection status of healthcare workers (HCWs) with coronavirus disease 2019 has become a major concern worldwide. In this study, we investigated the efficacy of the number of vaccine doses on symptoms after BA.5-adapted bivalent vaccination in HCWs.
    Methods: We analyzed the occupation, route of infection, symptoms, and vaccination history of all HCWs who tested positive for severe acute respiratory syndrome coronavirus 2 and worked in our hospital from November 2020 to March 2023. A logistic regression analysis was performed to examine the association between the presence of BA.5-adapted bivalent vaccination and symptoms.
    Results: During the observation period, 531 HCWs became infected. Of these, 72 % were women, with a median age of 30 years. Nurses accounted for 57 % of the infected cases, and many of the infection routes were from family members. We examined the relationship between symptoms in 352 HCWs infected with the Omicron BA.5* variant and the number of vaccine doses. As the number of vaccine doses increased, the rate of fever decreased, while symptoms such as a runny nose and sore throat tended to increase. The logistic regression analysis showed that the rate of fever tended to decrease (odds ratio = 0.52, 95 % confidence interval: 0.26-1.01, p = 0.056) and that of a runny nose increased (odds ratio = 3.68, 95 % confidence interval: 1.17-10.6, p = 0.018) after BA.5-adapted bivalent vaccination.
    Conclusion: This study shows that fever is reduced and mild symptoms are increased after BA.5-adapted bivalent vaccination in BA.5-infected HCWs. This result highlights the potential effectiveness of tailored vaccination strategies in the management of emerging COVID-19 variants.
    Language English
    Publishing date 2024-01-06
    Publishing country England
    Document type Journal Article
    ISSN 2590-1362
    ISSN (online) 2590-1362
    DOI 10.1016/j.jvacx.2024.100433
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  5. Article ; Online: Detection of the Omicron BA.2.75 subvariant in Japan.

    Hirotsu, Yosuke / Omata, Masao

    The Journal of infection

    2022  Volume 86, Issue 1, Page(s) e5–e7

    MeSH term(s) Humans ; Japan ; COVID-19/diagnosis
    Language English
    Publishing date 2022-09-07
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2022.08.038
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  6. Article ; Online: Simulation analysis of EGFR mutation detection: Oncomine Dx target test and AmoyDx panel impact on lung cancer treatment decisions.

    Hirotsu, Yosuke / Nakagomi, Takahiro / Nagakubo, Yuki / Goto, Taichiro / Omata, Masao

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 1594

    Abstract: Lung cancer is a leading cause of cancer-related deaths worldwide. Epidermal growth factor receptor (EGFR) driver mutations are crucial for treatment decisions for patients with non-small cell lung cancer (NSCLC). This study aimed to assess the ... ...

    Abstract Lung cancer is a leading cause of cancer-related deaths worldwide. Epidermal growth factor receptor (EGFR) driver mutations are crucial for treatment decisions for patients with non-small cell lung cancer (NSCLC). This study aimed to assess the differences in EGFR mutation detection between two companion diagnostic (CDx) tests-the Oncomine Dx Target Test (ODxTT) and the AmoyDx Pan Lung Cancer PCR Panel-and their impact on treatment applicability. To this end, we used an in-house targeted sequencing dataset of 282 samples from 127 EGFR-mutated NSCLC patients to simulate the concordance between the EGFR variants targeted by the ODxTT and AmoyDx panel, the oncogenicity of the variants, and their therapeutic potential. Of the 216 EGFR mutations identified by the in-house panel, 51% were detectable by both CDx tests, 3% were specific to ODxTT, and 46% were not targeted by either test. Most non-targeted mutations did not have oncogenicity and were located outside exons 18-21. Notably, 95% of the mutations detectable by both tests had potential oncogenicity. Furthermore, among the 96 patients harboring actionable EGFR mutations, 97% had mutations detectable by both CDx tests and 1% by ODxTT, while 2% had mutations not covered by either test. These findings suggest that while both CDx tests are effective in detecting almost all actionable EGFR mutations, ODxTT provides slightly broader coverage. These results emphasize the importance of selecting appropriate CDx tests to inform treatment decisions for EGFR-positive NSCLC patients.
    MeSH term(s) Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/diagnosis ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Mutation ; Exons ; ErbB Receptors/genetics ; ErbB Receptors/therapeutic use
    Chemical Substances ErbB Receptors (EC 2.7.10.1) ; EGFR protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-52006-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Detection of R.1 lineage severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with spike protein W152L/E484K/G769V mutations in Japan.

    Hirotsu, Yosuke / Omata, Masao

    PLoS pathogens

    2021  Volume 17, Issue 6, Page(s) e1009619

    Abstract: We aimed to investigate novel emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages in Japan that harbor variants in the spike protein receptor-binding domain (RBD). The total nucleic acid contents of samples from 159 patients ... ...

    Abstract We aimed to investigate novel emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages in Japan that harbor variants in the spike protein receptor-binding domain (RBD). The total nucleic acid contents of samples from 159 patients with coronavirus disease 2019 (COVID-19) were subjected to whole genome sequencing. The SARS-CoV-2 genome sequences from these patients were examined for variants in spike protein RBD. In January 2021, three family members (one aged in their 40s and two aged under 10 years old) were found to be infected with SARS-CoV-2 harboring W152L/E484K/G769V mutations. These three patients were living in Japan and had no history of traveling abroad. After identifying these cases, we developed a TaqMan assay to screen for the above hallmark mutations and identified an additional 14 patients with the same mutations. The associated virus strain was classified into the GR clade (Global Initiative on Sharing Avian Influenza Data [GISAID]), 20B clade (Nextstrain), and R.1 lineage (Phylogenetic Assignment of Named Global Outbreak [PANGO] Lineages). As of April 22, 2021, R.1 lineage SARS-CoV-2 has been identified in 2,388 SARS-CoV-2 entries in the GISAID database, many of which were from Japan (38.2%; 913/2,388) and the United States (47.1%; 1,125/2,388). Compared with that in the United States, the percentage of SARS-CoV-2 isolates belonging to the R.1 lineage in Japan increased more rapidly over the period from October 24, 2020 to April 18, 2021. R.1 lineage SARS-CoV-2 has potential escape mutations in the spike protein RBD (E484K) and N-terminal domain (W152L); therefore, it will be necessary to continue to monitor the R.1 lineage as it spreads around the world.
    MeSH term(s) Adult ; COVID-19/epidemiology ; COVID-19/transmission ; COVID-19/virology ; Child ; Humans ; Japan ; Mutation ; Phylogeny ; SARS-CoV-2/classification ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2021-06-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1009619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Discovery of a SARS-CoV-2 variant from the P.1 lineage harboring K417T/E484K/N501Y mutations in Kofu, Japan.

    Hirotsu, Yosuke / Omata, Masao

    The Journal of infection

    2021  Volume 82, Issue 6, Page(s) 276–316

    MeSH term(s) COVID-19 ; Humans ; Japan ; Mutation ; SARS-CoV-2 ; United Kingdom
    Language English
    Publishing date 2021-03-23
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2021.03.013
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    Zs.A 1501: Show issues Location:
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  9. Article ; Online: Liver dysfunction of Atezolizumab + Bevacizumab -a matter of life or death.

    Obi, Shuntaro / Omata, Masao

    Liver international : official journal of the International Association for the Study of the Liver

    2021  Volume 41, Issue 7, Page(s) 1702–1703

    MeSH term(s) Antibodies, Monoclonal, Humanized/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols ; Bevacizumab/therapeutic use ; Carcinoma, Hepatocellular/drug therapy ; Humans ; Liver Neoplasms/drug therapy
    Chemical Substances Antibodies, Monoclonal, Humanized ; Bevacizumab (2S9ZZM9Q9V) ; atezolizumab (52CMI0WC3Y)
    Language English
    Publishing date 2021-05-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.14947
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  10. Article ; Online: SARS-CoV-2 B.1.1.7 lineage rapidly spreads and replaces R.1 lineage in Japan: Serial and stationary observation in a community.

    Hirotsu, Yosuke / Omata, Masao

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

    2021  Volume 95, Page(s) 105088

    Abstract: Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) circulates in the world and acquires mutations during evolution. To identify the new emergent variants, the surveillance of the variants of concern (VOC) and variants of ... ...

    Abstract Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) circulates in the world and acquires mutations during evolution. To identify the new emergent variants, the surveillance of the variants of concern (VOC) and variants of interest (VOI) is ongoing. This study aimed to determine how the transition of viral lineage occurred by stationary genome analysis in Yamanashi, Japan.
    Methods: We performed the whole genome sequencing using SARS-CoV-2 positive samples collected from February 2020 to the end of June 2021. Viral lineage was defined by the Phylogenetic Assignment of Named Global Outbreak (PANGO) lineages.
    Results: We successfully obtained 325 viral genome sequences and the number of analyzed samples accounted for 15.4% of the total 2109 COVID-19 patients identified in our district. We identified 13 types of viral lineages including R.1, P.1, B.1.1.7 (Alpha) and B.1.617.2 (Delta). These virus lineages had distinct periods of expansion and decline. After the emerging of the R.1 lineage harboring E484K variant (designated VOI in Japan), the prevalent B.1.1.214 lineage were no longer identified. The R.1 lineages were temporarily prevalent afterwards, but the influx of B.1.1.7 lineage (designated VOC) led to a decline in R.1. Currently, B.1.1.7 has become dominant after mid-April 2021.
    Conclusion: We clearly elucidated the transition and replacement of viral lineage by the community-based analysis. The virus completely replaced by more infectious lineages, therefore, it will be necessary to continue to monitor the VOC and VOI.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/transmission ; COVID-19/virology ; Epidemiological Monitoring ; Genome, Viral ; Humans ; Japan/epidemiology ; Phylogeny ; Prevalence ; RNA, Viral/genetics ; SARS-CoV-2/classification ; SARS-CoV-2/genetics ; SARS-CoV-2/growth & development ; SARS-CoV-2/pathogenicity ; Whole Genome Sequencing
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2021-09-21
    Publishing country Netherlands
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2037068-4
    ISSN 1567-7257 ; 1567-1348
    ISSN (online) 1567-7257
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2021.105088
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