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Article ; Online: In Vitro

Orhan, Nilufer / Gökbulut, Alper / Deliorman Orhan, Didem

Turkish journal of pharmaceutical sciences

2021 Volume 18, Issue 2, Page(s) 204–212

Abstract: Objectives: In Turkey, the genus : Materials and methods: α-Glucosidase and α-amylase inhibitory activities, antioxidant effects, and total phenol and flavonoid contents of : Results: Among the investigated phenolic compounds, caffeic and ... ...

Abstract	Objectives: In Turkey, the genus Materials and methods: α-Glucosidase and α-amylase inhibitory activities, antioxidant effects, and total phenol and flavonoid contents of Results: Among the investigated phenolic compounds, caffeic and rosmarinic acids and rutin were determined and quantified in methanol extracts. Rutin was the major compound in the flower extract of Conclusion: Moltkia
Language	English
Publishing date	2021-04-23
Publishing country	Turkey
Document type	Journal Article
ISSN	2148-6247
ISSN (online)	2148-6247
DOI	10.4274/tjps.galenos.2020.12258
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A comparative evaluation of Juniperus species with antimicrobial magistrals.

Muftah, Hager / Ozçelik, Berrin / Oyardı, Ozlem / Kutluk, Ismet / Orhan, Nilufer

Pakistan journal of pharmaceutical sciences

2021 Volume 33, Issue 4, Page(s) 1443–1449

Abstract: The objective of this study was to evaluate the in vitro bioactivity of the active ingredient in selected antimicrobial magistral drug formulations and plant extracts used in folk medicine, comparatively. The active ingredients of magistrals such as; ... ...

Abstract	The objective of this study was to evaluate the in vitro bioactivity of the active ingredient in selected antimicrobial magistral drug formulations and plant extracts used in folk medicine, comparatively. The active ingredients of magistrals such as; boric acid, balsam of Peru, zinc oxide, Calendula tincture, thymol, resorcinol, crystal violet were used as well as fruit or leaf extracts of Juniperus excelsa (Je), J. sabina (Js), J. foetidissima (Jf), J. communis ssp. nana (Jcsn), and J. oxycedrus spp. oxycedrus ripe (Joso) to determine the antimicrobial activity against gram positive bacteria (S. pyogenes, S. aureus, S. epidermidis, E. faecalis), gram negative bacteria (K. pneumoniae, H. influenza, P. aeruginosa, A. baumannii, E. coli), and fungi (Candida. albicans, C. tropicalis, C. parapsilosis, C. krusei) by using microdilution method. The inhibition end point of the minimum inhibition concentrations (MICs) were determined as μ mL
MeSH term(s)	Anti-Infective Agents/pharmacology ; Antifungal Agents/pharmacology ; Fruit/chemistry ; Fungi/drug effects ; Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects ; Juniperus/chemistry ; Medicine, Traditional/methods ; Microbial Sensitivity Tests/methods ; Plant Extracts/chemistry ; Plant Extracts/pharmacology
Chemical Substances	Anti-Infective Agents ; Antifungal Agents ; Plant Extracts
Language	English
Publishing date	2021-02-15
Publishing country	Pakistan
Document type	Comparative Study ; Journal Article
ZDB-ID	885131-1
ISSN	1011-601X
ISSN	1011-601X
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Article: Standardization of

Gök, Hasya Nazlı / Orhan, Nilüfer / Özüpek, Burçin / Pekacar, Sultan / Selvi, Şeyma Nur / Orhan, Didem Deliorman

Iranian journal of pharmaceutical research : IJPR

2021 Volume 20, Issue 3, Page(s) 441–455

Abstract: ... ...

Abstract	Juniperus
Language	English
Publishing date	2021-10-31
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2578271-X
ISSN	1726-6890 ; 1735-0328 ; 1735-0328
ISSN (online)	1726-6890 ; 1735-0328
ISSN	1735-0328
DOI	10.22037/ijpr.2021.114838.15055
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Article: Comparative Analysis of Chemical Profile, Antioxidant,

Orhan, Nilüfer / Deliorman Orhan, Didem / Gökbulut, Alper / Aslan, Mustafa / Ergun, Fatma

Iranian journal of pharmaceutical research : IJPR

2018 Volume 16, Issue Suppl, Page(s) 64–74

Abstract: Fruit and leaves of junipers are commonly used internally as tea and pounded fruits are eaten to lower blood glucose levels in Anatolia. Thus, we aimed to evaluate antidiabetic and antioxidant potential and the chemical profile ... ...

Abstract	Fruit and leaves of junipers are commonly used internally as tea and pounded fruits are eaten to lower blood glucose levels in Anatolia. Thus, we aimed to evaluate antidiabetic and antioxidant potential and the chemical profile of
Language	English
Publishing date	2018-05-22
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2578271-X
ISSN	1726-6890 ; 1735-0328 ; 1735-0328
ISSN (online)	1726-6890 ; 1735-0328
ISSN	1735-0328
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Article: Anti-hyperglycaemic and antioxidant effects of

Orhan, Nilüfer / İçöz, Ülkü Gökçen / Altun, Levent / Aslan, Mustafa

Iranian journal of basic medical sciences

2016 Volume 19, Issue 10, Page(s) 1114–1124

Abstract: Objectives: Bidens: Materials and methods: Hypoglycaemic effects of : Results: Through : Conclusion: According to our results, ...

Abstract	Objectives: Bidens Materials and methods: Hypoglycaemic effects of Results: Through Conclusion: According to our results,
Language	English
Publishing date	2016-10-27
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2500485-2
ISSN	2008-3874 ; 2008-3866
ISSN (online)	2008-3874
ISSN	2008-3866
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Article: A bioactivity guided study on the antidiabetic activity of Juniperus oxycedrus subsp. oxycedrus L. leaves

Orhan, Nilüfer / Aslan, Mustafa / Demirci, Betül / Ergun, Fatma

Journal of ethnopharmacology. 2012 Mar. 27, v. 140, no. 2

2012

Abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Juniperus (Cupressaceae) species are widely used as folk medicine in spreading countries. Decoction of Juniperus oxycedrus subsp. oxycedrus L. leaves is used internally to lower blood glucose levels in Turkey. AIM OF THE ... ...

Abstract	ETHNOPHARMACOLOGICAL RELEVANCE: Juniperus (Cupressaceae) species are widely used as folk medicine in spreading countries. Decoction of Juniperus oxycedrus subsp. oxycedrus L. leaves is used internally to lower blood glucose levels in Turkey. AIM OF THE STUDY: To determine hypoglycaemic and antidiabetic activities of Juniperus oxycedrus subsp. oxycedrus leaves and to identify active compounds through bioactivity guided isolation technique. MATERIALS AND METHODS: Ethanol and water extracts of Juniperus oxycedrus subsp. oxycedrus (Joso), leaves on oral administration were studied using in vivo models in normal, glucose-hyperglycemic and streptozotocin-induced diabetic rats. Through in vivo bioactivity-guided fractionation processes, a nonpolar fraction was separated from the n-hexane subextract by silica gel column chromatography as the main active fraction. Subfractions of this fraction was found to possess antidiabetic activity and their chemical composition was investigated by GC-FID and GC–MS, simultaneously. RESULTS: This is the first report on the antidiabetic constituents of Joso leaves. Fatty acids, such as palmitic, linoleic and linolenic acid were found as the major compounds in subfractions. CONCLUSION: Results indicated that Joso leaf extract and its active constituents might be beneficial for diabetes mellitus.
Keywords	Juniperus oxycedrus ; blood glucose ; chemical composition ; chromatography ; diabetes mellitus ; ethanol ; fractionation ; glycemic effect ; herbal medicines ; hyperglycemia ; hypoglycemic agents ; in vivo studies ; isolation techniques ; leaf extracts ; leaves ; linoleic acid ; linolenic acid ; medicinal plants ; oral administration ; palmitic acid ; rats ; traditional medicine
Language	English
Dates of publication	2012-0327
Size	p. 409-415.
Publishing place	Elsevier Ireland Ltd
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2012.01.042
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effect of Gentiana olivieri on experimental epilepsy models.

Aslan, Mustafa / Orhan, Didem Delioman / Orhan, Nilufer

Pharmacognosy magazine

2012 Volume 7, Issue 28, Page(s) 344–349

Abstract: Background: Flowering herbs of Gentiana olivieri Griseb. (Gentianaceae) are widely used as bitter tonic, stomachic, stimulant of appetite, antipyretic, anticonvulsant, antidiabetic and for mental problems in the different regions of Turkey.: Objective! ...

Abstract	Background: Flowering herbs of Gentiana olivieri Griseb. (Gentianaceae) are widely used as bitter tonic, stomachic, stimulant of appetite, antipyretic, anticonvulsant, antidiabetic and for mental problems in the different regions of Turkey. Objective: To establish the anticonvulsant activity potential of G. olivieri. Materials and methods: In this work, the ethanol extract of G. olivieri was tested in three doses (200, 750 and 1000 mg/kg) for anticonvulsant activity against seizures produced in mice by pentylenetetrazole (PTZ), picrotoxin (PIC) and maximal electroshock (MES). Neurotoxicity of the ethanol extract was also determined by the Rota rod test to evaluate the safety. Ethosuximide (150 mg/kg), diazepam (0.5 mg/kg) and carbamazepine (30 mg/kg) were used as reference drugs. Results: Intraperitonally, injection of the extract significantly prolonged the onset of seizures at doses of 200 and 750 mg/kg, but did not alter the incidence of PTZ-induced seizures. Onset of PIC-induced seizures was delayed by the injection of the extract (1000 mg/kg). Moreover, only 750 mg/kg of the extract protected 25% of the mice against PIC-induced seizures. On the other hand, G. olivieri extract (200, 750 and 1000 mg/kg) showed a significant protective effect against MES-induced seizures. In the Rota rod test, the ethanol extract (200 mg/kg, ip) induced disturbance in motor coordination. Conclusion: The results indicate that G. olivieri has possessed anticonvulsant activity against MES-induced seizures in mice.
Language	English
Publishing date	2012-01-18
Publishing country	India
Document type	Journal Article
ZDB-ID	2274976-7
ISSN	0976-4062 ; 0973-1296
ISSN (online)	0976-4062
ISSN	0973-1296
DOI	10.4103/0973-1296.90419
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Article ; Online: A bioactivity guided study on the antidiabetic activity of Juniperus oxycedrus subsp. oxycedrus L. leaves.

Orhan, Nilüfer / Aslan, Mustafa / Demirci, Betül / Ergun, Fatma

Journal of ethnopharmacology

2012 Volume 140, Issue 2, Page(s) 409–415

Abstract: Ethnopharmacological relevance: Juniperus (Cupressaceae) species are widely used as folk medicine in spreading countries. Decoction of Juniperus oxycedrus subsp. oxycedrus L. leaves is used internally to lower blood glucose levels in Turkey.: Aim of ... ...

Abstract	Ethnopharmacological relevance: Juniperus (Cupressaceae) species are widely used as folk medicine in spreading countries. Decoction of Juniperus oxycedrus subsp. oxycedrus L. leaves is used internally to lower blood glucose levels in Turkey. Aim of the study: To determine hypoglycaemic and antidiabetic activities of Juniperus oxycedrus subsp. oxycedrus leaves and to identify active compounds through bioactivity guided isolation technique. Materials and methods: Ethanol and water extracts of Juniperus oxycedrus subsp. oxycedrus (Joso), leaves on oral administration were studied using in vivo models in normal, glucose-hyperglycemic and streptozotocin-induced diabetic rats. Through in vivo bioactivity-guided fractionation processes, a nonpolar fraction was separated from the n-hexane subextract by silica gel column chromatography as the main active fraction. Subfractions of this fraction was found to possess antidiabetic activity and their chemical composition was investigated by GC-FID and GC-MS, simultaneously. Results: This is the first report on the antidiabetic constituents of Joso leaves. Fatty acids, such as palmitic, linoleic and linolenic acid were found as the major compounds in subfractions. Conclusion: Results indicated that Joso leaf extract and its active constituents might be beneficial for diabetes mellitus.
MeSH term(s)	Animals ; Diabetes Mellitus, Experimental/drug therapy ; Fatty Acids/analysis ; Fatty Acids/pharmacology ; Fatty Acids/therapeutic use ; Hypoglycemic Agents/analysis ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Juniperus/chemistry ; Male ; Phytotherapy ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plant Leaves/chemistry ; Rats ; Rats, Wistar
Chemical Substances	Fatty Acids ; Hypoglycemic Agents ; Plant Extracts
Language	English
Publishing date	2012-03-27
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2012.01.042
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Article: Preventive treatment of calcium oxalate crystal deposition with immortal flowers

Orhan, Nilüfer / İlker Şen / İpek Işık Gönül / Metin Onaran / Mustafa Aslan

Journal of ethnopharmacology. 2015 Apr. 02, v. 163

2015

Abstract: A number of medicinal plants are used for their diuretic, urolithiatic and anti-inflammatory effects on urinary system problems in Turkey and the most common traditional remedy for kidney stones is the tea of immortal flowers. The aim of this study is to ...

Abstract	A number of medicinal plants are used for their diuretic, urolithiatic and anti-inflammatory effects on urinary system problems in Turkey and the most common traditional remedy for kidney stones is the tea of immortal flowers. The aim of this study is to evaluate the preventive effect of infusions prepared from capitulums of Helichrysum graveolens (M.Bieb.) Sweet (HG) and Helichrysum stoechas ssp. barellieri (Ten.) Nyman (HS) on formation of kidney stones.Sodium oxalate (Ox-70mg/kg intraperitoneally) was used to induce kidney stones on Wistar albino rats. At the same time, two different doses of the plant extracts (HG: 62.5 and 125mg/kg; HS: 78 and 156mg/kg) were dissolved in the drinking water and administered to animals for 5 days. Potassium citrate was used as positive control in the experiments. During the experiment, water intake, urine volume and body weights of the animals were recorded. At the end of the experiments, liver, kidney and body weights of the animals were determined; biochemical analysis were conducted on urine, blood and plasma samples. Histopathological changes in kidney tissues were examined and statistical analysis were evaluated.HS extract showed the highest preventive effect at 156mg/kg dose (stone formation score: 1.16), whereas a number of kidney stones were maximum in sodium oxalate group (stone formation score: 2.66). Helichrysum extracts decreased urine oxalate and uric acid levels and increased citrate levels significantly. In addition, Helichrysum extracts regulated the negative changes in biochemical and hematological parameters occurred after Ox injection.We conclude that Helichrysum extracts could reduce the formation and growth of kidney stones in Ox-induced urolithiasis and can be beneficial for patients with recurrent stones. In addition, this is the first study on the preventive effect of immortal flowers.
Keywords	anti-inflammatory activity ; blood ; body weight ; calcium oxalate ; citrates ; drinking water ; flowers ; Helichrysum ; hematologic tests ; histopathology ; kidneys ; liver ; medicinal plants ; patients ; plant extracts ; potassium ; rats ; renal calculi ; sodium ; statistical analysis ; tea ; tissues ; traditional medicine ; uric acid ; urine ; Turkey (country)
Language	English
Dates of publication	2015-0402
Size	p. 60-67.
Publishing place	Elsevier Ireland Ltd
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2015.01.009
Database	NAL-Catalogue (AGRICOLA)

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Article: Insights into cholinesterase inhibitory and antioxidant activities of five Juniperus species

Orhan, Nilufer / Orhan, Ilkay Erdogan / Ergun, Fatma

Food and chemical toxicology. 2011 Sept., v. 49, no. 9

2011

Abstract: In vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory and antioxidant activities of the aqueous and ethanol extracts of the leaves, ripe fruits, and unripe fruits of Juniperus communis ssp. nana, Juniperus oxycedrus ssp. ... ...

Abstract	In vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory and antioxidant activities of the aqueous and ethanol extracts of the leaves, ripe fruits, and unripe fruits of Juniperus communis ssp. nana, Juniperus oxycedrus ssp. oxycedrus, Juniperus sabina, Juniperus foetidissima, and Juniperus excelsa were investigated in the present study. Cholinesterase inhibition of the extracts was screened using ELISA microplate reader. Antioxidant activity of the extracts was tested by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and superoxide radical scavenging, ferrous ion-chelating, and ferric-reducing antioxidant power (FRAP) assays. Total phenol and flavonoid contents of the extracts were determined spectrophotometrically. The extracts had low or no inhibition towards AChE, whereas the leaf aqueous extract of J. foetidissima showed the highest BChE inhibition (93.94±0.01%). The leaf extracts usually exerted higher antioxidant activity. We herein describe the first study on anticholinesterase and antioxidant activity by the methods of ferrous ion-chelating, superoxide radical scavenging, and ferric-reducing antioxidant power (FRAP) assays of the mentioned Juniperus species.
Keywords	2,2-diphenyl-1-picrylhydrazyl ; Juniperus communis ; Juniperus excelsa ; Juniperus oxycedrus ; Juniperus sabina ; acetylcholinesterase ; antioxidant activity ; cholinesterase ; enzyme-linked immunosorbent assay ; ethanol ; flavonoids ; fruits ; leaf extracts ; leaves ; superoxide anion ; toxicology
Language	English
Dates of publication	2011-09
Size	p. 2305-2312.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2011.06.031
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