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  1. AU="Oostindjer, Andrew"
  2. AU="Diarra, Zoumana"
  3. AU="Saragoni, V G"

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  1. Article ; Online: Bempedoïnezuur, nieuwe lipidenverlagende medicatie.

    Oostindjer, Andrew / Roeters van Lennep, Jeanine E

    Nederlands tijdschrift voor geneeskunde

    2023  Volume 167

    Abstract: Statins have been de cornerstone for the treatment of hyperlipidaemia for decades now. More recently the introduction of the PCSK9 inhibitors, inclisiran and even more recently bempedoic acid have given us new options for the treatment of hyperlipidaemia. ...

    Title translation Bempedoic acid, a new cholesterol-lowering agent.
    Abstract Statins have been de cornerstone for the treatment of hyperlipidaemia for decades now. More recently the introduction of the PCSK9 inhibitors, inclisiran and even more recently bempedoic acid have given us new options for the treatment of hyperlipidaemia. Bempedoic acid is a prodrug which is metabolized in the liver and not in the peripheral tissues like muscles, this means that myalgia does not occur as a side effect. Its effect on the cholesterol synthesis occurs earlier in the chain of events than that of statins which work primarily via HMGcoA reductase. Other than that is has more or less the same effect as a statin. Next to cholesterol lowering effect it has a dampening effect on inflammation another important link in atherosclerosis. Bempedoic acid is cheap making it the drug of choice after statins and ezetimibe.
    MeSH term(s) Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Proprotein Convertase 9 ; Cholesterol ; Hyperlipidemias
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid (1EJ6Z6Q368) ; Cholesterol (97C5T2UQ7J)
    Language Dutch
    Publishing date 2023-11-23
    Publishing country Netherlands
    Document type English Abstract ; Journal Article
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Screening over 100 000 patients in 39 general practices in the Netherlands for anticoagulation underprescription in atrial fibrillation: a descriptive, cross-sectional study.

    Voorhout, Leonard / Pisters, Ron / Geurts, Constants H P H / Oostindjer, Andrew / van Doorn, Sander / Rila, Harrie / Fuijkschot, Wessel W / Verheugt, Freek / Hemels, Martin E W

    BMJ open

    2023  Volume 13, Issue 8, Page(s) e072655

    Abstract: Objectives: To investigate the underprescription of oral anticoagulation (OAC) in individual atrial fibrillation (AF) patients in primary care.: Setting: Screening of patient records in 39 participating general practitioners (GPs) across the ... ...

    Abstract Objectives: To investigate the underprescription of oral anticoagulation (OAC) in individual atrial fibrillation (AF) patients in primary care.
    Setting: Screening of patient records in 39 participating general practitioners (GPs) across the Netherlands.
    Participants: We screened 101 207 patient records identifying 2375 non-valvular AF patients.
    Methods: Using electronic patient files, we were able to screen the entire GP population for AF, CHA
    Results: We found a mean CHA
    Conclusions: In this large Dutch study among GPs, we observed 9.8% underprescription of OAC in AF patients. In 76% of the AF patients lacking a prescription for OAC, no documentation for deviating from the guidelines was found. Only in a minority of cases detection of OAC underprescription lead to OAC initiation.
    MeSH term(s) Female ; Male ; Humans ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Cross-Sectional Studies ; Netherlands ; General Practice ; Anticoagulants/therapeutic use
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-08-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-072655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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