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  1. Article: Evaluation of Lymphocyte Subgroups in Children with Glucose-6- Phosphate Dehydrogenase Deficiency.

    Orhan, Mehmet Fatih / Erkun, Olena / Özdemir, Öner / Büyükavcı, Mustafa

    Turkish archives of pediatrics

    2023  Volume 58, Issue 3, Page(s) 341–343

    Language English
    Publishing date 2023-04-05
    Publishing country Turkey
    Document type Journal Article
    ISSN 2757-6256
    ISSN 2757-6256
    DOI 10.5152/TurkArchPediatr.2023.22195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The effect of early and long-term propranolol therapy on learning and memory in mice.

    Orhan, Mehmet Fatih / Tanyeri, Pelin / Büyükokuroğlu, Mehmet Emin / Büyükavci, Mustafa

    Behavioural pharmacology

    2023  Volume 34, Issue 4, Page(s) 206–212

    Abstract: Propranolol is the treatment of choice for infantile hemangioma. We investigated the effects of long-term propranolol use in early infancy on learning and memory later in life in mice. At three weeks of age, mice were randomly divided into six ... ...

    Abstract Propranolol is the treatment of choice for infantile hemangioma. We investigated the effects of long-term propranolol use in early infancy on learning and memory later in life in mice. At three weeks of age, mice were randomly divided into six experimental groups. Groups 1 and 2 (controls) received only saline for 21 days. Groups 3 and 4 received propranolol (2.5 mg/kg) for 21 days. Groups 5 and 6 received propranolol (5 mg/kg) for 21 days. Groups 1, 3 and 5 were tested at the end of 21 days of treatment (week 6). However, groups 2, 4 and 6 received a 2-week break and then (week 8) exposed to tests. In the Morris water maze test, propranolol (2.5 and 5 mg/kg) dose-dependently increased the time spent in the target quadrant in mice at weeks 6 and 8. However, propranolol did not affect the swimming speed in both time periods. There were no significant effects of propranolol on the number of errors evaluated during the radial arm maze tests. In conclusion, long-term use of propranolol in early infancy did not disrupt the learning and memory of mice.
    MeSH term(s) Mice ; Animals ; Propranolol/pharmacology ; Memory ; Maze Learning ; Swimming
    Chemical Substances Propranolol (9Y8NXQ24VQ)
    Language English
    Publishing date 2023-05-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1027374-8
    ISSN 1473-5849 ; 0955-8810
    ISSN (online) 1473-5849
    ISSN 0955-8810
    DOI 10.1097/FBP.0000000000000725
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Major and minor subgroup profile of blood in patients receiving multiple transfusions and donors.

    Orhan, Mehmet Fatih / Adigül, Merve Pilavci / Altindiş, Mustafa / Köroğlu, Mehmet

    Asian journal of transfusion science

    2022  Volume 16, Issue 2, Page(s) 219–223

    Abstract: Objective: It was aimed to profile the blood subgroups of our region and to reveal the prevalence of auto/alloimmune sensitization in patients who had to undergo multiple erythrocyte transfusions and to establish the sensitization profile by screening ... ...

    Abstract Objective: It was aimed to profile the blood subgroups of our region and to reveal the prevalence of auto/alloimmune sensitization in patients who had to undergo multiple erythrocyte transfusions and to establish the sensitization profile by screening major and minor subgroups.
    Materials and methods: In this study, the distribution of ABO and Rh system major subgroups was studied in 100 donor blood. As the patient group, 50 patients who received three or more red blood cell transfusions were included. In addition to this group, Kell, Lewis, Duffy blood group systems were studied.
    Results: According to the ABO system, 35% of the donors were in O, 33% in A, 17% in AB, and 15% in B. According to the Rh system, 75% is Dvi positive. Rh system is 99% e positive and 33% E positive in major subgroups and Kell1 positivity is 8%. In the patient group, 22% D(-) was determined compared to Rh blood group. Among the major subgroups of Rh, C was 68%, E was 14%, c was 76%, and e positivity was found to be 100%. The Kell1 negativity rate is 96%. The highest negativity was found in 86% Lea antigen in Lewis system, in 36% S antigen in MNS system, 34% Fyb antigen in Duffy system, and 24% Jka antigen in Kidd system. When inappropriate blood is given for any antigen, a double population is formed. The double negativities we detected in our study occurred as follows according to blood group systems: E 18%, C 12%, c 8%, Cw 2%, Kell 1 2%, M 8%, N 4%, S 18%, s 6%, Fya 8%, Jka 6%, Jkb 22%. Indirect Agglutination Test (IAT) was negative in all patients.
    Conclusion: IAT negativity in all patient groups suggests that we do not develop alloimmunization, but the high rates of double population suggest a high risk of alloimmunization.
    Language English
    Publishing date 2022-11-12
    Publishing country India
    Document type Journal Article
    ZDB-ID 2267310-6
    ISSN 1998-3565 ; 0973-6247
    ISSN (online) 1998-3565
    ISSN 0973-6247
    DOI 10.4103/ajts.ajts_17_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Acquired Thrombotic Thrombocytopenic Purpura in a 5-Year-old Child With Wiskott-Aldrich Syndrome.

    Özdemir, Öner / Orhan, Mehmet Fatih / Büyükavcı, Mustafa / Görükmez, Orhan

    Journal of pediatric hematology/oncology

    2021  Volume 44, Issue 2, Page(s) e434–e437

    Abstract: Thrombocytopenia is often seen as a laboratory finding during childhood. A supposed idiopathic thrombocytopenic purpura patient who was later diagnosed as Wiskott-Aldrich syndrome (WAS) and developed acquired thrombotic thrombocytopenic purpura (aTTP). ... ...

    Abstract Thrombocytopenia is often seen as a laboratory finding during childhood. A supposed idiopathic thrombocytopenic purpura patient who was later diagnosed as Wiskott-Aldrich syndrome (WAS) and developed acquired thrombotic thrombocytopenic purpura (aTTP). Although autoimmune manifestations in WAS described, aTTP was reported just once. Five-year-old-boy was initially brought with cough, bloody stool (diarrhea), oral mucosal bleeding at 12th months of age. Following diagnosed with idiopathic thrombocytopenic purpura and receiving intravenous immunoglobulin, platelet count raised from 20,000 to 50,000/µL. One year after WAS diagnosis by mutation analysis, he presented with complaints of resistant fever, epistaxis, and melena. Hemoglobin decreased from 10 to 5.9 g/dL. Schistocytes in peripheral blood smear and high anti-ADAMTS-13 antibody level indicated development of aTTP.
    MeSH term(s) Child, Preschool ; Humans ; Male ; Platelet Count ; Purpura, Thrombocytopenic, Idiopathic/diagnosis ; Purpura, Thrombotic Thrombocytopenic/diagnosis ; Purpura, Thrombotic Thrombocytopenic/genetics ; Purpura, Thrombotic Thrombocytopenic/therapy ; Wiskott-Aldrich Syndrome/complications ; Wiskott-Aldrich Syndrome/diagnosis
    Language English
    Publishing date 2021-03-25
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/MPH.0000000000002150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: COVID-19’un Tanı ve Tedavi Sürecinde Hematolojik Parametreler ; Hematological Parameters in the Diagnosis and Treatment of COVID-19

    ORHAN, Mehmet Fatih / BÜYÜKAVCI, Mustafa

    123-127 ; 2587-1641 ; Journal of Biotechnology and Strategic Health Research

    2020  

    Abstract: COVID-19 tanısı alan hastaların tanı ve tedavi sürecinde gözlenen hematolojik parametrelerin, güncel literatür ışığında incelenmesi amaçlanmıştır. En sık yapılan test olan hemogramda görülebilecek bulgular: Lenfopeni, lökopeni/lökositoz, nötrofili, ... ...

    Abstract COVID-19 tanısı alan hastaların tanı ve tedavi sürecinde gözlenen hematolojik parametrelerin, güncel literatür ışığında incelenmesi amaçlanmıştır. En sık yapılan test olan hemogramda görülebilecek bulgular: Lenfopeni, lökopeni/lökositoz, nötrofili, monositoz, trombositopeni/trombositoz’dur. Koagülasyon parametrelerinden de PT uzunluğu, D-Dimer yüksekliği ve fibrinojen yüksekliği rapor edilen bulgulardandır. Dissemine intravasküler koagülasyon ortaya çıkma ihtimali nedeniyle de düşük molekül ağırlıklı heparin kullanımı gündeme gelmiştir. Tedavi algoritmalarında şu an kullanılmakta olan ve kullanılması olası etken maddelerin tüm hematolojik yan etkileri de özetlenmiştir. Önümüzdeki aylarda/yıllarda insanoğlunun henüz 3 aylık süredir tanıdığı bu SARS-CoV-2 virüsünün oluşturduğu hastalık hakkında bilgisi artmaya devam edecektir.
    Keywords Covid-19,SARS-CoV-2,Hematolojik Testler ; covid19
    Language Turkish
    Publishing date 2020-04-30T00:00:00Z
    Publisher Deneysel, Biyoteknolojik, Klinik ve Stratejik Sağlık Araştırmaları Derneği
    Publishing country tr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Design and Utilization of a Direct Methanol Fuel Cell.

    Ahmed, Aser Alaa / Al Labadidi, Malik / Hamada, Ahmed T / Orhan, Mehmet Fatih

    Membranes

    2022  Volume 12, Issue 12

    Abstract: This study introduces a step-by-step, summarized overview of direct methanol fuel cell (DMFC) fundamentals, thermodynamic-electrochemical principles, and system evaluation factors. In addition, a parametric investigation of a JENNY 600S DMFC is conducted ...

    Abstract This study introduces a step-by-step, summarized overview of direct methanol fuel cell (DMFC) fundamentals, thermodynamic-electrochemical principles, and system evaluation factors. In addition, a parametric investigation of a JENNY 600S DMFC is conducted to simulate cell performance behavior under varying operating conditions. The system is mathematically modeled and solved in MATLAB and accounts for multi-irreversibilities such as the activation and ohmic and concentration overpotentials. The performance of the modeled system was validated against theoretical and experimental results from the literature. The results indicated that increasing the fuel cell's operating temperature yields enhanced output cell voltages due to enhanced methanol oxidation reactions. Nevertheless, the maximum efficiency limits of the fuel cell tend to decrease with an increase in temperature. In addition, the model has also depicted that enhanced output cell voltages are associated with increased oxygen consumption, resulting in the lower exit flowrates of the reactants.
    Language English
    Publishing date 2022-12-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2614641-1
    ISSN 2077-0375
    ISSN 2077-0375
    DOI 10.3390/membranes12121266
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  7. Article: The Relationship between Soluble Angiotensin-Converting Enzyme Level and Coronavirus Disease 2019 in Children: A Prospective Cohort Study

    Melek Arsoy, Hacer Efnan / Elmas, Bahri / Tarim, Ayşe / Dervişoğlu Çavdar, Pınar / Orhan, Mehmet Fatih / Yazar, Hayrullah

    Journal of Pediatric Infectious Diseases

    2024  Volume 19, Issue 02, Page(s) 89–100

    Abstract: Objective: Our objective was to investigate soluble angiotensin-converting enzyme (sACE) levels in pediatric patients with coronavirus disease 2019 (COVID-19) and to identify factors associated with the occurrence and severity of pediatric COVID-19.: ... ...

    Abstract Objective: Our objective was to investigate soluble angiotensin-converting enzyme (sACE) levels in pediatric patients with coronavirus disease 2019 (COVID-19) and to identify factors associated with the occurrence and severity of pediatric COVID-19.
    Methods: This was a prospective cohort study conducted between April 2020 and July 2020. The study population consisted of 143 children (between 1 month and 18 years old), 103 of whom had COVID-19 and 40 of whom were negative for COVID-19 (randomly selected). The sACE levels and other laboratory data of all participants were measured at admission (day 0, baseline). Repeat measurements were performed in patients on the 5th day. Disease severity was documented at baseline and on the 5th day, and the change in severity between these time points was recorded.
    Results: Age and sex distribution were similar in the two groups. At baseline, 31 (30.1%) of the patients were asymptomatic, 58 (56.3%) had mild disease, and 14 (13.6%) had moderate disease. Baseline sACE levels were similar in the groups ( p  = 0.120). Higher weight was independently associated with low sACE levels in children ( p  = 0.037). The sACE level of patients on the 5th day was significantly lower compared with baseline ( p  = 0.007). Patients who experienced a decrease in disease severity were compared with those who did not demonstrate a decrease. Baseline sACE levels were significantly lower in those who experienced decreased severity ( p  = 0.039). Multiple linear regression revealed that COVID-19 severity at baseline was independently associated with the low sACE level at baseline ( p  = 0.023).
    Conclusion: Lower sACE at diagnosis was associated with COVID-19 severity in children. However, no strong evidence was found that could suggest the sACE level as an important predictor for the occurrence or severity of COVID-19 in children.
    Keywords children ; prospective study ; COVID-19 ; ACE ; angiotensin
    Language English
    Publishing date 2024-03-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2236947-8
    ISSN 1305-7693 ; 1305-7707 ; 1871-0336
    ISSN (online) 1305-7693
    ISSN 1305-7707 ; 1871-0336
    DOI 10.1055/s-0043-1777840
    Database Thieme publisher's database

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  8. Article ; Online: Epidural blockade for alternative management of priapism: A case report of child with T-cell acute lymphoblastic leukemia.

    Gokce, Ahmet / Gul, Deniz / Orhan, Mehmet Fatih / Büyükavci, Mustafa / Demir, Gurkan / Beyaz, Serbulent Gokhan

    Urology

    2021  Volume 156, Page(s) e121–e123

    Abstract: Priapism is a clinical condition that rarely presents with leukemia in childhood. Management of priapism treatment can become more complex and difficult when accompanied by acute leukemia. We presented a 16 years old child with t-cell acute lymphoblastic ...

    Abstract Priapism is a clinical condition that rarely presents with leukemia in childhood. Management of priapism treatment can become more complex and difficult when accompanied by acute leukemia. We presented a 16 years old child with t-cell acute lymphoblastic leukemia (ALL) who developed priapism. Due to the failure of conservative methods and intracavernosal drainage, we performed epidural blockade which has limited data reported with successful results in the literature before shunt surgery.
    MeSH term(s) Adolescent ; Anesthesia, Epidural ; Humans ; Male ; Nerve Block/methods ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/complications ; Priapism/etiology ; Priapism/therapy
    Language English
    Publishing date 2021-06-26
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2021.06.017
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  9. Article ; Online: Evaluation of taste and smell disorders in pediatric COVID-19 Cases.

    Elmas, Bahri / Çavdaroğlu, Pınar Derviʂoğlu / Orhan, Mehmet Fatih / Ay, Gizem / Caner, Ibrahim / Tarım, Ayʂe / Ateʂ, Ömer Faruk / Toptan, Hande

    Revista da Associacao Medica Brasileira (1992)

    2021  Volume 67, Issue 6, Page(s) 789–794

    Abstract: Objective: Pediatric coronavirus disease 2019 (COVID-19) cases have a high risk of contagiousness, as they usually progress with asymptomatic or mild respiratory symptoms. Disorder in taste and/or smell has rarely been reported in pediatric cases. In ... ...

    Abstract Objective: Pediatric coronavirus disease 2019 (COVID-19) cases have a high risk of contagiousness, as they usually progress with asymptomatic or mild respiratory symptoms. Disorder in taste and/or smell has rarely been reported in pediatric cases. In our study, early diagnosis and isolation measures were emphasized by evaluating the clinical, laboratory, and radiological imaging findings of pediatric COVID-19 cases presenting with symptoms of taste and/or smell disorder.
    Methods: Seven cases aged 0-18 years were included in the study. The severe acute respiratory syndrome coronavirus-2 polymerase chain reaction test was performed for the seven cases presented with taste and/or smell disorders. Clinical findings, laboratory tests, and radiological imaging of all the cases were evaluated on the day of admission and on the fifth day.
    Results: Seven (5.7%) of 122 pediatric COVID-19 cases had disorder in taste and/or smell. In two cases, pneumonia findings were detected in thorax computed tomography imaging. It was observed that all the patients fully recovered at the latest on the 21st day. In the cranial diffusion magnetic resonance imaging of a case, diffusion restriction was detected in the corpus callosum splenium.
    Conclusion: Although less common than adults, children with COVID-19 may also have taste and smell disorders, and this may be accompanied by central nervous system imaging findings.
    MeSH term(s) Adult ; COVID-19 ; Child ; Humans ; Olfaction Disorders/diagnostic imaging ; SARS-CoV-2 ; Taste ; Taste Disorders
    Language English
    Publishing date 2021-11-29
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.20200547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Pediyatrik COVID-19'da Elektrokardiyografi Değişiklikleri ve Laboratuvar Parametrelerinin Değerlendirilmesi ; Evaluation of Electrocardiographic Changes and Laboratory Parameters in Pediatric COVID-19

    DERVİŞOĞLU, Pınar / ELMAS, Bahri / ÖZDEMİR, Öner / ORHAN, Mehmet Fatih

    Volume: 10, Issue: 4 541-548 ; 2146-409X ; Sakarya Tıp Dergisi

    2020  

    Abstract: Amaç: Koronavirüs 19 hastalığının (COVID-19) kardiyak tutulumu elektrokardiyografik (EKG) değişikliklerle yansıtılabilir. Çocuklarda COVID-19 nedeniyle hastane başvurularında meydana gelebilecek EKG değişiklikleri henüz tam olarak değerlendirilmemiştir ... ...

    Abstract Amaç: Koronavirüs 19 hastalığının (COVID-19) kardiyak tutulumu elektrokardiyografik (EKG) değişikliklerle yansıtılabilir. Çocuklarda COVID-19 nedeniyle hastane başvurularında meydana gelebilecek EKG değişiklikleri henüz tam olarak değerlendirilmemiştir.Gereç ve Yöntemler: Kanıtlanmış COVID-19 tanısı ile hastaneye başvuran 83 çocuk değerlendirildi. Ayrıntılı klinik muayene, 12 derivasyonlu EKG ve laboratuvar testleri kaydedildi. Tüm laboratuvar değerleri yaşa göre değerlendirildi.Bulgular: P dalga amplitüdü çalışma popülasyonunun% 77.1'inde normal ve% 22.9'unda yüksek bulundu. P dalga amplitüdü normal olan grup ile yüksek grup arasında beyaz kan hücresi (WBC), lenfosit, nötrofil, aspartat aminotransferaz (AST), laktat dehidrojenaz (LDH), D-dimer değerlerinde anlamlı fark vardı. Hastaların % 13.3'ünde birinci derece AV blok varken % 86.7'sinde yoktu. Birinci derece AV blok olan ve olmayan gruplar arasında WBC, lenfosit, D-dimer, AST değerlerinde anlamlı fark vardı. Çalışmamızda 17 olgunun EKG'sinde sağ ventrikül hipertrofisi (RVH) vardı. RVH olan ve olmayan gruplar arasında WBC, lenfosit, D-dimer, LDH, AST değerlerinde anlamlı farklılık vardı. Ayrıca V1R, V6S, V1 R / S oranı ile WBC, lenfosit, D-dimer, kreatinin kinaz (CK), kreatinin kinaz izoform MB (CK-MB), LDH, AST değerleri arasında pozitif korelasyon saptandı.Sonuç: Patolojik EKG bulguları hastalığın seyrinde kullanılan laboratuvar değerleri ile ilişkilendirildi. EKG’nin çocuklarda COVID-19 seyrinde çok önemli bir test olduğunu ve doğru yorumlandığında klinisyenlerin hasta yönetimlerine ciddi katkılar sağlayabileceğini düşünüyoruz.

    Objective: Cardiac involvement of Coronavirus 19 disease (COVID-19) may be reflected by electrocardiographic (ECG) changes. ECG changes that may occur in hospital admission for COVID-19 in children have not yet been fully evaluated.Materials-Methods: We examined 83 children admitted to our hospital with proven COVID-19. A detailed clinical examination, 12-lead ECG and laboratory tests were recorded. And then all laboratory parameters were evaluated by age. Results: P wave amplitude was normal in 77.1% and high in 22.9% of study population. There was a significant difference in white blood cell (WBC), lymphocyte, neutrophil, aspartate aminotransferase (AST), lactate dehydrogenase (LDH), D-dimer values between the group with P wave amplitude normal and the high group. 13.3% of patients had first degree AV block and 86.7% did not. There was a significant difference between the groups in WBC, lymphocyte, D-dimer, AST values. In our study, there was right ventricular hypertrophy (RVH) in the ECG of 17 cases. There was a significant difference in WBC, lymphocyte, D-dimer, LDH, AST values between groups with and without RVH. In addition, there were positive correlations among V1R, V6S, V1 R / S ratio and WBC, lymphocyte, D-dimer, creatinine kinase (CK), creatinine kinase isoform MB (CK-MB), LDH, AST values.Conclusions: Pathological ECG findings were associated with laboratory values used in the course of the disease. We think that ECG is a test in the course of COVID-19 in children, which may make important contributions to clinicians to manage the patients when interpreted correctly.
    Keywords Çocuk,COVID-19,elektrokardiyografi ; Child,COVID-19,electrocardiography ; covid19
    Language English
    Publishing date 2020-12-15T00:00:00Z
    Publisher Sakarya Üniversitesi
    Publishing country tr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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