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  1. Article: Micromechanical analysis for effective thermal and electromagnetic properties of composite materials containing anisotropical and ellipsoidal fillers oriented randomly.

    Ono, Hiroyuki

    Heliyon

    2023  Volume 9, Issue 6, Page(s) e17445

    Abstract: In this study, micromechanical modeling will be performed for composite materials containing fillers oriented randomly in the matrix. The purpose of this study is to derive more general and explicit solutions for the effective thermal and electromagnetic ...

    Abstract In this study, micromechanical modeling will be performed for composite materials containing fillers oriented randomly in the matrix. The purpose of this study is to derive more general and explicit solutions for the effective thermal and electromagnetic properties of such composite materials without restricting the properties and shapes of the fillers. For this purpose, it is assumed that the physical properties of the filler are the same anisotropic properties as orthorhombic materials, and the shape of the fillers is ellipsoidal. This model is analyzed by micromechanics combining the Eshelby's equivalent inclusion method with the self-consistent method or the Mori-Tanaka's theory. Solutions of the effective thermal and electromagnetic properties both for composite materials containing many kinds of fillers with different shapes and physical properties and for polycrystalline materials can be also derived. Using the obtained solutions, the effect of the shape, the anisotropy, and the volume fraction of the filler on the effective thermal conductivity is examined for the carbon filler / polyethylene and the two types of quartz particles (and voids) / polyethylene. As a result, for the carbon filler / polyethylene, it is found that the effective thermal conductivity of the material when the shape of the filler is flat is about 20% higher than that when the shape of the filler is fibrous. Furthermore, when the shape of the carbon filler is flat, the result when the carbon filler is assumed to be isotropic is significantly different from that when the filler is assumed to be anisotropic. From the above, when the filler is oriented randomly in the material, it is found that simultaneously considering not only the shape of the filler but also its anisotropic properties is important to accurately evaluate the effective physical properties of the composite material. For two types of quartz particles (and voids) / polyethylene materials, the experimental result agrees better with the result of the Mori-Tanaka's theory than that of the self-consistent method, even if the volume fraction of the filler is more than 50%. From the above results, it is found that the analytical solutions of this study can generally explain the experimental results and can be applied to actual materials.
    Language English
    Publishing date 2023-06-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e17445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Career urgency and turnover intention among young adult workers: a comparison by gender and employment status.

    Ono, Hiromi

    BMC psychology

    2023  Volume 11, Issue 1, Page(s) 389

    Abstract: Background: This study aimed to analyze, by grouping young adult workers by gender and employment status, the model that states that the tendency for impatience in situations such as "stagnation in career exploration," "low evaluation from affiliation," ...

    Abstract Background: This study aimed to analyze, by grouping young adult workers by gender and employment status, the model that states that the tendency for impatience in situations such as "stagnation in career exploration," "low evaluation from affiliation," "upward comparison of careers between friends and acquaintances," and "lack of work-life balance" leads to turnover intention through career urgency such as the "feeling of being pressurized," having the "urge to develop one's career," and having "concern for one's career."
    Methods: An online survey was conducted targeting 400 young adult workers. A simultaneous multi-population analysis was performed.
    Results: For both male and female regular employees, the tendency for impatience when their career exploration stagnated led to their turnover intention by the "feeling of being pressurized." However, for both male and female non-regular employees, although the tendency for impatience promotes the "feeling of being pressurized" upon stagnation in career exploration, it does not lead to turnover intention. Further, the results showed that in the case of female non-regular employees, the tendency for impatience when comparing their own career to those of friends and acquaintances, who are in a more desirable state than their own, leads to turnover intention through "concern for one's career."
    Conclusions: Future research should consider marital status and the presence or absence of children in addition to gender and employment. Future studies should consider whether non-regular employees are of the involuntary type and whether they wish to change their status as regular employees.
    MeSH term(s) Child ; Humans ; Male ; Female ; Young Adult ; Intention ; Employment ; Personnel Turnover ; Surveys and Questionnaires ; Marital Status
    Language English
    Publishing date 2023-11-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2705921-2
    ISSN 2050-7283 ; 2050-7283
    ISSN (online) 2050-7283
    ISSN 2050-7283
    DOI 10.1186/s40359-023-01434-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: [Studies on the biological activities and emetic mechanism of staphylococcal enterotoxins].

    Ono, Hisaya

    Nihon saikingaku zasshi. Japanese journal of bacteriology

    2021  Volume 76, Issue 2, Page(s) 139–148

    Abstract: Staphylococcus aureus food poisoning was shown by Dack et al. in 1930 to be caused by staphylococcal enterotoxin (SE) produced by S. aureus, rather than by the bacterial infection. However, the emetic mechanism of SE has remained unclear. In this study, ... ...

    Abstract Staphylococcus aureus food poisoning was shown by Dack et al. in 1930 to be caused by staphylococcal enterotoxin (SE) produced by S. aureus, rather than by the bacterial infection. However, the emetic mechanism of SE has remained unclear. In this study, we analyzed the emetic activity of SE in several emetic animal models and tried to elucidate the mechanism of emesis. We established a small primate, common marmoset, as a novel emetic model for SE. We also analyzed the immunofluorescence analysis of the gastrointestinal tract of the common marmoset and found that SE binds to submucosal mast cells in the gastrointestinal tract and SE induces degranulation of the mast cells. Furthermore, we showed that SE induces histamine releases, which is inhibited by mast cell stabilizer. In addition, treatment of common marmosets with either mast cell stabilizer or histamine H
    MeSH term(s) Amino Acid Sequence ; Animals ; Callithrix ; Cell Degranulation/drug effects ; Disease Models, Animal ; Enterotoxins/adverse effects ; Enterotoxins/chemistry ; Enterotoxins/metabolism ; Histamine Antagonists/pharmacology ; Histamine Antagonists/therapeutic use ; Histamine Release/drug effects ; Intestinal Mucosa/cytology ; Mast Cells/metabolism ; Mast Cells/physiology ; Protein Conformation ; Shrews ; Vomiting/chemically induced ; Vomiting/drug therapy ; Vomiting/metabolism
    Chemical Substances Enterotoxins ; Histamine Antagonists
    Language Japanese
    Publishing date 2021-04-24
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604101-2
    ISSN 1882-4110 ; 0021-4930
    ISSN (online) 1882-4110
    ISSN 0021-4930
    DOI 10.3412/jsb.76.139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Functional characterization of an olfactory receptor in the Oriental fruit fly, Bactrocera dorsalis, that responds to eugenol and isoeugenol.

    Ono, Hajime

    Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology

    2021  Volume 258, Page(s) 110696

    Abstract: Most insects utilize a diverse array of olfactory cues for host finding and reproduction behaviors. Males of several Dacini fruit fly species (Tephritidae) are selectively attracted to certain phytochemicals to acquire sex pheromone precursors. Despite ... ...

    Abstract Most insects utilize a diverse array of olfactory cues for host finding and reproduction behaviors. Males of several Dacini fruit fly species (Tephritidae) are selectively attracted to certain phytochemicals to acquire sex pheromone precursors. Despite the importance of olfaction, only a limited number of olfactory receptors (ORs) in Dacini fruit flies have been characterized. In this study, I focused on the OR94b-2 subfamily, because a clade consisting of these homologs was distinctly localized from other OR clades in a constructed phylogenetic tree. To deorphanize the ORs, I used plant essential oils to screen ligands. Using heterologous expression in Xenopus oocytes, I analyzed the functional properties of BdorOR94b-2 and ZcucOR94b-2 from the Oriental fruit fly, Bactrocera dorsalis, and the melon fruit fly, Zeugodacus cucurbitae, respectively. I found that cinnamon leaf oil evoked responses in oocytes expressing BdorOR94b-2 and the corresponding co-receptor BdorORCO. Gas chromatography-mass spectrometry analysis indicated that eugenol is a major component of cinnamon leaf oil. In accordance with the response to cinnamon leaf oil containing eugenol, BdorOR94b-2/BdorORCO revealed a weak but significant response to eugenol. BdorOR94b-2/BdorORCO also responded to isoeugenol, but not to other related aromatic semiochemicals such as known male-specific attractants and sex pheromones. In contrast, ZcucOR94b-2/ZcucORCO did not respond to any of the phenolic compounds tested, including eugenol analogs. Therefore, BdorOR94b-2/BdorORCO is narrowly tuned to eugenol analogs, whereas ZcucOR94b-2/ZcucORCO likely binds to other compound(s).
    MeSH term(s) Animals ; Eugenol/analogs & derivatives ; Eugenol/pharmacology ; Male ; Pheromones ; Phylogeny ; Receptors, Odorant/genetics ; Tephritidae/genetics
    Chemical Substances Pheromones ; Receptors, Odorant ; Eugenol (3T8H1794QW) ; isoeugenol (5M0MWY797U)
    Language English
    Publishing date 2021-11-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 121247-3
    ISSN 1879-1107 ; 0305-0491 ; 1096-4959
    ISSN (online) 1879-1107
    ISSN 0305-0491 ; 1096-4959
    DOI 10.1016/j.cbpb.2021.110696
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Functional characterization of an olfactory receptor in the Oriental fruit fly, Bactrocera dorsalis, that responds to eugenol and isoeugenol

    Ono, Hajime

    Comparative biochemistry and physiology. 2022 Feb., Mar., v. 258

    2022  

    Abstract: Most insects utilize a diverse array of olfactory cues for host finding and reproduction behaviors. Males of several Dacini fruit fly species (Tephritidae) are selectively attracted to certain phytochemicals to acquire sex pheromone precursors. Despite ... ...

    Abstract Most insects utilize a diverse array of olfactory cues for host finding and reproduction behaviors. Males of several Dacini fruit fly species (Tephritidae) are selectively attracted to certain phytochemicals to acquire sex pheromone precursors. Despite the importance of olfaction, only a limited number of olfactory receptors (ORs) in Dacini fruit flies have been characterized. In this study, I focused on the OR94b-2 subfamily, because a clade consisting of these homologs was distinctly localized from other OR clades in a constructed phylogenetic tree. To deorphanize the ORs, I used plant essential oils to screen ligands. Using heterologous expression in Xenopus oocytes, I analyzed the functional properties of BdorOR94b-2 and ZcucOR94b-2 from the Oriental fruit fly, Bactrocera dorsalis, and the melon fruit fly, Zeugodacus cucurbitae, respectively. I found that cinnamon leaf oil evoked responses in oocytes expressing BdorOR94b-2 and the corresponding co-receptor BdorORCO. Gas chromatography–mass spectrometry analysis indicated that eugenol is a major component of cinnamon leaf oil. In accordance with the response to cinnamon leaf oil containing eugenol, BdorOR94b-2/BdorORCO revealed a weak but significant response to eugenol. BdorOR94b-2/BdorORCO also responded to isoeugenol, but not to other related aromatic semiochemicals such as known male-specific attractants and sex pheromones. In contrast, ZcucOR94b-2/ZcucORCO did not respond to any of the phenolic compounds tested, including eugenol analogs. Therefore, BdorOR94b-2/BdorORCO is narrowly tuned to eugenol analogs, whereas ZcucOR94b-2/ZcucORCO likely binds to other compound(s).
    Keywords Bactrocera dorsalis ; Xenopus ; Zeugodacus cucurbitae ; attractants ; cinnamon ; eugenol ; fruit flies ; fruits ; gas chromatography-mass spectrometry ; heterologous gene expression ; leaves ; ligands ; oils ; olfactory receptors ; oocytes ; phylogeny ; reproduction ; sex pheromones ; smell
    Language English
    Dates of publication 2022-02
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 121247-3
    ISSN 1879-1107 ; 0305-0491 ; 1096-4959
    ISSN (online) 1879-1107
    ISSN 0305-0491 ; 1096-4959
    DOI 10.1016/j.cbpb.2021.110696
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Static analysis of gain control for a few-mode erbium-doped fiber amplifier employing pump power adjustment.

    Ono, Hirotaka / Yamada, Makoto

    Applied optics

    2023  Volume 62, Issue 16, Page(s) 4180–4186

    Abstract: In mode-division multiplexing (MDM) optical transmission systems and MDM networks, the gain must be kept nearly constant even when the input signal power of the few-mode (FM), erbium-doped fiber amplifier (EDFA) changes. This paper investigates ... ...

    Abstract In mode-division multiplexing (MDM) optical transmission systems and MDM networks, the gain must be kept nearly constant even when the input signal power of the few-mode (FM), erbium-doped fiber amplifier (EDFA) changes. This paper investigates controllability of the gain in a 4-LP mode EDFA, whose EDF has signal modes of
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4522
    ISSN (online) 1539-4522
    DOI 10.1364/AO.488413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Sensing intracellular signatures with synthetic mRNAs.

    Ono, Hiroki / Saito, Hirohide

    RNA biology

    2023  Volume 20, Issue 1, Page(s) 588–602

    Abstract: The bottom-up assembly of biological components in synthetic biology has contributed to a better understanding of natural phenomena and the development of new technologies for practical applications. Over the past few decades, basic RNA research has ... ...

    Abstract The bottom-up assembly of biological components in synthetic biology has contributed to a better understanding of natural phenomena and the development of new technologies for practical applications. Over the past few decades, basic RNA research has unveiled the regulatory roles of RNAs underlying gene regulatory networks; while advances in RNA biology, in turn, have highlighted the potential of a wide variety of RNA elements as building blocks to construct artificial systems. In particular, synthetic mRNA-based translational regulators, which respond to signals in cells and regulate the production of encoded output proteins, are gaining attention with the recent rise of mRNA therapeutics. In this Review, we discuss recent progress in RNA synthetic biology, mainly focusing on emerging technologies for sensing intracellular protein and RNA molecules and controlling translation.
    MeSH term(s) RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA/genetics ; Gene Regulatory Networks ; Proteins/genetics ; Synthetic Biology
    Chemical Substances RNA, Messenger ; RNA (63231-63-0) ; Proteins
    Language English
    Publishing date 2023-08-15
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2159587-2
    ISSN 1555-8584 ; 1555-8584
    ISSN (online) 1555-8584
    ISSN 1555-8584
    DOI 10.1080/15476286.2023.2244791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [Helicobacter pylori associated peptic ulcer].

    Ono, Hideki / Okimoto, Tadayoshi

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

    2023  Volume 120, Issue 10, Page(s) 795–802

    MeSH term(s) Humans ; Helicobacter pylori ; Peptic Ulcer/etiology ; Helicobacter Infections/complications
    Language Japanese
    Publishing date 2023-10-12
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 708695-7
    ISSN 1349-7693 ; 0446-6586
    ISSN (online) 1349-7693
    ISSN 0446-6586
    DOI 10.11405/nisshoshi.120.795
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Molecular Mechanisms of Hypothalamic Insulin Resistance.

    Ono, Hiraku

    International journal of molecular sciences

    2019  Volume 20, Issue 6

    Abstract: Insulin exists in the central nervous system, where it executes two important functions in the hypothalamus: the suppression of food intake and the improvement of glucose metabolism. Recent studies have shown that both are exerted robustly in rodents and ...

    Abstract Insulin exists in the central nervous system, where it executes two important functions in the hypothalamus: the suppression of food intake and the improvement of glucose metabolism. Recent studies have shown that both are exerted robustly in rodents and humans. If intact, these functions exert beneficial effects on obesity and diabetes, respectively. Disruption of both occurs due to a condition known as hypothalamic insulin resistance, which is caused by obesity and the overconsumption of saturated fat. An enormous volume of literature addresses the molecular mechanisms of hypothalamic insulin resistance. IKKβ and JNK are major players in the inflammation pathway, which is activated by saturated fatty acids that induce hypothalamic insulin resistance. Two major tyrosine phosphatases, PTP-1B and TCPTP, are upregulated in chronic overeating. They dephosphorylate the insulin receptor and insulin receptor substrate proteins, resulting in hypothalamic insulin resistance. Prolonged hyperinsulinemia with excessive nutrition activates the mTOR/S6 kinase pathway, thereby enhancing IRS-1 serine phosphorylation to induce hypothalamic insulin resistance. Other mechanisms associated with this condition include hypothalamic gliosis and disturbed insulin transport into the central nervous system. Unveiling the precise molecular mechanisms involved in hypothalamic insulin resistance is important for developing new ways of treating obesity and type 2 diabetes.
    MeSH term(s) Animals ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/immunology ; Eating ; Humans ; Hypothalamus/metabolism ; I-kappa B Kinase/metabolism ; Insulin Resistance ; MAP Kinase Kinase 4/metabolism ; Obesity/complications ; Obesity/immunology ; Phosphorylation ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 2/metabolism ; Receptor, Insulin/metabolism ; Signal Transduction ; Up-Regulation
    Chemical Substances Receptor, Insulin (EC 2.7.10.1) ; I-kappa B Kinase (EC 2.7.11.10) ; IKBKB protein, human (EC 2.7.11.10) ; MAP Kinase Kinase 4 (EC 2.7.12.2) ; PTPN1 protein, human (EC 3.1.3.48) ; PTPN2 protein, human (EC 3.1.3.48) ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 (EC 3.1.3.48) ; Protein Tyrosine Phosphatase, Non-Receptor Type 2 (EC 3.1.3.48)
    Language English
    Publishing date 2019-03-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms20061317
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  10. Article ; Online: Accessory posterior cerebral artery.

    Endo, Hideki / Ono, Hidetoshi / Nakamura, Hirohiko

    Acta neurologica Belgica

    2024  

    Language English
    Publishing date 2024-02-29
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 127315-2
    ISSN 2240-2993 ; 0300-9009
    ISSN (online) 2240-2993
    ISSN 0300-9009
    DOI 10.1007/s13760-024-02489-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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