Article ; Online: In Vitro Assessment of Bacterial Adhesion and Biofilm Formation on Novel Bioactive, Biodegradable Electrospun Fiber Meshes Intended to Support Tendon Rupture Repair.
ACS applied materials & interfaces
2024 Volume 16, Issue 5, Page(s) 6348–6355
Abstract: The surgical repair of a ruptured tendon faces two major problems: specifically increased fibrous adhesion to the surrounding tissue and inferior mechanical properties of the scar tissue compared to the native tissue. Bacterial attachment to implant ... ...
| Abstract | The surgical repair of a ruptured tendon faces two major problems: specifically increased fibrous adhesion to the surrounding tissue and inferior mechanical properties of the scar tissue compared to the native tissue. Bacterial attachment to implant materials is an additional problem as it might lead to severe infections and impaired recovery. To counteract adhesion formation, two novel implant materials were fabricated by electrospinning, namely, a random fiber mesh containing hyaluronic acid (HA) and poly(ethylene oxide) (PEO) in a ratio of 1:1 (HA/PEO 1:1) and 1:4 (HA/PEO 1:4), respectively. Electrospun DegraPol (DP) treated with silver nanoparticles (DP-Ag) was developed to counteract the bacterial attachment. The three novel materials were compared to the previously described DP and DP with incorporated insulin-like growth factor-1 (DP-IGF-1), two implant materials that were also designed to improve tendon repair. To test whether the materials are prone to bacterial adhesion and biofilm formation, we assessed 10 strains of |
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| MeSH term(s) | Humans ; Bacterial Adhesion ; Silver/pharmacology ; Silver/chemistry ; Insulin-Like Growth Factor I/pharmacology ; Metal Nanoparticles/chemistry ; Tendon Injuries/surgery ; Anti-Bacterial Agents/pharmacology ; Biofilms ; Tendons |
| Chemical Substances | Silver (3M4G523W1G) ; Insulin-Like Growth Factor I (67763-96-6) ; Anti-Bacterial Agents |
| Language | English |
| Publishing date | 2024-01-30 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 1944-8252 |
| ISSN (online) | 1944-8252 |
| DOI | 10.1021/acsami.3c15710 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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