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  1. Article ; Online: Plasma Cluster Ions Reduce the IgE-Binding Capacity of House Dust Mite Allergens under a Simulated Indoor Environmental Condition.

    Okano, Hiroaki / Fujimura, Takashi / Fukuoka, Norihiko / Hayashi, Takaharu / Nishikawa, Kazuo / Ono, Kazuhisa / Kawamoto, Seiji

    International archives of allergy and immunology

    2017  Volume 173, Issue 4, Page(s) 199–203

    Abstract: Background: A high level of house dust mite (HDM) allergens in a living environment is a risk factor for both sensitization to these allergens and asthmatic attacks. We previously showed that plasma cluster ions (PCIs) impaired the IgE-binding capacity ... ...

    Abstract Background: A high level of house dust mite (HDM) allergens in a living environment is a risk factor for both sensitization to these allergens and asthmatic attacks. We previously showed that plasma cluster ions (PCIs) impaired the IgE-binding capacity of atomized crude allergens prepared from Japanese cedar pollen and fungus under experimental conditions.
    Objective: We evaluated the capacity of PCIs to impair the IgE-binding capacity of airborne HDM allergens under a simulated indoor environmental condition.
    Methods: For the determination of the effects of PCIs on HDM allergens under an experimental condition, HDM extract was atomized as aqueous mist into a cylindrical experimental apparatus filled with PCIs. For the evaluation of the effects of PCIs under a simulated natural indoor environmental condition, dried HDM allergens were floated as airborne particles in an acryl cubic apparatus in the presence of PCIs. The IgE-binding capacities of the PCI- and sham-treated HDM allergens were analyzed by an ELISA.
    Results: The IgE-binding capacity of the HDM allergens was significantly impaired after PCI treatment compared to that after sham treatment under both experimental and simulated environmental conditions. The ELISA results demonstrated that the IgE-binding capacities of HDM allergens after PCI treatment showed 68 and 74% reductions compared to those after sham treatment under the experimental and simulated environmental conditions, respectively.
    Conclusions: PCIs have the capacity to impair the IgE-binding capacity of airborne HDM allergens in a simulated environmental condition.
    MeSH term(s) Air Pollutants/immunology ; Air Pollution, Indoor ; Allergens/immunology ; Antibodies, Monoclonal/immunology ; Antigens, Dermatophagoides/immunology ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunoglobulin E/immunology ; Ions ; Plasma/immunology
    Chemical Substances Air Pollutants ; Allergens ; Antibodies, Monoclonal ; Antigens, Dermatophagoides ; Ions ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2017
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1108932-5
    ISSN 1423-0097 ; 1018-2438
    ISSN (online) 1423-0097
    ISSN 1018-2438
    DOI 10.1159/000477724
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.155: Show issues Location:
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  2. Article: Anti-hyperuricemic effect of fermented barley extract is associated with increased urinary uric acid excretion

    Hokazono, Hideki / Omori, Toshiro / Ono, Kazuhisa

    Food science and technology research. 2010 July, v. 16, no. 4

    2010  

    Keywords human diseases ; gout ; diet-related diseases ; disease prevention ; barley ; food processing ; fermented foods ; plant extracts ; medicinal properties ; urinary tract ; uric acid ; biosynthesis ; metabolism ; purines ; intestinal absorption ; adenine ; dose response ; urination ; animal models ; rats ; in vivo studies ; screening ; blood serum ; blood composition
    Language English
    Dates of publication 2010-07
    Size p. 295-304.
    Document type Article
    ZDB-ID 1469766-x
    ISSN 1344-6606
    ISSN 1344-6606
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 6664: Show issues

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  3. Article: Effects of Single and Combined Administration of Fermented Barley Extract and γ-Aminobutyric Acid on the Development of Atopic Dermatitis in NC/Nga Mice

    HOKAZONO, Hideki / OMORI, Toshiro / ONO, Kazuhisa

    Bioscience, biotechnology, and biochemistry. 2010 Jan. 23, v. 74, no. 1

    2010  

    Abstract: We examined the effects single and combined administration of fermented barley extract P (FBEP), prepared from barley-shochu distillery by-products, and γ-aminobutyric acid (GABA) on the development of atopic dermatitis (AD)-like skin lesions in NC/Nga ... ...

    Abstract We examined the effects single and combined administration of fermented barley extract P (FBEP), prepared from barley-shochu distillery by-products, and γ-aminobutyric acid (GABA) on the development of atopic dermatitis (AD)-like skin lesions in NC/Nga mice. Single administration of FBEP and GABA dose-dependently reduced the development of AD-like skin lesions in mice. GABA reduced the development of AD-like skin lesions by suppressing serum immunoglobulin E (IgE) and splenocyte interleukin (IL)-4 production, while FBEP reduced skin lesions without affecting the IgE or cytokine production. However, in mice with induced AD-like skin lesions, combined administration of FBEP and GABA decreased serum IgE levels and splenic cell IL-4 production, and increased splenic cell interferon-γ production. These results suggest that combined administration of FBEP and GABA alleviated AD-like skin lesions in the NC/Nga mice by adjusting the Th1/Th2 balance to a Th1-predominant immune response.
    Keywords atopic dermatitis ; barley ; biotechnology ; blood serum ; fermentation ; immune response ; immunoglobulin E ; interleukin-4 ; splenocytes
    Language English
    Dates of publication 2010-0123
    Size p. 135-139.
    Publishing place Japan Society for Bioscience, Biotechnology, and Agrochemistry
    Document type Article
    Note NAL-light
    ZDB-ID 1106450-x
    ISSN 1347-6947 ; 0916-8451
    ISSN (online) 1347-6947
    ISSN 0916-8451
    DOI 10.1271/bbb.90653
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    In stock of ZB MED Bonn / Germany

    Z 1783: Show issues

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  4. Article ; Online: Identification of amino acid residues that determine the substrate specificity of mammalian membrane-bound front-end fatty acid desaturases.

    Watanabe, Kenshi / Ohno, Makoto / Taguchi, Masahiro / Kawamoto, Seiji / Ono, Kazuhisa / Aki, Tsunehiro

    Journal of lipid research

    2015  Volume 57, Issue 1, Page(s) 89–99

    Abstract: Membrane-bound desaturases are physiologically and industrially important enzymes that are involved in the production of diverse fatty acids such as polyunsaturated fatty acids and their derivatives. Here, we identified amino acid residues that determine ...

    Abstract Membrane-bound desaturases are physiologically and industrially important enzymes that are involved in the production of diverse fatty acids such as polyunsaturated fatty acids and their derivatives. Here, we identified amino acid residues that determine the substrate specificity of rat Δ6 desaturase (D6d) acting on linoleoyl-CoA by comparing its amino acid sequence with that of Δ5 desaturase (D5d), which converts dihomo-γ-linolenoyl-CoA. The N-terminal cytochrome b5-like domain was excluded as a determinant by domain swapping analysis. Substitution of eight amino acid residues (Ser209, Asn211, Arg216, Ser235, Leu236, Trp244, Gln245, and Val344) of D6d with the corresponding residues of D5d by site-directed mutagenesis switched the substrate specificity from linoleoyl-CoA to dihomo-γ-linolenoyl-CoA. In addition, replacement of Leu323 of D6d with Phe323 on the basis of the amino acid sequence of zebra fish Δ5/6 bifunctional desaturase was found to render D6d bifunctional. Homology modeling of D6d using recent crystal structure data of human stearoyl-CoA (Δ9) desaturase revealed that Arg216, Trp244, Gln245, and Leu323 are located near the substrate-binding pocket. To our knowledge, this is the first report on the structural basis of the substrate specificity of a mammalian front-end fatty acid desaturase, which will aid in efficient production of value-added fatty acids.
    MeSH term(s) Acyl Coenzyme A/metabolism ; Amino Acid Sequence ; Animals ; Cloning, Molecular ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Fatty Acid Desaturases/chemistry ; Fatty Acid Desaturases/genetics ; Fatty Acid Desaturases/metabolism ; Fatty Acids, Unsaturated/metabolism ; Humans ; Linoleoyl-CoA Desaturase/chemistry ; Linoleoyl-CoA Desaturase/genetics ; Linoleoyl-CoA Desaturase/metabolism ; Membrane Proteins/metabolism ; Models, Molecular ; Molecular Sequence Data ; Mutagenesis, Site-Directed/methods ; Rats ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Structure-Activity Relationship ; Substrate Specificity
    Chemical Substances Acyl Coenzyme A ; Fatty Acids, Unsaturated ; Membrane Proteins ; stearoyl-coenzyme A (362-66-3) ; linoleoyl-coenzyme A (40757-80-0) ; Fatty Acid Desaturases (EC 1.14.19.-) ; Linoleoyl-CoA Desaturase (EC 1.14.19.3)
    Language English
    Publishing date 2015-11-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80154-9
    ISSN 1539-7262 ; 0022-2275
    ISSN (online) 1539-7262
    ISSN 0022-2275
    DOI 10.1194/jlr.M064121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 175: Show issues Location:
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  5. Article ; Online: Metabolism and synthesis of lipids in the polyunsaturated fatty acid-producing fungus Mortierella alliacea.

    Jermsuntiea, Worapol / Aki, Tsunehiro / Kawamoto, Seiji / Ono, Kazuhisa

    Journal of oleo science

    2010  Volume 60, Issue 1, Page(s) 11–17

    Abstract: The fungal strain Mortierella alliacea YN-15 is a promising industrial producer of polyunsaturated fatty acids (PUFAs), in particular arachidonic acid. In order to more efficiently produce PUFAs, the metabolism of an externally supplied plant oil, α- ... ...

    Abstract The fungal strain Mortierella alliacea YN-15 is a promising industrial producer of polyunsaturated fatty acids (PUFAs), in particular arachidonic acid. In order to more efficiently produce PUFAs, the metabolism of an externally supplied plant oil, α-linolenic acid (ALA)-rich linseed triacylglycerol (TAG), was examined, and time-dependent changes in the composition of its lipid and fatty acid metabolites were traced. Addition of linseed TAG to growing cultures resulted in a transient increase in extracellular 1,2-diacylglycerol (DAG), and even more so of 1,3-DAG, in the mycelia. This was followed by a decrease in both DAGs and an increase in TAG. Eicosapentaenoic acid (EPA), a desaturated and elongated product of ALA, accumulated to a greater extent in cellular phospholipids than in neutral lipids. Moreover, the addition of ALA in free fatty acid form to the culture led to the generation of EPA. However, EPA production was not observed upon addition of ALA-rich 1,2- or 1,3-DAG, indicating that fatty acids released from exogenous lipids were used for resynthesis of mycelial TAG. These results suggested that TAG might be hydrolyzed by extracellular lipases, whereas its synthesis might be catalyzed by intracellular enzymes. Appropriate regulation of such enzymes might be an effective strategy to enhance PUFA production under plant oil supplementation.
    MeSH term(s) Calibration ; Cell Culture Techniques/standards ; Cells, Cultured ; Culture Media/pharmacology ; Diglycerides/analysis ; Diglycerides/metabolism ; Fatty Acids/analysis ; Fatty Acids/metabolism ; Fatty Acids, Unsaturated/biosynthesis ; Fatty Acids, Unsaturated/metabolism ; Fungi/drug effects ; Fungi/growth & development ; Fungi/metabolism ; Linseed Oil/pharmacology ; Lipid Metabolism/drug effects ; Lipid Metabolism/physiology ; Mortierella/drug effects ; Mortierella/growth & development ; Mortierella/metabolism ; Plant Oils/chemistry ; Plant Oils/isolation & purification ; Plant Oils/metabolism ; Time Factors
    Chemical Substances 1,2-diacylglycerol ; Culture Media ; Diglycerides ; Fatty Acids ; Fatty Acids, Unsaturated ; Plant Oils ; Linseed Oil (8001-26-1)
    Language English
    Publishing date 2010-12-17
    Publishing country Japan
    Document type Journal Article
    ISSN 1347-3352
    ISSN (online) 1347-3352
    DOI 10.5650/jos.60.11
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Effects of single and combined administration of fermented barley extract and gamma-aminobutyric acid on the development of atopic dermatitis in NC/Nga mice.

    Hokazono, Hideki / Omori, Toshiro / Ono, Kazuhisa

    Bioscience, biotechnology, and biochemistry

    2010  Volume 74, Issue 1, Page(s) 135–139

    Abstract: We examined the effects single and combined administration of fermented barley extract P (FBEP), prepared from barley-shochu distillery by-products, and gamma-aminobutyric acid (GABA) on the development of atopic dermatitis (AD)-like skin lesions in NC/ ... ...

    Abstract We examined the effects single and combined administration of fermented barley extract P (FBEP), prepared from barley-shochu distillery by-products, and gamma-aminobutyric acid (GABA) on the development of atopic dermatitis (AD)-like skin lesions in NC/Nga mice. Single administration of FBEP and GABA dose-dependently reduced the development of AD-like skin lesions in mice. GABA reduced the development of AD-like skin lesions by suppressing serum immunoglobulin E (IgE) and splenocyte interleukin (IL)-4 production, while FBEP reduced skin lesions without affecting the IgE or cytokine production. However, in mice with induced AD-like skin lesions, combined administration of FBEP and GABA decreased serum IgE levels and splenic cell IL-4 production, and increased splenic cell interferon-gamma production. These results suggest that combined administration of FBEP and GABA alleviated AD-like skin lesions in the NC/Nga mice by adjusting the Th1/Th2 balance to a Th1-predominant immune response.
    MeSH term(s) Animals ; Body Weight/drug effects ; Cytokines/metabolism ; Dermatitis, Atopic/blood ; Dermatitis, Atopic/chemically induced ; Dermatitis, Atopic/physiopathology ; Dermatitis, Atopic/prevention & control ; Female ; Fermentation ; Hordeum/chemistry ; Hordeum/metabolism ; Immunoglobulin E/blood ; Mice ; Picryl Chloride/administration & dosage ; Picryl Chloride/pharmacology ; Plant Extracts/administration & dosage ; Plant Extracts/metabolism ; Plant Extracts/pharmacology ; gamma-Aminobutyric Acid/administration & dosage ; gamma-Aminobutyric Acid/pharmacology
    Chemical Substances Cytokines ; Plant Extracts ; Immunoglobulin E (37341-29-0) ; gamma-Aminobutyric Acid (56-12-2) ; Picryl Chloride (Z4ZG7O5SZ9)
    Language English
    Publishing date 2010
    Publishing country England
    Document type Journal Article
    ZDB-ID 1106450-x
    ISSN 1347-6947 ; 0916-8451
    ISSN (online) 1347-6947
    ISSN 0916-8451
    DOI 10.1271/bbb.90653
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4647: Show issues Location:
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  7. Article ; Online: A flavanone derivative from the Asian medicinal herb (Perilla frutescens) potently suppresses IgE-mediated immediate hypersensitivity reactions.

    Kamei, Rikiya / Fujimura, Takashi / Matsuda, Miki / Kakihara, Kotaro / Hirakawa, Noriko / Baba, Kenji / Ono, Kazuhisa / Arakawa, Kenji / Kawamoto, Seiji

    Biochemical and biophysical research communications

    2017  Volume 483, Issue 1, Page(s) 674–679

    Abstract: Perilla frutescens is a dietary leafy herb consumed as a traditional Japanese condiment as well as used for Chinese medicine with anti-inflammatory activity. Here we report a hitherto-unrecognized P. frutescens phytochemical that potently suppresses IgE- ... ...

    Abstract Perilla frutescens is a dietary leafy herb consumed as a traditional Japanese condiment as well as used for Chinese medicine with anti-inflammatory activity. Here we report a hitherto-unrecognized P. frutescens phytochemical that potently suppresses IgE-mediated type I hypersensitivity reactions. Structural analysis reveals that the purified anti-allergic compound (Perilla-derived methoxyflavanone, PDMF) is identified as 8-hydroxy-5,7-dimethoxyflavanone. PDMF significantly inhibits IgE-mediated histamine release from RBL-2H3 rat basophilic leukemia cells as compared with those seen in known P. frutescens-derived anti-inflammatory polyphenols. We also show that oral administration of PDMF not only suppresses passive cutaneous anaphylaxis, but also prevents allergic rhinitis-like nasal symptoms in a murine model of Japanese cedar pollinosis. Mechanistically, PDMF negatively regulates Akt phosphorylation and intracellular Ca
    MeSH term(s) Animals ; Anti-Allergic Agents/administration & dosage ; Anti-Allergic Agents/chemistry ; Anti-Allergic Agents/isolation & purification ; Anti-Allergic Agents/pharmacology ; Cell Line, Tumor ; Cryptomeria/immunology ; Disease Models, Animal ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/isolation & purification ; Drugs, Chinese Herbal/pharmacology ; Female ; Flavanones/administration & dosage ; Flavanones/chemistry ; Flavanones/isolation & purification ; Flavanones/pharmacology ; Histamine Release/drug effects ; Hypersensitivity, Immediate/prevention & control ; Immunoglobulin E/immunology ; Mice ; Mice, Inbred BALB C ; Passive Cutaneous Anaphylaxis/drug effects ; Perilla frutescens/chemistry ; Plants, Medicinal/chemistry ; Rats ; Receptors, IgE/immunology ; Rhinitis, Allergic, Seasonal/drug therapy ; Rhinitis, Allergic, Seasonal/prevention & control
    Chemical Substances 8-hydroxy-5,7-dimethoxyflavanone ; Anti-Allergic Agents ; Drugs, Chinese Herbal ; Flavanones ; Receptors, IgE ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2017-01-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2016.12.083
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 116: Show issues Location:
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  8. Article ; Online: A novel moonlight function of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) for immunomodulation.

    Nakano, Toshiaki / Goto, Shigeru / Takaoka, Yuki / Tseng, Hui-Peng / Fujimura, Takashi / Kawamoto, Seiji / Ono, Kazuhisa / Chen, Chao-Long

    BioFactors (Oxford, England)

    2017  Volume 44, Issue 6, Page(s) 597–608

    Abstract: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an energy metabolism-related enzyme, which generates NADH in glycolysis. Our previous study revealed a novel role of exogenous GAPDH in the amelioration of lipopolysaccharide (LPS)-induced sepsis- ... ...

    Abstract Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an energy metabolism-related enzyme, which generates NADH in glycolysis. Our previous study revealed a novel role of exogenous GAPDH in the amelioration of lipopolysaccharide (LPS)-induced sepsis-related, severe acute lung injury (ALI) in mice. Here, we show the effect of extracellular GAPDH on the physiological functions of macrophages, which play an important role in the onset of sepsis and ALI. GAPDH has no effect on cell viability, while it strongly suppressed cell adhesion, spreading, and phagocytic function of LPS-stimulated macrophages. GAPDH treatment significantly reduced tumor necrosis factor (TNF)-α, while it induced interleukin (IL)-10 production from LPS-stimulated macrophages in a dose-dependent manner. It is noteworthy that heat inactivation of GAPDH lost its immunomodulatory activity. Correspondingly, NADH significantly inhibited TNF-α and enhanced IL-10 production with elevation of both M1/M2 macrophage markers. These data suggest that extracellular GAPDH induces intermediate M1/M2 macrophages for termination of inflammation, partly through its enzyme activity for generation of NADH. © 2018 BioFactors, 44(6):597-608, 2018.
    MeSH term(s) Animals ; Cell Adhesion/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Gene Expression ; Glyceraldehyde-3-Phosphate Dehydrogenases/genetics ; Glyceraldehyde-3-Phosphate Dehydrogenases/immunology ; Glyceraldehyde-3-Phosphate Dehydrogenases/isolation & purification ; Glyceraldehyde-3-Phosphate Dehydrogenases/pharmacology ; Immunologic Factors/genetics ; Immunologic Factors/immunology ; Immunologic Factors/isolation & purification ; Immunologic Factors/pharmacology ; Interleukin-10/genetics ; Interleukin-10/immunology ; Lipopolysaccharides/antagonists & inhibitors ; Lipopolysaccharides/pharmacology ; Macrophage Activation/drug effects ; Mice ; Muscle, Skeletal/chemistry ; Muscle, Skeletal/enzymology ; NAD/immunology ; NAD/metabolism ; NAD/pharmacology ; Phagocytosis/drug effects ; RAW 264.7 Cells ; Rabbits ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/immunology
    Chemical Substances IL10 protein, mouse ; Immunologic Factors ; Lipopolysaccharides ; Tumor Necrosis Factor-alpha ; NAD (0U46U6E8UK) ; Interleukin-10 (130068-27-8) ; Glyceraldehyde-3-Phosphate Dehydrogenases (EC 1.2.1.-)
    Language English
    Publishing date 2017-07-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 59230-4
    ISSN 1872-8081 ; 0951-6433
    ISSN (online) 1872-8081
    ISSN 0951-6433
    DOI 10.1002/biof.1379
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    Zs.A 2473: Show issues Location:
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  9. Article: Synergistic tumor suppression by a Perilla frutescens-derived methoxyflavanone and anti-cancer tyrosine kinase inhibitors in A549 human lung adenocarcinoma.

    Abd El-Hafeez, Amer Ali / Fujimura, Takashi / Kamei, Rikiya / Hirakawa, Noriko / Baba, Kenji / Ono, Kazuhisa / Kawamoto, Seiji

    Cytotechnology

    2017  Volume 70, Issue 3, Page(s) 913–919

    Abstract: Anti-cancer tyrosine kinase inhibitors (TKIs) are effective in many types of cancers including non-small cell lung cancer, while appearance of TKI-resistant tumors suggests a need for the development of their potentiation strategies. We have previously ... ...

    Abstract Anti-cancer tyrosine kinase inhibitors (TKIs) are effective in many types of cancers including non-small cell lung cancer, while appearance of TKI-resistant tumors suggests a need for the development of their potentiation strategies. We have previously shown that a methoxyflavanone derivative from the Asian medicinal herb Perilla frutescens (Perilla-derived methoxyflavanone; PDMF) shows a prominent anti-tumor activity against A549 human lung adenocarcinoma. Here we show that PDMF and anti-cancer TKIs (nilotinib, bosutinib, dasatinib, and ponatinib) synergistically suppress proliferation of A549 cells. Flow cytometric analysis indicated that co-stimulation with nilotinib (4 μM) and PDMF induced G
    Language English
    Publishing date 2017-07-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1035772-5
    ISSN 0920-9069
    ISSN 0920-9069
    DOI 10.1007/s10616-017-0124-1
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  10. Article: A methoxyflavanone derivative from the Asian medicinal herb (Perilla frutescens) induces p53-mediated G

    Abd El-Hafeez, Amer Ali / Fujimura, Takashi / Kamei, Rikiya / Hirakawa, Noriko / Baba, Kenji / Ono, Kazuhisa / Kawamoto, Seiji

    Cytotechnology

    2017  Volume 70, Issue 3, Page(s) 899–912

    Abstract: Perilla frutescens is an Asian dietary herb consumed as an essential seasoning in Japanese cuisine as well as used for a Chinese medicine. Here, we report that a newly found methoxyflavanone derivative from P. frutescens (Perilla-derived methoxyflavanone, ...

    Abstract Perilla frutescens is an Asian dietary herb consumed as an essential seasoning in Japanese cuisine as well as used for a Chinese medicine. Here, we report that a newly found methoxyflavanone derivative from P. frutescens (Perilla-derived methoxyflavanone, PDMF; 8-hydroxy-5,7-dimethoxyflavanone) shows carcinostatic activity on human lung adenocarcinoma, A549. We found that treatment with PDMF significantly inhibited cell proliferation and decreased viability through induction of G
    Language English
    Publishing date 2017-07-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1035772-5
    ISSN 0920-9069
    ISSN 0920-9069
    DOI 10.1007/s10616-017-0116-1
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