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Article ; Online: Role of serum calprotectin in identifying familial Mediterranean fever attacks.

Polat, Merve Gokcen / Omma, Ahmet / Gokcen, Neslihan / Kilinckaya, Muhammed Fevzi / Ozkan Karaahmetoglu, Selma

2024

Abstract: Background/aim: The aim of the study was to evaluate serum calprotectin (CLP) levels in familial Mediterranean fever (FMF) patients and to investigate the utility of CLP in distinguishing patients with attack from patients without attack.: Material ... ...

Abstract	Background/aim: The aim of the study was to evaluate serum calprotectin (CLP) levels in familial Mediterranean fever (FMF) patients and to investigate the utility of CLP in distinguishing patients with attack from patients without attack. Material and method: FMF patients, rheumatoid arthritis (RA) patients, and healthy controls were included. Serum calprotectin levels were quantified utilizing the enzyme-linked immunosorbent assay (ELISA) method. Receiver operating characteristic (ROC) curve analysis was used to identify the cut-off value of serum CLP level to differentiate FMF patients with attack from those without. Logistic regression analysis was performed to identify predictors. Results: Significant differences were observed among the three groups concerning white blood cell (WBC), neutrophil, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and serum CLP levels (p = 0.003, p = 0.004, p < 0.001, p < 0.001, and p = 0.002, respectively). Higher ESR, CRP, and serum CLP levels were observed in FMF patients with attacks than those without (all, p < 0.001). Serum CLP was significantly higher in RA patients than in FMF patients in remission (p < 0.001). ROC analysis identified a threshold CLP concentration in FMF with an attack to be 47.1 pg/mL (83.3% sensitivity, 60.6% specificity, AUC = 0.74, 95% CI = 0.63-0.85, p < 0.001). In univariate logistic regression analysis, CLP (β = 1.045, 95% CI = 1.017-1.073, p = 0.001) was predictive of FMF patients experiencing an attack. Conclusion: Serum CLP proves to be as productive as ESR in illustrating inflammation and demonstrating the existence of attacks in FMF patients.
Language	English
Publishing date	2024-03-13
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	390895-1
ISSN	1863-4362 ; 0021-1265
ISSN (online)	1863-4362
ISSN	0021-1265
DOI	10.1007/s11845-024-03659-9
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Article: Comparative Metabolomic Profiles of Vascular Involvement in Behçet's Disease.

Yücel, Çiğdem / Sertoğlu, Erdim / Omma, Ahmet / Koçak, Engin / Erdoğan Kablan, Sevilay / Özgürtaş, Taner / Nemutlu, Emirhan

European journal of rheumatology

2023 Volume 10, Issue 4, Page(s) 130–135

Abstract: Background: Behçet's disease is a systemic, inflammatory disease affecting multiple organs. Vascular involvement is the main cause of morbidity and mortality in Behçet's disease patients. Though clinically well-defined, there is limited information ... ...

Abstract	Background: Behçet's disease is a systemic, inflammatory disease affecting multiple organs. Vascular involvement is the main cause of morbidity and mortality in Behçet's disease patients. Though clinically well-defined, there is limited information related to disease pathogenesis and vascular incidence in this patient group. The aim of this study is to investigate the unique metabolic signatures of Behçet's disease patients with vascular involvement. Methods: Metabolomic profiling was performed on serum samples of 48 Behçet's disease patients (18 with vascular involvement) and 40 healthy controls using gas chromatography-mass spectrometrybased untargeted metabolomics analysis. Multivariate and univariate statistical analyses were performed to find altered metabolites and pathways. Results: Untargeted metabolomics results showed that a total of 168 metabolites were identified. The comparison between the groups of Behçet's disease, vascular involvement in Behçet's disease, and the healthy control group showed that altered amino acid and oxidative stress pathways, especially with glutathione synthesis, could be an important stage for developing Behçet's disease. Conclusion: In the present work, the untargeted metabolomics approach provided new molecular insights for a better understanding of Behçet's disease pathogenesis and also developing vascular involvement in Behçet's disease at the metabolite level. The results showed that vascular involvement in Behçet's disease could be highly linked with amino acid metabolism and also the antioxidant system, and these disease-related pathways could be evaluated with further experiments for diagnosis and prognosis of Behçet's disease and also for vascular involvement in Behçet's disease.
Language	English
Publishing date	2023-10-17
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2873727-1
ISSN	2148-4279 ; 2147-9720
ISSN (online)	2148-4279
ISSN	2147-9720
DOI	10.5152/eurjrheum.2023.23062
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Article ; Online: Ustekinumab in enteropathic arthritis.

Ulusoy, Bahar Özdemir / Erden, Abdulsamet / Güven, Serdar Can / Armağan, Berkan / Yürekli, Öykü Tayfur / Özin, Yasemin Özderin / Omma, Ahmet / Küçükşahin, Orhan

Immunotherapy

2023 Volume 15, Issue 8, Page(s) 583–592

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Humans ; Ustekinumab/therapeutic use ; Inflammatory Bowel Diseases/drug therapy ; Spondylarthritis/drug therapy ; Gastrointestinal Diseases
Chemical Substances	Ustekinumab (FU77B4U5Z0)
Language	English
Publishing date	2023-04-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2495964-9
ISSN	1750-7448 ; 1750-743X
ISSN (online)	1750-7448
ISSN	1750-743X
DOI	10.2217/imt-2022-0197
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Article ; Online: Tofacitinib experience in patients with enteropathic arthritis.

Dağlı, Pınar Akyüz / Erden, Abdulsamet / Güven, Serdar Can / Armağan, Berkan / Yürekli, Öykü Tayfur / Özin, Yasemin Özderin / Omma, Ahmet / Küçükşahin, Orhan

Immunotherapy

2023 Volume 15, Issue 8, Page(s) 619–626

Abstract: Background/aim: ...

Abstract	Background/aim:
MeSH term(s)	Humans ; Janus Kinases ; Protein Kinase Inhibitors/therapeutic use ; Signal Transduction ; STAT Transcription Factors/metabolism ; Inflammatory Bowel Diseases/drug therapy ; Gastrointestinal Diseases ; Spondylarthritis/drug therapy ; Pyrroles/therapeutic use ; Colitis, Ulcerative/drug therapy
Chemical Substances	tofacitinib (87LA6FU830) ; Janus Kinases (EC 2.7.10.2) ; Protein Kinase Inhibitors ; STAT Transcription Factors ; Pyrroles
Language	English
Publishing date	2023-04-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2495964-9
ISSN	1750-7448 ; 1750-743X
ISSN (online)	1750-7448
ISSN	1750-743X
DOI	10.2217/imt-2022-0110
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Article: The Possible Relation of

Erden, Abdulsamet / Armağan, Berkan / Güven, Serdar Can / Karakaş, Özlem / Erden, Fatma / Özdemir, Bahar / Omma, Ahmet / Küçükşahin, Orhan

Iranian journal of parasitology

2023 Volume 18, Issue 2, Page(s) 237–243

Abstract: Background: We aimed to investigate the frequency of : Methods: Patients diagnosed with a connective tissue disease and had facial erythema were consecutively enrolled in the study from 2019-2020. An age and gender matched control group was formed ... ...

Abstract	Background: We aimed to investigate the frequency of Methods: Patients diagnosed with a connective tissue disease and had facial erythema were consecutively enrolled in the study from 2019-2020. An age and gender matched control group was formed from healthy volunteers. Presence of Results: A total of 31 connective tissue disease patients with facial erythema were enrolled. Control group included 31 healthy volunteers. Demographics and comorbidities were similar between groups. Conclusion: When evaluating facial cutaneous lesions,
Language	English
Publishing date	2023-07-05
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2388453-8
ISSN	2008-238X ; 1735-7020
ISSN (online)	2008-238X
ISSN	1735-7020
DOI	10.18502/ijpa.v18i2.13190
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Article ; Online: Effects of intrauterine device use on attack frequency and severity ın woman of reproductive age with familial Mediterranean fever.

Özdemir Ulusoy, Bahar / Güven, Serdar Can / Babaoğlu, Hakan / Ulusoy, Can Ozan / Armağan, Berkan / Kayacan Erdoğan, Esra / Maraş, Yüksel / Doğan, İsmail / Orhan, Kevser / Koçak Ulucaköy, Rezan / Atalar, Ebru / Omma, Ahmet / Küçükşahin, Orhan / Erten, Şükran

Archives of gynecology and obstetrics

2024 Volume 309, Issue 5, Page(s) 2041–2046

Abstract: Aim: Familial Mediterranean fever (FMF) is the most common inherited autoinflammatory disease in the world. There are known triggers to initiate an FMF attack, yet potential effects of intrauterine devices (IUD) in women of reproductive age have not ... ...

Abstract	Aim: Familial Mediterranean fever (FMF) is the most common inherited autoinflammatory disease in the world. There are known triggers to initiate an FMF attack, yet potential effects of intrauterine devices (IUD) in women of reproductive age have not been evaluated before. Method: Consecutive female patients with FMF who ever used IUD over the age of 18 were enrolled. Female patients with FMF were sub grouped according to the type of IUD they use. FMF attack frequency, severity, duration, presence of dysmenorrhea, severity of dysmenorrhea, having attacks during menstruation before and after IUD use were questioned. Demographic and clinical data were collected from hospital database. Results: When all patients with IUD use were evaluated, it was found that the frequency of attacks increased after IUD insertion at 3rd and 12th months (median [min-max] attack frequency at 3rd month, 1 (0-3) vs 1 (0-6), p = 0.002, median [min-max] attack frequency at 12th month, 2 (0-12) vs 3.5 (0-18), p = 0.028). Attack severity measured by VAS pain was also significantly increased. Attack duration and menstrual pain was similar before and after IUD use. Attack frequency at 3rd and 12th months, attack severity and menstrual pain was all increased significantly in Cu-IUD users, whereas none of these parameters deteriorated in LNG-IUD group. Conclusion: IUD use, especially Cu-IUD, may increase the frequency and severity of attacks in female patients with FMF. Clinicians may benefit from considering LGN-IUD if IUDs are preferred as contraception in women of childbearing age with FMF.
MeSH term(s)	Female ; Humans ; Adult ; Middle Aged ; Dysmenorrhea/etiology ; Familial Mediterranean Fever/complications ; Intrauterine Devices/adverse effects ; Contraceptive Agents, Female ; Contraception ; Intrauterine Devices, Copper/adverse effects
Chemical Substances	Contraceptive Agents, Female
Language	English
Publishing date	2024-03-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	896455-5
ISSN	1432-0711 ; 0932-0067
ISSN (online)	1432-0711
ISSN	0932-0067
DOI	10.1007/s00404-024-07413-5
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Article: Coronavirus Disease 2019 Outcomes in Amyloid A Protein Amyloidosis Secondary to Rheumatic Conditions and Signs of Post- Coronavirus Disease 2019 Proteinuria Progression.

Güven, Serdar Can / Erden, Abdulsamet / Küçük, Hamit / Apaydın, Hakan / Polat, Bünyamin / Kardaş, Rıza Can / Yıldırım, Derya / Usul, Eren / Armağan, Berkan / Küçükşahin, Orhan / Omma, Ahmet / Tufan, Abdurrahman

European journal of rheumatology

2024

Abstract: Background: We aimed to investigate coronavirus diease 2019 (COVID-19) outcomes in patients with amyloid A protein (AA) amyloidosis secondary to rheumatic diseases and discuss factors associated with disease course.: Methods: A retrospective cohort ... ...

Abstract	Background: We aimed to investigate coronavirus diease 2019 (COVID-19) outcomes in patients with amyloid A protein (AA) amyloidosis secondary to rheumatic diseases and discuss factors associated with disease course. Methods: A retrospective cohort was formed from adult patients with a diagnosis of AA amyloidosis. In patients with a positive severe acute respiratory syndrome coronavirus 2 polymerase chain reaction (PCR) test, rates of hospitalization, intensive care unit admission and mortality due to COVID-19 were collected from medical records. Data regarding to demographics, comorbidities, laboratory tests, medical treatments, adherence to previous treatments during COVID-19 and treatment administered for COVID-19 were collected from hospital databases and patient reviews. Results: In 96 patients with AA amyloidosis, 16 had COVID-19 with a positive PCR. Ten (62.5%) patients were hospitalized, 2 (12.5%) were admitted to ICU, 1 (6.25%) was died. Hospitalized patients tended to be older. Comorbidities seemed to be more frequent in hospitalized patients. None of the patients had rapid progression to end-stage renal disease post-COVID-19. Seven patients had pre-COVID-19 and post-COVID-19 proteinuria levels. Three had notable increase in proteinuria after COVID-19 in 2 of which amyloidosis treatment was revised accordingly. Conclusion: Despite high rates of hospitalization in AA amyloidosis patients, mortality was observed only in 1 patient. Progression of proteinuria requiring treatment adjustment may be an issue in these patients. Cite this article as: Güven SC, Erden A, Küçük H, et al. Coronavirus disease 2019 outcomes in amyloid A protein amyloidosis secondary to rheumatic conditions and signs of post-coronavirus disease 2019 proteinuria progression. Eur J Rheumatol. Published online April 4, 2024. DOI:10.5152/eurjrheum.2024.23050.
Language	English
Publishing date	2024-04-04
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2873727-1
ISSN	2148-4279 ; 2147-9720
ISSN (online)	2148-4279
ISSN	2147-9720
DOI	10.5152/eurjrheum.2024.23050
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Article ; Online: Is there a relationship between serum omentin level and acute phase response in patients with familial Mediterranean fever?

Can Sandikci, Sevinc / Omma, Ahmet / Yucel, Cigdem / Omma, Tulay

Clinical rheumatology

2020 Volume 40, Issue 2, Page(s) 669–674

Abstract: Objectives: Familial Mediterranean fever (FMF) is an autoinflammatory disease characterized by frequent attacks and chronic inflammation. Subclinical inflammation continues during the attack-free period. Omentin is an anti-inflammatory adipokine, which ... ...

Abstract	Objectives: Familial Mediterranean fever (FMF) is an autoinflammatory disease characterized by frequent attacks and chronic inflammation. Subclinical inflammation continues during the attack-free period. Omentin is an anti-inflammatory adipokine, which plays important roles in the adjustments of glucose metabolism, cardiovascular homeostasis and atherosclerosis. The aim is to investigate the omentin levels in FMF patients and to assess the association with markers of subclinical inflammation in FMF patients such as serum amyloid A (SAA), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). Method: This cross-sectional study included 54 consecutive adult FMF patients (27 male, 27 female) and 28 healthy individuals (16 male, 12 female). The FMF patients were separated into 3 groups: (1) attack-free group, (2) active-attack group and (3) colchicine-resistant group. Serum omentin levels were compared between the FMF patients and the healthy control group. Results: A significant difference was determined between the FMF patients and healthy control subjects in terms of omentin levels (108.05 (19.97-343.22) vs. 199.5 (42.98-339.41) p < 0.05). SAA values were significantly higher in the FMF patients compared with the healthy control group. When the FMF patients were examined as separate groups, serum omentin values were lower in the colchicine-resistant group than in the groups without resistance (76.64 (19.77-224.33) vs. 186.47 (28.41-343.21) p = 0.006). Conclusions: FMF patients with colchicine resistance are associated with decreased omentin concentrations, probably mediated by inflammation-driven mechanisms. Key Points • Omentin is a type of adipokine which has an anti-inflammatory effect by inhibiting the inflammatory cytokine network. • Decreased omentin levels are associated with increased obesity, insulin resistance and comorbidities. • We report that omentin levels fluctuate in various diseases. In addition, we have focused on the levels of omentin in patients with FMF, as it may act as a biomarker for colchicine resistance.
MeSH term(s)	Acute-Phase Reaction ; Adult ; Blood Sedimentation ; Colchicine/therapeutic use ; Cross-Sectional Studies ; Cytokines ; Familial Mediterranean Fever/drug therapy ; Female ; GPI-Linked Proteins ; Humans ; Lectins ; Male
Chemical Substances	Cytokines ; GPI-Linked Proteins ; ITLN1 protein, human ; Lectins ; Colchicine (SML2Y3J35T)
Language	English
Publishing date	2020-07-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	604755-5
ISSN	1434-9949 ; 0770-3198
ISSN (online)	1434-9949
ISSN	0770-3198
DOI	10.1007/s10067-020-05249-3
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Article ; Online: A case of human leukocyte antigen B27 positive reactive arthritis associated with severe acute respiratory syndrome coronavirus 2 infection.

Apaydin, Hakan / Guven, Serdar Can / Kucuksahin, Orhan / Omma, Ahmet / Erten, Sukran

Northern clinics of Istanbul

2021 Volume 8, Issue 4, Page(s) 423–424

Language	English
Publishing date	2021-08-25
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	3031921-3
ISSN	2536-4553 ; 2148-4902
ISSN (online)	2536-4553
ISSN	2148-4902
DOI	10.14744/nci.2020.88965
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Article ; Online: Serum VEGF-A and VEGFR-1 levels in patients with adult immunoglobulin A vasculitis.

Yücel, Çiğdem / Sertoğlu, Erdim / Fırat Oğuz, Esra / Hayran, Yıldız / Omma, Ahmet / Özgürtaş, Taner

International journal of rheumatic diseases

2021 Volume 24, Issue 6, Page(s) 789–794

Abstract: Aim: Immunoglobulin A vasculitis (IgAV) is classified as a leukocytoclastic vasculitis characterized by immune deposits in endothelial walls of small vessels causing vascular endothelial injury. The aim of the present study is to evaluate levels of ... ...

Abstract	Aim: Immunoglobulin A vasculitis (IgAV) is classified as a leukocytoclastic vasculitis characterized by immune deposits in endothelial walls of small vessels causing vascular endothelial injury. The aim of the present study is to evaluate levels of vascular endothelial growth factor-A (VEGF-A) and VEGF receptor-1 (VEGFR-1) levels in adult IgAV patients. Method: Thirty-seven adult IgAV patients admitted to the Rheumatology Clinic meeting the IgAV American College of Rheumatology (ACR) criteria and 32 control subjects were enrolled in the study. Disease activity was categorized as "remission" or "active" according to Birmingham Vasculitis Activity Score (BVAS). Serum VEGF-A, VEGFR-1 levels and VEGFR-1/VEGF-A ratio were evaluated in patient and control groups. Results: Serum median VEGF-A, VEGFR-1 and VEGFR-1/VEGF-A ratios were significantly higher in the patient group when compared to controls (235.9 [155-308.4] pg/mL vs. 78.8 [29.7-210.3] pg/mL, 400 [277.2-724.3] pg/mL vs. 31.5 [12.5-214.4] pg/mL and 1.85 [0.57-2.97] vs. 0.46 [0.38-0.63] respectively, all P values <.001). VEGFR-1 had the strongest predictive value with a cut-off value of 0.6 with 75% sensitivity and 73% specificity (P < .001). Conclusion: This study is the first report indicating elevated serum VEGF-A, VEGFR-1, and more importantly VEGFR-1/VEGF-A ratio can be good representatives of the inflammatory processes together with vascular endothelial injury in adult IgAV patients. VEGFR-1 seems to be a more important indicator of the ongoing inflammation.
MeSH term(s)	Adult ; Aged ; Biomarkers/blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; IgA Vasculitis/blood ; IgA Vasculitis/diagnosis ; IgA Vasculitis/metabolism ; Immunoglobulin A/blood ; Immunoglobulin A/immunology ; Male ; Middle Aged ; Vascular Endothelial Growth Factor A/blood ; Vascular Endothelial Growth Factor Receptor-1/blood
Chemical Substances	Biomarkers ; Immunoglobulin A ; VEGFA protein, human ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factor Receptor-1 (EC 2.7.10.1)
Language	English
Publishing date	2021-04-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2426924-4
ISSN	1756-185X ; 1756-1841
ISSN (online)	1756-185X
ISSN	1756-1841
DOI	10.1111/1756-185X.14115
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