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  1. Article: Kinetic studies of complex biomedical process by magnetic resonance: Cuban experiences.

    Cabal Mirabal, Carlos / Fernández García, Adolfo / Lores Guevara, Manuel / González, Evelio / Oramas Díaz, Leonardo

    Applied magnetic resonance

    2018  Volume 49, Issue 6, Page(s) 589–598

    Abstract: The potentials of the magnetic resonance (MR) methods in the research of biomedical systems have been demonstrated during the 70 years of its existence. It is presented that the Cuban experience in quantitative magnetic resonance associated with ... ...

    Abstract The potentials of the magnetic resonance (MR) methods in the research of biomedical systems have been demonstrated during the 70 years of its existence. It is presented that the Cuban experience in quantitative magnetic resonance associated with molecular, preclinical and clinical studies of significant diseases and drugs development. MR "in vitro" and "in vivo" studies of sickle cell disease, the diabetic foot ulcer, the brain tumor response and the magnetic nano-particle pharmacokinetics, are presented as example. Furthermore, contributions and restrictions of magnetic resonance to diagnostic and optimization of therapeutic pathways are discussed in some concrete cases.
    Language English
    Publishing date 2018-03-26
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 1480644-7
    ISSN 1613-7507 ; 0937-9347
    ISSN (online) 1613-7507
    ISSN 0937-9347
    DOI 10.1007/s00723-018-0985-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evidence of SARS-CoV-2 infection in postmortem lung, kidney, and liver samples, revealing cellular targets involved in COVID-19 pathogenesis.

    Falcón-Cama, Viviana / Montero-González, Teresita / Acosta-Medina, Emilio F / Guillen-Nieto, Gerardo / Berlanga-Acosta, Jorge / Fernández-Ortega, Celia / Alfonso-Falcón, Anabel / Gilva-Rodríguez, Nathalie / López-Nocedo, Lilianne / Cremata-García, Daina / Matos-Terrero, Mariuska / Pentón-Rol, Giselle / Valdés, Iris / Oramas-Díaz, Leonardo / Suarez-Batista, Anamarys / Noa-Romero, Enrique / Cruz-Sui, Otto / Sánchez, Daisy / Borrego-Díaz, Amanda I /
    Valdés-Carreras, Juan E / Vizcaino, Ananayla / Suárez-Alba, José / Valdés-Véliz, Rodolfo / Bergado, Gretchen / González, Miguel A / Hernandez, Tays / Alvarez-Arzola, Rydell / Ramírez-Suárez, Anna C / Casillas-Casanova, Dionne / Lemos-Pérez, Gilda / Blanco-Águila, Omar R / Díaz, Angelina / González, Yorexis / Bequet-Romero, Mónica / Marín-Prida, Javier / Hernández-Perera, Julio C / Del Rosario-Cruz, Leticia / Marin-Díaz, Alina P / González-Bravo, Maritza / Borrajero, Israel / Acosta-Rivero, Nelson

    Archives of virology

    2023  Volume 168, Issue 3, Page(s) 96

    Abstract: There is an urgent need to understand severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-host interactions involved in virus spread and pathogenesis, which might contribute to the identification of new therapeutic targets. In this study, we ... ...

    Abstract There is an urgent need to understand severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-host interactions involved in virus spread and pathogenesis, which might contribute to the identification of new therapeutic targets. In this study, we investigated the presence of SARS-CoV-2 in postmortem lung, kidney, and liver samples of patients who died with coronavirus disease (COVID-19) and its relationship with host factors involved in virus spread and pathogenesis, using microscopy-based methods. The cases analyzed showed advanced stages of diffuse acute alveolar damage and fibrosis. We identified the SARS-CoV-2 nucleocapsid (NC) in a variety of cells, colocalizing with mitochondrial proteins, lipid droplets (LDs), and key host proteins that have been implicated in inflammation, tissue repair, and the SARS-CoV-2 life cycle (vimentin, NLRP3, fibronectin, LC3B, DDX3X, and PPARγ), pointing to vimentin and LDs as platforms involved not only in the viral life cycle but also in inflammation and pathogenesis. SARS-CoV-2 isolated from a patient´s nasal swab was grown in cell culture and used to infect hamsters. Target cells identified in human tissue samples included lung epithelial and endothelial cells; lipogenic fibroblast-like cells (FLCs) showing features of lipofibroblasts such as activated PPARγ signaling and LDs; lung FLCs expressing fibronectin and vimentin and macrophages, both with evidence of NLRP3- and IL1β-induced responses; regulatory cells expressing immune-checkpoint proteins involved in lung repair responses and contributing to inflammatory responses in the lung; CD34
    MeSH term(s) Humans ; COVID-19/pathology ; Fibronectins ; Vimentin ; SARS-CoV-2 ; Endothelial Cells ; NLR Family, Pyrin Domain-Containing 3 Protein ; PPAR gamma ; Lung ; Inflammation/pathology ; Kidney ; Liver
    Chemical Substances Fibronectins ; Vimentin ; NLR Family, Pyrin Domain-Containing 3 Protein ; PPAR gamma
    Language English
    Publishing date 2023-02-26
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 7491-3
    ISSN 1432-8798 ; 0304-8608
    ISSN (online) 1432-8798
    ISSN 0304-8608
    DOI 10.1007/s00705-023-05711-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Evidence of SARS-CoV-2 infection in postmortem lung, kidney, and liver samples, revealing cellular targets involved in COVID-19 pathogenesis

    Falcón-Cama, Viviana / Montero-González, Teresita / Acosta-Medina, Emilio F. / Guillen-Nieto, Gerardo / Berlanga-Acosta, Jorge / Fernández-Ortega, Celia / Alfonso-Falcón, Anabel / Gilva-Rodríguez, Nathalie / López-Nocedo, Lilianne / Cremata-García, Daina / Matos-Terrero, Mariuska / Penton-Rol, Giselle / Valdés, Iris / Oramas-Díaz, Leonardo / Suarez-Batista, Anamarys / Noa-Romero, Enrique / Cruz-Sui, Otto / Sánchez, Daisy / Borrego-Díaz, Amanda I. /
    Valdés-Carreras, Juan E. / Vizcaino, Ananayla / Suárez-Alba, José / Valdés-Véliz, Rodolfo / Bergado, Gretchen / González, Miguel A. / Hernandez, Tays / Alvarez-Arzola, Rydell / Ramírez-Suárez, Anna C. / Casillas-Casanova, Dionne / Lemos-Pérez, Gilda / Blanco-Águila, Omar R. / Díaz, Angelina / González, Yorexis / Bequet-Romero, Mónica / Marín-Prida, Javier / Hernández-Perera, Julio C. / del Rosario-Cruz, Leticia / Marin-Díaz, Alina P. / González-Bravo, Maritza / Borrajero, Israel / Acosta-Rivero, Nelson

    Arch Virol. 2023 Mar., v. 168, no. 3 p.96-96

    2023  

    Abstract: There is an urgent need to understand severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-host interactions involved in virus spread and pathogenesis, which might contribute to the identification of new therapeutic targets. In this study, we ... ...

    Abstract There is an urgent need to understand severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-host interactions involved in virus spread and pathogenesis, which might contribute to the identification of new therapeutic targets. In this study, we investigated the presence of SARS-CoV-2 in postmortem lung, kidney, and liver samples of patients who died with coronavirus disease (COVID-19) and its relationship with host factors involved in virus spread and pathogenesis, using microscopy-based methods. The cases analyzed showed advanced stages of diffuse acute alveolar damage and fibrosis. We identified the SARS-CoV-2 nucleocapsid (NC) in a variety of cells, colocalizing with mitochondrial proteins, lipid droplets (LDs), and key host proteins that have been implicated in inflammation, tissue repair, and the SARS-CoV-2 life cycle (vimentin, NLRP3, fibronectin, LC3B, DDX3X, and PPARγ), pointing to vimentin and LDs as platforms involved not only in the viral life cycle but also in inflammation and pathogenesis. SARS-CoV-2 isolated from a patient´s nasal swab was grown in cell culture and used to infect hamsters. Target cells identified in human tissue samples included lung epithelial and endothelial cells; lipogenic fibroblast-like cells (FLCs) showing features of lipofibroblasts such as activated PPARγ signaling and LDs; lung FLCs expressing fibronectin and vimentin and macrophages, both with evidence of NLRP3- and IL1β-induced responses; regulatory cells expressing immune-checkpoint proteins involved in lung repair responses and contributing to inflammatory responses in the lung; CD34⁺ liver endothelial cells and hepatocytes expressing vimentin; renal interstitial cells; and the juxtaglomerular apparatus. This suggests that SARS-CoV-2 may directly interfere with critical lung, renal, and liver functions involved in COVID-19-pathogenesis.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; cell culture ; epithelium ; fibronectins ; fibrosis ; hepatocytes ; humans ; inflammation ; kidneys ; lipids ; liver ; lungs ; macrophages ; mitochondria ; nose ; nucleocapsid ; pathogenesis ; patients ; therapeutics ; tissue repair ; vimentin ; viruses
    Language English
    Dates of publication 2023-03
    Size p. 96.
    Publishing place Springer Vienna
    Document type Article ; Online
    ZDB-ID 7491-3
    ISSN 1432-8798 ; 0304-8608
    ISSN (online) 1432-8798
    ISSN 0304-8608
    DOI 10.1007/s00705-023-05711-y
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 70/128: Show issues

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  4. Article ; Online: Quantitative Studies of Diabetic Foot Ulcer Evolution Under Treatment by Digital Stereotactic Photography.

    Cabal Mirabal, Carlos Alberto / Berlanga Acosta, Jorge / Fernández Montequín, José / Oramas Díaz, Leonardo / González Dalmau, Evelio / Herrera Martínez, Luis / Sauri, José Esteban / Baldomero Hernández, Julio / Savigne Gutiérrez, Wiliam / Valdés, Jorge Luis / Tabio Reyes, Ana Ledia / Pérez Pérez, Salome Carmen / Valdés Pérez, Calixto / Armstrong, Alexandria A / Armstrong, David G

    Journal of diabetes science and technology

    2019  Volume 13, Issue 5, Page(s) 821–826

    Abstract: Background: Imaging the lower extremity reproducibly and accurately remains an elusive goal. This is particularly true in the high risk diabetic foot, where tissue loss, edema, and color changes are often concomitant. The purpose of this study was to ... ...

    Abstract Background: Imaging the lower extremity reproducibly and accurately remains an elusive goal. This is particularly true in the high risk diabetic foot, where tissue loss, edema, and color changes are often concomitant. The purpose of this study was to evaluate the reproducibility of a novel and inexpensive stereotaxic frame in assessment of wound healing.
    Methods: The main idea is to keep constant and reproducible the relative position of extremities related to the sensor used for the examination during a serial studies by stereotaxic digital photographic sequence. Ten healthy volunteers were evaluated at 10 different time moments to estimate the foot position variations in the stereotaxic frame. The evolution of 40 of DFU patients under treatment was evaluated before and during the epidemical grow factor intralesional treatment.
    Results: The wound closing and granulation speeds, the relative contribution of the contraction and tissue restauration mechanism were evaluated by stereotaxic digital photography.
    Conclusions: The results of this study suggest that the stereotaxic frame is a robust platform for serial study of the evolution of wound healing which allow to obtain consistent information from a variety of visible and hyperspectral measurement technologies. New stereotaxic digital photography evidences related to the diabetic foot ulcer healing process under treatment has been presented.
    MeSH term(s) Adult ; Diabetic Foot/diagnostic imaging ; Diagnostic Imaging/instrumentation ; Diagnostic Imaging/methods ; Female ; Humans ; Image Interpretation, Computer-Assisted/methods ; Male ; Photography/instrumentation ; Photography/methods ; Stereotaxic Techniques/instrumentation
    Language English
    Publishing date 2019-06-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-2968
    ISSN (online) 1932-2968
    DOI 10.1177/1932296819853843
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