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Article ; Online: Recurrent Cellulitis

Ong BS / Dotel R / Ngian VJJ

International Journal of General Medicine, Vol Volume 15, Pp 6561-

Who is at Risk and How Effective is Antibiotic Prophylaxis?

2022 Volume 6572

Abstract: Bin S Ong,1,2 Ravindra Dotel,1 Vincent Jiu Jong Ngian1,2 1Department of Ambulatory Care, Division of Medicine, Bankstown-Lidcombe Hospital, Sydney, New South Wales, Australia; 2University of New South Wales, Sydney, New South Wales, ... ...

Abstract	Bin S Ong,1,2 Ravindra Dotel,1 Vincent Jiu Jong Ngian1,2 1Department of Ambulatory Care, Division of Medicine, Bankstown-Lidcombe Hospital, Sydney, New South Wales, Australia; 2University of New South Wales, Sydney, New South Wales, AustraliaCorrespondence: Bin S Ong, Department of Ambulatory Care, Division of Medicine, Bankstown-Lidcombe Hospital, Eldridge Road, Bankstown, Sydney, New South Wales, 2200, Australia, Tel +61297228629, Fax +61297228623, Email Bin.Ong@health.nsw.gov.auAbstract: Recurrent cellulitis following successful treatment is common and prevention should be a major component in the management of cellulitis. Conditions that increase the risk of recurrence include chronic edema, venous disease, dermatomycosis and obesity. These risk factors should be actively managed as further episodes of cellulitis increases the risk of recurrence. The role of non-antibiotic measures is important and should be first-line in prevention. Antibiotic prophylaxis is effective, but its role is limited to non-purulent cellulitis where risk factors are appropriately managed.Keywords: cellulitis, recurrence, risk factors, edema, venous insufficiency, antibiotic prophylaxis
Keywords	cellulitis ; recurrence ; risk factors ; edema ; venous insufficiency ; antibiotic prophylaxis ; Medicine (General) ; R5-920
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sclerosing Angiomatoid Nodular Transformation (SANT): A Rare Splenic Tumor and Unusual Cause of Anemia.

Ong, Bee Shan / Thomas, Rebecca

The American journal of case reports

2021 Volume 22, Page(s) e933598

Abstract: BACKGROUND Sclerosing angiomatoid nodular transformation (SANT) of the spleen is a rare benign disease of the splenic red pulp of unknown etiology. Definite diagnosis is made on histopathology alone as it has no diagnostic radiologic characteristics. ... ...

Abstract	BACKGROUND Sclerosing angiomatoid nodular transformation (SANT) of the spleen is a rare benign disease of the splenic red pulp of unknown etiology. Definite diagnosis is made on histopathology alone as it has no diagnostic radiologic characteristics. CASE REPORT We present a case of a large incidental splenic mass in a middle-aged man, whose refractory anemia resolved with splenectomy. Our initial imaging studies failed to differentiate this lesion from other splenic lesions like hamartoma and haemangioma. To the best of our knowledge, no SANT cases in the literature have been investigated with red cell scan, as performed in our patient, nor has any case had resolved anemia after treatment. Splenectomy was offered as malignancy could not be safely excluded. Histopathology confirmed the diagnosis of SANT. The patient made good recovery and had no signs of recurrence 2 years later. CONCLUSIONS SANT of the spleen is a rare condition that can mimic many other splenic tumors and poses diagnostic challenge when histopathology is unavailable. Our case adds to the number of SANT reported in literature in the hope of elucidating the pathophysiology of this rare condition.
MeSH term(s)	Anemia/etiology ; Histiocytoma, Benign Fibrous ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Splenic Diseases/diagnosis ; Splenic Diseases/surgery ; Splenic Neoplasms/complications ; Splenic Neoplasms/diagnosis ; Splenic Neoplasms/surgery
Language	English
Publishing date	2021-11-13
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2517183-5
ISSN	1941-5923 ; 1941-5923
ISSN (online)	1941-5923
ISSN	1941-5923
DOI	10.12659/AJCR.933598
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Recurrent Cellulitis: Who is at Risk and How Effective is Antibiotic Prophylaxis?

Ong, Bin S / Dotel, Ravindra / Ngian, Vincent Jiu Jong

International journal of general medicine

2022 Volume 15, Page(s) 6561–6572

Abstract: Recurrent cellulitis following successful treatment is common and prevention should be a major component in the management of cellulitis. Conditions that increase the risk of recurrence include chronic edema, venous disease, dermatomycosis and obesity. ... ...

Abstract	Recurrent cellulitis following successful treatment is common and prevention should be a major component in the management of cellulitis. Conditions that increase the risk of recurrence include chronic edema, venous disease, dermatomycosis and obesity. These risk factors should be actively managed as further episodes of cellulitis increases the risk of recurrence. The role of non-antibiotic measures is important and should be first-line in prevention. Antibiotic prophylaxis is effective, but its role is limited to non-purulent cellulitis where risk factors are appropriately managed.
Language	English
Publishing date	2022-08-10
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S326459
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Article: Introducing the "Twilight" operating room concept: a feasibility study to improve operating room utilization.

Ong, Bee Shan / Thomas, Rebecca / Jenkins, Simon

Patient safety in surgery

2022 Volume 16, Issue 1, Page(s) 23

Abstract: Background: The efficient use of operating room is important to ensure optimum cost-benefit for the hospital and to reduce elective surgery waiting times. We introduced a concept of non-commissioned "Twilight" operating room to reduce patient waiting ... ...

Abstract	Background: The efficient use of operating room is important to ensure optimum cost-benefit for the hospital and to reduce elective surgery waiting times. We introduced a concept of non-commissioned "Twilight" operating room to reduce patient waiting list and mitigate consequences of non-availability of elective operative time due to closure of an affiliated hospital operating suite. Methods: A retrospective audit was performed during a 10-month period where "Twilight" operating room was implemented in our institution. Additionally, we included patients that were operated on 13 non-commissioned whole day operative sessions on Saturdays during the same period. Results: A total of 223 surgical procedures were performed during the study time window. Most patients have American Society of Anaesthesiologists (ASA) Class 2. Participating subspecialties were General Surgery, Orthopaedic surgery, Gynaecology, Urology, Plastic surgery and Dental surgery. A wide range of operations was performed in the "Twilight" operating room. No major complications were observed. Conclusion: Our study demonstrated the feasibility of conducting elective surgeries after hours with the advantage of reducing the hospital's elective surgery waiting time. Importantly, no major post-operative complications were reported. This model is a feasible and safe strategy to restore surgical activity impacted by the COVID-19 pandemic.
Language	English
Publishing date	2022-07-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2409244-7
ISSN	1754-9493
ISSN	1754-9493
DOI	10.1186/s13037-022-00335-8
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Article ; Online: Cost-utility analysis of sacituzumab govitecan versus chemotherapy for the treatment of metastatic triple-negative breast cancer in Singapore.

Cher, Boon Piang / Goh, Sharon / Aziz, Mohamed Ismail Abdul / Wong, Grace / Ng Chee Hui, Raymond / Ong, Benjamin Shao-Kiat / Ng, Kwong-Hoe

Expert review of pharmacoeconomics & outcomes research

2024 Volume 24, Issue 2, Page(s) 217–225

Abstract: Objective: To assess the cost-effectiveness of sacituzumab govitecan for treating relapsed or refractory metastatic triple-negative breast cancer (TNBC) in Singapore.: Methods: A three-state partitioned survival model was developed to evaluate the ... ...

Abstract	Objective: To assess the cost-effectiveness of sacituzumab govitecan for treating relapsed or refractory metastatic triple-negative breast cancer (TNBC) in Singapore. Methods: A three-state partitioned survival model was developed to evaluate the cost-effectiveness of sacituzumab govitecan from a healthcare system perspective over 5 years. Clinical inputs were obtained from the ASCENT trial. Health state utilities were retrieved from the literature and direct costs were sourced from public healthcare institutions in Singapore. Sensitivity and scenario analyses were conducted to explore the impact of uncertainties and assumptions on cost-effectiveness results. Results: Compared with single-agent chemotherapy, sacituzumab govitecan was associated with a base-case incremental cost-effectiveness ratio (ICER) of S$328,000 (US$237,816) per quality-adjusted life year (QALY) gained. One-way sensitivity analyses showed that the ICER was most sensitive to the cost of sacituzumab govitecan and progression-free utility values. Regardless of variation in these parameters, the ICER remained high, and a substantial price reduction was required to reduce the ICER. Conclusion: At its current price, sacituzumab govitecan does not represent a cost-effective treatment for relapsed or refractory metastatic TNBC in Singapore. Our findings will be useful to inform funding decisions alongside other factors including clinical effectiveness, safety, and budget impact considerations.
MeSH term(s)	Humans ; Antineoplastic Agents ; Cost-Benefit Analysis ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/pathology ; Singapore ; Camptothecin/analogs & derivatives ; Immunoconjugates ; Antibodies, Monoclonal, Humanized
Chemical Substances	sacituzumab govitecan (M9BYU8XDQ6) ; Antineoplastic Agents ; Camptothecin (XT3Z54Z28A) ; Immunoconjugates ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2208481-2
ISSN	1744-8379 ; 1473-7167
ISSN (online)	1744-8379
ISSN	1473-7167
DOI	10.1080/14737167.2023.2291155
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Article ; Online: Out Of Hospital And In Hospital Management Of Cellulitis Requiring Intravenous Therapy

Ong BS / Ngian VJJ / Yeong C / Keighley C

International Journal of General Medicine, Vol Volume 12, Pp 447-

2019 Volume 453

Abstract: Bin S Ong,1–3 Vincent Jiu Jong Ngian,1,2 Clarence Yeong,1 Caitlin Keighley1 1Bankstown-Lidcombe Hospital, Bankstown, NSW, Australia; 2University of New South Wales, Sydney, NSW, Australia; 3Department of Ambulatory Care, Bankstown-Lidcombe Hospital, ... ...

Abstract	Bin S Ong,1–3 Vincent Jiu Jong Ngian,1,2 Clarence Yeong,1 Caitlin Keighley1 1Bankstown-Lidcombe Hospital, Bankstown, NSW, Australia; 2University of New South Wales, Sydney, NSW, Australia; 3Department of Ambulatory Care, Bankstown-Lidcombe Hospital, Bankstown, NSW 2200, AustraliaCorrespondence: Bin S OngDepartment of Ambulatory Care, Bankstown-Lidcombe Hospital, Eldridge Road, Bankstown, NSW 2200, AustraliaTel +61 2 97228637Email Bin.Ong@health.nsw.gov.auBackground: Cellulitis requiring intravenous therapy can be managed via out of hospital programs, but a high number of patients are still admitted to hospital.Objective: We aimed to review the clinical features, management and outcomes of patients with cellulitis requiring intravenous therapy in a Hospital in the Home (HITH) program compared to patients who are admitted to hospital.Methods: A prospective cohort study of patients with limb cellulitis requiring intravenous antibiotics was conducted at a metropolitan principal referral hospital.Results: A total of 100 patients out of 113 eligible patients were recruited. Forty-eight were treated entirely in hospital and 52 were treated entirely or partially via HITH. Patients treated in hospital were older (mean 69.2 vs 56.7 years, p<0.001), less mobile, have more comorbidities (Charlson Comorbidity Index mean 2.2 vs 1.2, P=0.005) and more associated active illness. All patients with Eron Class III were admitted to hospital. Patients treated in hospital had a higher incidence of acute renal failure (27.1% vs 3.8%, p=0.001), nosocomial infection (10.4% vs 0.0%, P=0.023), and a higher 28-day hospital readmission rate (10.4% vs 0.0%, P=0.023).Conclusion: Approximately half of the patients who require intravenous therapy can be treated via an out of hospital program. Patients admitted to hospital were more unwell and more likely to suffer complications. The presence of comorbid illness does not necessarily exclude participation in HITH and careful selection is essential to ensure safe outcomes.Keywords: cellulitis, ...
Keywords	cellulitis ; hospital in the home ; outpatient parenteral antimicrobial therapy ; Medicine (General) ; R5-920
Language	English
Publishing date	2019-11-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A delayed presentation of traumatic right hemidiaphragm injury repaired via a laparoscopic approach: A case report.

Ong, Bee S / Heitmann, Paul T / Shenfine, Jon

Annals of medicine and surgery (2012)

2020 Volume 53, Page(s) 16–19

Abstract: Introduction: Diaphragmatic injury is a rare clinical entity which presents a diagnostic and therapeutic challenge. It is three times more common following blunt trauma than penetrating trauma and results in larger tears. A high index of suspicion is ... ...

Abstract	Introduction: Diaphragmatic injury is a rare clinical entity which presents a diagnostic and therapeutic challenge. It is three times more common following blunt trauma than penetrating trauma and results in larger tears. A high index of suspicion is required to diagnose diaphragmatic injury. A missed diagnosis following acute injury can later result in life-threatening complications. Case presentation: We describe the successful management of a right hemidiaphragmatic injury presenting two weeks following blunt thoracoabdominal trauma using a laparoscopic mesh repair. Discussion: Diaphragmatic injury is rare, with right-sided injuries less common due to the buffering effect of the liver. The diagnosis is made within 24 hours of injury in 75% of cases (Haranal and et al., 2018) [1]. In our patient, symptoms of a right-sided diaphragmatic injury manifested two weeks following a motor vehicle collision. A CT scan of the chest and abdomen confirmed the diagnosis. According to DeBlasio, intermittent symptoms of visceral herniation or incorrect x-ray interpretation are the main reasons for a delayed diagnosis (DeBlasio et al., 1994) [2]. Contrary to common practice where thoracotomy is the preferred method for repair in the absence of associated abdominal injuries, we demonstrated that a right-sided diaphragmatic injury can be successfully managed with a laparoscopic mesh repair. Conclusion: Traumatic diaphragmatic injury remains a challenge to emergency physicians and trauma surgeons. Clinicians should be aware of the differing clinical presentations, investigations, and management. Surgical repair can be achieved via laparoscopy, thoracoscopy, laparotomy, and/or thoracotomy. In the case of an isolated right-sided diaphragmatic injury, laparoscopic mesh repair should be considered.
Language	English
Publishing date	2020-03-25
Publishing country	England
Document type	Case Reports
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1016/j.amsu.2020.03.002
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Article ; Online: Real-world impact of a subsidy decision of sofosbuvir-velpatasvir for treatment of chronic hepatitis C on clinical practice and patient outcomes.

Tan, Chee-Kiat / Luo, Xue-Shi / Ong, Benjamin Shao-Kiat / Lin, Liang / Ng, Kwong-Hoe

JGH open : an open access journal of gastroenterology and hepatology

2022 Volume 7, Issue 1, Page(s) 48–54

Abstract: Background and aim: Sofosbuvir-velpatasvir was recommended for subsidy to treat chronic hepatitis C in Singapore in 2018. We measured the impact of the subsidy decision on clinical practice and patient outcomes. Specifically, we looked at pre- and post- ... ...

Abstract	Background and aim: Sofosbuvir-velpatasvir was recommended for subsidy to treat chronic hepatitis C in Singapore in 2018. We measured the impact of the subsidy decision on clinical practice and patient outcomes. Specifically, we looked at pre- and post-subsidy changes in the utilization and prescribing pattern of chronic hepatitis C treatment and the real-world clinical effectiveness. Method: Utilization trends and prescribing patterns were assessed using aggregated drug utilization data from public hospitals' dispensing systems and clinical data from the national electronic health record database, respectively. An audit was conducted to evaluate sustained virological response rate 12 weeks post treatment (SVR12). Results: Use of sofosbuvir-velpatasvir increased sharply since its subsidy listing and dropped subsequently, whereas the utilization of comparator drugs remained low. Prescribing rate of sofosbuvir-velpatasvir increased from 13.7% in the pre-subsidy period to 90.2% in the post-subsidy period; 39.1% of patients previously on pegylated interferon and ribavirin switched to sofosbuvir-velpatasvir following its subsidy listing. In the audit, 365 out of 375 patients (97.3% [95% confidence interval: 95.1-98.6%]) achieved SVR12. Conclusion: The subsidy decision led to increased accessibility to patients and intended changes in clinical practice. Sofosbuvir-velpatasvir was also clinically effective in the real world. These findings augur well for the continued eradication of chronic hepatitis C infection in Singapore.
Language	English
Publishing date	2022-11-29
Publishing country	Australia
Document type	Journal Article
ISSN	2397-9070
ISSN (online)	2397-9070
DOI	10.1002/jgh3.12850
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Article: Attitudes, perceptions, and responses of purchasers versus subscribers-only for daily deals on hospitality products

Ong, Beng Soo

Journal of hospitality marketing & management Vol. 24, No. 1/2 , p. 180-201

2015 Volume 24, Issue 1, Page(s) 180–201

Author's details	Beng Soo Ong
Keywords	daily deals ; price discount perceptions ; social coupons ; customer satisfaction ; customer value ; purchasers versus nonpurchasers
Language	English
Publisher	Taylor & Francis
Publishing place	Philadelphia, Pa
Document type	Article
ZDB-ID	2493700-9
ISSN	1936-8623
Database	ECONomics Information System

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Article: Out Of Hospital And In Hospital Management Of Cellulitis Requiring Intravenous Therapy.

Ong, Bin S / Ngian, Vincent Jiu Jong / Yeong, Clarence / Keighley, Caitlin

International journal of general medicine

2019 Volume 12, Page(s) 447–453

Abstract: Background: Cellulitis requiring intravenous therapy can be managed via out of hospital programs, but a high number of patients are still admitted to hospital.: Objective: We aimed to review the clinical features, management and outcomes of patients ... ...

Abstract	Background: Cellulitis requiring intravenous therapy can be managed via out of hospital programs, but a high number of patients are still admitted to hospital. Objective: We aimed to review the clinical features, management and outcomes of patients with cellulitis requiring intravenous therapy in a Hospital in the Home (HITH) program compared to patients who are admitted to hospital. Methods: A prospective cohort study of patients with limb cellulitis requiring intravenous antibiotics was conducted at a metropolitan principal referral hospital. Results: A total of 100 patients out of 113 eligible patients were recruited. Forty-eight were treated entirely in hospital and 52 were treated entirely or partially via HITH. Patients treated in hospital were older (mean 69.2 vs 56.7 years, p<0.001), less mobile, have more comorbidities (Charlson Comorbidity Index mean 2.2 vs 1.2, P=0.005) and more associated active illness. All patients with Eron Class III were admitted to hospital. Patients treated in hospital had a higher incidence of acute renal failure (27.1% vs 3.8%, p=0.001), nosocomial infection (10.4% vs 0.0%, P=0.023), and a higher 28-day hospital readmission rate (10.4% vs 0.0%, P=0.023). Conclusion: Approximately half of the patients who require intravenous therapy can be treated via an out of hospital program. Patients admitted to hospital were more unwell and more likely to suffer complications. The presence of comorbid illness does not necessarily exclude participation in HITH and careful selection is essential to ensure safe outcomes.
Language	English
Publishing date	2019-11-29
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S230054
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