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  1. Article: Skin and Soft Tissue Lesions in a District Hospital in Central Nigeria: A Histopathological Study.

    Duduyemi, Babatunde M / Omonisi, Abidemi E / Titiloye, Nicholas A

    Dermatology research and practice

    2019  Volume 2019, Page(s) 8143680

    Abstract: Introduction: Method: A cross sectional study was done using secondary data of all skin and soft tissue specimens over a 3 year period. Patients' demographics, sites of specimen, and histological diagnoses were extracted from the surgical day book. ... ...

    Abstract Introduction
    Method: A cross sectional study was done using secondary data of all skin and soft tissue specimens over a 3 year period. Patients' demographics, sites of specimen, and histological diagnoses were extracted from the surgical day book. The data were analysed in terms of age and sex distribution and histological characteristics of pathologic lesions using the SPSS version 22. The data for these patients were presented in tables and figures.
    Result: 451 skin and soft tissue specimens constituting 18% of all the specimens with an M : F ratio of 1 : 1.2. The age range of our patients was 4-85 years with a mean of 33.52 ± 15.05 years. The peak age of occurrence was 30-39 years. Most of our cases were seen in the extremities (50.7%) followed by head (22.2%), while the least common sites were the perineal and neck areas (5.3% each). The commonest site in females was the upper limb (32.4%); the head and lower limb were the commonest sites in males (28.4% each). Most of our patients have neoplastic lesions of skin and soft tissue constituting 68.3%, inflammatory lesions (16.9%), and the least common lesion being hamartoma (0.2%). The most common category of lesions includes inflammatory (nonspecific dermatitis 6.5%); cysts (dermoid cyst 6%); reactive (hypertrophic scar 1%); and neoplastic (lipoma 32.4%). The benign neoplasms were more common (92.9%) than the malignant ones (7.1%). The neoplastic lesions were relatively more common in males than females and the reverse was true for the inflammatory lesions.
    Conclusion: Skin and soft tissue lesions are relatively common in our environment with majority being benign neoplastic lesion.
    Language English
    Publishing date 2019-12-26
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2548952-5
    ISSN 1687-6113 ; 1687-6105
    ISSN (online) 1687-6113
    ISSN 1687-6105
    DOI 10.1155/2019/8143680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Characteristics, management, and outcomes of patients with hepatocellular carcinoma in Africa: a multicountry observational study from the Africa Liver Cancer Consortium.

    Yang, Ju Dong / Mohamed, Essa A / Aziz, Ashraf O Abdel / Shousha, Hend I / Hashem, Mohamed B / Nabeel, Mohamed M / Abdelmaksoud, Ahmed H / Elbaz, Tamer M / Afihene, Mary Y / Duduyemi, Babatunde M / Ayawin, Joshua P / Gyedu, Adam / Lohouès-Kouacou, Marie-Jeanne / Ndam, Antonin W Ndjitoyap / Moustafa, Ehab F / Hassany, Sahar M / Moussa, Abdelmajeed M / Ugiagbe, Rose A / Omuemu, Casimir E /
    Anthony, Richard / Palmer, Dennis / Nyanga, Albert F / Malu, Abraham O / Obekpa, Solomon / Abdo, Abdelmounem E / Siddig, Awatif I / Mudawi, Hatim M Y / Okonkwo, Uchenna / Kooffreh-Ada, Mbang / Awuku, Yaw A / Nartey, Yvonne A / Abbew, Elizabeth T / Awuku, Nana A / Otegbayo, Jesse A / Akande, Kolawole O / Desalegn, Hailemichael M / Omonisi, Abidemi E / Ajayi, Akande O / Okeke, Edith N / Duguru, Mary J / Davwar, Pantong M / Okorie, Michael C / Mustapha, Shettima / Debes, Jose D / Ocama, Ponsiano / Lesi, Olufunmilayo A / Odeghe, Emuobor / Bello, Ruth / Onyekwere, Charles / Ekere, Francis / Igetei, Rufina / Mah'moud, Mitchell A / Addissie, Benyam / Ali, Hawa M / Gores, Gregory J / Topazian, Mark D / Roberts, Lewis R

    The lancet. Gastroenterology & hepatology

    2016  Volume 2, Issue 2, Page(s) 103–111

    Abstract: Background: Hepatocellular carcinoma is a leading cause of cancer-related death in Africa, but there is still no comprehensive description of the current status of its epidemiology in Africa. We therefore initiated an African hepatocellular carcinoma ... ...

    Abstract Background: Hepatocellular carcinoma is a leading cause of cancer-related death in Africa, but there is still no comprehensive description of the current status of its epidemiology in Africa. We therefore initiated an African hepatocellular carcinoma consortium aiming to describe the clinical presentation, management, and outcomes of patients with hepatocellular carcinoma in Africa.
    Methods: We did a multicentre, multicountry, retrospective observational cohort study, inviting investigators from the African Network for Gastrointestinal and Liver Diseases to participate in the consortium to develop hepatocellular carcinoma research databases and biospecimen repositories. Participating institutions were from Cameroon, Egypt, Ethiopia, Ghana, Ivory Coast, Nigeria, Sudan, Tanzania, and Uganda. Clinical information-demographic characteristics, cause of disease, liver-related blood tests, tumour characteristics, treatments, last follow-up date, and survival status-for patients diagnosed with hepatocellular carcinoma between Aug 1, 2006, and April 1, 2016, were extracted from medical records by participating investigators. Because patients from Egypt showed differences in characteristics compared with patients from the other countries, we divided patients into two groups for analysis; Egypt versus other African countries. We undertook a multifactorial analysis using the Cox proportional hazards model to identify factors affecting survival (assessed from the time of diagnosis to last known follow-up or death).
    Findings: We obtained information for 2566 patients at 21 tertiary referral centres (two in Egypt, nine in Nigeria, four in Ghana, and one each in the Ivory Coast, Cameroon, Sudan, Ethiopia, Tanzania, and Uganda). 1251 patients were from Egypt and 1315 were from the other African countries (491 from Ghana, 363 from Nigeria, 277 from Ivory Coast, 59 from Cameroon, 51 from Sudan, 33 from Ethiopia, 21 from Tanzania, and 20 from Uganda). The median age at which hepatocellular carcinoma was diagnosed significantly later in Egypt than the other African countries (58 years [IQR 53-63] vs 46 years [36-58]; p<0·0001). Hepatitis C virus was the leading cause of hepatocellular carcinoma in Egypt (1054 [84%] of 1251 patients), and hepatitis B virus was the leading cause in the other African countries (597 [55%] of 1082 patients). Substantially fewer patients received treatment specifically for hepatocellular carcinoma in the other African countries than in Egypt (43 [3%] of 1315 vs 956 [76%] of 1251; p<0·0001). Among patients with survival information (605 [48%] of 1251 in Egypt and 583 [44%] of 1315 in other African countries), median survival was shorter in the other African countries than in Egypt (2·5 months [95% CI 2·0-3·1] vs 10·9 months [9·6-12·0]; p<0·0001). Factors independently associated with poor survival were: being from an African countries other than Egypt (hazard ratio [HR] 1·59 [95% CI 1·13-2·20]; p=0·01), hepatic encephalopathy (2·81 [1·72-4·42]; p=0·0004), diameter of the largest tumour (1·07 per cm increase [1·04-1·11]; p<0·0001), log α-fetoprotein (1·10 per unit increase [1·02-1·20]; p=0·0188), Eastern Cooperative Oncology Group performance status 3-4 (2·92 [2·13-3·93]; p<0·0001) and no treatment (1·79 [1·44-2·22]; p<0·0001).
    Interpretation: Characteristics of hepatocellular carcinoma differ between Egypt and other African countries. The proportion of patients receiving specific treatment in other African countries was low and their outcomes were extremely poor. Urgent efforts are needed to develop health policy strategies to decrease the burden of hepatocellular carcinoma in Africa.
    Funding: None.
    MeSH term(s) Adult ; Africa/epidemiology ; Age of Onset ; Carcinoma, Hepatocellular/epidemiology ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/therapy ; Egypt/epidemiology ; Female ; Hepatitis C/complications ; Humans ; Incidence ; Liver Neoplasms/epidemiology ; Liver Neoplasms/etiology ; Liver Neoplasms/mortality ; Liver Neoplasms/therapy ; Male ; Middle Aged ; Prevalence ; Retrospective Studies ; Survival Rate
    Language English
    Publishing date 2016-12-03
    Publishing country Netherlands
    Document type Journal Article ; Multicenter Study ; Observational Study
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(16)30161-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019.

    Kocarnik, Jonathan M / Compton, Kelly / Dean, Frances E / Fu, Weijia / Gaw, Brian L / Harvey, James D / Henrikson, Hannah Jacqueline / Lu, Dan / Pennini, Alyssa / Xu, Rixing / Ababneh, Emad / Abbasi-Kangevari, Mohsen / Abbastabar, Hedayat / Abd-Elsalam, Sherief M / Abdoli, Amir / Abedi, Aidin / Abidi, Hassan / Abolhassani, Hassan / Adedeji, Isaac Akinkunmi /
    Adnani, Qorinah Estiningtyas Sakilah / Advani, Shailesh M / Afzal, Muhammad Sohail / Aghaali, Mohammad / Ahinkorah, Bright Opoku / Ahmad, Sajjad / Ahmad, Tauseef / Ahmadi, Ali / Ahmadi, Sepideh / Ahmed Rashid, Tarik / Ahmed Salih, Yusra / Akalu, Gizachew Taddesse / Aklilu, Addis / Akram, Tayyaba / Akunna, Chisom Joyqueenet / Al Hamad, Hanadi / Alahdab, Fares / Al-Aly, Ziyad / Ali, Saqib / Alimohamadi, Yousef / Alipour, Vahid / Aljunid, Syed Mohamed / Alkhayyat, Motasem / Almasi-Hashiani, Amir / Almasri, Nihad A / Al-Maweri, Sadeq Ali Ali / Almustanyir, Sami / Alonso, Nivaldo / Alvis-Guzman, Nelson / Amu, Hubert / Anbesu, Etsay Woldu / Ancuceanu, Robert / Ansari, Fereshteh / Ansari-Moghaddam, Alireza / Antwi, Maxwell Hubert / Anvari, Davood / Anyasodor, Anayochukwu Edward / Aqeel, Muhammad / Arabloo, Jalal / Arab-Zozani, Morteza / Aremu, Olatunde / Ariffin, Hany / Aripov, Timur / Arshad, Muhammad / Artaman, Al / Arulappan, Judie / Asemi, Zatollah / Asghari Jafarabadi, Mohammad / Ashraf, Tahira / Atorkey, Prince / Aujayeb, Avinash / Ausloos, Marcel / Awedew, Atalel Fentahun / Ayala Quintanilla, Beatriz Paulina / Ayenew, Temesgen / Azab, Mohammed A / Azadnajafabad, Sina / Azari Jafari, Amirhossein / Azarian, Ghasem / Azzam, Ahmed Y / Badiye, Ashish D / Bahadory, Saeed / Baig, Atif Amin / Baker, Jennifer L / Balakrishnan, Senthilkumar / Banach, Maciej / Bärnighausen, Till Winfried / Barone-Adesi, Francesco / Barra, Fabio / Barrow, Amadou / Behzadifar, Masoud / Belgaumi, Uzma Iqbal / Bezabhe, Woldesellassie M Mequanint / Bezabih, Yihienew Mequanint / Bhagat, Devidas S / Bhagavathula, Akshaya Srikanth / Bhardwaj, Nikha / Bhardwaj, Pankaj / Bhaskar, Sonu / Bhattacharyya, Krittika / Bhojaraja, Vijayalakshmi S / Bibi, Sadia / Bijani, Ali / Biondi, Antonio / Bisignano, Catherine / Bjørge, Tone / Bleyer, Archie / Blyuss, Oleg / Bolarinwa, Obasanjo Afolabi / Bolla, Srinivasa Rao / Braithwaite, Dejana / Brar, Amanpreet / Brenner, Hermann / Bustamante-Teixeira, Maria Teresa / Butt, Nadeem Shafique / Butt, Zahid A / Caetano Dos Santos, Florentino Luciano / Cao, Yin / Carreras, Giulia / Catalá-López, Ferrán / Cembranel, Francieli / Cerin, Ester / Cernigliaro, Achille / Chakinala, Raja Chandra / Chattu, Soosanna Kumary / Chattu, Vijay Kumar / Chaturvedi, Pankaj / Chimed-Ochir, Odgerel / Cho, Daniel Youngwhan / Christopher, Devasahayam J / Chu, Dinh-Toi / Chung, Michael T / Conde, Joao / Cortés, Sanda / Cortesi, Paolo Angelo / Costa, Vera Marisa / Cunha, Amanda Ramos / Dadras, Omid / Dagnew, Amare Belachew / Dahlawi, Saad M A / Dai, Xiaochen / Dandona, Lalit / Dandona, Rakhi / Darwesh, Aso Mohammad / das Neves, José / De la Hoz, Fernando Pio / Demis, Asmamaw Bizuneh / Denova-Gutiérrez, Edgar / Dhamnetiya, Deepak / Dhimal, Mandira Lamichhane / Dhimal, Meghnath / Dianatinasab, Mostafa / Diaz, Daniel / Djalalinia, Shirin / Do, Huyen Phuc / Doaei, Saeid / Dorostkar, Fariba / Dos Santos Figueiredo, Francisco Winter / Driscoll, Tim Robert / Ebrahimi, Hedyeh / Eftekharzadeh, Sahar / El Tantawi, Maha / El-Abid, Hassan / Elbarazi, Iffat / Elhabashy, Hala Rashad / Elhadi, Muhammed / El-Jaafary, Shaimaa I / Eshrati, Babak / Eskandarieh, Sharareh / Esmaeilzadeh, Firooz / Etemadi, Arash / Ezzikouri, Sayeh / Faisaluddin, Mohammed / Faraon, Emerito Jose A / Fares, Jawad / Farzadfar, Farshad / Feroze, Abdullah Hamid / Ferrero, Simone / Ferro Desideri, Lorenzo / Filip, Irina / Fischer, Florian / Fisher, James L / Foroutan, Masoud / Fukumoto, Takeshi / Gaal, Peter Andras / Gad, Mohamed M / Gadanya, Muktar A / Gallus, Silvano / Gaspar Fonseca, Mariana / Getachew Obsa, Abera / Ghafourifard, Mansour / Ghashghaee, Ahmad / Ghith, Nermin / Gholamalizadeh, Maryam / Gilani, Syed Amir / Ginindza, Themba G / Gizaw, Abraham Tamirat T / Glasbey, James C / Golechha, Mahaveer / Goleij, Pouya / Gomez, Ricardo Santiago / Gopalani, Sameer Vali / Gorini, Giuseppe / Goudarzi, Houman / Grosso, Giuseppe / Gubari, Mohammed Ibrahim Mohialdeen / Guerra, Maximiliano Ribeiro / Guha, Avirup / Gunasekera, D Sanjeeva / Gupta, Bhawna / Gupta, Veer Bala / Gupta, Vivek Kumar / Gutiérrez, Reyna Alma / Hafezi-Nejad, Nima / Haider, Mohammad Rifat / Haj-Mirzaian, Arvin / Halwani, Rabih / Hamadeh, Randah R / Hameed, Sajid / Hamidi, Samer / Hanif, Asif / Haque, Shafiul / Harlianto, Netanja I / Haro, Josep Maria / Hasaballah, Ahmed I / Hassanipour, Soheil / Hay, Roderick J / Hay, Simon I / Hayat, Khezar / Heidari, Golnaz / Heidari, Mohammad / Herrera-Serna, Brenda Yuliana / Herteliu, Claudiu / Hezam, Kamal / Holla, Ramesh / Hossain, Md Mahbub / Hossain, Mohammad Bellal Hossain / Hosseini, Mohammad-Salar / Hosseini, Mostafa / Hosseinzadeh, Mehdi / Hostiuc, Mihaela / Hostiuc, Sorin / Househ, Mowafa / Hsairi, Mohamed / Huang, Junjie / Hugo, Fernando N / Hussain, Rabia / Hussein, Nawfal R / Hwang, Bing-Fang / Iavicoli, Ivo / Ibitoye, Segun Emmanuel / Ida, Fidelia / Ikuta, Kevin S / Ilesanmi, Olayinka Stephen / Ilic, Irena M / Ilic, Milena D / Irham, Lalu Muhammad / Islam, Jessica Y / Islam, Rakibul M / Islam, Sheikh Mohammed Shariful / Ismail, Nahlah Elkudssiah / Isola, Gaetano / Iwagami, Masao / Jacob, Louis / Jain, Vardhmaan / Jakovljevic, Mihajlo B / Javaheri, Tahereh / Jayaram, Shubha / Jazayeri, Seyed Behzad / Jha, Ravi Prakash / Jonas, Jost B / Joo, Tamas / Joseph, Nitin / Joukar, Farahnaz / Jürisson, Mikk / Kabir, Ali / Kahrizi, Danial / Kalankesh, Leila R / Kalhor, Rohollah / Kaliyadan, Feroze / Kalkonde, Yogeshwar / Kamath, Ashwin / Kameran Al-Salihi, Nawzad / Kandel, Himal / Kapoor, Neeti / Karch, André / Kasa, Ayele Semachew / Katikireddi, Srinivasa Vittal / Kauppila, Joonas H / Kavetskyy, Taras / Kebede, Sewnet Adem / Keshavarz, Pedram / Keykhaei, Mohammad / Khader, Yousef Saleh / Khalilov, Rovshan / Khan, Gulfaraz / Khan, Maseer / Khan, Md Nuruzzaman / Khan, Moien A B / Khang, Young-Ho / Khater, Amir M / Khayamzadeh, Maryam / Kim, Gyu Ri / Kim, Yun Jin / Kisa, Adnan / Kisa, Sezer / Kissimova-Skarbek, Katarzyna / Kopec, Jacek A / Koteeswaran, Rajasekaran / Koul, Parvaiz A / Koulmane Laxminarayana, Sindhura Lakshmi / Koyanagi, Ai / Kucuk Bicer, Burcu / Kugbey, Nuworza / Kumar, G Anil / Kumar, Narinder / Kumar, Nithin / Kurmi, Om P / Kutluk, Tezer / La Vecchia, Carlo / Lami, Faris Hasan / Landires, Iván / Lauriola, Paolo / Lee, Sang-Woong / Lee, Shaun Wen Huey / Lee, Wei-Chen / Lee, Yo Han / Leigh, James / Leong, Elvynna / Li, Jiarui / Li, Ming-Chieh / Liu, Xuefeng / Loureiro, Joana A / Lunevicius, Raimundas / Magdy Abd El Razek, Muhammed / Majeed, Azeem / Makki, Alaa / Male, Shilpa / Malik, Ahmad Azam / Mansournia, Mohammad Ali / Martini, Santi / Masoumi, Seyedeh Zahra / Mathur, Prashant / McKee, Martin / Mehrotra, Ravi / Mendoza, Walter / Menezes, Ritesh G / Mengesha, Endalkachew Worku / Mesregah, Mohamed Kamal / Mestrovic, Tomislav / Miao Jonasson, Junmei / Miazgowski, Bartosz / Miazgowski, Tomasz / Michalek, Irmina Maria / Miller, Ted R / Mirzaei, Hamed / Mirzaei, Hamid Reza / Misra, Sanjeev / Mithra, Prasanna / Moghadaszadeh, Masoud / Mohammad, Karzan Abdulmuhsin / Mohammad, Yousef / Mohammadi, Mokhtar / Mohammadi, Seyyede Momeneh / Mohammadian-Hafshejani, Abdollah / Mohammed, Shafiu / Moka, Nagabhishek / Mokdad, Ali H / Molokhia, Mariam / Monasta, Lorenzo / Moni, Mohammad Ali / Moosavi, Mohammad Amin / Moradi, Yousef / Moraga, Paula / Morgado-da-Costa, Joana / Morrison, Shane Douglas / Mosapour, Abbas / Mubarik, Sumaira / Mwanri, Lillian / Nagarajan, Ahamarshan Jayaraman / Nagaraju, Shankar Prasad / Nagata, Chie / Naimzada, Mukhammad David / Nangia, Vinay / Naqvi, Atta Abbas / Narasimha Swamy, Sreenivas / Ndejjo, Rawlance / Nduaguba, Sabina O / Negoi, Ionut / Negru, Serban Mircea / Neupane Kandel, Sandhya / Nguyen, Cuong Tat / Nguyen, Huong Lan Thi / Niazi, Robina Khan / Nnaji, Chukwudi A / Noor, Nurulamin M / Nuñez-Samudio, Virginia / Nzoputam, Chimezie Igwegbe / Oancea, Bogdan / Ochir, Chimedsuren / Odukoya, Oluwakemi Ololade / Ogbo, Felix Akpojene / Olagunju, Andrew T / Olakunde, Babayemi Oluwaseun / Omar, Emad / Omar Bali, Ahmed / Omonisi, Abidemi E Emmanuel / Ong, Sokking / Onwujekwe, Obinna E / Orru, Hans / Ortega-Altamirano, Doris V / Otstavnov, Nikita / Otstavnov, Stanislav S / Owolabi, Mayowa O / P A, Mahesh / Padubidri, Jagadish Rao / Pakshir, Keyvan / Pana, Adrian / Panagiotakos, Demosthenes / Panda-Jonas, Songhomitra / Pardhan, Shahina / Park, Eun-Cheol / Park, Eun-Kee / Pashazadeh Kan, Fatemeh / Patel, Harsh K / Patel, Jenil R / Pati, Siddhartha / Pattanshetty, Sanjay M / Paudel, Uttam / Pereira, David M / Pereira, Renato B / Perianayagam, Arokiasamy / Pillay, Julian David / Pirouzpanah, Saeed / Pishgar, Farhad / Podder, Indrashis / Postma, Maarten J / Pourjafar, Hadi / Prashant, Akila / Preotescu, Liliana / Rabiee, Mohammad / Rabiee, Navid / Radfar, Amir / Radhakrishnan, Raghu Anekal / Radhakrishnan, Venkatraman / Rafiee, Ata / Rahim, Fakher / Rahimzadeh, Shadi / Rahman, Mosiur / Rahman, Muhammad Aziz / Rahmani, Amir Masoud / Rajai, Nazanin / Rajesh, Aashish / Rakovac, Ivo / Ram, Pradhum / Ramezanzadeh, Kiana / Ranabhat, Kamal / Ranasinghe, Priyanga / Rao, Chythra R / Rao, Sowmya J / Rawassizadeh, Reza / Razeghinia, Mohammad Sadegh / Renzaho, Andre M N / Rezaei, Negar / Rezaei, Nima / Rezapour, Aziz / Roberts, Thomas J / Rodriguez, Jefferson Antonio Buendia / Rohloff, Peter / Romoli, Michele / Ronfani, Luca / Roshandel, Gholamreza / Rwegerera, Godfrey M / S, Manjula / Sabour, Siamak / Saddik, Basema / Saeed, Umar / Sahebkar, Amirhossein / Sahoo, Harihar / Salehi, Sana / Salem, Marwa Rashad / Salimzadeh, Hamideh / Samaei, Mehrnoosh / Samy, Abdallah M / Sanabria, Juan / Sankararaman, Senthilkumar / Santric-Milicevic, Milena M / Sardiwalla, Yaeesh / Sarveazad, Arash / Sathian, Brijesh / Sawhney, Monika / Saylan, Mete / Schneider, Ione Jayce Ceola / Sekerija, Mario / Seylani, Allen / Shafaat, Omid / Shaghaghi, Zahra / Shaikh, Masood Ali / Shamsoddin, Erfan / Shannawaz, Mohammed / Sharma, Rajesh / Sheikh, Aziz / Sheikhbahaei, Sara / Shetty, Adithi / Shetty, Jeevan K / Shetty, Pavanchand H / Shibuya, Kenji / Shirkoohi, Reza / Shivakumar, K M / Shivarov, Velizar / Siabani, Soraya / Siddappa Malleshappa, Sudeep K / Silva, Diego Augusto Santos / Singh, Jasvinder A / Sintayehu, Yitagesu / Skryabin, Valentin Yurievich / Skryabina, Anna Aleksandrovna / Soeberg, Matthew J / Sofi-Mahmudi, Ahmad / Sotoudeh, Houman / Steiropoulos, Paschalis / Straif, Kurt / Subedi, Ranjeeta / Sufiyan, Mu'awiyyah Babale / Sultan, Iyad / Sultana, Saima / Sur, Daniel / Szerencsés, Viktória / Szócska, Miklós / Tabarés-Seisdedos, Rafael / Tabuchi, Takahiro / Tadbiri, Hooman / Taherkhani, Amir / Takahashi, Ken / Talaat, Iman M / Tan, Ker-Kan / Tat, Vivian Y / Tedla, Bemnet Amare A / Tefera, Yonas Getaye / Tehrani-Banihashemi, Arash / Temsah, Mohamad-Hani / Tesfay, Fisaha Haile / Tessema, Gizachew Assefa / Thapar, Rekha / Thavamani, Aravind / Thoguluva Chandrasekar, Viveksandeep / Thomas, Nihal / Tohidinik, Hamid Reza / Touvier, Mathilde / Tovani-Palone, Marcos Roberto / Traini, Eugenio / Tran, Bach Xuan / Tran, Khanh Bao / Tran, Mai Thi Ngoc / Tripathy, Jaya Prasad / Tusa, Biruk Shalmeno / Ullah, Irfan / Ullah, Saif / Umapathi, Krishna Kishore / Unnikrishnan, Bhaskaran / Upadhyay, Era / Vacante, Marco / Vaezi, Maryam / Valadan Tahbaz, Sahel / Velazquez, Diana Zuleika / Veroux, Massimiliano / Violante, Francesco S / Vlassov, Vasily / Vo, Bay / Volovici, Victor / Vu, Giang Thu / Waheed, Yasir / Wamai, Richard G / Ward, Paul / Wen, Yi Feng / Westerman, Ronny / Winkler, Andrea Sylvia / Yadav, Lalit / Yahyazadeh Jabbari, Seyed Hossein / Yang, Lin / Yaya, Sanni / Yazie, Taklo Simeneh Yazie / Yeshaw, Yigizie / Yonemoto, Naohiro / Younis, Mustafa Z / Yousefi, Zabihollah / Yu, Chuanhua / Yuce, Deniz / Yunusa, Ismaeel / Zadnik, Vesna / Zare, Fariba / Zastrozhin, Mikhail Sergeevich / Zastrozhina, Anasthasia / Zhang, Jianrong / Zhong, Chenwen / Zhou, Linghui / Zhu, Cong / Ziapour, Arash / Zimmermann, Ivan R / Fitzmaurice, Christina / Murray, Christopher J L / Force, Lisa M

    JAMA oncology

    2022  Volume 8, Issue 3, Page(s) 420–444

    Abstract: Importance: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden.: Objective: To ... ...

    Abstract Importance: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden.
    Objective: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019.
    Evidence review: The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs).
    Findings: In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles.
    Conclusions and relevance: The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world.
    MeSH term(s) Disability-Adjusted Life Years ; Global Burden of Disease ; Global Health ; Humans ; Incidence ; Neoplasms/epidemiology ; Prevalence ; Quality-Adjusted Life Years ; Risk Factors
    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2021.6987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study.

    Fitzmaurice, Christina / Abate, Degu / Abbasi, Naghmeh / Abbastabar, Hedayat / Abd-Allah, Foad / Abdel-Rahman, Omar / Abdelalim, Ahmed / Abdoli, Amir / Abdollahpour, Ibrahim / Abdulle, Abdishakur S M / Abebe, Nebiyu Dereje / Abraha, Haftom Niguse / Abu-Raddad, Laith Jamal / Abualhasan, Ahmed / Adedeji, Isaac Akinkunmi / Advani, Shailesh M / Afarideh, Mohsen / Afshari, Mahdi / Aghaali, Mohammad /
    Agius, Dominic / Agrawal, Sutapa / Ahmadi, Ayat / Ahmadian, Elham / Ahmadpour, Ehsan / Ahmed, Muktar Beshir / Akbari, Mohammad Esmaeil / Akinyemiju, Tomi / Al-Aly, Ziyad / AlAbdulKader, Assim M / Alahdab, Fares / Alam, Tahiya / Alamene, Genet Melak / Alemnew, Birhan Tamene T / Alene, Kefyalew Addis / Alinia, Cyrus / Alipour, Vahid / Aljunid, Syed Mohamed / Bakeshei, Fatemeh Allah / Almadi, Majid Abdulrahman Hamad / Almasi-Hashiani, Amir / Alsharif, Ubai / Alsowaidi, Shirina / Alvis-Guzman, Nelson / Amini, Erfan / Amini, Saeed / Amoako, Yaw Ampem / Anbari, Zohreh / Anber, Nahla Hamed / Andrei, Catalina Liliana / Anjomshoa, Mina / Ansari, Fereshteh / Ansariadi, Ansariadi / Appiah, Seth Christopher Yaw / Arab-Zozani, Morteza / Arabloo, Jalal / Arefi, Zohreh / Aremu, Olatunde / Areri, Habtamu Abera / Artaman, Al / Asayesh, Hamid / Asfaw, Ephrem Tsegay / Ashagre, Alebachew Fasil / Assadi, Reza / Ataeinia, Bahar / Atalay, Hagos Tasew / Ataro, Zerihun / Atique, Suleman / Ausloos, Marcel / Avila-Burgos, Leticia / Avokpaho, Euripide F G A / Awasthi, Ashish / Awoke, Nefsu / Ayala Quintanilla, Beatriz Paulina / Ayanore, Martin Amogre / Ayele, Henok Tadesse / Babaee, Ebrahim / Bacha, Umar / Badawi, Alaa / Bagherzadeh, Mojtaba / Bagli, Eleni / Balakrishnan, Senthilkumar / Balouchi, Abbas / Bärnighausen, Till Winfried / Battista, Robert J / Behzadifar, Masoud / Behzadifar, Meysam / Bekele, Bayu Begashaw / Belay, Yared Belete / Belayneh, Yaschilal Muche / Berfield, Kathleen Kim Sachiko / Berhane, Adugnaw / Bernabe, Eduardo / Beuran, Mircea / Bhakta, Nickhill / Bhattacharyya, Krittika / Biadgo, Belete / Bijani, Ali / Bin Sayeed, Muhammad Shahdaat / Birungi, Charles / Bisignano, Catherine / Bitew, Helen / Bjørge, Tone / Bleyer, Archie / Bogale, Kassawmar Angaw / Bojia, Hunduma Amensisa / Borzì, Antonio M / Bosetti, Cristina / Bou-Orm, Ibrahim R / Brenner, Hermann / Brewer, Jerry D / Briko, Andrey Nikolaevich / Briko, Nikolay Ivanovich / Bustamante-Teixeira, Maria Teresa / Butt, Zahid A / Carreras, Giulia / Carrero, Juan J / Carvalho, Félix / Castro, Clara / Castro, Franz / Catalá-López, Ferrán / Cerin, Ester / Chaiah, Yazan / Chanie, Wagaye Fentahun / Chattu, Vijay Kumar / Chaturvedi, Pankaj / Chauhan, Neelima Singh / Chehrazi, Mohammad / Chiang, Peggy Pei-Chia / Chichiabellu, Tesfaye Yitna / Chido-Amajuoyi, Onyema Greg / Chimed-Ochir, Odgerel / Choi, Jee-Young J / Christopher, Devasahayam J / Chu, Dinh-Toi / Constantin, Maria-Magdalena / Costa, Vera M / Crocetti, Emanuele / Crowe, Christopher Stephen / Curado, Maria Paula / Dahlawi, Saad M A / Damiani, Giovanni / Darwish, Amira Hamed / Daryani, Ahmad / das Neves, José / Demeke, Feleke Mekonnen / Demis, Asmamaw Bizuneh / Demissie, Birhanu Wondimeneh / Demoz, Gebre Teklemariam / Denova-Gutiérrez, Edgar / Derakhshani, Afshin / Deribe, Kalkidan Solomon / Desai, Rupak / Desalegn, Beruk Berhanu / Desta, Melaku / Dey, Subhojit / Dharmaratne, Samath Dhamminda / Dhimal, Meghnath / Diaz, Daniel / Dinberu, Mesfin Tadese Tadese / Djalalinia, Shirin / Doku, David Teye / Drake, Thomas M / Dubey, Manisha / Dubljanin, Eleonora / Duken, Eyasu Ejeta / Ebrahimi, Hedyeh / Effiong, Andem / Eftekhari, Aziz / El Sayed, Iman / Zaki, Maysaa El Sayed / El-Jaafary, Shaimaa I / El-Khatib, Ziad / Elemineh, Demelash Abewa / Elkout, Hajer / Ellenbogen, Richard G / Elsharkawy, Aisha / Emamian, Mohammad Hassan / Endalew, Daniel Adane / Endries, Aman Yesuf / Eshrati, Babak / Fadhil, Ibtihal / Fallah Omrani, Vahid / Faramarzi, Mahbobeh / Farhangi, Mahdieh Abbasalizad / Farioli, Andrea / Farzadfar, Farshad / Fentahun, Netsanet / Fernandes, Eduarda / Feyissa, Garumma Tolu / Filip, Irina / Fischer, Florian / Fisher, James L / Force, Lisa M / Foroutan, Masoud / Freitas, Marisa / Fukumoto, Takeshi / Futran, Neal D / Gallus, Silvano / Gankpe, Fortune Gbetoho / Gayesa, Reta Tsegaye / Gebrehiwot, Tsegaye Tewelde / Gebremeskel, Gebreamlak Gebremedhn / Gedefaw, Getnet Azeze / Gelaw, Belayneh K / Geta, Birhanu / Getachew, Sefonias / Gezae, Kebede Embaye / Ghafourifard, Mansour / Ghajar, Alireza / Ghashghaee, Ahmad / Gholamian, Asadollah / Gill, Paramjit Singh / Ginindza, Themba T G / Girmay, Alem / Gizaw, Muluken / Gomez, Ricardo Santiago / Gopalani, Sameer Vali / Gorini, Giuseppe / Goulart, Bárbara Niegia Garcia / Grada, Ayman / Ribeiro Guerra, Maximiliano / Guimaraes, Andre Luiz Sena / Gupta, Prakash C / Gupta, Rahul / Hadkhale, Kishor / Haj-Mirzaian, Arvin / Haj-Mirzaian, Arya / Hamadeh, Randah R / Hamidi, Samer / Hanfore, Lolemo Kelbiso / Haro, Josep Maria / Hasankhani, Milad / Hasanzadeh, Amir / Hassen, Hamid Yimam / Hay, Roderick J / Hay, Simon I / Henok, Andualem / Henry, Nathaniel J / Herteliu, Claudiu / Hidru, Hagos D / Hoang, Chi Linh / Hole, Michael K / Hoogar, Praveen / Horita, Nobuyuki / Hosgood, H Dean / Hosseini, Mostafa / Hosseinzadeh, Mehdi / Hostiuc, Mihaela / Hostiuc, Sorin / Househ, Mowafa / Hussen, Mohammedaman Mama / Ileanu, Bogdan / Ilic, Milena D / Innos, Kaire / Irvani, Seyed Sina Naghibi / Iseh, Kufre Robert / Islam, Sheikh Mohammed Shariful / Islami, Farhad / Jafari Balalami, Nader / Jafarinia, Morteza / Jahangiry, Leila / Jahani, Mohammad Ali / Jahanmehr, Nader / Jakovljevic, Mihajlo / James, Spencer L / Javanbakht, Mehdi / Jayaraman, Sudha / Jee, Sun Ha / Jenabi, Ensiyeh / Jha, Ravi Prakash / Jonas, Jost B / Jonnagaddala, Jitendra / Joo, Tamas / Jungari, Suresh Banayya / Jürisson, Mikk / Kabir, Ali / Kamangar, Farin / Karch, André / Karimi, Narges / Karimian, Ansar / Kasaeian, Amir / Kasahun, Gebremicheal Gebreslassie / Kassa, Belete / Kassa, Tesfaye Dessale / Kassaw, Mesfin Wudu / Kaul, Anil / Keiyoro, Peter Njenga / Kelbore, Abraham Getachew / Kerbo, Amene Abebe / Khader, Yousef Saleh / Khalilarjmandi, Maryam / Khan, Ejaz Ahmad / Khan, Gulfaraz / Khang, Young-Ho / Khatab, Khaled / Khater, Amir / Khayamzadeh, Maryam / Khazaee-Pool, Maryam / Khazaei, Salman / Khoja, Abdullah T / Khosravi, Mohammad Hossein / Khubchandani, Jagdish / Kianipour, Neda / Kim, Daniel / Kim, Yun Jin / Kisa, Adnan / Kisa, Sezer / Kissimova-Skarbek, Katarzyna / Komaki, Hamidreza / Koyanagi, Ai / Krohn, Kristopher J / Bicer, Burcu Kucuk / Kugbey, Nuworza / Kumar, Vivek / Kuupiel, Desmond / La Vecchia, Carlo / Lad, Deepesh P / Lake, Eyasu Alem / Lakew, Ayenew Molla / Lal, Dharmesh Kumar / Lami, Faris Hasan / Lan, Qing / Lasrado, Savita / Lauriola, Paolo / Lazarus, Jeffrey V / Leigh, James / Leshargie, Cheru Tesema / Liao, Yu / Limenih, Miteku Andualem / Listl, Stefan / Lopez, Alan D / Lopukhov, Platon D / Lunevicius, Raimundas / Madadin, Mohammed / Magdeldin, Sameh / El Razek, Hassan Magdy Abd / Majeed, Azeem / Maleki, Afshin / Malekzadeh, Reza / Manafi, Ali / Manafi, Navid / Manamo, Wondimu Ayele / Mansourian, Morteza / Mansournia, Mohammad Ali / Mantovani, Lorenzo Giovanni / Maroufizadeh, Saman / Martini, Santi Martini S / Mashamba-Thompson, Tivani Phosa / Massenburg, Benjamin Ballard / Maswabi, Motswadi Titus / Mathur, Manu Raj / McAlinden, Colm / McKee, Martin / Meheretu, Hailemariam Abiy Alemu / Mehrotra, Ravi / Mehta, Varshil / Meier, Toni / Melaku, Yohannes A / Meles, Gebrekiros Gebremichael / Meles, Hagazi Gebre / Melese, Addisu / Melku, Mulugeta / Memiah, Peter T N / Mendoza, Walter / Menezes, Ritesh G / Merat, Shahin / Meretoja, Tuomo J / Mestrovic, Tomislav / Miazgowski, Bartosz / Miazgowski, Tomasz / Mihretie, Kebadnew Mulatu M / Miller, Ted R / Mills, Edward J / Mir, Seyed Mostafa / Mirzaei, Hamed / Mirzaei, Hamid Reza / Mishra, Rashmi / Moazen, Babak / Mohammad, Dara K / Mohammad, Karzan Abdulmuhsin / Mohammad, Yousef / Darwesh, Aso Mohammad / Mohammadbeigi, Abolfazl / Mohammadi, Hiwa / Mohammadi, Moslem / Mohammadian, Mahdi / Mohammadian-Hafshejani, Abdollah / Mohammadoo-Khorasani, Milad / Mohammadpourhodki, Reza / Mohammed, Ammas Siraj / Mohammed, Jemal Abdu / Mohammed, Shafiu / Mohebi, Farnam / Mokdad, Ali H / Monasta, Lorenzo / Moodley, Yoshan / Moosazadeh, Mahmood / Moossavi, Maryam / Moradi, Ghobad / Moradi-Joo, Mohammad / Moradi-Lakeh, Maziar / Moradpour, Farhad / Morawska, Lidia / Morgado-da-Costa, Joana / Morisaki, Naho / Morrison, Shane Douglas / Mosapour, Abbas / Mousavi, Seyyed Meysam / Muche, Achenef Asmamaw / Muhammed, Oumer Sada S / Musa, Jonah / Nabhan, Ashraf F / Naderi, Mehdi / Nagarajan, Ahamarshan Jayaraman / Nagel, Gabriele / Nahvijou, Azin / Naik, Gurudatta / Najafi, Farid / Naldi, Luigi / Nam, Hae Sung / Nasiri, Naser / Nazari, Javad / Negoi, Ionut / Neupane, Subas / Newcomb, Polly A / Nggada, Haruna Asura / Ngunjiri, Josephine W / Nguyen, Cuong Tat / Nikniaz, Leila / Ningrum, Dina Nur Anggraini / Nirayo, Yirga Legesse / Nixon, Molly R / Nnaji, Chukwudi A / Nojomi, Marzieh / Nosratnejad, Shirin / Shiadeh, Malihe Nourollahpour / Obsa, Mohammed Suleiman / Ofori-Asenso, Richard / Ogbo, Felix Akpojene / Oh, In-Hwan / Olagunju, Andrew T / Olagunju, Tinuke O / Oluwasanu, Mojisola Morenike / Omonisi, Abidemi E / Onwujekwe, Obinna E / Oommen, Anu Mary / Oren, Eyal / Ortega-Altamirano, Doris D V / Ota, Erika / Otstavnov, Stanislav S / Owolabi, Mayowa Ojo / P A, Mahesh / Padubidri, Jagadish Rao / Pakhale, Smita / Pakpour, Amir H / Pana, Adrian / Park, Eun-Kee / Parsian, Hadi / Pashaei, Tahereh / Patel, Shanti / Patil, Snehal T / Pennini, Alyssa / Pereira, David M / Piccinelli, Cristiano / Pillay, Julian David / Pirestani, Majid / Pishgar, Farhad / Postma, Maarten J / Pourjafar, Hadi / Pourmalek, Farshad / Pourshams, Akram / Prakash, Swayam / Prasad, Narayan / Qorbani, Mostafa / Rabiee, Mohammad / Rabiee, Navid / Radfar, Amir / Rafiei, Alireza / Rahim, Fakher / Rahimi, Mahdi / Rahman, Muhammad Aziz / Rajati, Fatemeh / Rana, Saleem M / Raoofi, Samira / Rath, Goura Kishor / Rawaf, David Laith / Rawaf, Salman / Reiner, Robert C / Renzaho, Andre M N / Rezaei, Nima / Rezapour, Aziz / Ribeiro, Ana Isabel / Ribeiro, Daniela / Ronfani, Luca / Roro, Elias Merdassa / Roshandel, Gholamreza / Rostami, Ali / Saad, Ragy Safwat / Sabbagh, Parisa / Sabour, Siamak / Saddik, Basema / Safiri, Saeid / Sahebkar, Amirhossein / Salahshoor, Mohammad Reza / Salehi, Farkhonde / Salem, Hosni / Salem, Marwa Rashad / Salimzadeh, Hamideh / Salomon, Joshua A / Samy, Abdallah M / Sanabria, Juan / Santric Milicevic, Milena M / Sartorius, Benn / Sarveazad, Arash / Sathian, Brijesh / Satpathy, Maheswar / Savic, Miloje / Sawhney, Monika / Sayyah, Mehdi / Schneider, Ione J C / Schöttker, Ben / Sekerija, Mario / Sepanlou, Sadaf G / Sepehrimanesh, Masood / Seyedmousavi, Seyedmojtaba / Shaahmadi, Faramarz / Shabaninejad, Hosein / Shahbaz, Mohammad / Shaikh, Masood Ali / Shamshirian, Amir / Shamsizadeh, Morteza / Sharafi, Heidar / Sharafi, Zeinab / Sharif, Mehdi / Sharifi, Ali / Sharifi, Hamid / Sharma, Rajesh / Sheikh, Aziz / Shirkoohi, Reza / Shukla, Sharvari Rahul / Si, Si / Siabani, Soraya / Silva, Diego Augusto Santos / Silveira, Dayane Gabriele Alves / Singh, Ambrish / Singh, Jasvinder A / Sisay, Solomon / Sitas, Freddy / Sobngwi, Eugène / Soofi, Moslem / Soriano, Joan B / Stathopoulou, Vasiliki / Sufiyan, Mu'awiyyah Babale / Tabarés-Seisdedos, Rafael / Tabuchi, Takahiro / Takahashi, Ken / Tamtaji, Omid Reza / Tarawneh, Mohammed Rasoul / Tassew, Segen Gebremeskel / Taymoori, Parvaneh / Tehrani-Banihashemi, Arash / Temsah, Mohamad-Hani / Temsah, Omar / Tesfay, Berhe Etsay / Tesfay, Fisaha Haile / Teshale, Manaye Yihune / Tessema, Gizachew Assefa / Thapa, Subash / Tlaye, Kenean Getaneh / Topor-Madry, Roman / Tovani-Palone, Marcos Roberto / Traini, Eugenio / Tran, Bach Xuan / Tran, Khanh Bao / Tsadik, Afewerki Gebremeskel / Ullah, Irfan / Uthman, Olalekan A / Vacante, Marco / Vaezi, Maryam / Varona Pérez, Patricia / Veisani, Yousef / Vidale, Simone / Violante, Francesco S / Vlassov, Vasily / Vollset, Stein Emil / Vos, Theo / Vosoughi, Kia / Vu, Giang Thu / Vujcic, Isidora S / Wabinga, Henry / Wachamo, Tesfahun Mulatu / Wagnew, Fasil Shiferaw / Waheed, Yasir / Weldegebreal, Fitsum / Weldesamuel, Girmay Teklay / Wijeratne, Tissa / Wondafrash, Dawit Zewdu / Wonde, Tewodros Eshete / Wondmieneh, Adam Belay / Workie, Hailemariam Mekonnen / Yadav, Rajaram / Yadegar, Abbas / Yadollahpour, Ali / Yaseri, Mehdi / Yazdi-Feyzabadi, Vahid / Yeshaneh, Alex / Yimam, Mohammed Ahmed / Yimer, Ebrahim M / Yisma, Engida / Yonemoto, Naohiro / Younis, Mustafa Z / Yousefi, Bahman / Yousefifard, Mahmoud / Yu, Chuanhua / Zabeh, Erfan / Zadnik, Vesna / Moghadam, Telma Zahirian / Zaidi, Zoubida / Zamani, Mohammad / Zandian, Hamed / Zangeneh, Alireza / Zaki, Leila / Zendehdel, Kazem / Zenebe, Zerihun Menlkalew / Zewale, Taye Abuhay / Ziapour, Arash / Zodpey, Sanjay / Murray, Christopher J L

    JAMA oncology

    2019  Volume 5, Issue 12, Page(s) 1749–1768

    Abstract: Importance: Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting ... ...

    Abstract Importance: Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting the 2011 Political Declaration on the Prevention and Control of Noncommunicable Diseases and the third Sustainable Development Goal. Lack of situational analyses, priority setting, and budgeting have been identified as major obstacles in achieving these goals. All of these have in common that they require information on the local cancer epidemiology. The Global Burden of Disease (GBD) study is uniquely poised to provide these crucial data.
    Objective: To describe cancer burden for 29 cancer groups in 195 countries from 1990 through 2017 to provide data needed for cancer control planning.
    Evidence review: We used the GBD study estimation methods to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life-years (DALYs). Results are presented at the national level as well as by Socio-demographic Index (SDI), a composite indicator of income, educational attainment, and total fertility rate. We also analyzed the influence of the epidemiological vs the demographic transition on cancer incidence.
    Findings: In 2017, there were 24.5 million incident cancer cases worldwide (16.8 million without nonmelanoma skin cancer [NMSC]) and 9.6 million cancer deaths. The majority of cancer DALYs came from years of life lost (97%), and only 3% came from years lived with disability. The odds of developing cancer were the lowest in the low SDI quintile (1 in 7) and the highest in the high SDI quintile (1 in 2) for both sexes. In 2017, the most common incident cancers in men were NMSC (4.3 million incident cases); tracheal, bronchus, and lung (TBL) cancer (1.5 million incident cases); and prostate cancer (1.3 million incident cases). The most common causes of cancer deaths and DALYs for men were TBL cancer (1.3 million deaths and 28.4 million DALYs), liver cancer (572 000 deaths and 15.2 million DALYs), and stomach cancer (542 000 deaths and 12.2 million DALYs). For women in 2017, the most common incident cancers were NMSC (3.3 million incident cases), breast cancer (1.9 million incident cases), and colorectal cancer (819 000 incident cases). The leading causes of cancer deaths and DALYs for women were breast cancer (601 000 deaths and 17.4 million DALYs), TBL cancer (596 000 deaths and 12.6 million DALYs), and colorectal cancer (414 000 deaths and 8.3 million DALYs).
    Conclusions and relevance: The national epidemiological profiles of cancer burden in the GBD study show large heterogeneities, which are a reflection of different exposures to risk factors, economic settings, lifestyles, and access to care and screening. The GBD study can be used by policy makers and other stakeholders to develop and improve national and local cancer control in order to achieve the global targets and improve equity in cancer care.
    MeSH term(s) Disabled Persons ; Global Burden of Disease ; Global Health ; Humans ; Incidence ; Neoplasms/epidemiology ; Quality-Adjusted Life Years
    Language English
    Publishing date 2019-11-02
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2019.2996
    Database MEDical Literature Analysis and Retrieval System OnLINE

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