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  1. Article: Salapoliisin työtä mikroskoopin ääressä - ihobiopsia johdatti kuppadiagnoosiin.

    Huotari-Orava, Riitta

    Duodecim; laaketieteellinen aikakauskirja

    2013  Volume 129, Issue 10, Page(s) 1103–1106

    Abstract: Skin biopsy is one of the most important diagnostic tools in dermatologic disorders. It is, however, necessary to combine histological findings with the clinical picture, and diagnosis will not necessarily be reached even from a technically successful ... ...

    Title translation Skin biopsy as a clue - case report.
    Abstract Skin biopsy is one of the most important diagnostic tools in dermatologic disorders. It is, however, necessary to combine histological findings with the clinical picture, and diagnosis will not necessarily be reached even from a technically successful biopsy without proper referral data. We describe a case in which biopsies taken from the skin rash of a febrile middle-aged man led to the correct tracks and the syphilis diagnosis was reached in collaboration with the clinician.
    MeSH term(s) Biopsy/methods ; Diagnosis, Differential ; Humans ; Male ; Middle Aged ; Syphilis, Cutaneous/diagnosis ; Syphilis, Cutaneous/pathology
    Language Finnish
    Publishing date 2013
    Publishing country Finland
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 127604-9
    ISSN 0012-7183
    ISSN 0012-7183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Melatonin immunoreactivity of epidermal skin is higher in the evening than morning but does not account for erythema sensitivity.

    Nikkola, Veera / Huotari-Orava, Riitta / Joronen, Heli / Grönroos, Mari / Kautiainen, Hannu / Ylianttila, Lasse / Snellman, Erna / Partonen, Timo

    Chronobiology international

    2022  Volume 40, Issue 2, Page(s) 132–144

    Abstract: The skin is a site of melatonin synthesis, and melatonin has a role in protecting against ultraviolet radiation-induced damage. Ultraviolet B (UVB) induced erythema seems to vary between morning and evening. We investigated whether epidermal melatonin ... ...

    Abstract The skin is a site of melatonin synthesis, and melatonin has a role in protecting against ultraviolet radiation-induced damage. Ultraviolet B (UVB) induced erythema seems to vary between morning and evening. We investigated whether epidermal melatonin immunoreactivities in the morning differed from those in the evening, and whether UVB-induced erythema was associated with these melatonin immunoreactivities in healthy volunteers. Erythema sensitivity of the skin was determined in the morning and in the evening by scoring the Minimal Erythema Dose and quantifying the erythema index (EI). We took biopsies from the non-UVB-exposed skin of healthy volunteers (n = 39) in the morning and in the evening to study melatonin immunoreactivity with immunohistochemistry (IHC). In the IHC staining, there was more melatonin immunoreactivity in the evening than in the morning (
    MeSH term(s) Humans ; Melatonin ; Ultraviolet Rays ; Circadian Rhythm ; Skin ; Erythema
    Chemical Substances Melatonin (JL5DK93RCL)
    Language English
    Publishing date 2022-12-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 998996-1
    ISSN 1525-6073 ; 0742-0528
    ISSN (online) 1525-6073
    ISSN 0742-0528
    DOI 10.1080/07420528.2022.2157733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Expression of Estrogen-Related Receptors in Localized Provoked Vulvodynia.

    Aalto, Anu / Huotari-Orava, Riitta / Luhtala, Satu / Mäenpää, Johanna / Staff, Synnöve

    BioResearch open access

    2020  Volume 9, Issue 1, Page(s) 13–21

    Abstract: Eight percent of women suffer from vulvodynia, a chronic pain condition with unknown etiology. Inflammation and dysregulation of estrogen signaling have been suggested to play a role in the pathogenesis of localized provoked vulvodynia (LPV). Therefore, ... ...

    Abstract Eight percent of women suffer from vulvodynia, a chronic pain condition with unknown etiology. Inflammation and dysregulation of estrogen signaling have been suggested to play a role in the pathogenesis of localized provoked vulvodynia (LPV). Therefore, the aim of the study was to analyze protein expression levels of estrogen-related receptors ERRα, ERRß, ERRγ, estrogen receptor (ERα), and progesterone receptor (PRα) and CD3-positive T cells in the vulvar vestibulum obtained from women suffering from LPV in comparison to healthy, unaffected controls. Vulvar vestibulum tissue specimens were obtained from LPV patients (
    Language English
    Publishing date 2020-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2662245-2
    ISSN 2164-7860 ; 2164-7844
    ISSN (online) 2164-7860
    ISSN 2164-7844
    DOI 10.1089/biores.2019.0049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reduction in ERRα is associated with lichen sclerosus and vulvar squamous cell carcinoma.

    Lagerstedt, M / Huotari-Orava, R / Nyberg, R / Mäenpää, J U / Snellman, E / Laasanen, S-L

    Gynecologic oncology

    2015  Volume 139, Issue 3, Page(s) 536–540

    Abstract: Objective: ERRs (estrogen-related receptors) regulate energy metabolism, the cell cycle and inflammatory processes in both normal and cancer cells. Chronic inflammation induced by lichen sclerosus (LS) or human papilloma virus (HPV) precedes vulvar ... ...

    Abstract Objective: ERRs (estrogen-related receptors) regulate energy metabolism, the cell cycle and inflammatory processes in both normal and cancer cells. Chronic inflammation induced by lichen sclerosus (LS) or human papilloma virus (HPV) precedes vulvar squamous cell carcinoma (vulvar SCC). We investigated the expression of ERRα, ERRβ and ERRγ in normal vulvar skin, LS as well as LS-dependent and LS-independent/HPV-related vulvar SCC.
    Methods: A total of 203 samples were analyzed for ERRα, ERRβ and ERRγ by using immunohistochemistry. These included 37 normal vulvar skin samples, 110 LS samples, 6 vulvar intraepithelial neoplasia (VIN) samples and 50 vulvar SCC samples.
    Results: A substantial reduction in or disappearance of ERRα was detected in all vulvar SCC samples. A total of 79% of childhood-onset LS and 51% of adulthood-onset LS lesions showed decreases in ERRα staining. A gradual reduction in ERRα cytoplasmic staining was observed from healthy vulvar skin to precursor lesions and further to SCC. Nuclear ERRα staining was observed in 8/33 (24%) LS-dependent and 10/17 (59%) LS-independent SCC samples.
    Conclusions: ERRα, a key regulator of cell energy metabolism, may play a role in the pathogenesis of both LS and vulvar SCC.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma in Situ/chemistry ; Carcinoma in Situ/etiology ; Carcinoma, Squamous Cell/etiology ; Carcinoma, Squamous Cell/metabolism ; Child ; Child, Preschool ; Female ; Humans ; Middle Aged ; Receptors, Estrogen/metabolism ; Skin/chemistry ; Vulva/chemistry ; Vulvar Lichen Sclerosus/complications ; Vulvar Lichen Sclerosus/metabolism ; Vulvar Neoplasms/etiology ; Vulvar Neoplasms/metabolism ; Young Adult ; ERRalpha Estrogen-Related Receptor
    Chemical Substances ESRRG protein, human ; Receptors, Estrogen ; estrogen receptor-related receptor beta
    Language English
    Publishing date 2015-10-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 801461-9
    ISSN 1095-6859 ; 0090-8258
    ISSN (online) 1095-6859
    ISSN 0090-8258
    DOI 10.1016/j.ygyno.2015.10.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Increased Incidence of Cutaneous Vasculitic Ulcers: 30-year Results from a Population-based Retrospective Study.

    Kimpimäki, Teija / Huotari-Orava, Riitta / Antonen, Jaakko / Vaalasti, Annikki

    Acta dermato-venereologica

    2017  Volume 97, Issue 5, Page(s) 653–654

    Language English
    Publishing date 2017--08
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/00015555-2608
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  6. Article ; Online: Diurnal Preference Contributes to Maximal UVB Sensitivity by the Hour of the Day in Human Skin In Vivo.

    Raita, Annina / Häggqvist, Iina-Maria / Joronen, Heli / Nikkola, Veera / Huotari-Orava, Riitta / Ylianttila, Lasse / Kautiainen, Hannu / Snellman, Erna / Pasternack, Rafael / Partonen, Timo

    The Journal of investigative dermatology

    2022  Volume 142, Issue 8, Page(s) 2289–2291.e5

    MeSH term(s) Humans ; Skin ; Ultraviolet Rays/adverse effects
    Language English
    Publishing date 2022-02-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2022.01.021
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  7. Article ; Online: Tumor cell-specific Serpin A1 expression in vulvar squamous cell carcinoma.

    Lagerstedt, Maria / Huotari-Orava, R / Nyberg, R / Nissinen, L / Farshchian, M / Laasanen, S-L / Snellman, E / Mäenpää, J U / Kähäri, V-M

    Archives of gynecology and obstetrics

    2019  Volume 299, Issue 5, Page(s) 1345–1351

    Abstract: Purpose: The two main etiological factors for vulvar squamous cell carcinoma (vSCC) are the vulvar dermatosis lichen sclerosus (LS) and high-risk human papillomavirus (hrHPV). Serpin A1 (α1-antitrypsin) is a serine protease inhibitor, which plays a role ...

    Abstract Purpose: The two main etiological factors for vulvar squamous cell carcinoma (vSCC) are the vulvar dermatosis lichen sclerosus (LS) and high-risk human papillomavirus (hrHPV). Serpin A1 (α1-antitrypsin) is a serine protease inhibitor, which plays a role in the tumorigenesis of various cancer types. The aim of the study was to evaluate the expressions of Serpin A1 in LS, premalignant vulvar lesions, and vSCC using immunohistochemistry (IHC) and serum analysis, and to compare Serpin A1 stainings to the tumor markers p53 and p16.
    Methods: In total, 120 samples from 74 patients were studied with IHC for Serpin A1, p53 and p16: 18 normal vulvar skin, 53 LS, 9 premalignant vulvar lesions (dVIN/HSIL) and 40 vSCC samples. Serum concentrations of Serpin A1 were analyzed from 30 LS, 44 vSCC and 10 control patients. Expressions were compared to clinical data.
    Results: Tumor cell-specific Serpin A1 overexpression was detected in 88% of vSCC samples, independent of the etiology. The intensity of Serpin A1 expression was significantly higher in vSCC than in healthy vulvar skin, LS, or premalignant vulvar lesions. Serpin A1 showed an association with p53 positivity. No difference in overall survival was found between Serpin A1-, p53-, or p16-positive vSCC patients. Serum concentrations of Serpin A1 were equal in the LS, vSCC, and control groups.
    Conclusion: Tumor cell-specific Serpin A1 overexpression is a potential biomarker in vSCC.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Female ; Humans ; Middle Aged ; Vulvar Neoplasms/genetics ; Vulvar Neoplasms/pathology ; alpha 1-Antitrypsin/metabolism
    Chemical Substances SERPINA1 protein, human ; alpha 1-Antitrypsin
    Language English
    Publishing date 2019-01-04
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-018-5015-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Narrow-band ultraviolet B radiation induces the expression of β-endorphin in human skin in vivo.

    Jussila, Anna / Huotari-Orava, Riitta / Ylianttila, Lasse / Partonen, Timo / Snellman, Erna

    Journal of photochemistry and photobiology. B, Biology

    2016  Volume 155, Page(s) 104–108

    Abstract: Background: Ultraviolet radiation (UVR) from the sun and solaria has addictive properties that may develop into dependence. In mice, UVR addiction was connected to β-endorphin (β-END) formed in the skin after UVR exposure. In humans, the formation of β- ... ...

    Abstract Background: Ultraviolet radiation (UVR) from the sun and solaria has addictive properties that may develop into dependence. In mice, UVR addiction was connected to β-endorphin (β-END) formed in the skin after UVR exposure. In humans, the formation of β-END in skin keratinocytes has not been confirmed in vivo.
    Objective: To determine with immunohistochemistry if sub-erythematous narrow-band UV-B (NB-UV-B) exposures stimulate p53 mediated expression of pro-opiomelanocortin (POMC), β-END and α-melanocyte stimulating hormone (α-MSH) in human skin keratinocytes in vivo.
    Methods: Within 12 healthy volunteers, 7 received a single 1 standard erythema dose (SED) of NB-UV-B on their whole body, and 5 volunteers received a cumulative dose of 3 SED delivered on two subsequent days i.e., 1+2 SED. Skin biopsies were taken immediately before the first exposure and at 24h from the last UV-B exposure to assess p53, β-END, POMC, and α-MSH expression.
    Results: Nuclear p53 expression increased in all samples taken at 24h after NB-UV-B exposure. UV-B irradiation also increased epidermal β-END expression in 11 out of 12 samples taken at 24h after UV-B exposure. The brownish staining was localized in the cytoplasm of keratinocytes and around the nuclei, being more pronounced in the basal cell layers. POMC and α-MSH staining showed no obvious meaningful increase since only one section of each showed any change compared with basal levels.
    Conclusions: Our study is the first to show that UV-B exposures increase β-END expression in epidermal keratinocytes of human skin in vivo, which could be the link to proposed UVR addiction.
    MeSH term(s) Adult ; Epidermis/metabolism ; Epidermis/pathology ; Epidermis/radiation effects ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Pro-Opiomelanocortin/metabolism ; Skin/metabolism ; Skin/pathology ; Skin/radiation effects ; Tumor Suppressor Protein p53/metabolism ; Ultraviolet Rays ; alpha-MSH/metabolism ; beta-Endorphin/metabolism
    Chemical Substances Tumor Suppressor Protein p53 ; alpha-MSH (581-05-5) ; beta-Endorphin (60617-12-1) ; Pro-Opiomelanocortin (66796-54-1)
    Language English
    Publishing date 2016-02
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 623022-2
    ISSN 1873-2682 ; 1011-1344
    ISSN (online) 1873-2682
    ISSN 1011-1344
    DOI 10.1016/j.jphotobiol.2016.01.007
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  9. Book ; Conference proceedings: Proceedings of the Conference on Physics and Experiments with Linear Colliders

    Orava, R

    : Saariselkä, Finland, 9 - 14 September 1991

    (International journal of modern physics : A. Proceedings supplements ; 1B)

    1993  

    Institution Conference on Physics and Experiments with Linear Colliders
    Event/congress Conference on Physics and Experiments with Linear Colliders (1991.09.09-14, Saariselkä) ; Linear Collider Workshop (1991.09.09-14, Saariselkä)
    Author's details ed. by R. Orava
    Series title International journal of modern physics : A. Proceedings supplements ; 1B
    Language English
    Size VII, S. 451 - 852
    Publisher World Scientific
    Publishing place Singapore u.a.
    Document type Book ; Conference proceedings
    ISBN 9810219679 ; 9789810219673
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Book ; Conference proceedings: Proceedings of the Conference on Physics and Experiments with Linear Colliders

    Orava, R

    : Saariselkä, Finland, 9 - 14 September 1991

    (International journal of modern physics : A. Proceedings supplements ; 1A)

    1993  

    Institution Conference on Physics and Experiments with Linear Colliders
    Event/congress Conference on Physics and Experiments with Linear Colliders (1991.09.09-14, Saariselkä) ; Linear Collider Workshop (1991.09.09-14, Saariselkä)
    Author's details ed. by R. Orava
    Series title International journal of modern physics : A. Proceedings supplements ; 1A
    Language English
    Size IX, 450 S
    Publisher World Scientific
    Publishing place Singapore u.a.
    Document type Book ; Conference proceedings
    ISBN 9810219660 ; 9789810219666
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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